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Colistin Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 35 

Distal Ileal Obstruction Syndrome, Constipation (8419028-X)
on May 21, 2012 Male from UNITED STATES , 33 years of age, weighting 116.4 lb, was treated with Colistin (colistin). Directly after, patient experienced the unwanted or unexpected Colistin side effects: distal ileal obstruction syndrome, constipation. Colistin (colistin) dosage: N/A.
Associated medications used:
  • Boniva
  • Albuterol
  • Cayston
  • Pulmozyme
  • Hypersol B (budesonide)
  • Mephyton (phytomenadione)
  • Spiriva
  • Vitamin D
Patient was hospitalized.

Confusional State, Renal Failure, Acute Respiratory Distress Syndrome, Overdose, Condition Aggravated, Hypotension (8352005-6)
Patient was taking Colistin Sulfate. Patient felt the following Colistin side effects: confusional state, renal failure, acute respiratory distress syndrome, overdose, condition aggravated, hypotension on Apr 24, 2012 from FRANCE Additional patient health information: Male , 29 years of age, was diagnosed with
  • pseudomonas infection
and. Colistin Sulfate dosage: N/A.
Multiple prescriptions taken:
  • Pegzerepoetin Alfa
  • Na Polystyrene Sulfonate
  • Azithromycin
  • Posaconazole
  • Valaciclovir Hydrochlorid
  • Pancreatin Triple Strength Cap
  • Colecalciferol
  • Bisoprolol Fumarate
Patient was hospitalized.

Respiratory Failure, Neutropenic Colitis, Sepsis (8294454-0)
Adverse event was reported on Apr 16, 2012 by a Male taking Colistin Sulfate (Dosage: 100 Mg, Qid) was diagnosed with
  • prophylaxis
  • haematological malignancy
and. Location: BELGIUM , weighting 176.4 lb, After Colistin was administered, patient encountered several Colistin side effects: respiratory failure, neutropenic colitis, sepsis.
Multiple concurrent drugs taken:
  • Evoltra (10 Mg/m2, Qod, On Days 2, 4, 6, 8, 10)
  • Allopurinol (300 Mg, Qd)
  • Valacyclovir Hydrochloride (500 Mg, Bid)
  • Cytarabine (100 Mg/m2, Qd)
  • Acyclovir (250 Mg, Qd)
  • Ceftazidime (1000 Mg, Qid)
  • Idarubicin Hcl (10 Mg/m2, Qod, On Days 1, 3, 5)
  • Acyclovir (500 Mg, Bid)


Anaphylactic Shock, Dyspnoea, Feeling Hot (8266414-7)
on Mar 23, 2012 Female from GERMANY , weighting 94.80 lb, was treated with Colistin Sulfate. Directly after, patient experienced the unwanted or unexpected Colistin side effects: anaphylactic shock, dyspnoea, feeling hot. Colistin Sulfate dosage: Unk.
Associated medications used:
  • Meropenem (Unk)
  • Ambisome (120 Mg, Uid/qd)
Patient was hospitalized.


Quadriparesis, Rhabdomyolysis, Hypernatraemia (7998704-7)
on Dec 14, 2011 Male from ITALY , 62 years of age, was treated with Colistin. Patient felt the following Colistin side effects: quadriparesis, rhabdomyolysis, hypernatraemia. Colistin dosage: Unk.
Multiple prescriptions taken:
  • Amikacin (1g Daily)
  • Tygacil (50 Mg, 2x/day)
  • Tygacil (100 Mg, 2x/day)


Dehydration, Hypotension, Tachycardia, Pseudomembranous Colitis, Abdominal Distension (7746107-2)
Patient was taking Colistin Sulfate. After Colistin was administered, patient encountered several Colistin side effects: dehydration, hypotension, tachycardia, pseudomembranous colitis, abdominal distension on Aug 24, 2011 from UNITED KINGDOM Additional patient health information: Male , 34 years of age, . Colistin Sulfate dosage: Intravenous.
Multiple concurrent drugs taken:
  • Meropenem (Intravenous)
  • Clarithromycin
  • Tobramycin
  • Omeprazole
  • Interferon Gamma Nos (Subcutaneous)
  • Minocycline Hcl
  • Ciprofloxacin
Patient was hospitalized.

