Common Cyclobenzaprine Side Effects


The most commonly reported Cyclobenzaprine side effects (click to view or check a box to report):

Completed Suicide (160)
Toxicity To Various Agents (127)
Cardiac Arrest (64)
Respiratory Arrest (59)
Overdose (36)
Pain (28)
Cardio-respiratory Arrest (24)
Dizziness (24)
Confusional State (23)
Death (21)
Exposure Via Ingestion (20)
Nausea (18)
Fall (16)
Depression (15)
Convulsion (15)
Constipation (15)
Anxiety (14)
Hallucination (14)
Headache (14)
Hypotension (14)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Cyclobenzaprine Side Effects Reported to FDA



Cyclobenzaprine Side Effect Report#9995751
Convulsion
This is a report of a 37-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclobenzaprine (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Convulsion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclobenzaprine treatment in female patients, resulting in Convulsion side effect. The patient was hospitalized.
Cyclobenzaprine Side Effect Report#9981372
Heart Rate Irregular, Heart Rate Increased, Depression
This report suggests a potential Cyclobenzaprine Heart Rate Irregular side effect(s) that can have serious consequences. A 58-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: temporomandibular joint syndrome and used Cyclobenzaprine (dosage: NA) starting
Feb 28, 2014. After starting Cyclobenzaprine the patient began experiencing various side effects, including: Heart Rate Irregular, Heart Rate Increased, DepressionAdditional drugs used concurrently: NA. Although Cyclobenzaprine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Heart Rate Irregular, may still occur.
Cyclobenzaprine Side Effect Report#9969702
Constipation, Diarrhoea, Abdominal Distension, Abdominal Pain Upper
This Constipation problem was reported by a consumer or non-health professional from US. A 44-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: muscle spasms,restless legs syndrome. On
Feb 10, 2014 this consumer started treatment with Cyclobenzaprine Hcl (dosage: 1 Pill, Twice Daily, Taken By Mouth). The following drugs were being taken at the same time: NA. When using Cyclobenzaprine Hcl, the patient experienced the following unwanted symptoms/side effects: Constipation, Diarrhoea, Abdominal Distension, Abdominal Pain UpperAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Constipation, may become evident only after a product is in use by the general population.
Cyclobenzaprine Side Effect Report#9914196
Completed Suicide, Exposure Via Ingestion, Toxicity To Various Agents
This Completed Suicide side effect was reported by a pharmacist from US. A 49-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclobenzaprine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Alprazolam
  • Diltiazem
  • Trazodone (trazodone)
.After starting to take Cyclobenzaprine the consumer reported adverse symptoms, such as: Completed Suicide, Exposure Via Ingestion, Toxicity To Various AgentsThese side effects may potentially be related to Cyclobenzaprine.
Cyclobenzaprine Side Effect Report#9914125
Completed Suicide, Toxicity To Various Agents
This is a report of a 39-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclobenzaprine (cyclobenzaprine) (dosage: NA, start time: NS), combined with:
  • Tramadol (tramadol)
  • Ethanol (ethanol)
and developed a serious reaction and side effect(s): Completed Suicide, Toxicity To Various Agents after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclobenzaprine (cyclobenzaprine) treatment in male patients, resulting in Completed Suicide side effect.
Cyclobenzaprine Side Effect Report#9914074
Exposure Via Ingestion, Toxicity To Various Agents
This report suggests a potential Cyclobenzaprine (cyclobenzaprine) Exposure Via Ingestion side effect(s) that can have serious consequences. A 32-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclobenzaprine (cyclobenzaprine) (dosage: NA) starting NS. After starting Cyclobenzaprine (cyclobenzaprine) the patient began experiencing various side effects, including: Exposure Via Ingestion, Toxicity To Various AgentsAdditional drugs used concurrently:
  • Oxycodone
  • Methadone (methadone) (Oral)
  • Clonazepam (clonazepam) (clonazepam)
  • Meprobamate (meprobamate)
  • Oxcarbazepine
  • Trazodone (trazodone)
Although Cyclobenzaprine (cyclobenzaprine) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Exposure Via Ingestion, may still occur.
Cyclobenzaprine Side Effect Report#9914012
Toxicity To Various Agents, Exposure Via Ingestion
This Toxicity To Various Agents problem was reported by a pharmacist from US. A 41-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclobenzaprine (cyclobenzaprine) (dosage: NA). The following drugs were being taken at the same time:
  • Ethylene Glycol
When using Cyclobenzaprine (cyclobenzaprine), the patient experienced the following unwanted symptoms/side effects: Toxicity To Various Agents, Exposure Via IngestionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Toxicity To Various Agents, may become evident only after a product is in use by the general population.
Cyclobenzaprine Side Effect Report#9913743
Toxicity To Various Agents, Exposure Via Ingestion
This Toxicity To Various Agents side effect was reported by a pharmacist from US. A 23-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclobenzaprine (cyclobenzaprine) (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Heroin (diamorphine) (diamorphine) (Parenteral)
  • Diazepam (diazepam)
  • Trazodone (trazodone)
  • Codeine
.After starting to take Cyclobenzaprine (cyclobenzaprine) the consumer reported adverse symptoms, such as: Toxicity To Various Agents, Exposure Via IngestionThese side effects may potentially be related to Cyclobenzaprine (cyclobenzaprine).
