Common Chloraprep Side Effects


The most commonly reported Chloraprep side effects (click to view or check a box to report):

Skin Irritation (53)
Application Site Rash (27)
Anaphylactic Reaction (17)
Erythema (16)
Pruritus (15)
Application Site Erythema (13)
Procedural Complication (12)
Application Site Reaction (12)
Application Site Pruritus (12)
Blister (9)
Rash (9)
Application Site Vesicles (8)
Burns Second Degree (8)
Thermal Burn (7)
Scab (7)
Rash Papular (7)
Burns First Degree (7)
Chemical Injury (6)
Scratch (6)
Post Procedural Infection (6)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Chloraprep Side Effects Reported to FDA



Chloraprep Side Effect Report#9912997
Skin Irritation, Pruritus, Erythema, Scab, Wound Drainage, Skin Disorder, Staphylococcal Infection, Skin Discolouration
This is a report of a 38-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: preoperative care, who was treated with Chloraprep (dosage: NA, start time:
Oct 16, 2013), combined with: NA. and developed a serious reaction and side effect(s): Skin Irritation, Pruritus, Erythema, Scab, Wound Drainage, Skin Disorder, Staphylococcal Infection, Skin Discolouration after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chloraprep treatment in female patients, resulting in Skin Irritation side effect. The patient was hospitalized.
Chloraprep Side Effect Report#9858694
Thermal Burn, Procedural Complication, Accident
This report suggests a potential Chloraprep Thermal Burn side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: preoperative care and used Chloraprep (dosage: NA) starting
Dec 06, 2013. After starting Chloraprep the patient began experiencing various side effects, including: Thermal Burn, Procedural Complication, AccidentAdditional drugs used concurrently:
  • Chloraprep (2%chg/70% Ipa) With Fd+c Yellow # 6
Although Chloraprep demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Thermal Burn, may still occur.
Chloraprep Side Effect Report#9858668
Chemical Injury, Procedural Complication, Scab
This Chemical Injury problem was reported by a health professional from US. A 64-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: preoperative care. On
Jan 01, 2014 this consumer started treatment with Chloraprep (2% Chg/70% Ipa) With Fd + C Yellow# 6 (dosage: NA). The following drugs were being taken at the same time: NA. When using Chloraprep (2% Chg/70% Ipa) With Fd + C Yellow# 6, the patient experienced the following unwanted symptoms/side effects: Chemical Injury, Procedural Complication, ScabAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Chemical Injury, may become evident only after a product is in use by the general population.
Chloraprep Side Effect Report#9767821
Pruritus, Choking, Pharyngeal Oedema, Burning Sensation, Rhinorrhoea, Parosmia, Anaphylactic Reaction
This Pruritus side effect was reported by a consumer or non-health professional from US. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Chloraprep (drug dosage: NA), which was initiated on
Oct 25, 2013. Concurrently used drugs:
  • Cartia
  • Aspirin
  • Potassium
  • Magnesium
.After starting to take Chloraprep the consumer reported adverse symptoms, such as: Pruritus, Choking, Pharyngeal Oedema, Burning Sensation, Rhinorrhoea, Parosmia, Anaphylactic ReactionThese side effects may potentially be related to Chloraprep.
Chloraprep Side Effect Report#9713808
Culture Positive, Bacterial Test Positive
This is a report of a 8-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: therapeutic skin care topical,preoperative care, who was treated with Chloraprep (dosage: 10.5ml, Topical Once, start time:
Sep 27, 2013), combined with: NA. and developed a serious reaction and side effect(s): Culture Positive, Bacterial Test Positive after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chloraprep treatment in male patients, resulting in Culture Positive side effect.
Chloraprep Side Effect Report#9700425
Scratch, Application Site Reaction, Product Contamination Physical
This report suggests a potential Chloraprep Scratch side effect(s) that can have serious consequences. A 8-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Chloraprep (dosage: NA) starting NS. After starting Chloraprep the patient began experiencing various side effects, including: Scratch, Application Site Reaction, Product Contamination PhysicalAdditional drugs used concurrently: NA. Although Chloraprep demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Scratch, may still occur.
Chloraprep Side Effect Report#9700167
Anaphylactic Reaction
This Anaphylactic Reaction problem was reported by a health professional from US. A 65-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: preoperative care. On
Jun 01, 2013 this consumer started treatment with Chloraprep (dosage: NA). The following drugs were being taken at the same time:
  • Metoprolol
  • Captopril
  • Aspirin
  • Atorvastatin
  • Naproxen
When using Chloraprep, the patient experienced the following unwanted symptoms/side effects: Anaphylactic ReactionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anaphylactic Reaction, may become evident only after a product is in use by the general population.
Chloraprep Side Effect Report#9680770
Scratch, Application Site Reaction, Application Site Haemorrhage
This Scratch side effect was reported by a health professional from US. A 27-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Chloraprep (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Chloraprep the consumer reported adverse symptoms, such as: Scratch, Application Site Reaction, Application Site HaemorrhageThese side effects may potentially be related to Chloraprep.
