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Cyclophospham Side Effects

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Common Cyclophospham Side Effects


The most commonly reported Cyclophospham side effects (click to view or check a box to report):

Febrile Neutropenia (430)
Neutropenia (388)
Pyrexia (363)
Nausea (229)
White Blood Cell Count Decreased (196)
Vomiting (187)
Diarrhoea (186)
Pneumonia (186)
Hypotension (182)
Dyspnoea (181)
Anaemia (164)
Fatigue (161)
Neutrophil Count Decreased (156)
Sepsis (148)
Dehydration (143)
Abdominal Pain (139)
Haemoglobin Decreased (132)
Thrombocytopenia (131)
Asthenia (126)
Pancytopenia (121)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Cyclophospham Side Effects Reported to FDA



Cyclophospham Side Effect Report#9994666
Loss Of Consciousness, Tonic Clonic Movements, Convulsion, Syncope
This is a report of a 35-year-old female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: NA, who was treated with Cyclophosphamide (dosage: NA, start time: NS), combined with:
  • Doxorubicin Hydrochloride
and developed a serious reaction and side effect(s): Loss Of Consciousness, Tonic Clonic Movements, Convulsion, Syncope after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide treatment in female patients, resulting in Loss Of Consciousness side effect. The patient was hospitalized.
Cyclophospham Side Effect Report#9994305
Oedema Peripheral, Anaemia
This report suggests a potential Cyclophosphamide For Injection, Usp Oedema Peripheral side effect(s) that can have serious consequences. A 85-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: plasma cell myeloma and used Cyclophosphamide For Injection, Usp (dosage: NA) starting
May 17, 2013. After starting Cyclophosphamide For Injection, Usp the patient began experiencing various side effects, including: Oedema Peripheral, AnaemiaAdditional drugs used concurrently:
  • Velcade
  • Dexamethasone
The patient was hospitalized. Although Cyclophosphamide For Injection, Usp demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Oedema Peripheral, may still occur.
Cyclophospham Side Effect Report#9983584
Cardiac Failure Congestive, Exposure During Pregnancy
This Cardiac Failure Congestive problem was reported by a health professional from US. A 34-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: breast cancer. On NS this consumer started treatment with Cyclophosphamide (dosage: NA). The following drugs were being taken at the same time:
  • Metoclopramide
  • Promethazine
  • Acetaminophen
  • Doxorubicin
  • Dolasetron Mesylate
  • Aprepitant
  • Doxylamine
  • Hydrocodone
When using Cyclophosphamide, the patient experienced the following unwanted symptoms/side effects: Cardiac Failure Congestive, Exposure During PregnancyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cardiac Failure Congestive, may become evident only after a product is in use by the general population.
Cyclophospham Side Effect Report#9982209
Acute Myeloid Leukaemia
This Acute Myeloid Leukaemia side effect was reported by a physician from US. A 45-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclophosphamide (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Fludarabine Phosphate
  • Rituximab (moab C2b8 Anti Cd20, Chimeric)
.After starting to take Cyclophosphamide the consumer reported adverse symptoms, such as: Acute Myeloid LeukaemiaThese side effects may potentially be related to Cyclophosphamide. The patient was hospitalized.
Cyclophospham Side Effect Report#9981988
Catheter Site Pain, Catheter Site Discharge, Culture Positive, Staphylococcal Bacteraemia, Apnoea
This is a report of a 64-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclophosphamide (dosage: NA, start time: NS), combined with:
  • Doxorubicin Hydrochloride
  • Enulapril
  • Gliclazide
  • Indapamide
  • Januvia
  • Metformin
  • Simvastin
and developed a serious reaction and side effect(s): Catheter Site Pain, Catheter Site Discharge, Culture Positive, Staphylococcal Bacteraemia, Apnoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide treatment in female patients, resulting in Catheter Site Pain side effect. The patient was hospitalized.
Cyclophospham Side Effect Report#9975932
Hepatitis B
This report suggests a potential Cyclophosphamide Hepatitis B side effect(s) that can have serious consequences. A 43-year-old male patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: non-hodgkin^s lymphoma and used Cyclophosphamide (dosage: NA) starting 2005. After starting Cyclophosphamide the patient began experiencing various side effects, including: Hepatitis BAdditional drugs used concurrently: NA. Although Cyclophosphamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hepatitis B, may still occur.
Cyclophospham Side Effect Report#9975190
Castleman^s Disease
This Castleman^s Disease problem was reported by a physician from GB. A 65-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: castleman^s disease. On NS this consumer started treatment with Cyclophosphamide Injection 1g (dosage: NA). The following drugs were being taken at the same time:
  • Cisplatin
  • Cytarabine
  • Dexamethasone
  • Doxorubicin Hydrochloride
  • Prednisone
  • Rituximab
  • Vincristine
When using Cyclophosphamide Injection 1g, the patient experienced the following unwanted symptoms/side effects: Castleman^s DiseaseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Castleman^s Disease, may become evident only after a product is in use by the general population.
Cyclophospham Side Effect Report#9964129
No Therapeutic Response
This No Therapeutic Response side effect was reported by a health professional from GB. A 41-year-old male patient (weight:NA) experienced the following symptoms/conditions: poems syndrome.The patient was prescribed Cyclophosphamide Injection 1g (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Dexamethasone
