Common Clonidine Side Effects


The most commonly reported Clonidine side effects (click to view or check a box to report):

Blood Pressure Increased (136)
Completed Suicide (121)
Hypotension (117)
Hypertension (95)
Product Adhesion Issue (72)
Headache (68)
Product Substitution Issue (64)
Dizziness (62)
Dyspnoea (55)
Product Quality Issue (54)
Poisoning (53)
Bradycardia (52)
Death (49)
Cardiac Arrest (47)
Nausea (45)
Somnolence (43)
Dry Mouth (42)
Fatigue (41)
Anxiety (40)
Asthenia (39)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Clonidine Side Effects Reported to FDA



Clonidine Side Effect Report#9995978
Pruritus, Erythema, Scab, Hypertension, Headache, Dry Skin
This is a report of a 66-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: hypertension, who was treated with Clonidine Transdermal System (dosage: NA, start time: 201207), combined with: NA. and developed a serious reaction and side effect(s): Pruritus, Erythema, Scab, Hypertension, Headache, Dry Skin after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clonidine Transdermal System treatment in female patients, resulting in Pruritus side effect.
Clonidine Side Effect Report#9985450
Application Site Infection, Hypersensitivity, Application Site Erythema, Application Site Pruritus, Urticaria, Application Site Burn, Application Site Scar
This report suggests a potential Clonidine Application Site Infection side effect(s) that can have serious consequences. A 66-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hypertension and used Clonidine (dosage: NA) starting
Dec 21, 2013. After starting Clonidine the patient began experiencing various side effects, including: Application Site Infection, Hypersensitivity, Application Site Erythema, Application Site Pruritus, Urticaria, Application Site Burn, Application Site ScarAdditional drugs used concurrently: NA. Although Clonidine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Application Site Infection, may still occur.
Clonidine Side Effect Report#9981918
Psychomotor Hyperactivity, Abnormal Behaviour, Disturbance In Attention, Product Substitution Issue, Logorrhoea
This Psychomotor Hyperactivity problem was reported by a physician from US. A 10-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: attention deficit/hyperactivity disorder. On
Apr 14, 2013 this consumer started treatment with Clonidine (dosage: NA). The following drugs were being taken at the same time:
  • Vyvanse
When using Clonidine, the patient experienced the following unwanted symptoms/side effects: Psychomotor Hyperactivity, Abnormal Behaviour, Disturbance In Attention, Product Substitution Issue, LogorrhoeaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Psychomotor Hyperactivity, may become evident only after a product is in use by the general population.
Clonidine Side Effect Report#9940673
Rhabdomyolysis, Hyperkalaemia, Bradycardia, Electrocardiogram T Wave Peaked, Ventricular Failure
This Rhabdomyolysis side effect was reported by a health professional from Country Not Specified. A 6-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Clonidine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Sevoflurane
  • Fentanyl
  • Hydrocortisone
  • Cephazolin
.After starting to take Clonidine the consumer reported adverse symptoms, such as: Rhabdomyolysis, Hyperkalaemia, Bradycardia, Electrocardiogram T Wave Peaked, Ventricular FailureThese side effects may potentially be related to Clonidine.
Clonidine Side Effect Report#9925053
Sinus Bradycardia, Respiratory Acidosis, Hypercapnia, Suicide Attempt, Intentional Overdose
This is a report of a 28-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: suicide attempt, who was treated with Clonidine (watson Laboratories) (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Sinus Bradycardia, Respiratory Acidosis, Hypercapnia, Suicide Attempt, Intentional Overdose after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clonidine (watson Laboratories) treatment in male patients, resulting in Sinus Bradycardia side effect. The patient was hospitalized.
Clonidine Side Effect Report#9916125
Erectile Dysfunction
This report suggests a potential Clonidine (clonidine) Erectile Dysfunction side effect(s) that can have serious consequences. A 52-year-old male patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: pain and used Clonidine (clonidine) (dosage: 66 Ug/d) starting NS. After starting Clonidine (clonidine) the patient began experiencing various side effects, including: Erectile DysfunctionAdditional drugs used concurrently: NA. Although Clonidine (clonidine) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Erectile Dysfunction, may still occur.
Clonidine Side Effect Report#9912647
Syncope, Sinus Bradycardia, Ventricular Arrhythmia, Ventricular Extrasystoles, Extrasystoles, Ventricular Tachycardia, Torsade De Pointes, Electrocardiogram Qt Prolonged
This Syncope problem was reported by a consumer or non-health professional from US. A 26-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Clonidine (dosage: NA). The following drugs were being taken at the same time:
  • Cocaine
When using Clonidine, the patient experienced the following unwanted symptoms/side effects: Syncope, Sinus Bradycardia, Ventricular Arrhythmia, Ventricular Extrasystoles, Extrasystoles, Ventricular Tachycardia, Torsade De Pointes, Electrocardiogram Qt ProlongedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Syncope, may become evident only after a product is in use by the general population.
