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Cefazolin Side Effects

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Common Cefazolin Side Effects


The most commonly reported Cefazolin side effects (click to view or check a box to report):

Anaphylactic Reaction (64)
Anaphylactic Shock (49)
Blood Pressure Decreased (48)
Rash (48)
Pyrexia (43)
Erythema (41)
Hypotension (39)
Urticaria (34)
Dyspnoea (24)
Pruritus (22)
Depressed Level Of Consciousness (21)
Convulsion (20)
Headache (20)
Tachycardia (20)
Status Epilepticus (19)
Hepatic Function Abnormal (19)
Aspartate Aminotransferase Increased (18)
Alanine Aminotransferase Increased (17)
Dysarthria (16)
Loss Of Consciousness (16)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Cefazolin Side Effects Reported to FDA



Cefazolin Side Effect Report#9892679
Clostridium Difficile Infection
This is a report of a 74-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cefazolin Injection (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Clostridium Difficile Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cefazolin Injection treatment in female patients, resulting in Clostridium Difficile Infection side effect.
Cefazolin Side Effect Report#9892676
Clostridium Difficile Infection, Skin Infection, Soft Tissue Infection
This report suggests a potential Cefazolin Injection Clostridium Difficile Infection side effect(s) that can have serious consequences. A 70-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cefazolin Injection (dosage: NA) starting NS. After starting Cefazolin Injection the patient began experiencing various side effects, including: Clostridium Difficile Infection, Skin Infection, Soft Tissue InfectionAdditional drugs used concurrently: NA. Although Cefazolin Injection demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Clostridium Difficile Infection, may still occur.
Cefazolin Side Effect Report#9875987
Anaphylactic Reaction
This Anaphylactic Reaction problem was reported by a health professional from US. A 22-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: infection prophylaxis. On
Jan 24, 2014 this consumer started treatment with Cefazolin (dosage: NA). The following drugs were being taken at the same time:
  • Rocuronium
  • Succinocholine
  • Famotidine
  • Ondansetron
  • Metoclopramide
When using Cefazolin, the patient experienced the following unwanted symptoms/side effects: Anaphylactic ReactionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anaphylactic Reaction, may become evident only after a product is in use by the general population.
Cefazolin Side Effect Report#9805919
Erythema, Tachycardia, Oxygen Saturation Decreased, Airway Complication Of Anaesthesia, Erythema, Erythema, Bronchospasm
This Erythema side effect was reported by a consumer or non-health professional from AU. A 32-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cefazolin (cefazolin) (drug dosage: NA), which was initiated on
Sep 24, 2013. Concurrently used drugs:
  • Midazolam Hcl
  • Propofol (propofol)
  • Dexamethasone (dexamethasone)
  • Fentanyl Citrate
  • Rocuronium Bromide
.After starting to take Cefazolin (cefazolin) the consumer reported adverse symptoms, such as: Erythema, Tachycardia, Oxygen Saturation Decreased, Airway Complication Of Anaesthesia, Erythema, Erythema, BronchospasmThese side effects may potentially be related to Cefazolin (cefazolin). The patient was hospitalized.
Cefazolin Side Effect Report#9805374
Gait Disturbance, Tachycardia, Rectal Prolapse, Electrolyte Imbalance, Clostridium Difficile Colitis, Sepsis, Malaise, Ascites, Colitis
This is a report of a 19-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: antibiotic prophylaxis, who was treated with Cefazolin (dosage: NA, start time: NS), combined with:
  • Cefalexin (200 Mg (500 Mg,4 In 1 D))
  • Tetracycline (1000 Mg (500 Mg,2 In 1 D))
  • Morphine (morphine)
  • Dexamethasone (dexamethasone)
  • Ketorolac (ketorolac)
  • Ondansetron (ondansetron)
  • Oxycodone/acetaminophen (oxycocet)
  • Ibuprofen (ibuprofen)
and developed a serious reaction and side effect(s): Gait Disturbance, Tachycardia, Rectal Prolapse, Electrolyte Imbalance, Clostridium Difficile Colitis, Sepsis, Malaise, Ascites, Colitis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cefazolin treatment in female patients, resulting in Gait Disturbance side effect. The patient was hospitalized.
Cefazolin Side Effect Report#9735668
Clostridium Difficile Colitis, Septic Shock, Metabolic Acidosis, Renal Failure Acute, Flatulence, Bandaemia, Intestinal Ischaemia, Gastrointestinal Necrosis
