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Cercine Side Effects

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Common Cercine Side Effects


The most commonly reported Cercine side effects (click to view or check a box to report):

Disseminated Intravascular Coagulation (5)
Hyperthermia (3)
Convulsion (3)
Multi-organ Failure (3)
Musculoskeletal Stiffness (3)
Tonic Convulsion (3)
Pyrexia (3)
Tachycardia (3)
Neuroleptic Malignant Syndrome (3)
Arterial Therapeutic Procedure (2)
Anuria (2)
Graft Dysfunction (2)
Perinephric Collection (2)
Incisional Drainage (2)
Nephrectomy (2)
Ischaemia (1)
Klebsiella Infection (1)
Hypopnoea (1)
Hyperventilation (1)
Infusion Related Reaction (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Cercine Side Effects Reported to FDA



Cercine Side Effect Report#6338560-6
Depressed Level Of Consciousness, Hypopnoea, Therapeutic Response Prolonged
This is a report of a 80-year-old female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Cercine Injection (diazepam) (dosage: 8 Mg (8 Mg,1 In 1 D), Intravenous, start time:
May 27, 2009), combined with:
  • Opystan (pethidine Hydrochloride) (50 Mg (50 Mg, 1 In 1 D), Intravenous)
  • Dezolam (etizolam) (0.5 Mg (0.5 Mg,1 In 1 D), Per Oral)
  • Takepron 0d (lansoprazole)
  • Pravastatin Sodium
and developed a serious reaction and side effect(s): Depressed Level Of Consciousness, Hypopnoea, Therapeutic Response Prolonged after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cercine Injection (diazepam) treatment in female patients, resulting in Depressed Level Of Consciousness side effect.
Cercine Side Effect Report#6306162-3
Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion
This report suggests a potential Cercine Convulsion side effect(s) that can have serious consequences. A 82-year-old male patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: neuralgia and used Cercine (dosage: NA) starting
Nov 19, 2008. After starting Cercine the patient began experiencing various side effects, including: Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic ConvulsionAdditional drugs used concurrently:
  • Artist
  • Paxil
  • Paxil
  • Paxil
  • Serevent (Reported As Salmeterol Xinofoate Accuhaler (diskus). Serevent 50)
  • Frusemide
  • Klaricid
  • Uniphyl
The patient was hospitalized. Although Cercine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Convulsion, may still occur.
Cercine Side Effect Report#6160847-0
Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion
This Convulsion problem was reported by a pharmacist from United Kingdom. A 82-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Nov 19, 2008 this consumer started treatment with Cercine (dosage: NA). The following drugs were being taken at the same time:
  • Artist
  • Digoxin
  • Serevent
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Dogmatyl
  • Frusemide
When using Cercine, the patient experienced the following unwanted symptoms/side effects: Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic ConvulsionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Convulsion, may become evident only after a product is in use by the general population.
Cercine Side Effect Report#6148032-X
Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion
This Convulsion side effect was reported by a pharmacist from United Kingdom. A 82-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cercine (drug dosage: NA), which was initiated on
Nov 19, 2008. Concurrently used drugs:
  • Artist
  • Digoxin
  • Serevent
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Dogmatyl
  • Frusemide
.After starting to take Cercine the consumer reported adverse symptoms, such as: Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic ConvulsionThese side effects may potentially be related to Cercine. The patient was hospitalized.
Cercine Side Effect Report#5392296-7
Liver Disorder, Oculomucocutaneous Syndrome, Sepsis
This is a report of a 70-year-old male patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: convulsion prophylaxis, who was treated with Cercine (dosage: NA, start time:
Sep 25, 2006), combined with:
  • Rohypnol
  • Rohypnol
  • Rohypnol
  • Rohypnol
  • Naproxen
  • Amoban
  • Amoban
  • Amoban
