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Creon Side Effects

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Common Creon Side Effects


The most commonly reported Creon side effects (click to view or check a box to report):

Diarrhoea (67)
Abdominal Pain (41)
Nausea (33)
Abdominal Pain Upper (29)
Flatulence (29)
Weight Decreased (29)
Vomiting (26)
Constipation (20)
Abdominal Distension (19)
Dizziness (16)
Abdominal Discomfort (14)
Dyspnoea (14)
Rash (13)
Malaise (12)
Pancreatitis (11)
Asthenia (11)
Pain (10)
Pneumonia (10)
Pyrexia (10)
Off Label Use (9)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Creon Side Effects Reported to FDA



Creon Side Effect Report#9993726
Disorientation, Blood Glucose Increased, Hypertension
This is a report of a 48-year-old male patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: pancreatitis chronic,hypertension,diabetes mellitus, who was treated with Creon (dosage: NA, start time:
Nov 15, 2013), combined with:
  • Metoprolol
  • Lantus
  • Apidra
and developed a serious reaction and side effect(s): Disorientation, Blood Glucose Increased, Hypertension after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Creon treatment in male patients, resulting in Disorientation side effect. The patient was hospitalized.
Creon Side Effect Report#9993384
Pulmonary Oedema, Diarrhoea, Weight Decreased, Rash
This report suggests a potential Creon Pulmonary Oedema side effect(s) that can have serious consequences. A 77-year-old female patient (weight: NA) from AU was diagnosed with the following symptoms/conditions: NA and used Creon (dosage: 25,000 Units With Meals) starting 2013. After starting Creon the patient began experiencing various side effects, including: Pulmonary Oedema, Diarrhoea, Weight Decreased, RashAdditional drugs used concurrently: NA.The patient was hospitalized. Although Creon demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pulmonary Oedema, may still occur.
Creon Side Effect Report#9920552
Pancreatic Carcinoma Recurrent, Blood Glucose Decreased, Constipation, Diarrhoea
This Pancreatic Carcinoma Recurrent problem was reported by a pharmacist from US. A 85-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Feb 15, 2014 this consumer started treatment with Creon (dosage: NA). The following drugs were being taken at the same time: NA. When using Creon, the patient experienced the following unwanted symptoms/side effects: Pancreatic Carcinoma Recurrent, Blood Glucose Decreased, Constipation, DiarrhoeaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pancreatic Carcinoma Recurrent, may become evident only after a product is in use by the general population.
Creon Side Effect Report#9916749
Skin Papilloma, Dysentery
This Skin Papilloma side effect was reported by a consumer or non-health professional from BR. A 79-year-old male patient (weight:NA) experienced the following symptoms/conditions: dyspepsia.The patient was prescribed Creon (drug dosage: Form Strength: 25.000 Ui, Before Breakfast And Before Lunch), which was initiated on 2013. Concurrently used drugs:
  • Pancreatin
  • Omeprazole (At 8:00am)
  • Aradois (At 9:00am And At 8:00pm)
  • Selozok (At 9:20am)
  • Combodart (At 2:00pm)
  • Frontal (At 11:00pm)
  • Sinvascor (At Night)
.After starting to take Creon the consumer reported adverse symptoms, such as: Skin Papilloma, DysenteryThese side effects may potentially be related to Creon.
Creon Side Effect Report#9897404
Adverse Event
This is a report of a 47-year-old female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: pancreatitis chronic, who was treated with Creon (dosage: NA, start time: NS), combined with:
  • Atenolol
  • Dicyclomine
  • Acetaminophen W/hydrocodone Bitartrate
  • Protonix
  • Reglan
and developed a serious reaction and side effect(s): Adverse Event after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Creon treatment in female patients, resulting in Death side effect. The patient was hospitalized.
Creon Side Effect Report#9892671
Small Intestine Carcinoma Metastatic, Bile Duct Obstruction, Cholangitis, Bacteraemia
This report suggests a potential Creon Small Intestine Carcinoma Metastatic side effect(s) that can have serious consequences. A female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: pancreatic insufficiency and used Creon (dosage: 12,000 U-38,000 U, 60,000 U (dr/ec) 1-2 Caps W/meals) starting
Apr 18, 2013. After starting Creon the patient began experiencing various side effects, including: Small Intestine Carcinoma Metastatic, Bile Duct Obstruction, Cholangitis, BacteraemiaAdditional drugs used concurrently:
  • Enoxaparin (60 Mg/0.6 Ml Syringe)
  • Hydrocodone/apap
  • Aspirin (Dr/ec)
  • Docusate
  • Gas Relief
  • Lantus
  • Lisinopril
  • Lorazepam (1/2 Tab At Bedtime)
Although Creon demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Small Intestine Carcinoma Metastatic, may still occur.
Creon Side Effect Report#9863089
Eye Haemorrhage, Eye Operation
This Eye Haemorrhage problem was reported by a consumer or non-health professional from US. A 66-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pancreatitis,hypertension,blood cholesterol increased. On NS this consumer started treatment with Creon (dosage: NA). The following drugs were being taken at the same time:
  • Altace
  • Zocor
When using Creon, the patient experienced the following unwanted symptoms/side effects: Eye Haemorrhage, Eye OperationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eye Haemorrhage, may become evident only after a product is in use by the general population.
Creon Side Effect Report#9863067
Pneumonia, Liver Disorder, Asthenia, Emphysema
This Pneumonia side effect was reported by a consumer or non-health professional from Country Not Specified. A 54-year-old female patient (weight:NA) experienced the following symptoms/conditions: pancreatitis,depression,gastric ph decreased.The patient was prescribed Creon (drug dosage: NA), which was initiated on 201401. Concurrently used drugs:
  • Prozac
.After starting to take Creon the consumer reported adverse symptoms, such as: Pneumonia, Liver Disorder, Asthenia, EmphysemaThese side effects may potentially be related to Creon. The patient was hospitalized.
Creon Side Effect Report#9817175
Lung Transplant
This is a report of a 34-year-old male patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: cystic fibrosis, who was treated with Creon (dosage: 6 Capsules Per Meal, start time: 200501), combined with: NA. and developed a serious reaction and side effect(s): Lung Transplant after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Creon treatment in male patients, resulting in Lung Transplant side effect.
Creon Side Effect Report#9787901
Pneumonia, Bacterial Infection, Syncope
This report suggests a potential Creon Pneumonia side effect(s) that can have serious consequences. A 78-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: cystic fibrosis carrier and used Creon (dosage: NA) starting NS. After starting Creon the patient began experiencing various side effects, including: Pneumonia, Bacterial Infection, SyncopeAdditional drugs used concurrently:
  • Bumex
  • K-dur
  • Lopressor
  • Glipizide
  • Synthroid
  • Albuterol
  • Digoxin
  • Coumadin
The patient was hospitalized. Although Creon demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pneumonia, may still occur.
Creon Side Effect Report#9779792
Pancreatitis Acute
This Pancreatitis Acute problem was reported by a physician from Country Not Specified. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pancreatic insufficiency. On
May 17, 2013 this consumer started treatment with Creon (dosage: NA). The following drugs were being taken at the same time:
  • Sodium Rabeprazole
  • Camostat Mesilate
  • Lansoprazole
  • Maintenance Medium
When using Creon, the patient experienced the following unwanted symptoms/side effects: Pancreatitis AcuteThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pancreatitis Acute, may become evident only after a product is in use by the general population.
Creon Side Effect Report#9773754
Diabetes Mellitus, Pain, Pancreatitis
This Diabetes Mellitus side effect was reported by a consumer or non-health professional from US. A 39-year-old male patient (weight:NA) experienced the following symptoms/conditions: pancreatitis.The patient was prescribed Creon (drug dosage: NA), which was initiated on
Nov 21, 2013. Concurrently used drugs: NA..After starting to take Creon the consumer reported adverse symptoms, such as: Diabetes Mellitus, Pain, PancreatitisThese side effects may potentially be related to Creon. The patient was hospitalized.
Creon Side Effect Report#9746614
Meningitis, Sensory Loss, Decreased Appetite, Asthenia, Diarrhoea
This is a report of a 59-year-old male patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: pancreatitis chronic,nausea,fluid retention,impaired gastric emptying,abdominal pain,breakthrough pain, who was treated with Creon (dosage: NA, start time: 2000), combined with:
  • Zofran
  • Bumex
  • Reglan
  • Ms Contin
  • Opana
and developed a serious reaction and side effect(s): Meningitis, Sensory Loss, Decreased Appetite, Asthenia, Diarrhoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Creon treatment in male patients, resulting in Meningitis side effect. The patient was hospitalized.
Creon Side Effect Report#9737500
Respiratory Distress, Oedema Mucosal, Angioedema
This report suggests a potential Creon Respiratory Distress side effect(s) that can have serious consequences. A 85-year-old female patient (weight: NA) from CH was diagnosed with the following symptoms/conditions: pancreatic insufficiency,diarrhoea and used Creon (dosage: NA) starting
Nov 14, 2013. After starting Creon the patient began experiencing various side effects, including: Respiratory Distress, Oedema Mucosal, AngioedemaAdditional drugs used concurrently: NA. Although Creon demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Respiratory Distress, may still occur.
Creon Side Effect Report#9726295
Intestinal Perforation, Abdominal Pain, Diverticulitis, Pyrexia, Pneumoperitoneum, Ascites, Recurrent Cancer
This Intestinal Perforation problem was reported by a health professional from US. A 69-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pancreatic carcinoma. On 201306 this consumer started treatment with Creon (dosage: See Narrative). The following drugs were being taken at the same time:
  • Protonix
  • Multivitamin
When using Creon, the patient experienced the following unwanted symptoms/side effects: Intestinal Perforation, Abdominal Pain, Diverticulitis, Pyrexia, Pneumoperitoneum, Ascites, Recurrent CancerThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Intestinal Perforation, may become evident only after a product is in use by the general population.
Creon Side Effect Report#9713821
Duodenal Neoplasm, Thyroid Neoplasm, Blood Urine Present
This Duodenal Neoplasm side effect was reported by a consumer or non-health professional from Country Not Specified. A female patient (weight:NA) experienced the following symptoms/conditions: pancreatic insufficiency.The patient was prescribed Creon (drug dosage: NA), which was initiated on 201202. Concurrently used drugs:
  • Azanthiopine
  • Fergon
  • Folic Acid
  • Megace
.After starting to take Creon the consumer reported adverse symptoms, such as: Duodenal Neoplasm, Thyroid Neoplasm, Blood Urine PresentThese side effects may potentially be related to Creon.
Creon Side Effect Report#9709280
Pneumonia, Cystic Fibrosis, Acute Respiratory Distress Syndrome, Lung Transplant, Complications Of Transplanted Lung, Diabetes Mellitus, Herpes Zoster
This is a report of a 26-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: cystic fibrosis, who was treated with Creon (dosage: 8-10 Per Meal, start time: NS), combined with:
  • Prednisone
and developed a serious reaction and side effect(s): Pneumonia, Cystic Fibrosis, Acute Respiratory Distress Syndrome, Lung Transplant, Complications Of Transplanted Lung, Diabetes Mellitus, Herpes Zoster after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Creon treatment in male patients, resulting in Pneumonia side effect. The patient was hospitalized.
Creon Side Effect Report#9699031
Heart Valve Stenosis, Atrial Fibrillation
This report suggests a potential Creon Heart Valve Stenosis side effect(s) that can have serious consequences. A female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: pancreatic neoplasm and used Creon (dosage: 12,000 U: 2 With Each Meal, 6 Per Day) starting 2003. After starting Creon the patient began experiencing various side effects, including: Heart Valve Stenosis, Atrial FibrillationAdditional drugs used concurrently:
  • Aspirin
  • Amlodipine
  • Lipitor
  • Plavix
  • Novolog
  • Lantus
  • Dyazide
Although Creon demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Heart Valve Stenosis, may still occur.
Creon Side Effect Report#9696647
Irritable Bowel Syndrome, Pancreatitis, Nausea
This Irritable Bowel Syndrome problem was reported by a consumer or non-health professional from Country Not Specified. A 57-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pancreatitis,chronic obstructive pulmonary disease. On 201307 this consumer started treatment with Creon (dosage: Tid With Meals). The following drugs were being taken at the same time:
  • Advair
  • Buspar
  • Coreg
  • Zocor
  • Cymbalta
  • Duoneb
  • Hyzaar
  • Neurontin
When using Creon, the patient experienced the following unwanted symptoms/side effects: Irritable Bowel Syndrome, Pancreatitis, NauseaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Irritable Bowel Syndrome, may become evident only after a product is in use by the general population.
Creon Side Effect Report#9686276
Dehydration, Pancreatitis Acute, Pain, Diarrhoea
This Dehydration side effect was reported by a consumer or non-health professional from US. A 48-year-old female patient (weight:NA) experienced the following symptoms/conditions: pancreatitis chronic,crohn^s disease.The patient was prescribed Creon (drug dosage: 5 Caps With Meals And 3 Caps With Snacks), which was initiated on NS. Concurrently used drugs: NA..After starting to take Creon the consumer reported adverse symptoms, such as: Dehydration, Pancreatitis Acute, Pain, DiarrhoeaThese side effects may potentially be related to Creon. The patient was hospitalized.
Creon Side Effect Report#9684522
Pancreatic Carcinoma, Flatulence, Pancreatic Operation, Diarrhoea, Incorrect Dose Administered
This is a report of a male patient (weight: NA) from AU, suffering from the following health symptoms/conditions: pancreaticoduodenectomy, who was treated with Creon (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Pancreatic Carcinoma, Flatulence, Pancreatic Operation, Diarrhoea, Incorrect Dose Administered after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Creon treatment in male patients, resulting in Pancreatic Carcinoma side effect.
Creon Side Effect Report#9666288
Incorrect Dose Administered, Distal Intestinal Obstruction Syndrome
This report suggests a potential Creon Incorrect Dose Administered side effect(s) that can have serious consequences. A 30-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: pancreatic insufficiency and used Creon (dosage: 2-3 Tablets With Meal) starting
Sep 02, 2013. After starting Creon the patient began experiencing various side effects, including: Incorrect Dose Administered, Distal Intestinal Obstruction SyndromeAdditional drugs used concurrently: NA.The patient was hospitalized. Although Creon demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Incorrect Dose Administered, may still occur.
Creon Side Effect Report#9665071
Coronary Artery Disease, Myocardial Infarction, Chest Pain, Coronary Artery Occlusion, Chronic Obstructive Pulmonary Disease, Blood Sodium Decreased, Anxiety, Weight Decreased
This Coronary Artery Disease problem was reported by a physician from Country Not Specified. A 61-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pancreatic insufficiency,chronic obstructive pulmonary disease,blood pressure. On 2010 this consumer started treatment with Creon (dosage: NA). The following drugs were being taken at the same time:
  • Spireva
  • Cavidolol
  • Lisinopril
  • Calcium Carbonate
When using Creon, the patient experienced the following unwanted symptoms/side effects: Coronary Artery Disease, Myocardial Infarction, Chest Pain, Coronary Artery Occlusion, Chronic Obstructive Pulmonary Disease, Blood Sodium Decreased, Anxiety, Weight DecreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Coronary Artery Disease, may become evident only after a product is in use by the general population.
Creon Side Effect Report#9605350
Pancreatectomy, Pancreatic Neuroendocrine Tumour
This Pancreatectomy side effect was reported by a health professional from GB. A 60-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Creon (drug dosage: 120-160,000 Units With Food And 80,000 With Snacks), which was initiated on NS. Concurrently used drugs: NA..After starting to take Creon the consumer reported adverse symptoms, such as: Pancreatectomy, Pancreatic Neuroendocrine TumourThese side effects may potentially be related to Creon.
Creon Side Effect Report#9587371
Diarrhoea Haemorrhagic, Abdominal Pain, Weight Decreased
This is a report of a patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: pancreatic insufficiency, who was treated with Creon (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Diarrhoea Haemorrhagic, Abdominal Pain, Weight Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Creon treatment in patients, resulting in Diarrhoea Haemorrhagic side effect.