.After starting to take Cyclophosphamide Injection 1g the consumer reported adverse symptoms, such as: No Therapeutic ResponseThese side effects may potentially be related to Cyclophosphamide Injection 1g.
Cyclophospham Side Effect Report#9928516
Staphylococcal Bacteraemia, Catheter Site Pain, Catheter Site Discharge, Apnoea, Weaning Failure
This is a report of a 64-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclophosphamide (dosage: NA, start time: NS), combined with:
  • Doxorubicin Hydrochloride
  • Enalapril
  • Gliclazide
  • Indapamide
  • Januvia
  • Metformin
  • Simvastin
and developed a serious reaction and side effect(s): Staphylococcal Bacteraemia, Catheter Site Pain, Catheter Site Discharge, Apnoea, Weaning Failure after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide treatment in female patients, resulting in Staphylococcal Bacteraemia side effect. The patient was hospitalized.
Cyclophospham Side Effect Report#9916744
Progressive Multifocal Leukoencephalopathy, Pneumonia, Neutropenia, Ophthalmic Herpes Simplex, Clostridium Difficile Colitis
This report suggests a potential Cyclophosphamide Tablets Usp Death side effect(s) that can have serious consequences. A 65-year-old female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: b-cell lymphoma and used Cyclophosphamide Tablets Usp (dosage: NA) starting NS. After starting Cyclophosphamide Tablets Usp the patient began experiencing various side effects, including: Progressive Multifocal Leukoencephalopathy, Pneumonia, Neutropenia, Ophthalmic Herpes Simplex, Clostridium Difficile ColitisAdditional drugs used concurrently:
  • Fludarabine
  • Rituximab
The patient was hospitalized. Although Cyclophosphamide Tablets Usp demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Cyclophospham Side Effect Report#9915959
Fatigue, Hyperhidrosis, Chills, Febrile Neutropenia, Infection, Pulmonary Oedema, Productive Cough
This Fatigue problem was reported by a consumer or non-health professional from US. A 47-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclophosphamide (dosage: NA). The following drugs were being taken at the same time:
  • Doxorubicin Hydrochloride
  • Etoposide (vp-16)
  • Rituximab
  • Vincristine Sulfate
When using Cyclophosphamide, the patient experienced the following unwanted symptoms/side effects: Fatigue, Hyperhidrosis, Chills, Febrile Neutropenia, Infection, Pulmonary Oedema, Productive CoughThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Fatigue, may become evident only after a product is in use by the general population.
Cyclophospham Side Effect Report#9914129
Neutropenic Sepsis, Febrile Neutropenia, Tremor, Malaise
This Neutropenic Sepsis side effect was reported by a physician from GB. A 40-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer.The patient was prescribed Cyclophosphamide (drug dosage: Unk), which was initiated on
Nov 20, 2013. Concurrently used drugs:
  • Epirubicin Hcl (Unk)
  • 5 Fu (Unk)
  • Neulasta (Unk, 3/52)
.After starting to take Cyclophosphamide the consumer reported adverse symptoms, such as: Neutropenic Sepsis, Febrile Neutropenia, Tremor, MalaiseThese side effects may potentially be related to Cyclophosphamide. The patient was hospitalized.
Cyclophospham Side Effect Report#9912650
Weaning Failure, Tracheal Injury, Angiopathy, Soft Tissue Necrosis
This is a report of a 80-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: diffuse large b-cell lymphoma stage ii, who was treated with Cyclophosphamide (cyclophosphamide) (dosage: NA, start time: NS), combined with:
  • Vincristine
  • Prednisolone
  • Rituximab
and developed a serious reaction and side effect(s): Weaning Failure, Tracheal Injury, Angiopathy, Soft Tissue Necrosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide (cyclophosphamide) treatment in female patients, resulting in Weaning Failure side effect.
Cyclophospham Side Effect Report#9912614
Tachycardia, Hypotension, Malaise, Body Temperature Increased
This report suggests a potential Cyclophosphamide Tachycardia side effect(s) that can have serious consequences. A 14-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclophosphamide (dosage: NA) starting NS. After starting Cyclophosphamide the patient began experiencing various side effects, including: Tachycardia, Hypotension, Malaise, Body Temperature IncreasedAdditional drugs used concurrently:
  • Cytarabine
  • Mercaptopurine
  • Peg-l-asparaginase (k-h)
The patient was hospitalized. Although Cyclophosphamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Tachycardia, may still occur.
Cyclophospham Side Effect Report#9900084
Bone Marrow Failure, Pneumococcal Bacteraemia, Atrioventricular Block Second Degree
This Bone Marrow Failure problem was reported by a health professional from BE. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: small cell lung cancer. On NS this consumer started treatment with Cyclophosphamide For Injection, Usp (dosage: 1 G/m2, On Day 1). The following drugs were being taken at the same time: NA. When using Cyclophosphamide For Injection, Usp, the patient experienced the following unwanted symptoms/side effects: Bone Marrow Failure, Pneumococcal Bacteraemia, Atrioventricular Block Second DegreeAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Bone Marrow Failure, may become evident only after a product is in use by the general population.
Cyclophospham Side Effect Report#9892711
Progressive Multifocal Leukoencephalopathy, Pyrexia, Pneumonia, Neutropenia, Hypoacusis, Balance Disorder, Optic Atrophy, Neurological Symptom, Condition Aggravated
This Progressive Multifocal Leukoencephalopathy side effect was reported by a health professional from IT. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: non-hodgkin^s lymphoma.The patient was prescribed Cyclophosphamide (drug dosage: 6 Cycles Received), which was initiated on NS. Concurrently used drugs:
  • Fludarabine (6 Cycles Received)
  • Rituximab (6 Cycles Received)