Jugular Vein Thrombosis, Chills, Pyrexia (7734905-0)
Adverse event was reported on Aug 24, 2011 by a Female taking Colistin (Dosage: N/A) . Location: ITALY , 59 years of age, weighting 352.7 lb, Directly after, patient experienced the unwanted or unexpected Colistin side effects: jugular vein thrombosis, chills, pyrexia.
Associated medications used:
  • Cubicin
  • Immunoglobulins
  • Meropenem
  • Cubicin


Hypoxic-ischaemic Encephalopathy, Metabolic Encephalopathy (7717396-5)
on Aug 15, 2011 Female from BRAZIL , 21 years of age, was diagnosed with
  • convulsion
and was treated with Colistin. Patient felt the following Colistin side effects: hypoxic-ischaemic encephalopathy, metabolic encephalopathy. Colistin dosage: N/A.
Multiple prescriptions taken:
  • Imipenem
  • Amlodipine
  • Atenolol
  • Ranitidine
  • Clonazine
  • Cubicin
  • Clonidine Hydrochloride
  • Solutions For Parenteral Nutrition


Pseudomembranous Colitis, Clostridium Difficile Colitis (7717107-3)
on Aug 17, 2011 Male from UNITED KINGDOM , 34 years of age, was treated with Colistin Sulfate. After Colistin was administered, patient encountered several Colistin side effects: pseudomembranous colitis, clostridium difficile colitis. Colistin Sulfate dosage: N/A.
Multiple concurrent drugs taken:
  • Interferon Gamma Nos
  • Clarithromycin
  • Tobi (Unk)
  • Omeprazole (Unk)
  • Meropenem (Unk)
  • Minocycline Hcl (Unk)
  • Tobramycin (Unk)
  • Azithromycin (Unk)
Patient was hospitalized.

Liver Disorder (7683774-6)
Patient was taking Colistin. Directly after, patient experienced the unwanted or unexpected Colistin side effects: liver disorder on Jun 21, 2011 from HUNGARY Additional patient health information: Female , weighting 110.2 lb, was diagnosed with
  • sepsis
and. Colistin dosage: Unk Iu, Unk.
Associated medications used:
  • Solu-medrol
  • Furosemide (Unk)
  • Amikacin (1 G, Uid/qd)
  • Propofol (Unk)
  • Pantoprazole Sodium (40 Mg, Bid)
  • Tobramycin (80 Mg, Tid)
  • Fluconazole (200 Mg, Bid)
  • Vancomycin (0.5 G, Tid)


Macular Oedema, Retinal Artery Occlusion, Ocular Vasculitis, Vision Blurred, Visual Acuity Reduced, Diabetic Retinopathy, Venous Occlusion (7620761-8)
Adverse event was reported on Jan 31, 2011 by a Female taking Colistin Sulfate (Dosage: N/A) was diagnosed with
  • respiratory tract infection
  • immunosuppression
and. Location: UNITED KINGDOM , 21 years of age, Patient felt the following Colistin side effects: macular oedema, retinal artery occlusion, ocular vasculitis, vision blurred, visual acuity reduced, diabetic retinopathy, venous occlusion.
Multiple prescriptions taken:
  • Tacrolimus (Unk)
  • Tobramycin
  • Creon (Unk)
  • Cotrim (Unk)
  • Meropenem
  • Ranitidine


Dyspnoea, Flushing, Paraesthesia, Body Temperature Increased, Hypersensitivity (7605196-6)
on Jun 21, 2011 Female from UNITED KINGDOM , 45 years of age, weighting 87.52 lb, was treated with Colistin Sulfate. After Colistin was administered, patient encountered several Colistin side effects: dyspnoea, flushing, paraesthesia, body temperature increased, hypersensitivity. Colistin Sulfate dosage: N/A.
Multiple concurrent drugs taken:
  • Adcal D3
  • Meropenem (2 Grams, 1 Day, Intravenous Bolus)
  • Meropenem (2 Grams, 1 Day, Intravenous Bolus)
  • Creon
  • Megestrol Acetate
  • Carbocisteine
  • Pulmozyme
  • Symbicort
Patient was hospitalized.