Chloraprep Side Effect Report#9656536
Chemical Injury, Erythema, Burns First Degree
This is a report of a male patient (weight: NA) from US, suffering from the following health symptoms/conditions: therapeutic procedure, who was treated with Chloraprep W/ Tint (dosage: NA, start time:
Oct 14, 2013), combined with: NA. and developed a serious reaction and side effect(s): Chemical Injury, Erythema, Burns First Degree after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chloraprep W/ Tint treatment in male patients, resulting in Chemical Injury side effect.
Chloraprep Side Effect Report#9651136
Chemical Injury, Burns Second Degree, Erythema, Application Site Burn
This report suggests a potential Chloraprep Chemical Injury side effect(s) that can have serious consequences. A male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: central venous catheterisation,infection prophylaxis and used Chloraprep (dosage: 1 Applicator, X1, Topical) starting
Oct 14, 2013. After starting Chloraprep the patient began experiencing various side effects, including: Chemical Injury, Burns Second Degree, Erythema, Application Site BurnAdditional drugs used concurrently: NA. Although Chloraprep demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Chemical Injury, may still occur.
Chloraprep Side Effect Report#9640867
Bacterial Infection, Product Contamination Microbial, Product Quality Issue, Culture Positive
This Bacterial Infection problem was reported by a health professional from US. A 7-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: preoperative care. On
Aug 19, 2013 this consumer started treatment with Chloraprep (dosage: NA). The following drugs were being taken at the same time: NA. When using Chloraprep, the patient experienced the following unwanted symptoms/side effects: Bacterial Infection, Product Contamination Microbial, Product Quality Issue, Culture PositiveAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Bacterial Infection, may become evident only after a product is in use by the general population.
Chloraprep Side Effect Report#9639134
Bacillus Test Positive, Product Contamination
This Bacillus Test Positive side effect was reported by a health professional from US. A 8-year-old male patient (weight:NA) experienced the following symptoms/conditions: preoperative care,infection prophylaxis.The patient was prescribed Chloraprep (drug dosage: NA), which was initiated on
Sep 27, 2013. Concurrently used drugs: NA..After starting to take Chloraprep the consumer reported adverse symptoms, such as: Bacillus Test Positive, Product ContaminationThese side effects may potentially be related to Chloraprep.
Chloraprep Side Effect Report#9625675
Bacterial Infection, Device Related Infection
This is a report of a 7-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: preoperative care, who was treated with Chloraprep (dosage: Swab, Once Skin Prep, start time:
Aug 19, 2013), combined with: NA. and developed a serious reaction and side effect(s): Bacterial Infection, Device Related Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chloraprep treatment in female patients, resulting in Bacterial Infection side effect.
Chloraprep Side Effect Report#9625670
Lymphoma, Culture Positive
This report suggests a potential Chloraprep Lymphoma side effect(s) that can have serious consequences. A 22-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: preoperative care,therapeutic skin care topical and used Chloraprep (dosage: Swab, Once, Skin Prep) starting
Sep 25, 2013. After starting Chloraprep the patient began experiencing various side effects, including: Lymphoma, Culture PositiveAdditional drugs used concurrently: NA. Although Chloraprep demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Lymphoma, may still occur.
Chloraprep Side Effect Report#9625669
Lymphoma, Bacterial Infection
This Lymphoma problem was reported by a health professional from US. A 8-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: antibiotic prophylaxis. On
Sep 27, 2013 this consumer started treatment with Chloraprep (dosage: Swab, Once, Skin Prep). The following drugs were being taken at the same time: NA. When using Chloraprep, the patient experienced the following unwanted symptoms/side effects: Lymphoma, Bacterial InfectionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Lymphoma, may become evident only after a product is in use by the general population.
Chloraprep Side Effect Report#9542141
Application Site Erythema, Application Site Vesicles, Skin Exfoliation, Pruritus
This Application Site Erythema side effect was reported by a consumer or non-health professional from US. A 36-year-old female patient (weight:NA) experienced the following symptoms/conditions: surgery.The patient was prescribed Chloraprep (drug dosage: NA), which was initiated on
Sep 13, 2013. Concurrently used drugs: NA..After starting to take Chloraprep the consumer reported adverse symptoms, such as: Application Site Erythema, Application Site Vesicles, Skin Exfoliation, PruritusThese side effects may potentially be related to Chloraprep.
Chloraprep Side Effect Report#9478859
Burns First Degree, Burns Second Degree, Accident
This is a report of a 83-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: therapeutic procedure, who was treated with Chloraprep (dosage: 26ml, Once, Topical, start time:
Jun 27, 2013), combined with: NA. and developed a serious reaction and side effect(s): Burns First Degree, Burns Second Degree, Accident after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chloraprep treatment in male patients, resulting in Burns First Degree side effect.