Cyclobenzaprine Side Effect Report#9913683
Toxicity To Various Agents
This is a report of a 51-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclobenzaprine (dosage: NA, start time: NS), combined with:
  • Cocaine (cocaine)
  • Diphenhydramine
  • Doxylamine
  • Dextromethorphan
and developed a serious reaction and side effect(s): Toxicity To Various Agents after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclobenzaprine treatment in female patients, resulting in Toxicity To Various Agents side effect.
Cyclobenzaprine Side Effect Report#9913600
Exposure Via Ingestion, Toxicity To Various Agents
This report suggests a potential Cyclobenzaprine (cyclobenzaprine) Exposure Via Ingestion side effect(s) that can have serious consequences. A 59-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclobenzaprine (cyclobenzaprine) (dosage: NA) starting NS. After starting Cyclobenzaprine (cyclobenzaprine) the patient began experiencing various side effects, including: Exposure Via Ingestion, Toxicity To Various AgentsAdditional drugs used concurrently:
  • Hydrocodone+paracetamol (paracetamol, Hydrocodone)
  • Methamphetamine
Although Cyclobenzaprine (cyclobenzaprine) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Exposure Via Ingestion, may still occur.
Cyclobenzaprine Side Effect Report#9913584
Exposure Via Ingestion, Toxicity To Various Agents
This Exposure Via Ingestion problem was reported by a pharmacist from US. A 50-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclobenzaprine (dosage: NA). The following drugs were being taken at the same time:
  • Heroin (diamorphine) (diamorphine)
  • Diazepam
  • Diltiazem
  • Ethanol
When using Cyclobenzaprine, the patient experienced the following unwanted symptoms/side effects: Exposure Via Ingestion, Toxicity To Various AgentsAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Exposure Via Ingestion, may become evident only after a product is in use by the general population.
Cyclobenzaprine Side Effect Report#9913286
Completed Suicide, Exposure Via Ingestion, Toxicity To Various Agents, Intentional Self-injury
This Completed Suicide side effect was reported by a pharmacist from US. A 41-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclobenzaprine (cyclobenzaprine) (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Olanzapine (olanzapine)
  • Alprazolam (alprazolam)
  • Verapamil (verapamil)
  • Acetaminophen Oxycodone
.After starting to take Cyclobenzaprine (cyclobenzaprine) the consumer reported adverse symptoms, such as: Completed Suicide, Exposure Via Ingestion, Toxicity To Various Agents, Intentional Self-injuryThese side effects may potentially be related to Cyclobenzaprine (cyclobenzaprine).
Cyclobenzaprine Side Effect Report#9912772
Hypersomnia, Visual Impairment, Dyspnoea, Dysphagia
This is a report of a 57-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclobenzaprine (dosage: NA, start time:
Dec 06, 2013), combined with: NA. and developed a serious reaction and side effect(s): Hypersomnia, Visual Impairment, Dyspnoea, Dysphagia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclobenzaprine treatment in female patients, resulting in Hypersomnia side effect.
Cyclobenzaprine Side Effect Report#9909990
Toxicity To Various Agents
This report suggests a potential Cyclobenzaprine Toxicity To Various Agents side effect(s) that can have serious consequences. A 57-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclobenzaprine (dosage: NA) starting NS. After starting Cyclobenzaprine the patient began experiencing various side effects, including: Toxicity To Various AgentsAdditional drugs used concurrently:
  • Fluoxetine (fluoxetine)
  • Zolpidem (zolpidem)
  • Morphine
  • Diazepam
  • Diphenhydramine
Although Cyclobenzaprine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Toxicity To Various Agents, may still occur.
Cyclobenzaprine Side Effect Report#9909671
Exposure Via Ingestion, Toxicity To Various Agents
This Exposure Via Ingestion problem was reported by a pharmacist from US. A 15-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclobenzaprine (dosage: NA). The following drugs were being taken at the same time:
  • Methadone (methadone)
When using Cyclobenzaprine, the patient experienced the following unwanted symptoms/side effects: Exposure Via Ingestion, Toxicity To Various AgentsAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Exposure Via Ingestion, may become evident only after a product is in use by the general population.
Cyclobenzaprine Side Effect Report#9909622
Exposure Via Ingestion, Toxicity To Various Agents
This Exposure Via Ingestion side effect was reported by a pharmacist from US. A 72-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclobenzaprine (cyclobenzaprine) (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Zolpidem (zolpidem)
.After starting to take Cyclobenzaprine (cyclobenzaprine) the consumer reported adverse symptoms, such as: Exposure Via Ingestion, Toxicity To Various AgentsThese side effects may potentially be related to Cyclobenzaprine (cyclobenzaprine).
Cyclobenzaprine Side Effect Report#9908894
Exposure Via Ingestion, Toxicity To Various Agents
This is a report of a 48-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclobenzaprine (cyclobenzaprine) (dosage: NA, start time: NS), combined with:
  • Heroin (diamorphine) (diamorphine)
  • Promethazine (promethazine)
  • Ethanol
and developed a serious reaction and side effect(s): Exposure Via Ingestion, Toxicity To Various Agents after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclobenzaprine (cyclobenzaprine) treatment in female patients, resulting in Exposure Via Ingestion side effect.
Cyclobenzaprine Side Effect Report#9908731
Toxicity To Various Agents, Exposure Via Ingestion
