PatientsVille.com Logo

PatientsVille

Cyclophospham Side Effects

Common Cyclophospham Side Effects


The most commonly reported Cyclophospham side effects (click to view or check a box to report):

Febrile Neutropenia (430)
Neutropenia (388)
Pyrexia (363)
Nausea (229)
White Blood Cell Count Decreased (196)
Vomiting (187)
Diarrhoea (186)
Pneumonia (186)
Hypotension (182)
Dyspnoea (181)
Anaemia (164)
Fatigue (161)
Neutrophil Count Decreased (156)
Sepsis (148)
Dehydration (143)
Abdominal Pain (139)
Haemoglobin Decreased (132)
Thrombocytopenia (131)
Asthenia (126)
Pancytopenia (121)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Cyclophospham Side Effects Reported to FDA

The following Cyclophospham reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Cyclophospham on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Loss Of Consciousness, Tonic Clonic Movements, Convulsion, Syncope
This is a report of a 35-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED, suffering from the following symptoms/conditions: NA, who was treated with Cyclophosphamide (dosage: NA, start time: NS), combined with:
  • Doxorubicin Hydrochloride
and developed a serious reaction and side effect(s). The consumer presented with:
  • Loss Of Consciousness
  • Tonic Clonic Movements
  • Convulsion
  • Syncope
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide treatment in female patients, resulting in loss of consciousness side effect. The patient was hospitalized.

Oedema Peripheral, Anaemia
This report suggests a potential Cyclophosphamide For Injection, Usp Oedema Peripheral, Anaemia side effect(s) that can have serious consequences. A 85-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: plasma cell myeloma and used Cyclophosphamide For Injection, Usp (dosage: NA) starting May 17, 2013. Soon after starting Cyclophosphamide For Injection, Usp the patient began experiencing various side effects, including:
  • Oedema Peripheral
  • Anaemia
Drugs used concurrently:
  • Velcade
  • Dexamethasone
The patient was hospitalized. Although Cyclophosphamide For Injection, Usp demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as oedema peripheral, may still occur.

Cardiac Failure Congestive, Exposure During Pregnancy
This Cardiac Failure Congestive, Exposure During Pregnancy problem was reported by a health professional from US. A 34-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: breast cancer. On NS this consumer started treatment with Cyclophosphamide (dosage: NA). The following drugs were being taken at the same time:
  • Metoclopramide
  • Promethazine
  • Acetaminophen
  • Doxorubicin
  • Dolasetron Mesylate
  • Aprepitant
  • Doxylamine
  • Hydrocodone
When commencing Cyclophosphamide, the patient experienced the following unwanted symptoms/side effects:
  • Cardiac Failure Congestive
  • Exposure During Pregnancy
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as cardiac failure congestive, may become evident only after a product is in use by the general population.

Acute Myeloid Leukaemia
This is a report of a 45-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Cyclophosphamide (dosage: NA) starting NS. Concurrently used drugs:
  • Fludarabine Phosphate
  • Rituximab (moab C2b8 Anti Cd20, Chimeric)
Soon after that, the consumer experienced the following side effects:
  • Acute Myeloid Leukaemia
The patient was hospitalized. This opens a possibility that Cyclophosphamide treatment could cause the above reactions, including acute myeloid leukaemia, and some female subjects may be more susceptible.


Catheter Site Pain, Catheter Site Discharge, Culture Positive, Staphylococcal Bacteraemia, Apnoea
A 64-year-old female patient (weight: NA) from US with the following symptoms/conditions: NA started Cyclophosphamide treatment (dosage: NA) on NS. Soon after starting Cyclophosphamide treatment, the subject experienced various side effects, including:
  • Catheter Site Pain
  • Catheter Site Discharge
  • Culture Positive
  • Staphylococcal Bacteraemia
  • Apnoea
Concurrently used drugs:
  • Doxorubicin Hydrochloride
  • Enulapril
  • Gliclazide
  • Indapamide
  • Januvia
  • Metformin
  • Simvastin
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Cyclophosphamide.

Hepatitis B
A 43-year-old male patient from CN (weight: NA) experienced symptoms, such as: non-hodgkin^s lymphoma and was treated with Cyclophosphamide(dosage: NA). The treatment was initiated on 2005. After that a consumer reported the following side effect(s):
  • Hepatitis B
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Cyclophosphamide efficacy: NA.