Chloraprep Side Effect Report#9450427
Application Site Rash, Application Site Vesicles, Application Site Pruritus
This report suggests a potential Chloraprep (2%chg/70%ipa) Application Site Rash side effect(s) that can have serious consequences. A 62-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: preoperative care,therapeutic skin care topical and used Chloraprep (2%chg/70%ipa) (dosage: NA) starting NS. After starting Chloraprep (2%chg/70%ipa) the patient began experiencing various side effects, including: Application Site Rash, Application Site Vesicles, Application Site PruritusAdditional drugs used concurrently: NA. Although Chloraprep (2%chg/70%ipa) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Application Site Rash, may still occur.
Chloraprep Side Effect Report#9355831
Eye Burns, Chemical Injury, Post Procedural Complication
This Eye Burns problem was reported by a physician from IE. A 44-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: preoperative care. On
May 16, 2013 this consumer started treatment with Chloraprep (2% Chg/70%/pa) With Tint (fd+c Yellow#6) (dosage: NA). The following drugs were being taken at the same time:
  • Propofol
  • Fentanyl
  • Sevoflurane
  • Surgical Drapes
  • Corneal Protectors
When using Chloraprep (2% Chg/70%/pa) With Tint (fd+c Yellow#6), the patient experienced the following unwanted symptoms/side effects: Eye Burns, Chemical Injury, Post Procedural ComplicationThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eye Burns, may become evident only after a product is in use by the general population.
Chloraprep Side Effect Report#9333201
Anaphylactic Reaction, Dyspnoea
This Anaphylactic Reaction side effect was reported by a health professional from GB. A 81-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Chloraprep (2%chg/70946ipa) Sepp (drug dosage: NA), which was initiated on
Apr 26, 2013. Concurrently used drugs:
  • Home Oxygen-5-8l
  • Terbutaline
  • Budesonide
  • Tiotropium Bromide
  • Nicorandil
  • Monumil
  • Omeprazole
  • Simvastatin
.After starting to take Chloraprep (2%chg/70946ipa) Sepp the consumer reported adverse symptoms, such as: Anaphylactic Reaction, DyspnoeaThese side effects may potentially be related to Chloraprep (2%chg/70946ipa) Sepp.
Chloraprep Side Effect Report#9285683
Laceration, Product Packaging Issue
This is a report of a 77-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Chloraprep (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Laceration, Product Packaging Issue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chloraprep treatment in male patients, resulting in Laceration side effect.
Chloraprep Side Effect Report#9281240
Application Site Rash, Postoperative Wound Infection, Rash
This report suggests a potential Chloraprep (2% Chg/70%/pa) With Tint (fd+c Yellow#6) Application Site Rash side effect(s) that can have serious consequences. A 21-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: preoperative care and used Chloraprep (2% Chg/70%/pa) With Tint (fd+c Yellow#6) (dosage: NA) starting
Mar 21, 2013. After starting Chloraprep (2% Chg/70%/pa) With Tint (fd+c Yellow#6) the patient began experiencing various side effects, including: Application Site Rash, Postoperative Wound Infection, RashAdditional drugs used concurrently: NA. Although Chloraprep (2% Chg/70%/pa) With Tint (fd+c Yellow#6) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Application Site Rash, may still occur.
Chloraprep Side Effect Report#9207374
Application Site Pruritus, Postoperative Wound Complication
This Application Site Pruritus problem was reported by a physician from US. A 48-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: preoperative care. On
Dec 15, 2011 this consumer started treatment with Chloraprep (dosage: NA). The following drugs were being taken at the same time: NA. When using Chloraprep, the patient experienced the following unwanted symptoms/side effects: Application Site Pruritus, Postoperative Wound ComplicationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Application Site Pruritus, may become evident only after a product is in use by the general population.
Chloraprep Side Effect Report#9174389
Catheter Site Pain, Postoperative Wound Infection, Staphylococcus Test Positive, Pathogen Resistance
This Catheter Site Pain side effect was reported by a health professional from US. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: preoperative care.The patient was prescribed Chloraprep (2%chg/70%ipa) With Tint (fd+c Yellow #6) (drug dosage: NA), which was initiated on
Jan 14, 2013. Concurrently used drugs: NA..After starting to take Chloraprep (2%chg/70%ipa) With Tint (fd+c Yellow #6) the consumer reported adverse symptoms, such as: Catheter Site Pain, Postoperative Wound Infection, Staphylococcus Test Positive, Pathogen ResistanceThese side effects may potentially be related to Chloraprep (2%chg/70%ipa) With Tint (fd+c Yellow #6). The patient was hospitalized.
Chloraprep Side Effect Report#9174370
Postoperative Wound Infection, Incisional Drainage, Staphylococcus Test Positive
This is a report of a 69-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: preoperative care, who was treated with Chloraprep (dosage: NA, start time:
Dec 10, 2012), combined with: NA. and developed a serious reaction and side effect(s): Postoperative Wound Infection, Incisional Drainage, Staphylococcus Test Positive after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chloraprep treatment in male patients, resulting in Postoperative Wound Infection side effect. The patient was hospitalized.