C-reactive Protein Increased, Pyrexia, Abdominal Pain, Clostridium Difficile Colitis, Nausea, Abdominal Distension, Pseudomembranous Colitis, Tachycardia (7595276-6)
on Jun 27, 2011 Male from UNITED KINGDOM , 34 years of age, was diagnosed with
  • mycobacterium abscessus infection
and was treated with Colistin Sulfate. Directly after, patient experienced the unwanted or unexpected Colistin side effects: c-reactive protein increased, pyrexia, abdominal pain, clostridium difficile colitis, nausea, abdominal distension, pseudomembranous colitis, tachycardia. Colistin Sulfate dosage: N/A.
Associated medications used:
  • Azithromycin (Not Reported)
  • Tobramycin (Not Reported)
  • Interferon Gamma-1a (Not Reported)
Patient was hospitalized.

Pneumonia Klebsiella, Sepsis, Febrile Infection, Urinary Tract Infection (7557740-5)
Patient was taking Colistin. Patient felt the following Colistin side effects: pneumonia klebsiella, sepsis, febrile infection, urinary tract infection on Jun 02, 2011 from FRANCE Additional patient health information: Male , 60 years of age, . Colistin dosage: N/A.
Multiple prescriptions taken:
  • Primaxin
  • Amikacin
  • Teicoplanin
Patient was hospitalized.

Acidosis, Blood Creatine Increased, Haemodialysis, Azotaemia, Tubulointerstitial Nephritis (7536178-0)
Adverse event was reported on Jun 08, 2011 by a Male taking Colistin Sulfate (Dosage: 200 Mg Q12h Iv) was diagnosed with
  • cellulitis
and. Location: UNITED STATES , 93 years of age, After Colistin was administered, patient encountered several Colistin side effects: acidosis, blood creatine increased, haemodialysis, azotaemia, tubulointerstitial nephritis. Patient was hospitalized.

Tracheal Haemorrhage (7279668-0)
on Feb 03, 2011 Female from UNITED STATES , 32 years of age, weighting 280.0 lb, was diagnosed with
  • lung infection pseudomonal
and was treated with Colistin Sulfate. Directly after, patient experienced the unwanted or unexpected Colistin side effects: tracheal haemorrhage. Colistin Sulfate dosage: 75 Mg Q 12 Hours Inhal.
Associated medications used:
  • Amikacin
Patient was hospitalized.

Renal Failure Acute (6731718-3)
on May 18, 2010 Male from UNITED STATES , 84 years of age, was diagnosed with
  • pneumonia
  • sepsis
  • urinary tract infection
and was treated with Colistin Sulfate. Patient felt the following Colistin side effects: renal failure acute. Colistin Sulfate dosage: 150 Mg Q12h Iv Bolus. Patient was hospitalized.

Acinetobacter Infection, Blood Creatinine Increased, Extradural Abscess (6519730-0)
Patient was taking Colistin 150mg. After Colistin was administered, patient encountered several Colistin side effects: acinetobacter infection, blood creatinine increased, extradural abscess on Dec 28, 2009 from UNITED STATES Additional patient health information: Female , 31 years of age, was diagnosed with
  • osteomyelitis
and. Colistin 150mg dosage: 100mg Q8h Po.
Multiple concurrent drugs taken:
  • Vancomycin (1000mg Q12h Po)