Clonidine Side Effect Report#9910485
Torsade De Pointes, Syncope, Sinus Bradycardia, Electrocardiogram Qt Prolonged, Ventricular Extrasystoles, Extrasystoles, Ventricular Tachycardia
This Torsade De Pointes side effect was reported by a health professional from Country Not Specified. A 26-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Clonidine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Methadone
  • Benzodiazepines
.After starting to take Clonidine the consumer reported adverse symptoms, such as: Torsade De Pointes, Syncope, Sinus Bradycardia, Electrocardiogram Qt Prolonged, Ventricular Extrasystoles, Extrasystoles, Ventricular TachycardiaThese side effects may potentially be related to Clonidine. The patient was hospitalized.
Clonidine Side Effect Report#9908938
Agitation, Middle Insomnia, Poor Quality Sleep, Abnormal Behaviour, Disturbance In Attention, Product Substitution Issue
This is a report of a 9-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: attention deficit/hyperactivity disorder, who was treated with Clonidine (dosage: NA, start time:
Oct 23, 2013), combined with: NA. and developed a serious reaction and side effect(s): Agitation, Middle Insomnia, Poor Quality Sleep, Abnormal Behaviour, Disturbance In Attention, Product Substitution Issue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clonidine treatment in male patients, resulting in Agitation side effect.
Clonidine Side Effect Report#9891374
Palpitations, Dyspnoea, Chest Discomfort, Hypotension, Tachycardia
This report suggests a potential Clonidine Palpitations side effect(s) that can have serious consequences. A 60-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hypertension and used Clonidine (dosage: NA) starting
Oct 23, 2013. After starting Clonidine the patient began experiencing various side effects, including: Palpitations, Dyspnoea, Chest Discomfort, Hypotension, TachycardiaAdditional drugs used concurrently: NA.The patient was hospitalized. Although Clonidine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Palpitations, may still occur.
Clonidine Side Effect Report#9884818
Product Substitution Issue
This Product Substitution Issue problem was reported by a physician from US. A 7-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: attention deficit/hyperactivity disorder. On
Dec 11, 2013 this consumer started treatment with Clonidine Hcl (dosage: NA). The following drugs were being taken at the same time: NA. When using Clonidine Hcl, the patient experienced the following unwanted symptoms/side effects: Product Substitution IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Product Substitution Issue, may become evident only after a product is in use by the general population.
Clonidine Side Effect Report#9880596
Product Substitution Issue
This Product Substitution Issue side effect was reported by a physician from US. A 7-year-old male patient (weight:NA) experienced the following symptoms/conditions: attention deficit/hyperactivity disorder.The patient was prescribed Clonidine Hcl (drug dosage: Two Po Bid), which was initiated on
Dec 11, 2013. Concurrently used drugs: NA..After starting to take Clonidine Hcl the consumer reported adverse symptoms, such as: Product Substitution IssueThese side effects may potentially be related to Clonidine Hcl.
Clonidine Side Effect Report#9880516
Poisoning, Completed Suicide
This is a report of a 50-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Clonidine (dosage: (db Oral), start time: NS), combined with:
  • Labetalol ((df Oral))
  • Lisinopril ((df Oral))
  • Zolpidem ((df Oral))
  • Iron ((df Oral))
  • Citalopram ((df Oral))
and developed a serious reaction and side effect(s): Poisoning, Completed Suicide after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clonidine treatment in female patients, resulting in Poisoning side effect.
Clonidine Side Effect Report#9880513
Poisoning, Completed Suicide
This report suggests a potential Clonidine Poisoning side effect(s) that can have serious consequences. A 53-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Clonidine (dosage: Df Oral) starting NS. After starting Clonidine the patient began experiencing various side effects, including: Poisoning, Completed SuicideAdditional drugs used concurrently:
  • Atenolol (Df Oral)
Although Clonidine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Poisoning, may still occur.
Clonidine Side Effect Report#9880490
Completed Suicide
This Completed Suicide problem was reported by a health professional from US. A 54-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Clonidine (dosage: NA). The following drugs were being taken at the same time:
  • Nifedipine
When using Clonidine, the patient experienced the following unwanted symptoms/side effects: Completed SuicideAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Completed Suicide, may become evident only after a product is in use by the general population.
Clonidine Side Effect Report#9880487
Poisoning, Completed Suicide
This Poisoning side effect was reported by a pharmacist from US. A 57-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Clonidine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Atenolol
  • Nifedipine
  • Efavirenz\emtricitabine\tenofovir Disoproxil Fumarate
  • Muscle Relaxants
  • Diphenhydramine
  • Furosemide
  • Acetaminophen
.After starting to take Clonidine the consumer reported adverse symptoms, such as: Poisoning, Completed SuicideThese side effects may potentially be related to Clonidine.