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The appearance of Chloraprep on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Chloraprep Side Effects for Women?

Women Side Effects Reports
Skin Irritation 31
Application Site Rash 14
Pruritus 10
Anaphylactic Reaction 9
Erythema 9
Blister 7
Application Site Erythema 6
Application Site Reaction 6
Rash 6
Application Site Pruritus 5

What are common Chloraprep Side Effects for Men?

Men Side Effects Reports
Skin Irritation 21
Application Site Rash 13
Procedural Complication 9
Anaphylactic Reaction 8
Application Site Erythema 7
Application Site Pruritus 7
Burns First Degree 7
Application Site Reaction 6
Erythema 6
Chemical Injury 5

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Chloraprep reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Chloraprep Safety Alerts, Active Ingredients, Usage Information

    NDC 54365-400
    Type HUMAN OTC DRUG
    Proprietary Name ChloraPrep One-Step
    Name chlorhexidine gluconate and isopropyl alcohol
    Dosage Form SOLUTION
    Route TOPICAL
    On market since 20140723
    Labeler CareFusion 213 LLC
    Active Ingredient(s) CHLORHEXIDINE GLUCONATE; ISOPROPYL ALCOHOL
    Strength(s) 20; .7
    Unit(s) mg/mL; mL/mL
    Pharma Class

    More About Chloraprep

    Side Effects reported to FDA: 221

    Chloraprep safety alerts: No

    Reported deaths: 4

    Reported hospitalizations: 16

    Latest Chloraprep clinical trials