This report suggests a potential Cefazolin Clostridium Difficile Colitis side effect(s) that can have serious consequences. A 78-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: prophylaxis and used Cefazolin (dosage: NA) starting NS. After starting Cefazolin the patient began experiencing various side effects, including: Clostridium Difficile Colitis, Septic Shock, Metabolic Acidosis, Renal Failure Acute, Flatulence, Bandaemia, Intestinal Ischaemia, Gastrointestinal NecrosisAdditional drugs used concurrently:
  • Methotrexate (methotrexate)
  • Prednisone (prednisone)
The patient was hospitalized. Although Cefazolin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Clostridium Difficile Colitis, may still occur.
Cefazolin Side Effect Report#9729080
Circulatory Collapse, Respiratory Arrest, Convulsion
This Death problem was reported by a health professional from CZ. A 52-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: antibiotic prophylaxis. On
Nov 25, 2013 this consumer started treatment with Cefazolin Sandoz (dosage: 1 G). The following drugs were being taken at the same time:
  • Dipidolor (1 Df)
When using Cefazolin Sandoz, the patient experienced the following unwanted symptoms/side effects: Circulatory Collapse, Respiratory Arrest, ConvulsionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Cefazolin Side Effect Report#9702712
Blood Pressure Decreased, Flushing, Heart Rate Increased, Lip Swelling, Oedema Peripheral, Swollen Tongue
This Blood Pressure Decreased side effect was reported by a health professional from CA. A 52-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cefazolin (drug dosage: Df), which was initiated on NS. Concurrently used drugs:
  • Propofol (Df)
  • Rocuronium Bromide
  • Paracetamol
  • Lactobacillus Reuteri
  • Ranitidine
  • Zopiclone
.After starting to take Cefazolin the consumer reported adverse symptoms, such as: Blood Pressure Decreased, Flushing, Heart Rate Increased, Lip Swelling, Oedema Peripheral, Swollen TongueThese side effects may potentially be related to Cefazolin. The patient was hospitalized.
Cefazolin Side Effect Report#9688607
Blood Pressure Decreased, Flushing, Heart Rate Increased, Lip Swelling, Oedema Peripheral, Swollen Tongue
This is a report of a 52-year-old female patient (weight: NA) from CA, suffering from the following health symptoms/conditions: NA, who was treated with Cefazolin (dosage: Intramuscular, start time: NS), combined with:
  • Propofol
  • Rocuronium Bromide (Intravenous (not Otherwise Indicated))
  • Acetaminophen
  • Probiotic
  • Ranitidine
  • Zopiclone
and developed a serious reaction and side effect(s): Blood Pressure Decreased, Flushing, Heart Rate Increased, Lip Swelling, Oedema Peripheral, Swollen Tongue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cefazolin treatment in female patients, resulting in Blood Pressure Decreased side effect. The patient was hospitalized.
Cefazolin Side Effect Report#9656829
Anaphylactic Reaction
This report suggests a potential Cefazolin Anaphylactic Reaction side effect(s) that can have serious consequences. A 64-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cefazolin (dosage: NA) starting
Oct 17, 2013. After starting Cefazolin the patient began experiencing various side effects, including: Anaphylactic ReactionAdditional drugs used concurrently: NA.The patient was hospitalized. Although Cefazolin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Anaphylactic Reaction, may still occur.
Cefazolin Side Effect Report#9638443
Anaphylactic Shock, Cold Sweat, Syncope, Vomiting
This Anaphylactic Shock problem was reported by a physician from IT. A 76-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: bronchitis. On
Jul 09, 2013 this consumer started treatment with Cefazolina Teva (dosage: 1 Dosage Forms Daily; Powder And Solvent For Solution For Injection). The following drugs were being taken at the same time: NA. When using Cefazolina Teva, the patient experienced the following unwanted symptoms/side effects: Anaphylactic Shock, Cold Sweat, Syncope, VomitingAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anaphylactic Shock, may become evident only after a product is in use by the general population.
Cefazolin Side Effect Report#9609447
Tachycardia, Hypotension, Ill-defined Disorder
This Tachycardia side effect was reported by a pharmacist from US. A 26-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cefazolin (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Cefazolin the consumer reported adverse symptoms, such as: Tachycardia, Hypotension, Ill-defined DisorderThese side effects may potentially be related to Cefazolin. The patient was hospitalized.
Cefazolin Side Effect Report#9565304
Abdominal Pain Upper, Retching, Vertigo, Loss Of Consciousness, Cardiac Arrest
