Bosentan Side Effects summary

Total Bosentan reports: 34. View

Bosentan FDA safety alerts: 2006 .

Reported deaths: 4

Reported hospitalizations: 27.

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Recently reported Bosentan Side Effects


Common Bosentan Side Effects
Alanine aminotransferase increased 24%
Aspartate aminotransferase increased 24%
Autoimmune hepatitis 18%
Fatigue 18%
International normalised ratio increased 15%
Pregnancy  What is  Pregnancy                                                                                                                                                                                               15%
Abdominal pain  What is  Abdominal pain                                                                                                                                                                                          12%
Abortion spontaneous 12%
Blood alkaline phosphatase increased 12%
Dizziness  What is  Dizziness                                                                                                                                                                                               12%
Asthenia 9%
Blood albumin decreased 9%
Blood lactate dehydrogenase increased 9%
Cholangiolitis 9%
Condition aggravated 9%
Constipation  What is  Constipation                                                                                                                                                                                            9%
Disease progression 9%
Nausea  What is  Nausea                                                                                                                                                                                                  9%
Palpitations 9%
Anaemia 6%
Blood bilirubin increased 6%
Blood creatine phosphokinase increased 6%
Chest pain  What is  Chest pain                                                                                                                                                                                              6%
Cholangitis 6%
Decreased appetite 6%
Diaphragmatic hernia 6%
Dyspnoea exertional 6%
Epstein-barr virus antibody positive 6%
Erosive duodenitis 6%
Gamma-glutamyltransferase increased 6%
Gastrointestinal haemorrhage 6%
Haematocrit decreased 6%
Haemoglobin decreased 6%
Hepatitis  What is  Hepatitis                                                                                                                                                                                               6%
Hepatitis chronic active 6%
Illogical thinking 6%
Jaundice cholestatic 6%
Liver function test abnormal 6%
Malaise 6%
Muscle spasms 6%
Platelet count decreased 6%
Pneumonia  What is  Pneumonia                                                                                                                                                                                               6%
Prothrombin time prolonged 6%
Pulmonary hypertension  What is  Pulmonary hypertension                                                                                                                                                                                  6%
Pyrexia 6%
Retroperitoneal haematoma 6%
Vomiting 6%
Weight decreased 6%

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Bosentan Side Effects Report #5211793-8
Physician from KOREA, REPUBLIC OF reported Bosentan side effect on Jan 05, 2007. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, constipation What is  constipation, fatigue, gamma-glutamyltransferase increased. Bosentan dosage: unknown. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #5245902-1
Bosentan side effect was reported by a Physician from KOREA, REPUBLIC OF on Jan 31, 2007. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: constipation What is  constipation, fatigue, hepatic steatosis, hepatitis What is  hepatitis, splenomegaly. Bosentan dosage: unknown. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #5196466-2
Health Professional from KOREA, REPUBLIC OF reported Bosentan side effect on Dec 13, 2006. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, constipation What is  constipation, fatigue. Bosentan dosage: unknown. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #5412057-X
Bosentan side effect was reported by a Physician from UNITED STATES on July 25, 2007. Female patient, child 2 years of age, weighting 27.34 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: autoimmune hepatitis, hepatitis chronic active. Bosentan dosage: 48 MG, BID, ORAL, 24 MG, BID, ORAL; 40 MG, BID, ORAL, 24 MG, BID, ORAL, 24 MG, BID, ORAL. During the same period patient was treated with SYNTHROID, LASIX. Patient recovered.




Bosentan Side Effects Report #5463787-5
Physician from UNITED STATES reported Bosentan side effect on Sept 06, 2007. Female patient, child 2 years of age, weighting 27.34 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: autoimmune hepatitis, diaphragmatic hernia, epstein-barr virus antibody positive, hepatitis chronic active. Bosentan dosage: 48 MG, BID, ORAL, 24 MG, BID, ORAL, 40 MGM BID, ORAL. During the same period patient was treated with SYNTHROID, LASIX. Patient recovered.



Bosentan Side Effects Report #5574359-6
Bosentan side effect was reported by a Physician from UNITED STATES on Dec 06, 2007. Female patient, child 2 years of age, weighting 27.34 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: autoimmune hepatitis, diaphragmatic hernia, epstein-barr virus antibody positive. Bosentan dosage: 48 MG, BID, ORAL; 24 MG, BID, ORAL; 40 MG, BID, ORAL; 24 MB, BID, ORAL; 24 MG, BID, ORAL. During the same period patient was treated with SYNTHROID, LASIX. Patient recovered.