Blood Creatinine Increased, Paraesthesia, Paraesthesia Oral (6160514-3)
Adverse event was reported on Apr 15, 2009 by a Female taking Colistin Sulfate (Dosage: 150 Mg Q12 Hours Iv Bolus) was diagnosed with
  • cystic fibrosis lung
  • condition aggravated
and. Location: UNITED STATES , 25 years of age, weighting 103.6 lb, Directly after, patient experienced the unwanted or unexpected Colistin side effects: blood creatinine increased, paraesthesia, paraesthesia oral.
Associated medications used:
  • Trimethoprim-sulfamethoxazole (1 Tablet Bid Po)
Patient was hospitalized and became disabled.

Pneumothorax (5573376-X)
on Dec 20, 2007 Female from UNITED STATES , 55 years of age, weighting 147.0 lb, was diagnosed with
  • pneumonia
and was treated with Colistin 150 Mg Parke-davis. Patient felt the following Colistin side effects: pneumothorax. Colistin 150 Mg Parke-davis dosage: 75mg 8 Endotracheal.

Paraesthesia, Renal Failure Acute (5527850-2)
on Nov 26, 2007 Female from UNITED STATES , weighting 132.3 lb, was diagnosed with
  • cystic fibrosis
and was treated with Colistin Sulfate. After Colistin was administered, patient encountered several Colistin side effects: paraesthesia, renal failure acute. Colistin Sulfate dosage: 500 Mg Q 8 Hr Iv.

Condition Aggravated, Cystic Fibrosis, Dyspnoea, Lobar Pneumonia, Lung Infiltration, Oxygen Saturation Decreased, Pyrexia, Tachycardia (5402786-6)
Patient was taking Colistin Sulfate. Directly after, patient experienced the unwanted or unexpected Colistin side effects: condition aggravated, cystic fibrosis, dyspnoea, lobar pneumonia, lung infiltration, oxygen saturation decreased, pyrexia, tachycardia on Jul 30, 2007 from UNITED STATES Additional patient health information: Female , 37 years of age, weighting 130.0 lb, . Colistin Sulfate dosage: N/A. Patient was hospitalized.

Renal Failure Acute (5378660-0)
Adverse event was reported on Jul 02, 2007 by a Male taking Colistin Sulfate (Dosage: 160mg Q12h Iv) was diagnosed with
  • pancreatitis
and. Location: UNITED STATES , 54 years of age, weighting 205.0 lb, Patient felt the following Colistin side effects: renal failure acute. Patient was hospitalized.

Acute Respiratory Distress Syndrome, Multi-organ Failure, Respiratory Failure (5361970-0)
on Jun 19, 2007 Female from UNITED STATES , 29 years of age, was treated with Colistin Aerosol 75 Mg Bid Compounding. After Colistin was administered, patient encountered several Colistin side effects: acute respiratory distress syndrome, multi-organ failure, respiratory failure. Colistin Aerosol 75 Mg Bid Compounding dosage: 75 Mg Bid.

Acute Respiratory Failure, Pancreatitis, Renal Failure Acute (5341508-4)
on May 30, 2007 Male from UNITED STATES , 45 years of age, weighting 224.9 lb, was treated with Colistin Sulfate. Directly after, patient experienced the unwanted or unexpected Colistin side effects: acute respiratory failure, pancreatitis, renal failure acute. Colistin Sulfate dosage: 250mg Q12h Iv.
Associated medications used:
  • Clonidine
  • Lisinopril
  • Premix
  • M.v.i.
  • Docusate
  • Baclofen
  • Tegretol
  • Nsaid
Patient was hospitalized.

Showing 1-25 of 35 

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Colistin Information

Alternative COLISTIN Names:COLY-MYCIN S CORTISPORIN-TC

Active Ingredient: COLISTIN

More About Colistin

Side Effects reported to FDA: 35. View Colistin Adverse Reports

Colistin safety alerts: No

Reported deaths: 3

Reported hospitalizations: 14

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