This report suggests a potential Cyclobenzaprine (cyclobenzaprine) Toxicity To Various Agents side effect(s) that can have serious consequences. A 46-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclobenzaprine (cyclobenzaprine) (dosage: NA) starting NS. After starting Cyclobenzaprine (cyclobenzaprine) the patient began experiencing various side effects, including: Toxicity To Various Agents, Exposure Via IngestionAdditional drugs used concurrently:
  • Gabapentin (gabapentin)
  • Zolpidem (zolpidem)
  • Fentanyl (fentanyl) (Oral)
  • Diazepam (diazepam)
Although Cyclobenzaprine (cyclobenzaprine) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Toxicity To Various Agents, may still occur.
Cyclobenzaprine Side Effect Report#9908702
Exposure Via Ingestion, Toxicity To Various Agents
This Exposure Via Ingestion problem was reported by a pharmacist from US. A 43-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclobenzaprine (cyclobenzaprine) (dosage: NA). The following drugs were being taken at the same time:
  • Venlafaxine (venlafaxine)
  • Methadone (methadone) (Oral)
  • Morphine
  • Trazodone (trazodone)
When using Cyclobenzaprine (cyclobenzaprine), the patient experienced the following unwanted symptoms/side effects: Exposure Via Ingestion, Toxicity To Various AgentsAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Exposure Via Ingestion, may become evident only after a product is in use by the general population.
Cyclobenzaprine Side Effect Report#9908654
Completed Suicide, Respiratory Arrest, Cardiac Arrest, Exposure Via Ingestion, Toxicity To Various Agents, Intentional Self-injury
This Completed Suicide side effect was reported by a pharmacist from US. A 45-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclobenzaprine (cyclobenzaprine) (drug dosage: Oral), which was initiated on NS. Concurrently used drugs:
  • Methadone (methadone)
  • Clonazepam (clonazepam) (clonazepam)
.After starting to take Cyclobenzaprine (cyclobenzaprine) the consumer reported adverse symptoms, such as: Completed Suicide, Respiratory Arrest, Cardiac Arrest, Exposure Via Ingestion, Toxicity To Various Agents, Intentional Self-injuryThese side effects may potentially be related to Cyclobenzaprine (cyclobenzaprine).
Cyclobenzaprine Side Effect Report#9908487
Completed Suicide, Cardiac Arrest, Respiratory Arrest, Toxicity To Various Agents, Exposure Via Ingestion
This is a report of a 26-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclobenzaprine (cyclobenzaprine) (dosage: NA, start time: NS), combined with:
  • Citalopram (citalopram)
  • Amitriptyline (amitriptyline) (Oral)
and developed a serious reaction and side effect(s): Completed Suicide, Cardiac Arrest, Respiratory Arrest, Toxicity To Various Agents, Exposure Via Ingestion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclobenzaprine (cyclobenzaprine) treatment in female patients, resulting in Completed Suicide side effect.
Cyclobenzaprine Side Effect Report#9891848
Convulsion, Toxicity To Various Agents, Acidosis, Hypotension, Electrocardiogram Qrs Complex Prolonged, Exposure Via Ingestion, Depressed Level Of Consciousness
This report suggests a potential Cyclobenzaprine (cyclobenzaprine) Convulsion side effect(s) that can have serious consequences. A 50-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclobenzaprine (cyclobenzaprine) (dosage: NA) starting NS. After starting Cyclobenzaprine (cyclobenzaprine) the patient began experiencing various side effects, including: Convulsion, Toxicity To Various Agents, Acidosis, Hypotension, Electrocardiogram Qrs Complex Prolonged, Exposure Via Ingestion, Depressed Level Of ConsciousnessAdditional drugs used concurrently:
  • Trazodone (trazodone)
  • Doxepin (doxepin) (doxepin)
The patient was hospitalized. Although Cyclobenzaprine (cyclobenzaprine) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Convulsion, may still occur.
Cyclobenzaprine Side Effect Report#9891767
Poisoning, Exposure Via Ingestion
This Poisoning problem was reported by a pharmacist from US. A 38-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclobenzaprine (cyclobenzaprine) (dosage: NA). The following drugs were being taken at the same time:
  • Fluoxetine (fluoxetine)
  • Phencyclidine
  • Diphenhydramine (diphenhydramine)
  • Acetaminophen (paracetamol)
  • Ethanol
When using Cyclobenzaprine (cyclobenzaprine), the patient experienced the following unwanted symptoms/side effects: Poisoning, Exposure Via IngestionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Poisoning, may become evident only after a product is in use by the general population.
Cyclobenzaprine Side Effect Report#9887637
Exposure Via Ingestion, Toxicity To Various Agents
This Exposure Via Ingestion side effect was reported by a pharmacist from US. A 39-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclobenzaprine (cyclobenzaprine) (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Cyclobenzaprine (cyclobenzaprine) the consumer reported adverse symptoms, such as: Exposure Via Ingestion, Toxicity To Various AgentsThese side effects may potentially be related to Cyclobenzaprine (cyclobenzaprine).
Cyclobenzaprine Side Effect Report#9879545
Serotonin Syndrome, Psychotic Disorder, Myoclonus, Dystonia
This is a report of a 55-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: intervertebral discitis,spinal pain, who was treated with Cyclobenzaprine Hydrochloride (watson Laboratories) (dosage: 10 Mg, Tid, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Serotonin Syndrome, Psychotic Disorder, Myoclonus, Dystonia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclobenzaprine Hydrochloride (watson Laboratories) treatment in male patients, resulting in Serotonin Syndrome side effect.