and developed a serious reaction and side effect(s): Liver Disorder, Oculomucocutaneous Syndrome, Sepsis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cercine treatment in male patients, resulting in Liver Disorder side effect.
Cercine Side Effect Report#5176387-1
Abdominal Distension, Blood Pressure Increased, Chest Discomfort, Fatigue, Hyperventilation, Infusion Related Reaction
This report suggests a potential Cercine Abdominal Distension side effect(s) that can have serious consequences. A 83-year-old female patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: sedation and used Cercine (dosage: NA) starting
Oct 16, 2006. After starting Cercine the patient began experiencing various side effects, including: Abdominal Distension, Blood Pressure Increased, Chest Discomfort, Fatigue, Hyperventilation, Infusion Related ReactionAdditional drugs used concurrently:
  • Anexate Tab
  • Saline (Drip; Admixture With Midazolam)
  • Scopolamine (Sporamin)
  • Alosenn
  • Maglax
  • Ferromia
  • Sigmart
  • Miltex (As Needed. Miltax)
Although Cercine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Abdominal Distension, may still occur.
Cercine Side Effect Report#4664525-6
Anuria, Arterial Therapeutic Procedure, Decubitus Ulcer, Disseminated Intravascular Coagulation, Graft Dysfunction, Incisional Drainage, Klebsiella Infection, Nephrectomy, Perinephric Collection
This Anuria problem was reported by a physician from . A 57-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jul 26, 2004 this consumer started treatment with Cercine (dosage: NA). The following drugs were being taken at the same time:
  • Pariet
  • Bup-4
  • Malfa
  • Povidone Iodine
  • Epogin
  • Fty720 Vs Mycophenolate Mofetil
  • Neoral (140 Mg, Bid)
  • Medrol (12 Mg, Qd)
When using Cercine, the patient experienced the following unwanted symptoms/side effects: Anuria, Arterial Therapeutic Procedure, Decubitus Ulcer, Disseminated Intravascular Coagulation, Graft Dysfunction, Incisional Drainage, Klebsiella Infection, Nephrectomy, Perinephric CollectionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anuria, may become evident only after a product is in use by the general population.
Cercine Side Effect Report#4557453-8
Anuria, Arterial Therapeutic Procedure, Disseminated Intravascular Coagulation, Graft Dysfunction, Haemodialysis, Incisional Drainage, Ischaemia, Nephrectomy, Perinephric Collection
This Anuria side effect was reported by a physician from . A 57-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cercine (drug dosage: NA), which was initiated on
Jul 26, 2004. Concurrently used drugs:
  • Rabeprazole Sodium
  • Bup-4
  • Malfa
  • Povidone Iodine
  • Epogin
  • Fty720 Vs Mycophenolate Mofetil
  • Neoral (140 Mg, Bid)
  • Medrol (12 Mg, Qd)
.After starting to take Cercine the consumer reported adverse symptoms, such as: Anuria, Arterial Therapeutic Procedure, Disseminated Intravascular Coagulation, Graft Dysfunction, Haemodialysis, Incisional Drainage, Ischaemia, Nephrectomy, Perinephric CollectionThese side effects may potentially be related to Cercine. The patient was hospitalized.
Cercine Side Effect Report#4546223-2
Alanine Aminotransferase Increased, Blood Creatine Phosphokinase Increased, Gamma-glutamyltransferase Increased
This is a report of a 62-year-old male patient (weight: NA) from , suffering from the following health symptoms/conditions: convulsion, who was treated with Cercine (dosage: Route: Ij, start time:
Nov 16, 2004), combined with:
  • Dormicum (inj) (Route Reported As Injection. Dosage: 1ml/h By Continuous Infusion.)
  • Phenytoin
  • Phenytoin
and developed a serious reaction and side effect(s): Alanine Aminotransferase Increased, Blood Creatine Phosphokinase Increased, Gamma-glutamyltransferase Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cercine treatment in male patients, resulting in Alanine Aminotransferase Increased side effect. The patient was hospitalized.



The appearance of Cercine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Cercine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    More About Cercine

    Side Effects reported to FDA: 9

    Cercine safety alerts: No

    Reported deaths: 4

    Reported hospitalizations: 6

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