.After starting to take Cyclophosphamide the consumer reported adverse symptoms, such as: Progressive Multifocal Leukoencephalopathy, Pyrexia, Pneumonia, Neutropenia, Hypoacusis, Balance Disorder, Optic Atrophy, Neurological Symptom, Condition AggravatedThese side effects may potentially be related to Cyclophosphamide. The patient was hospitalized.
Cyclophospham Side Effect Report#9892678
Dermatitis Exfoliative, Thrombophlebitis Septic, Osteomyelitis, Staphylococcal Infection
This is a report of a 64-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: mycosis fungoides, who was treated with Cyclophosphamide For Injection, Usp (dosage: NA, start time: NS), combined with:
  • Doxorubicin
  • Vincristine
  • Prednisone
  • Methotrexate
and developed a serious reaction and side effect(s): Dermatitis Exfoliative, Thrombophlebitis Septic, Osteomyelitis, Staphylococcal Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide For Injection, Usp treatment in male patients, resulting in Dermatitis Exfoliative side effect. The patient was hospitalized.
Cyclophospham Side Effect Report#9888975
Pruritus, Pruritus, Rash
This report suggests a potential Cyclophosphamide For Injection, Usp Pruritus side effect(s) that can have serious consequences. A female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: breast cancer and used Cyclophosphamide For Injection, Usp (dosage: NA) starting
Dec 03, 2013. After starting Cyclophosphamide For Injection, Usp the patient began experiencing various side effects, including: Pruritus, Pruritus, RashAdditional drugs used concurrently: NA. Although Cyclophosphamide For Injection, Usp demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pruritus, may still occur.
Cyclophospham Side Effect Report#9879601
Splenic Rupture
This Splenic Rupture problem was reported by a health professional from US. A 33-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: acute myeloid leukaemia. On NS this consumer started treatment with Cyclophosphamide For Injection, Usp (dosage: NA). The following drugs were being taken at the same time:
  • Cytarabine
  • Daunorubicin
When using Cyclophosphamide For Injection, Usp, the patient experienced the following unwanted symptoms/side effects: Splenic RuptureThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Splenic Rupture, may become evident only after a product is in use by the general population.
Cyclophospham Side Effect Report#9877940
Atrioventricular Block Complete
This Atrioventricular Block Complete side effect was reported by a physician from US. A 35-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer.The patient was prescribed Cyclophosphamide For Injection, Usp (drug dosage: NA), which was initiated on
May 01, 1992. Concurrently used drugs: NA..After starting to take Cyclophosphamide For Injection, Usp the consumer reported adverse symptoms, such as: Atrioventricular Block CompleteThese side effects may potentially be related to Cyclophosphamide For Injection, Usp.
Cyclophospham Side Effect Report#9870455
Graft Versus Host Disease
This is a report of a 22-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclophosphamide For Injection, Usp (dosage: NA, start time: NS), combined with:
  • Fludarabine
  • Melphalan
and developed a serious reaction and side effect(s): Graft Versus Host Disease after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide For Injection, Usp treatment in male patients, resulting in Graft Versus Host Disease side effect.
Cyclophospham Side Effect Report#9869679
Pneumonia, Haemoptysis
This report suggests a potential Cyclophosphamide Pneumonia side effect(s) that can have serious consequences. A 23-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclophosphamide (dosage: NA) starting NS. After starting Cyclophosphamide the patient began experiencing various side effects, including: Pneumonia, HaemoptysisAdditional drugs used concurrently:
  • Cytarabine
  • Daunorubicin
  • Mercaptopurine
  • Methotrexate
  • Peg-l-asparaginase (k-h)
  • Thioguanine
  • Vincristine Sulfate
The patient was hospitalized. Although Cyclophosphamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pneumonia, may still occur.
Cyclophospham Side Effect Report#9868831
Graft Versus Host Disease
This Graft Versus Host Disease problem was reported by a physician from US. A 34-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclophosphamide For Injection, Usp (dosage: NA). The following drugs were being taken at the same time:
  • Fludarabine
  • Melphalan
When using Cyclophosphamide For Injection, Usp, the patient experienced the following unwanted symptoms/side effects: Graft Versus Host DiseaseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Graft Versus Host Disease, may become evident only after a product is in use by the general population.
Cyclophospham Side Effect Report#9868827
Graft Versus Host Disease
This Graft Versus Host Disease side effect was reported by a physician from US. A 16-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Cyclophosphamide For Injection, Usp (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Fludarabine
  • Melphalan
.After starting to take Cyclophosphamide For Injection, Usp the consumer reported adverse symptoms, such as: Graft Versus Host DiseaseThese side effects may potentially be related to Cyclophosphamide For Injection, Usp.
Cyclophospham Side Effect Report#9858770
Abdominal Pain Upper, Beta Haemolytic Streptococcal Infection, Back Pain
This is a report of a 59-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Cyclophosphamide (dosage: NA, start time:
Jul 15, 2013), combined with:
  • Morphine
  • Lorazepam
  • Ondansetron
  • Soma
  • Dexamethasone
  • Dronabinol
  • Gabapentin
  • Triamcinolone Cream
and developed a serious reaction and side effect(s): Abdominal Pain Upper, Beta Haemolytic Streptococcal Infection, Back Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide treatment in male patients, resulting in Abdominal Pain Upper side effect. The patient was hospitalized.