This is a report of a 57-year-old male patient (weight: NA) from IT, suffering from the following health symptoms/conditions: prophylaxis, who was treated with Cefazolina Teva (dosage: 2 Gram Daily;, start time:
Sep 09, 2013), combined with:
  • Marcaina (.5 Milligram Daily; Hyperbaric Injectable Solution)
and developed a serious reaction and side effect(s): Abdominal Pain Upper, Retching, Vertigo, Loss Of Consciousness, Cardiac Arrest after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cefazolina Teva treatment in male patients, resulting in Abdominal Pain Upper side effect.
Cefazolin Side Effect Report#9549607
Loss Of Consciousness, Bradycardia, Pruritus
This report suggests a potential Cefazolina Teva 200 Mg Loss Of Consciousness side effect(s) that can have serious consequences. A 61-year-old male patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: antibiotic prophylaxis and used Cefazolina Teva 200 Mg (dosage: 200 Milligram Daily;) starting
Sep 09, 2013. After starting Cefazolina Teva 200 Mg the patient began experiencing various side effects, including: Loss Of Consciousness, Bradycardia, PruritusAdditional drugs used concurrently:
  • Zyloric 300 Mg (300 Milligram Daily;)
  • Lobivon (2.5 Milligram Daily;)
Although Cefazolina Teva 200 Mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Loss Of Consciousness, may still occur.
Cefazolin Side Effect Report#9531770
Pancytopenia
This Pancytopenia problem was reported by a pharmacist from US. A 44-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: arthritis bacterial. On
Apr 28, 2011 this consumer started treatment with Cefazolin (dosage: NA). The following drugs were being taken at the same time:
  • Acetaminophen
  • Benztropine
  • Calcium
  • Chlorpromazine
  • Efavirenz
  • Emtricitabine + Tenofovir
  • Hydromorphone
  • Lansoprazole
When using Cefazolin, the patient experienced the following unwanted symptoms/side effects: PancytopeniaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pancytopenia, may become evident only after a product is in use by the general population.
Cefazolin Side Effect Report#9528369
Anaphylactic Shock, Product Quality Issue
This Anaphylactic Shock side effect was reported by a health professional from PT. A 64-year-old female patient (weight:NA) experienced the following symptoms/conditions: infection prophylaxis,diagnostic procedure,lymphatic mapping.The patient was prescribed Cefazolina (drug dosage: 2 G, [total] Intravenous (not Otherwise Specified)), which was initiated on
Jan 17, 2013. Concurrently used drugs:
  • Blue Patente V
  • Blue Patente V
  • Midazolam
  • Mioflex
  • Fentanyl
  • Propofol Fresenius
  • Atracurium
  • Paracetamol
.After starting to take Cefazolina the consumer reported adverse symptoms, such as: Anaphylactic Shock, Product Quality IssueThese side effects may potentially be related to Cefazolina.
Cefazolin Side Effect Report#9527775
Anaphylactic Shock, Sinus Tachycardia, Nodal Rhythm, Metabolic Acidosis, Propofol Infusion Syndrome, Procedural Complication
This is a report of a male patient (weight: NA) from US, suffering from the following health symptoms/conditions: antibiotic prophylaxis,hypotonia, who was treated with Cefazolin (dosage: NA, start time: NS), combined with:
  • Rocuronium 50 Mg
  • Fentanyl
  • Propofol
  • Desflurane
  • Versed
and developed a serious reaction and side effect(s): Anaphylactic Shock, Sinus Tachycardia, Nodal Rhythm, Metabolic Acidosis, Propofol Infusion Syndrome, Procedural Complication after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cefazolin treatment in male patients, resulting in Anaphylactic Shock side effect.
Cefazolin Side Effect Report#9503642
Propofol Infusion Syndrome, Metabolic Acidosis, Anaphylactic Shock, Circulatory Collapse, Angioedema, Swelling, Sinus Tachycardia
This report suggests a potential Cefazolin Propofol Infusion Syndrome side effect(s) that can have serious consequences. A 50-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: antibiotic prophylaxis and used Cefazolin (dosage: 2 G, Unk) starting NS. After starting Cefazolin the patient began experiencing various side effects, including: Propofol Infusion Syndrome, Metabolic Acidosis, Anaphylactic Shock, Circulatory Collapse, Angioedema, Swelling, Sinus TachycardiaAdditional drugs used concurrently:
  • Rocuronium Bromide (50 Mg, Unk)
  • Propofol (200 Mg, Unk)
  • Fentanyl
  • Desflurane
The patient was hospitalized. Although Cefazolin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Propofol Infusion Syndrome, may still occur.
Cefazolin Side Effect Report#9487024
Tubulointerstitial Nephritis, Psoas Abscess, Renal Abscess
This Tubulointerstitial Nephritis problem was reported by a pharmacist from AU. A 74-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Apr 09, 2012 this consumer started treatment with Cefazolin (dosage: NA). The following drugs were being taken at the same time:
  • Amiodarone
  • Atorvastatin
  • Metoclopramide
  • Plavix
  • Aspirin (acetylsalicylic Acid)
  • Coversyl (perindopril Erbumine)
  • Diamicron Mr (gliclazide)
  • Insulin Glargine
When using Cefazolin, the patient experienced the following unwanted symptoms/side effects: Tubulointerstitial Nephritis, Psoas Abscess, Renal AbscessAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Tubulointerstitial Nephritis, may become evident only after a product is in use by the general population.
Cefazolin Side Effect Report#9476054
Tubulointerstitial Nephritis
This Tubulointerstitial Nephritis side effect was reported by a consumer or non-health professional from AU. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cefazolin (cefazolin) (drug dosage: NA), which was initiated on
Jun 29, 2012. Concurrently used drugs:
  • Esomeprazole
  • Flucloxacillin (flucloxacillin)
  • Paracetamol (paracetamol)
  • Vancomycin (vancomycin)
.After starting to take Cefazolin (cefazolin) the consumer reported adverse symptoms, such as: Tubulointerstitial NephritisThese side effects may potentially be related to Cefazolin (cefazolin). The patient was hospitalized.
Cefazolin Side Effect Report#9471120
Anaphylactic Reaction
This is a report of a 50-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cefazolin Injection (dosage: NA, start time: NS), combined with:
  • Suprane_desflurane 100.00 %_inhalation Vapour, Liquid_bottle, Glass (4.5% To 6.0%)
  • Fentanyl
  • Propofol
  • Rocuronium
and developed a serious reaction and side effect(s): Anaphylactic Reaction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cefazolin Injection treatment in male patients, resulting in Anaphylactic Reaction side effect.
Cefazolin Side Effect Report#9450254
Somnolence, Dyspnoea, Pyrexia, Red Man Syndrome
This report suggests a potential Cefazolin (cefazolin) Somnolence side effect(s) that can have serious consequences. A 30-year-old female patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: haemophilus infection,alpha haemolytic streptococcal infection and used Cefazolin (cefazolin) (dosage: NA) starting NS. After starting Cefazolin (cefazolin) the patient began experiencing various side effects, including: Somnolence, Dyspnoea, Pyrexia, Red Man SyndromeAdditional drugs used concurrently: NA. Although Cefazolin (cefazolin) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Somnolence, may still occur.
Cefazolin Side Effect Report#9435144
Hypersensitivity, Rash, Urticaria, Eyelid Oedema
This Hypersensitivity problem was reported by a physician from IT. A 56-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: antibiotic prophylaxis,postoperative analgesia. On
Jul 18, 2013 this consumer started treatment with Cefazolina Teva 1 G (dosage: 2 Gram Daily; Powder And Solvent Fot Injectable Solution). The following drugs were being taken at the same time:
  • Artrosilene (100 Milligram Daily; Powder And Solvent Fot Injectable Solution)
When using Cefazolina Teva 1 G, the patient experienced the following unwanted symptoms/side effects: Hypersensitivity, Rash, Urticaria, Eyelid OedemaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypersensitivity, may become evident only after a product is in use by the general population.
Cefazolin Side Effect Report#9434998
Shock, Erythema
This Shock side effect was reported by a health professional from DE. A 71-year-old male patient (weight:NA) experienced the following symptoms/conditions: antibiotic prophylaxis.The patient was prescribed Cefazolin (drug dosage: NA), which was initiated on
Jan 21, 2013. Concurrently used drugs:
  • Propofol
  • Ultiva
  • Mivacron
.After starting to take Cefazolin the consumer reported adverse symptoms, such as: Shock, ErythemaThese side effects may potentially be related to Cefazolin.
Cefazolin Side Effect Report#9434800
Body Temperature Fluctuation, Inflammatory Marker Increased, Muscle Spasms, Pain In Extremity, Agitation, Burning Sensation, Pain, Infusion Related Reaction, Heart Rate Increased
This is a report of a 13-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: staphylococcal osteomyelitis, who was treated with Cefazolin (dosage: NA, start time:
Jul 05, 2013), combined with: NA. and developed a serious reaction and side effect(s): Body Temperature Fluctuation, Inflammatory Marker Increased, Muscle Spasms, Pain In Extremity, Agitation, Burning Sensation, Pain, Infusion Related Reaction, Heart Rate Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cefazolin treatment in male patients, resulting in Body Temperature Fluctuation side effect. The patient was hospitalized.