Bosentan Side Effects Report #5763794-9
Pharmacist from UNITED STATES reported Bosentan side effect on June 04, 2008. Male patient, weighting 15.21 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, pulmonary hypertension What is  pulmonary hypertension. Bosentan dosage: 15.6 MG Q12 HOURS PO. Patient recovered.



Bosentan Side Effects Report #5778149-0
Bosentan side effect was reported by a Physician from UNITED STATES on June 03, 2008. Female patient, 57 years of age, weighting 110.0 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension, cardiac valve prosthesis user and was treated with Bosentan. After drug was administered, patient experienced the following side effects: dizziness What is  dizziness, fatigue, haematocrit decreased, haemoglobin decreased, illogical thinking, muscle spasms, palpitations. Bosentan dosage: 62.5 MG, BID, ORAL. During the same period patient was treated with COUMADIN, NEXIUM, TRIAZOLAM, FERROUS SULPHATE, REQUIP, SPIRONOLACTONE, LEVOTHYROXINE. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #5792697-9
Physician from UNITED STATES reported Bosentan side effect on June 11, 2008. Female patient, 57 years of age, weighting 110.0 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension, cardiac valve prosthesis user and was treated with Bosentan. After drug was administered, patient experienced the following side effects: anaemia, dizziness What is  dizziness, fatigue, illogical thinking, international normalised ratio increased, muscle spasms, palpitations, prothrombin time prolonged. Bosentan dosage: 62.5 MG, BID, ORAL. During the same period patient was treated with COUMADIN, ASPIRIN, NEXIUM, TRIAZOLAM, FERROUS SULPHATE, REQUIP, SPIRONOLACTONE, LEVOTHYROXINE. Patient was hospitalized. Patient recovered.




Bosentan Side Effects Report #6081439-8
Bosentan side effect was reported by a Physician from UNITED STATES on Jan 28, 2009. Female patient, 47 years of age, was diagnosed with pulmonary arterial hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: arthralgia, autoimmune hepatitis, cardiovascular disorder, chest discomfort, chest pain What is  chest pain, chronic hepatic failure, condition aggravated, dizziness What is  dizziness, dysphagia. Bosentan dosage: 125 MG, BID; 62.5 MG, BID, ORAL. During the same period patient was treated with BOSENTAN VS UNBLINED, SILDENAFIL, DIGOXIN, ALDACTONE, NEXIUM, LASIX, ULTRAM, PREDNISONE. Patient was hospitalized. Patient died on 01/15/2008.



Bosentan Side Effects Report #4559588-2
Physician from reported Bosentan side effect on Jan 13, 2005. Male patient, 63 years of age, weighting 162.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension, connective tissue disorder What is  connective tissue disorder and was treated with Bosentan. After drug was administered, patient experienced the following side effects: asthenia, nausea What is  nausea, weight decreased. Bosentan dosage: 125 + 62.5 MG, BID, ORAL. During the same period patient was treated with AZATHIOPRINE, PREDNISOLONE, OMEPRAZOLE, COLCHICINA. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4560646-7
Bosentan side effect was reported by a Health Professional from on Jan 13, 2005. Male patient, 63 years of age, weighting 162.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension, connective tissue disorder What is  connective tissue disorder and was treated with Bosentan. After drug was administered, patient experienced the following side effects: asthenia, nausea What is  nausea, weight decreased. Bosentan dosage: unknown. During the same period patient was treated with PREDNISOLONE, OMEPRAZOLE, COLCHICINA, AZATHIOPRINE. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4579179-7
Pharmacist from reported Bosentan side effect on Feb 08, 2005. Male patient, 61 years of age, weighting 242.0 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: hepatic enzyme increased. Bosentan dosage: unknown. During the same period patient was treated with PROTONIX, METOPROLOL, LEXAPRO, LIPITOR, PREDNISONE, ASPIRIN. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4586772-4
Bosentan side effect was reported by a Pharmacist from on Feb 17, 2005. Male patient, 79 years of age, weighting 200.6 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension, heart valve replacement and was treated with Bosentan. After drug was administered, patient experienced the following side effects: asthenia, decreased appetite, fluid retention, international normalised ratio increased, liver function test abnormal, malaise, pneumonia What is  pneumonia. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN NOT DOCUMENTED NOT DOCUMENTED. Patient was hospitalized. Patient recovered.




