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Clotiazepam Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Pyrexia, Rash, Depression, Constipation, Anaemia, White Blood Cell Count Decreased, Hyperglycaemia (8450446-X)
on Jun 12, 2012 Male from JAPAN , weighting 165.3 lb, was treated with Clotiazepam. Directly after, patient experienced the unwanted or unexpected Clotiazepam side effects: pyrexia, rash, depression, constipation, anaemia, white blood cell count decreased, hyperglycaemia. Clotiazepam dosage: 15 Mg, Uid/qd.
Associated medications used:
  • Loxoprofen /00890702/ (60-120 Mg / Day)
  • Lansoprazole (15 Mg, Uid/qd)
  • Granisetron Hydrochloride (1 Mg, Uid/qd)
  • Erlotinib Hydrochloride (100 Mg, Uid/qd)
  • Gemcitabine (1000 Mg/m2, Uid/qd)
  • Gemcitabine (1000 Mg/m2, Uid/qd)
  • Gemcitabine (1000 Mg/m2, Uid/qd)
  • Loxoprofen /00890702/ (180 Mg, Uid/qd)
Patient was hospitalized.

Incorrect Dose Administered, Electrocardiogram Qt Prolonged (8173728-8)
Patient was taking Clotiazepam. Patient felt the following Clotiazepam side effects: incorrect dose administered, electrocardiogram qt prolonged on Feb 13, 2012 from JAPAN Additional patient health information: Male , 71 years of age, . Clotiazepam dosage: N/A.
Multiple prescriptions taken:
  • Phenobarbital Tab
  • Sertraline Hydrochloride
  • Amiodarone Hcl (11.4 Gm;x1;po; 4gm;x1;po)


Angle Closure Glaucoma (7714911-2)
Adverse event was reported on Aug 23, 2011 by a Female taking Clotiazepam (Dosage: N/A) was diagnosed with
  • depression
and. Location: UNITED KINGDOM , 71 years of age, After Clotiazepam was administered, patient encountered several Clotiazepam side effects: angle closure glaucoma.
Multiple concurrent drugs taken:
  • Alprazolam (Unk)
  • Maprotiline (Unk)


Suicide Attempt (7555822-5)
on Jun 14, 2011 Female from JAPAN , 26 years of age, weighting 99.21 lb, was diagnosed with
  • depression
and was treated with Clotiazepam. Directly after, patient experienced the unwanted or unexpected Clotiazepam side effects: suicide attempt. Clotiazepam dosage: Daily Dose 5 Mg.
Associated medications used:
  • Paxil
  • Zoloft
  • Sepazon (Daily Dose 2 Mg)
  • Diazepam (Daily Dose 5 Mg)
  • Ajireru
  • Yaz (1 Df, Once)
  • Amoxapine (Daily Dose 25 Mg)
  • Lorazepam



Back Pain, Cardiac Failure, Headache, Dyspnoea, Restless Legs Syndrome, Arthralgia, Delirium (7526052-8)
on May 25, 2011 Female from JAPAN , weighting 63.93 lb, was treated with Clotiazepam. Patient felt the following Clotiazepam side effects: back pain, cardiac failure, headache, dyspnoea, restless legs syndrome, arthralgia, delirium. Clotiazepam dosage: N/A.
Multiple prescriptions taken:
  • Theophylline
  • Tracleer (31.25 Mg, Bid)
  • Tracleer (31.25 Mg, Bid)
  • Ambroxol Hydrochloride
  • Antibiotics-resistant Lactic Acid Bacteriae
  • Salbutamol Sulfate
  • Diflucortolone Valerate
  • Tiquizium Bromide


Hepatic Function Abnormal (7279142-1)
Patient was taking Clotiazepam. After Clotiazepam was administered, patient encountered several Clotiazepam side effects: hepatic function abnormal on Feb 04, 2011 from JAPAN Additional patient health information: Male , 68 years of age, . Clotiazepam dosage: N/A.
Multiple concurrent drugs taken:
  • Fenofibrate
  • Bisoprolol Fumarate
  • Nizatidine
  • Octotiamine
  • Silodosin


Altered State Of Consciousness, Convulsion, Overdose, Vocal Cord Paralysis (6817674-8)
Adverse event was reported on Jun 24, 2010 by a Female taking Clotiazepam (Dosage: 100 Mg, Single) was diagnosed with
  • intentional self-injury
  • depression
and. Location: JAPAN , 16 years of age, Directly after, patient experienced the unwanted or unexpected Clotiazepam side effects: altered state of consciousness, convulsion, overdose, vocal cord paralysis.
Associated medications used:
  • Solanax (Unk)
  • Diphenhydramine Hydrochloride (120 Df, Single)
Patient was hospitalized.