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The appearance of Cyclobenzaprine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Cyclobenzaprine Side Effects for Women?

Women Side Effects Reports
Completed Suicide 94
Toxicity To Various Agents 71
Respiratory Arrest 39
Cardiac Arrest 38
Overdose 27
Pain 20
Exposure Via Ingestion 14
Anxiety 13
Cardio-respiratory Arrest 13
Dizziness 13

What are common Cyclobenzaprine Side Effects for Men?

Men Side Effects Reports
Toxicity To Various Agents 56
Completed Suicide 53
Cardiac Arrest 25
Respiratory Arrest 19
Confusional State 16
Dizziness 11
Myoclonus 11
Constipation 10
Death 9
Delirium 9

Track Your Side Effects

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It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Cyclobenzaprine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Cyclobenzaprine Safety Alerts, Active Ingredients, Usage Information

    NDC 0179-0057
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name cyclobenzaprine hydrochloride
    Name cyclobenzaprine hydrochloride
    Dosage Form TABLET
    Route ORAL
    On market since 20100302
    Labeler KAISER FOUNDATION HOSPITALS
    Active Ingredient(s) CYCLOBENZAPRINE HYDROCHLORIDE
    Strength(s) 10
    Unit(s) mg/1
    Pharma Class Centrally-mediated Muscle Relaxation [PE],Muscle Relaxant [EPC]

    More About Cyclobenzaprine

    Side Effects reported to FDA: 625

    Cyclobenzaprine safety alerts: No

    Reported deaths: 169

    Reported hospitalizations: 90

    Latest Cyclobenzaprine clinical trials

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