Castleman^s Disease
In this report, Cyclophosphamide Injection 1g was administered for the following condition: castleman^s disease.A 65-year-old male consumer from GB (weight: NA) started Cyclophosphamide Injection 1g treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Castleman^s Disease
A possible interaction with other drugs could have contributed to this reaction:
  • Cisplatin
  • Cytarabine
  • Dexamethasone
  • Doxorubicin Hydrochloride
  • Prednisone
  • Rituximab
  • Vincristine
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Cyclophosphamide Injection 1g treatment could be related to the listed above side effect(s).

No Therapeutic Response
This is a report of the following Cyclophosphamide Injection 1g side effect(s):
  • No Therapeutic Response
A 41-year-old male patient from GB (weight: NA) presented with the following condition: poems syndrome and received a treatment with Cyclophosphamide Injection 1g (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions:
  • Dexamethasone
This report suggests that a Cyclophosphamide Injection 1g treatment could be associated with the listed above side effect(s).

Staphylococcal Bacteraemia, Catheter Site Pain, Catheter Site Discharge, Apnoea, Weaning Failure
This Cyclophosphamide report was submitted by a 64-year-old female consumer from US (weight: NA). The patient was diagnosed with: NA and Cyclophosphamide was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Staphylococcal Bacteraemia
  • Catheter Site Pain
  • Catheter Site Discharge
  • Apnoea
  • Weaning Failure
Other drugs used simultaneously:
  • Doxorubicin Hydrochloride
  • Enalapril
  • Gliclazide
  • Indapamide
  • Januvia
  • Metformin
  • Simvastin
The patient was hospitalized.Those unexpected symptoms could be linked to a Cyclophosphamide treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Progressive Multifocal Leukoencephalopathy, Pneumonia, Neutropenia, Ophthalmic Herpes Simplex, Clostridium Difficile Colitis
This is a report of a possible correlation between Cyclophosphamide Tablets Usp use and the following symptoms/side effect(s):
  • Progressive Multifocal Leukoencephalopathy
  • Pneumonia
  • Neutropenia
  • Ophthalmic Herpes Simplex
  • Clostridium Difficile Colitis
which could contribute to an assessment of Cyclophosphamide Tablets Usp risk profile.A 65-year-old female consumer from COUNTRY NOT SPECIFIED (weight: NA) was suffering from b-cell lymphoma and was treated with Cyclophosphamide Tablets Usp (dosage: NA) starting NS.Other concurrent medications:
  • Fludarabine
  • Rituximab
The patient was hospitalized.

Fatigue, Hyperhidrosis, Chills, Febrile Neutropenia, Infection, Pulmonary Oedema, Productive Cough
A 47-year-old male patient from US (weight: NA) presented with the following symptoms: NA and after a treatment with Cyclophosphamide (dosage: NA) experienced the following side effect(s):
  • Fatigue
  • Hyperhidrosis
  • Chills
  • Febrile Neutropenia
  • Infection
  • Pulmonary Oedema
  • Productive Cough
The treatment was started on NS. Cyclophosphamide was used in combination with the following drugs:
  • Doxorubicin Hydrochloride
  • Etoposide (vp-16)
  • Rituximab
  • Vincristine Sulfate
The patient was hospitalized.This report could alert potential Cyclophosphamide consumers.

Neutropenic Sepsis, Febrile Neutropenia, Tremor, Malaise
In this report, a 40-year-old female patient from GB (weight: NA) was affected by a possible Cyclophosphamide side effect.The patient was diagnosed with breast cancer. After a treatment with Cyclophosphamide (dosage: Unk, start date: Nov 20, 2013), the patient experienced the following side effect(s):
  • Neutropenic Sepsis
  • Febrile Neutropenia
  • Tremor
  • Malaise
The following simultaneously used drugs could have led to this reaction:
  • Epirubicin Hcl (Unk)
  • 5 Fu (Unk)
  • Neulasta (Unk, 3/52)
The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Cyclophosphamide treatment.

Weaning Failure, Tracheal Injury, Angiopathy, Soft Tissue Necrosis
This is a report of a 80-year-old female patient from US (weight: NA), who used Cyclophosphamide (cyclophosphamide) (dosage: NA) for a treatment of diffuse large b-cell lymphoma stage ii. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Weaning Failure
  • Tracheal Injury
  • Angiopathy
  • Soft Tissue Necrosis
The following drugs could possibly have interacted with the Cyclophosphamide (cyclophosphamide) treatment
  • Vincristine
  • Prednisolone
  • Rituximab
Taken together, these observations suggest that a Cyclophosphamide (cyclophosphamide) treatment could be related to side effect(s), such as Weaning Failure, Tracheal Injury, Angiopathy, Soft Tissue Necrosis.