Altered State Of Consciousness, Convulsion, Overdose (6810503-8)
on Jun 18, 2010 Female from JAPAN , 16 years of age, was diagnosed with
  • intentional self-injury
and was treated with Clotiazepam. Patient felt the following Clotiazepam side effects: altered state of consciousness, convulsion, overdose. Clotiazepam dosage: 100 Mg, Single.
Multiple prescriptions taken:
  • Solanax (Unk)
  • Diphenhydramine Hydrochloride (120 Df, Single)
Patient was hospitalized.

Eye Rolling, Fall, Hypotension, Loss Of Consciousness, Transient Ischaemic Attack (4651061-6)
on Mar 23, 2005 Female from , 76 years of age, weighting 92.59 lb, was diagnosed with
  • autonomic nervous system imbalance
and was treated with Clotiazepam. After Clotiazepam was administered, patient encountered several Clotiazepam side effects: eye rolling, fall, hypotension, loss of consciousness, transient ischaemic attack. Clotiazepam dosage: 10 Mg, Unk.
Multiple concurrent drugs taken:
  • Diovan (80 Mg, Qd)


Blood Pressure Systolic Decreased, Eye Rolling, Fall, Loss Of Consciousness, Transient Ischaemic Attack (4641448-X)
Patient was taking Clotiazepam. Directly after, patient experienced the unwanted or unexpected Clotiazepam side effects: blood pressure systolic decreased, eye rolling, fall, loss of consciousness, transient ischaemic attack on Mar 23, 2005 from Additional patient health information: Female , 76 years of age, weighting 92.59 lb, was diagnosed with
  • autonomic nervous system imbalance
  • hypertension
and. Clotiazepam dosage: 10 Mg, Unk.
Associated medications used:
  • Diovan (80 Mg, Qd)


Blood Pressure Systolic Decreased, Fall, Loss Of Consciousness, Transient Ischaemic Attack (4625477-8)
Adverse event was reported on Mar 23, 2005 by a Female taking Clotiazepam (Dosage: 5 Mg, Unk) . Location: , 76 years of age, Patient felt the following Clotiazepam side effects: blood pressure systolic decreased, fall, loss of consciousness, transient ischaemic attack.
Multiple prescriptions taken:
  • Diovan (80 Mg, Qd)


Conjunctival Hyperaemia, Corneal Oedema, Eye Pain, Flat Anterior Chamber Of Eye, Intraocular Pressure Increased, Iris Atrophy, Lenticular Opacities, Mydriasis (4596478-3)
on Oct 30, 2000 Female from , 71 years of age, was diagnosed with
  • depression
and was treated with Clotiazepam. After Clotiazepam was administered, patient encountered several Clotiazepam side effects: conjunctival hyperaemia, corneal oedema, eye pain, flat anterior chamber of eye, intraocular pressure increased, iris atrophy, lenticular opacities, mydriasis. Clotiazepam dosage: N/A.
Multiple concurrent drugs taken:
  • Alprazolam (ngx)
  • Maprotiline Hydrochloride


Conjunctival Hyperaemia, Corneal Oedema, Eye Pain, Flat Anterior Chamber Of Eye, Iris Atrophy, Mydriasis (4596460-6)
on Oct 30, 2000 Female from , 71 years of age, was diagnosed with
  • depression
and was treated with Clotiazepam. Directly after, patient experienced the unwanted or unexpected Clotiazepam side effects: conjunctival hyperaemia, corneal oedema, eye pain, flat anterior chamber of eye, iris atrophy, mydriasis. Clotiazepam dosage: N/A.
Associated medications used:
  • Alprazolam
  • Maprotiline Hydrochloride


Conjunctival Hyperaemia, Corneal Oedema, Eye Pain, Flat Anterior Chamber Of Eye, Iris Atrophy, Mydriasis (4590292-0)
Patient was taking Clotiazepam. Patient felt the following Clotiazepam side effects: conjunctival hyperaemia, corneal oedema, eye pain, flat anterior chamber of eye, iris atrophy, mydriasis on Oct 30, 2000 from Additional patient health information: Female , 71 years of age, was diagnosed with
  • depression
and. Clotiazepam dosage: N/A.
Multiple prescriptions taken:
  • Alprazolam
  • Maprotiline Hydrochloride


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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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