Bosentan Side Effects Report #4618525-2
Health Professional from reported Bosentan side effect on Mar 09, 2005. Female patient, 24 years of age, weighting 136.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: pregnancy What is  pregnancy, syncope vasovagal. Bosentan dosage: unknown. Patient recovered.



Bosentan Side Effects Report #4628575-8
Bosentan side effect was reported by a Health Professional from on Mar 22, 2005. Female patient, 24 years of age, weighting 136.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abortion induced, abortion spontaneous, pregnancy What is  pregnancy, uterus evacuation. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4638357-9
Health Professional from reported Bosentan side effect on Apr 05, 2005. Female patient, 24 years of age, weighting 136.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abortion spontaneous, pregnancy What is  pregnancy. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4649910-0
Bosentan side effect was reported by a Health Professional from on Apr 14, 2005. Female patient, 24 years of age, weighting 136.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abortion spontaneous, pregnancy What is  pregnancy. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4692174-2
Consumer or non-health professional from reported Bosentan side effect on June 03, 2005. Male patient, 55 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, decreased appetite, gamma-glutamyltransferase increased, hepatic function abnormal, nasopharyngitis, pyrexia. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN, LANIRAPID, MARZULENE, PROTECADIN. Patient was hospitalized. Patient recovered.




Bosentan Side Effects Report #4693817-X
Bosentan side effect was reported by a Physician from on June 08, 2005. Female patient, 39 years of age, weighting 127.9 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, body temperature decreased, chest pain What is  chest pain, dermatitis, disease progression, malaise. Bosentan dosage: unknown. During the same period patient was treated with PREDNISONE, DIPYRIDAMOLE, ENALAPRIL, FAMOTIDINE, JUVELA NICOTINATE, NIFEDIPINE. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4699439-9
Physician from reported Bosentan side effect on June 08, 2005. Female patient, 39 years of age, weighting 120.2 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, international normalised ratio decreased, menorrhagia, platelet count decreased, prothrombin time prolonged, pyrexia, red blood cell count decreased. Bosentan dosage: 62.5 MG, QD, ORAL. During the same period patient was treated with PREDNISOLONE, ENALAPRIL MALEATE, ROCALTROL, JUVELA NICOTINATE. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4758559-0
Bosentan side effect was reported by a Physician from NETHERLANDS on Aug 22, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: gastrointestinal haemorrhage, international normalised ratio increased, liver function test abnormal. Bosentan dosage: 62.5 + 125 MG, BID, ORAL SEE IMAGE. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4766525-4
Physician from NETHERLANDS reported Bosentan side effect on Aug 29, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal pain What is  abdominal pain, alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, haematemesis, international normalised ratio increased, pneumonia What is  pneumonia, retroperitoneal haematoma. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4777467-2
Bosentan side effect was reported by a Physician from UNITED KINGDOM on Sept 08, 2005. Female patient, 34 years of age, weighting 192.9 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: dizziness What is  dizziness, haematocrit increased, haemoglobin increased, nausea What is  nausea, palpitations, platelet count decreased, red blood cell count increased, ventricular extrasystoles. Bosentan dosage: unknown. During the same period patient was treated with SPIRONOLACTONE, ALBUTEROL SULPHATE HFA, BECLOMETHASONE DIPROPIONATE, ALLOPURINOL, DIGOXIN, FERROUS SULPHATE, NIFEDIPINE. Patient was hospitalized. Patient recovered.