Clonidine Side Effect Report#9880482
Completed Suicide
This is a report of a 62-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Clonidine (dosage: (df Oral), start time: NS), combined with:
  • Verapamil ((df Oral))
and developed a serious reaction and side effect(s): Completed Suicide after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clonidine treatment in female patients, resulting in Completed Suicide side effect.
Clonidine Side Effect Report#9880468
Poisoning
This report suggests a potential Clonidine Poisoning side effect(s) that can have serious consequences. A 75-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Clonidine (dosage: Df) starting NS. After starting Clonidine the patient began experiencing various side effects, including: PoisoningAdditional drugs used concurrently:
  • Diltiazem (Df)
  • Labetalol (Df)
Although Clonidine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Poisoning, may still occur.
Clonidine Side Effect Report#9880422
Unresponsive To Stimuli, Aspiration, Overdose
This Unresponsive To Stimuli problem was reported by a health professional from US. A 2-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Clonidine (dosage: NA). The following drugs were being taken at the same time: NA. When using Clonidine, the patient experienced the following unwanted symptoms/side effects: Unresponsive To Stimuli, Aspiration, OverdoseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Unresponsive To Stimuli, may become evident only after a product is in use by the general population.
Clonidine Side Effect Report#9875271
Poisoning, Respiratory Arrest, Cardiac Arrest
This Poisoning side effect was reported by a pharmacist from US. A 43-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Clonidine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Oxycodone
  • Amitriptyline
  • Buspirone
  • Gabapentin
  • Metoprolol
  • Risperidone
.After starting to take Clonidine the consumer reported adverse symptoms, such as: Poisoning, Respiratory Arrest, Cardiac ArrestThese side effects may potentially be related to Clonidine.
Clonidine Side Effect Report#9875260
Respiratory Arrest, Cardiac Arrest
This is a report of a 51-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Clonidine (dosage: (df Oral), start time: NS), combined with:
  • Propofol ((df Oral))
  • Naloxone ((df Oral))
  • Buprenorphine W/naloxone ((df Oral))
and developed a serious reaction and side effect(s): Respiratory Arrest, Cardiac Arrest after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clonidine treatment in male patients, resulting in Respiratory Arrest side effect.
Clonidine Side Effect Report#9875108
Completed Suicide, Unresponsive To Stimuli, Coma, Cardiac Arrest, Status Epilepticus, Posturing, Cardiogenic Shock, Arrhythmia, Compartment Syndrome
This report suggests a potential Clonidine 0.1 Mg Completed Suicide side effect(s) that can have serious consequences. A 28-year-old patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Clonidine 0.1 Mg (dosage: NA) starting 2012. After starting Clonidine 0.1 Mg the patient began experiencing various side effects, including: Completed Suicide, Unresponsive To Stimuli, Coma, Cardiac Arrest, Status Epilepticus, Posturing, Cardiogenic Shock, Arrhythmia, Compartment SyndromeAdditional drugs used concurrently:
  • Flecainide
  • Fluoxetine
  • Clonazepam 0.5 Mg Tablet
  • Lisinopril 40 Mg Lupin Pharmace
  • Furosemide
  • Potassium Chloride
  • Cocaine
  • Ethanol
The patient was hospitalized. Although Clonidine 0.1 Mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Completed Suicide, may still occur.
Clonidine Side Effect Report#9875094
Completed Suicide
This Completed Suicide problem was reported by a pharmacist from US. A 38-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Clonidine (dosage: Df Po). The following drugs were being taken at the same time:
  • Atenolol (Df Oral)
  • Duloxetine (Df Oral)
  • Lamotrigine (Df Po)
  • Gabapentin (Df Oral)
  • Clonazepam (Df Oral)
  • Metaxalone (Df Oral)
  • Citalopram (Df Po)
  • Hydroxyzine (Df Po)
When using Clonidine, the patient experienced the following unwanted symptoms/side effects: Completed SuicideAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Completed Suicide, may become evident only after a product is in use by the general population.
Clonidine Side Effect Report#9875080
Completed Suicide, Exposure Via Ingestion
This Completed Suicide side effect was reported by a pharmacist from US. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Clonidine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Tramadol
  • Acetaminophen
  • Temazepam
  • Hydrochlorothiazide
.After starting to take Clonidine the consumer reported adverse symptoms, such as: Completed Suicide, Exposure Via IngestionThese side effects may potentially be related to Clonidine.
Clonidine Side Effect Report#9871480
Dry Mouth, Dysgeusia, Oral Discomfort, Hypoaesthesia Oral
This is a report of a 77-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: hypertension, who was treated with Clonidine (dosage: NA, start time: NS), combined with:
  • Armoua
  • Thyroid
  • Felodipine
  • Lasix
  • Coreg
  • Losactine
  • Vit D
and developed a serious reaction and side effect(s): Dry Mouth, Dysgeusia, Oral Discomfort, Hypoaesthesia Oral after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clonidine treatment in female patients, resulting in Dry Mouth side effect.