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The appearance of Cyclophospham on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Cyclophospham Side Effects for Women?

Women Side EffectsReports
Febrile Neutropenia 238
Neutropenia 237
Pyrexia 223
Nausea 146
White Blood Cell Count Decreased 141
Dyspnoea 132
Vomiting 119
Diarrhoea 110
Fatigue 110
Neutrophil Count Decreased 105

What are common Cyclophospham Side Effects for Men?

Men Side EffectsReports
Febrile Neutropenia 189
Neutropenia 144
Pyrexia 137
Pneumonia 92
Hypotension 89
Nausea 82
Diarrhoea 75
Anaemia 70
Vomiting 67
Sepsis 66

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Why Your Notes are Important

Your notes could be helpful in several ways:

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  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Cyclophospham reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Discuss Cyclophospham Side Effects

    Did You Have a Cyclophospham Side Effect?

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    How Effective is Cyclophospham for You?

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    Cyclophospham Safety Alerts, Active Ingredients, Usage Information

    NDC0054-0382
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameCyclophosphamide
    NameCyclophosphamide
    Dosage FormCAPSULE
    RouteORAL
    On market since20130916
    LabelerRoxane Laboratories, Inc.
    Active Ingredient(s)CYCLOPHOSPHAMIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma ClassAlkylating Activity [MoA],Alkylating Drug [EPC]

    More About Cyclophospham

    Side Effects reported to FDA: 4915

    Cyclophospham safety alerts: No

    Reported deaths: 945

    Reported hospitalizations: 2610

    Latest Cyclophospham clinical trials