Tachycardia, Hypotension, Malaise, Body Temperature Increased
This tachycardia side effect was reported by a consumer or non-health professional from US. A 14-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Cyclophosphamide (dosage: NA), which was started on NS. Concurrently used drugs:
  • Cytarabine
  • Mercaptopurine
  • Peg-l-asparaginase (k-h)
When starting to take Cyclophosphamide the consumer reported the following symptoms:
  • Tachycardia
  • Hypotension
  • Malaise
  • Body Temperature Increased
The patient was hospitalized. These side effects may potentially be related to Cyclophosphamide.

Bone Marrow Failure, Pneumococcal Bacteraemia, Atrioventricular Block Second Degree
This is a Cyclophosphamide For Injection, Usp side effect report of a 59-year-old male patient (weight:NA) from BE, suffering from the following symptoms/conditions: small cell lung cancer, who was treated with Cyclophosphamide For Injection, Usp (dosage:1 G/m2, On Day 1, start time: NS), combined with: NA., and developed a serious reaction and a bone marrow failure side effect. The patient presented with:
  • Bone Marrow Failure
  • Pneumococcal Bacteraemia
  • Atrioventricular Block Second Degree
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Cyclophosphamide For Injection, Usp treatment in male patients suffering from small cell lung cancer, resulting in bone marrow failure.

Progressive Multifocal Leukoencephalopathy, Pyrexia, Pneumonia, Neutropenia, Hypoacusis, Balance Disorder, Optic Atrophy, Neurological Symptom, Condition Aggravated
This report suggests a potential Cyclophosphamide progressive multifocal leukoencephalopathy side effect(s) that can have serious consequences. A 65-year-old female patient from IT (weight:NA) was diagnosed with the following health condition(s): non-hodgkin^s lymphoma and used Cyclophosphamide (dosage: 6 Cycles Received) starting NS. Soon after starting Cyclophosphamide the patient began experiencing various side effects, including:
  • Progressive Multifocal Leukoencephalopathy
  • Pyrexia
  • Pneumonia
  • Neutropenia
  • Hypoacusis
  • Balance Disorder
  • Optic Atrophy
  • Neurological Symptom
  • Condition Aggravated
Drugs used concurrently:
  • Fludarabine (6 Cycles Received)
  • Rituximab (6 Cycles Received)
The patient was hospitalized. Although Cyclophosphamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as progressive multifocal leukoencephalopathy, may still occur.

Dermatitis Exfoliative, Thrombophlebitis Septic, Osteomyelitis, Staphylococcal Infection
This dermatitis exfoliative problem was reported by a health professional from US. A 64-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): mycosis fungoides.On NS a consumer started treatment with Cyclophosphamide For Injection, Usp (dosage: NA). The following drugs/medications were being taken at the same time:
  • Doxorubicin
  • Vincristine
  • Prednisone
  • Methotrexate
When commencing Cyclophosphamide For Injection, Usp, the patient experienced the following unwanted symptoms /side effects:
  • Dermatitis Exfoliative
  • Thrombophlebitis Septic
  • Osteomyelitis
  • Staphylococcal Infection
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as dermatitis exfoliative, may become evident only after a product is in use by the general population.

Pruritus, Rash
This is a Cyclophosphamide For Injection, Usp side effect report of a female patient (weight: NA) from US. The patient developed the following symptoms/conditions: breast cancer and was treated with Cyclophosphamide For Injection, Usp (dosage: NA) starting Dec 03, 2013. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Pruritus
  • Rash
This opens a possibility that Cyclophosphamide For Injection, Usp could cause pruritus and that some female patients may be more susceptible.

Splenic Rupture
A 33-year-old female patient (weight: NA) from US with the following symptoms: acute myeloid leukaemia started Cyclophosphamide For Injection, Usp treatment (dosage: NA) on NS. Soon after starting Cyclophosphamide For Injection, Usp treatment, the consumer experienced several side effects, including:
  • Splenic Rupture
. Concurrently used drugs:
  • Cytarabine
  • Daunorubicin
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Cyclophosphamide For Injection, Usp side effects, such as splenic rupture.