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The appearance of Clonidine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Clonidine Side Effects for Women?

Women Side Effects Reports
Blood Pressure Increased 93
Hypotension 55
Headache 53
Hypertension 52
Completed Suicide 51
Product Adhesion Issue 44
Dizziness 37
Dyspnoea 33
Product Substitution Issue 32
Nausea 29

What are common Clonidine Side Effects for Men?

Men Side Effects Reports
Hypotension 61
Blood Pressure Increased 43
Hypertension 43
Completed Suicide 42
Bradycardia 35
Product Quality Issue 32
Product Substitution Issue 32
Agitation 29
Product Adhesion Issue 27
Dizziness 25

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Clonidine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    How Effective is Clonidine for You?

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    Clonidine Safety Alerts, Active Ingredients, Usage Information

    NDC 0115-9611
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name Clonidine Hydrochloride
    Name Clonidine Hydrochloride
    Dosage Form TABLET
    Route ORAL
    On market since 20091201
    Labeler Global Pharmaceuticals, Division of Impax Laboratories Inc.
    Active Ingredient(s) CLONIDINE HYDROCHLORIDE
    Strength(s) 0.1
    Unit(s) mg/1
    Pharma Class Adrenergic alpha2-Agonists [MoA],Central alpha-2 Adrenergic Agonist [EPC]

    More About Clonidine

    Side Effects reported to FDA: 1407

    Clonidine safety alerts: No

    Reported deaths: 219

    Reported hospitalizations: 387

    Latest Clonidine clinical trials

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