Bosentan Side Effects Report #4777919-5
Physician from NETHERLANDS reported Bosentan side effect on Sept 05, 2005. Female patient, 23 years of age, was treated with Bosentan. After drug was administered, patient experienced the following side effects: blood albumin decreased, cholangiolitis, haematocrit decreased, haemoglobin decreased, hepatitis What is  hepatitis, international normalised ratio increased, pneumonia viral, retroperitoneal haematoma, upper gastrointestinal haemorrhage. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT, PREDNISOLONE. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4802959-7
Bosentan side effect was reported by a Physician from NETHERLANDS on Sept 29, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal pain What is  abdominal pain, autoimmune hepatitis, blood albumin decreased, blood immunoglobulin g increased, blood urine present, cholangiolitis, dilatation ventricular, erosive duodenitis, gastrointestinal haemorrhage. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4802962-7
Consumer or non-health professional from SOUTH AFRICA reported Bosentan side effect on Oct 04, 2005. Male patient, 25 years of age, weighting 147.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: condition aggravated, disease progression, pulmonary hypertension What is  pulmonary hypertension, venoocclusive disease. Bosentan dosage: 62.5 MG, BID, ORAL; 125 MG, BID, ORAL. During the same period patient was treated with WARFARIN. Patient died on 05/01/2005.



Bosentan Side Effects Report #4822732-3
Bosentan side effect was reported by a Pharmacist from UNITED STATES on Nov 07, 2005. Female patient, 20 years of age, weighting 112.4 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension, malaise, pyrexia and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal distension, aplasia pure red cell, coagulopathy, diarrhoea, dyspnoea, dyspnoea exertional, epistaxis, hepatic cirrhosis, hepatic neoplasm. Bosentan dosage: 62.5 MG BID PO. During the same period patient was treated with ACETAMINOPHEN. Patient died on 10/07/2005.



Bosentan Side Effects Report #4824740-5
Physician from NETHERLANDS reported Bosentan side effect on Oct 25, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal haematoma, abdominal pain What is  abdominal pain, ascites, autoimmune hepatitis, blood albumin decreased, blood amylase increased, blood potassium decreased, cholangiolitis, erosive duodenitis. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.




Bosentan Side Effects Report #4875777-1
Bosentan side effect was reported by a Physician from FRANCE on Dec 22, 2005. Female patient, 76 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal pain What is  abdominal pain, anaesthetic complication, blood pressure systolic decreased, cardiac failure, condition aggravated, cytolytic hepatitis, fall What is  fall, femur fracture, haemodynamic instability. Bosentan dosage: unknown. During the same period patient was treated with MORPHINE, OXYGEN, SINTROM, FUROSEMIDE, CACIT, REMEGEL. Patient was hospitalized. Patient died on 01/01/2004.



Bosentan Side Effects Report #4875778-3
Health Professional from NETHERLANDS reported Bosentan side effect on Dec 22, 2005. Female patient, 74 years of age, was diagnosed with hypertension, atrial fibrillation What is  atrial fibrillation and was treated with Bosentan. After drug was administered, patient experienced the following side effects: anaemia, arrhythmia What is  arrhythmia, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, disease progression, dyspnoea exertional, fatigue, hyponatraemia, hypothyroidism. Bosentan dosage: 125 MG, BID, ORAL. During the same period patient was treated with DICLOFENAC, ACENOCOUMAROL, KETANSERIN, MOVICOLON, PANTOPRAZOLE, PREDNISONE. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4886673-8
Bosentan side effect was reported by a Physician from ITALY on Jan 02, 2006. Female patient, 24 years of age, weighting 136.7 lb, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abortion spontaneous, pregnancy What is  pregnancy. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4913394-5
Physician from SPAIN reported Bosentan side effect on Jan 31, 2006. Female patient, 73 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension, osteoporosis What is  osteoporosis and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, cholangitis, jaundice cholestatic, wound What is  wound. Bosentan dosage: 125 MG, BID, ORAL. During the same period patient was treated with LOSARTAN POTASSIUM, ACENOCOUMAROL, RISEDRONIC ACID. Patient was hospitalized. Patient recovered.



Bosentan Side Effects Report #4924542-5
Bosentan side effect was reported by a Physician from SPAIN on Feb 08, 2006. Female patient, 73 years of age, was diagnosed with pulmonary hypertension What is  pulmonary hypertension and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, bile duct obstruction, bile duct stone, biliary dilatation, blood alkaline phosphatase increased, cholangitis, jaundice cholestatic. Bosentan dosage: 125 MG, BID, ORAL. During the same period patient was treated with LOSARTAN POTASSIUM, ACENOCOUMAROL, RISEDRONIC ACID, DOMPERIDONE, FLUOXETINE, CALCIUM, OMEPRAZOLE, HYDROCHLOROTHIAZIDE. Patient was hospitalized. Patient recovered.





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