Atrioventricular Block Complete
This atrioventricular block complete side effect was reported by a physician from US. A 35-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer.The patient was prescribed Cyclophosphamide For Injection, Usp (dosage: NA), which was started on May 01, 1992. Concurrently used drugs: NA..When starting to take Cyclophosphamide For Injection, Usp the consumer reported symptoms, such as:
  • Atrioventricular Block Complete
These side effects may potentially be related to Cyclophosphamide For Injection, Usp.

Graft Versus Host Disease
This is a report of a 22-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Cyclophosphamide For Injection, Usp (dosage: NA, start time: NS), combined with:
  • Fludarabine
  • Melphalan
and developed a serious reaction and side effect(s). The consumer presented with:
  • Graft Versus Host Disease
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cyclophosphamide For Injection, Usp treatment in male patients, resulting in graft versus host disease side effect.

Pneumonia, Haemoptysis
This report suggests a potential Cyclophosphamide Pneumonia, Haemoptysis side effect(s) that can have serious consequences. A 23-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Cyclophosphamide (dosage: NA) starting NS. Soon after starting Cyclophosphamide the patient began experiencing various side effects, including:
  • Pneumonia
  • Haemoptysis
Drugs used concurrently:
  • Cytarabine
  • Daunorubicin
  • Mercaptopurine
  • Methotrexate
  • Peg-l-asparaginase (k-h)
  • Thioguanine
  • Vincristine Sulfate
The patient was hospitalized. Although Cyclophosphamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pneumonia, may still occur.

Graft Versus Host Disease
This Graft Versus Host Disease problem was reported by a physician from US. A 34-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Cyclophosphamide For Injection, Usp (dosage: NA). The following drugs were being taken at the same time:
  • Fludarabine
  • Melphalan
When commencing Cyclophosphamide For Injection, Usp, the patient experienced the following unwanted symptoms/side effects:
  • Graft Versus Host Disease
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as graft versus host disease, may become evident only after a product is in use by the general population.

Graft Versus Host Disease
This is a report of a 16-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Cyclophosphamide For Injection, Usp (dosage: NA) starting NS. Concurrently used drugs:
  • Fludarabine
  • Melphalan
Soon after that, the consumer experienced the following side effects:
  • Graft Versus Host Disease
This opens a possibility that Cyclophosphamide For Injection, Usp treatment could cause the above reactions, including graft versus host disease, and some female subjects may be more susceptible.

Abdominal Pain Upper, Beta Haemolytic Streptococcal Infection, Back Pain
A 59-year-old male patient (weight: NA) from US with the following symptoms/conditions: NA started Cyclophosphamide treatment (dosage: NA) on Jul 15, 2013. Soon after starting Cyclophosphamide treatment, the subject experienced various side effects, including:
  • Abdominal Pain Upper
  • Beta Haemolytic Streptococcal Infection
  • Back Pain
Concurrently used drugs:
  • Morphine
  • Lorazepam
  • Ondansetron
  • Soma
  • Dexamethasone
  • Dronabinol
  • Gabapentin
  • Triamcinolone Cream
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Cyclophosphamide.

1 of 197 



Top 10 Cyclophospham Side Effects for Women

Women Side EffectsReports
Febrile Neutropenia 238
Neutropenia 237
Pyrexia 223
Nausea 146
White Blood Cell Count Decreased 141
Dyspnoea 132
Vomiting 119
Diarrhoea 110
Fatigue 110
Neutrophil Count Decreased 105

Top 10 Cyclophospham Side Effects for Men

Men Side EffectsReports
Febrile Neutropenia 189
Neutropenia 144
Pyrexia 137
Pneumonia 92
Hypotension 89
Nausea 82
Diarrhoea 75
Anaemia 70
Vomiting 67
Sepsis 66

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Cyclophospham Side Effects

    Did You Have a Cyclophospham Side Effect?

    Yes, Severe
    Yes, Moderate
    Yes, Minor
    No

    How Effective is Cyclophospham for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Cyclophospham Safety Alerts, Active Ingredients, Usage Information

    NDC0054-0382
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameCyclophosphamide
    NameCyclophosphamide
    Dosage FormCAPSULE
    RouteORAL
    On market since20130916
    LabelerRoxane Laboratories, Inc.
    Active Ingredient(s)CYCLOPHOSPHAMIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma ClassAlkylating Activity [MoA],Alkylating Drug [EPC]

    More About Cyclophospham

    Side Effects reported to FDA: 4915

    Cyclophospham safety alerts: No

    Reported deaths: 945

    Reported hospitalizations: 2610

    Latest Cyclophospham clinical trials