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The appearance of Creon on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Creon Side Effects for Women?

Women Side EffectsReports
Diarrhoea 41
Abdominal Pain 28
Nausea 24
Abdominal Pain Upper 21
Flatulence 20
Abdominal Distension 15
Vomiting 15
Dizziness 14
Weight Decreased 14
Constipation 12

What are common Creon Side Effects for Men?

Men Side EffectsReports
Diarrhoea 25
Weight Decreased 14
Abdominal Pain 12
Vomiting 11
Flatulence 9
Nausea 9
Abdominal Pain Upper 8
Constipation 8
Pneumonia 8
Death 7

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Creon reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Creon Side Effects

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    How Effective is Creon for You?

    Exceeded Expectations
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    Creon Safety Alerts, Active Ingredients, Usage Information

    NDC0032-1203
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameCreon
    NamePancrelipase
    Dosage FormCAPSULE, DELAYED RELEASE
    RouteORAL
    On market since20100813
    LabelerAbbVie Inc.
    Active Ingredient(s)PANCRELIPASE AMYLASE; PANCRELIPASE LIPASE; PANCRELIPASE PROTEASE
    Strength(s)15000; 3000; 9500
    Unit(s)[USP'U]/1; [USP'U]/1; [USP'U]/1
    Pharma Class

    More About Creon

    Side Effects reported to FDA: 382

    Creon safety alerts: No

    Reported deaths: 41

    Reported hospitalizations: 153

    Latest Creon clinical trials