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The appearance of Cefazolin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Cefazolin Side Effects for Women?

Women Side EffectsReports
Anaphylactic Reaction 32
Blood Pressure Decreased 29
Anaphylactic Shock 25
Pyrexia 21
Status Epilepticus 19
Erythema 17
Rash 16
Hypotension 15
Urticaria 15
Dyspnoea 14

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    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Cefazolin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Cefazolin Safety Alerts, Active Ingredients, Usage Information

    NDC0143-9665
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameCefazolin
    NameCefazolin
    Dosage FormINJECTION, POWDER, FOR SOLUTION
    RouteINTRAVENOUS
    On market since20041018
    LabelerWest-Ward Pharmaceutical Corp
    Active Ingredient(s)CEFAZOLIN SODIUM
    Strength(s)20
    Unit(s)g/1
    Pharma ClassCephalosporin Antibacterial [EPC],Cephalosporins [Chemical/Ingredient]

    Cefazolin Dosage, Warnings, Usage.

    Side Effects reported to FDA: 571

    Cefazolin safety alerts: 2006

    Reported deaths: 53

    Reported hospitalizations: 191

    Cefazolin for Injection

    Audience: Healthcare professionals and hosptal risk managers
    [Posted 03/01/2006] Hanford Pharmaceuticals and FDA notified healthcare professionals about the recall of four lots (379,975 vials) of Cefazolin for Injection, USP, 1 g/10 mL vials, an antibiotic used in a hospital environment to treat skin and skin structure, respiratory and other infections.The product was distributed by Sandoz, Inc. of Broomfield, CO and Watson Pharmaceuticals, Inc. of Corona, CA. Certain lots of the active ingredient used to manufacture the product have been shown to contain microbial contamination (Bacillus pumilus, Staphylococcus hominis, Propionibacterium acnes, or Micrococcus luteus) which may pose a serious or life-threatening risk for some patients. Hospitals, clinics, and users should stop using the affected lots immediately.

    [February 2006 ?? Press Release ?? G.C. Hanford Manufacturing Co.]

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