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Cyclophospham Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 4407 

Pneumonia (8457279-9)
on Jun 14, 2012 Female from UNITED STATES , weighting 157.6 lb, was treated with Cyclophosphamide. Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: pneumonia. Cyclophosphamide dosage: N/A.
Associated medications used:
  • Rituximab
  • Fludarabine Phosphate
Patient was hospitalized.

Ascites, Hypotension, Urine Output Decreased, Polyserositis, Dyspnoea, Oedema Peripheral (8457108-3)
Patient was taking Cyclophosphamide. Patient felt the following Cyclophospham side effects: ascites, hypotension, urine output decreased, polyserositis, dyspnoea, oedema peripheral on Jun 06, 2012 from ISRAEL Additional patient health information: Male , child 11 years of age, was diagnosed with
  • bone marrow conditioning regimen
and. Cyclophosphamide dosage: N/A.
Multiple prescriptions taken:
  • Busulfan
  • Methotrexate
  • Cyclosporine


Renal Failure, Small Intestinal Obstruction, Sepsis, Abdominal Compartment Syndrome, Febrile Neutropenia, Hypertension (8457101-0)
Adverse event was reported on Jun 08, 2012 by a Female taking Cyclophosphamide (Dosage: 300 Mg/m2 As Part Of Cop) was diagnosed with
  • burkitt's lymphoma stage iii
and. Location: UNITED STATES , child 10 years of age, After Cyclophospham was administered, patient encountered several Cyclophospham side effects: renal failure, small intestinal obstruction, sepsis, abdominal compartment syndrome, febrile neutropenia, hypertension.
Multiple concurrent drugs taken:
  • Methotrexate (As Part Of Copadm1)
  • Vincristine (As Part Of Copadm2)
  • Cytarabine (Continuous Infusion Of 100 Mg/m2 Daily For 5 Days)
  • Vincristine (As Part Of Cop)
  • Methotrexate (As Part Of Copadm2 And Cym1)
  • Hydrocortisone (Administered Once With Cytarabine As Part Of Cym1)
  • Doxorubicin Hcl (As Part Of Copadm1)
  • Cytarabine (Administered Once With Hydrocortisone As Part Of Cym1)


Lower Respiratory Tract Infection (8456281-0)
on Jun 08, 2012 Female from UNITED KINGDOM , 71 years of age, was diagnosed with
  • multiple myeloma
and was treated with Cyclophosphamide. Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: lower respiratory tract infection. Cyclophosphamide dosage: N/A.
Associated medications used:
  • Revlimid
  • Dexamethasone Sodium Posphate
Patient was hospitalized.


Wheezing, Urticaria, Flushing, Rash, Oxygen Saturation Decreased (8455942-7)
on Jun 15, 2012 Male from IRELAND , 76 years of age, was diagnosed with
  • non-hodgkin's lymphoma
and was treated with Cyclophosphamide. Patient felt the following Cyclophospham side effects: wheezing, urticaria, flushing, rash, oxygen saturation decreased. Cyclophosphamide dosage: N/A.
Multiple prescriptions taken:
  • Vincristine
  • Nebivolol Hcl
  • Mabthera
  • Chlorpheniramine Maleate
  • Acetaminophen
  • Hydrocortisone
  • Hydrocortisone
  • Prednisolone


Abdominal Compartment Syndrome, Sepsis, Pancytopenia, Hypertension, Renal Failure, Febrile Neutropenia, Small Intestinal Obstruction (8452958-1)
Patient was taking Cyclophosphamide. After Cyclophospham was administered, patient encountered several Cyclophospham side effects: abdominal compartment syndrome, sepsis, pancytopenia, hypertension, renal failure, febrile neutropenia, small intestinal obstruction on Jun 14, 2012 from UNITED STATES Additional patient health information: Female , child 10 years of age, . Cyclophosphamide dosage: 250 Mg/m2, Bid For 6 Doses.
Multiple concurrent drugs taken:
  • Vincristine (2 Mg/m2, Unk)
  • Methotrexate (1500 Mg/m2, Unk)
  • Doxorubicin Hcl (30 Mg/m2, Unk)


Sepsis, White Blood Cell Count Increased, Tachycardia, Hypotension, Cardiac Arrest, Haemorrhoids, Proctalgia, Cellulitis, Skin Disorder (8450848-1)
Adverse event was reported on Jun 15, 2012 by a Female taking Cyclophosphamide (Dosage: 1245 Mg) . Location: UNITED STATES , weighting 269.0 lb, Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: sepsis, white blood cell count increased, tachycardia, hypotension, cardiac arrest, haemorrhoids, proctalgia, cellulitis, skin disorder.
Associated medications used:
  • Prilosec
  • Doxorubicin Hydrochloride (125 Mg)
  • Pegfilgrastin
  • Celexa
Patient was hospitalized.

Cardiac Failure, Bacterial Sepsis, Enterococcal Sepsis, Staphylococcal Sepsis, Candida Sepsis (8447019-1)
on Jun 11, 2012 Female from JAPAN , weighting 119.0 lb, was diagnosed with
  • aplastic anaemia
  • bone marrow conditioning regimen
and was treated with Cyclophosphamide Monohydrate. Patient felt the following Cyclophospham side effects: cardiac failure, bacterial sepsis, enterococcal sepsis, staphylococcal sepsis, candida sepsis. Cyclophosphamide Monohydrate dosage: Unk.
Multiple prescriptions taken:
  • Thymoglobulin (132.5 Mg, Qd)
  • Ondansetron (Unk)
  • Methylprednisolone Sodium Succinate (Unk)
  • Fludarabine Phosphate (Unk)
  • Acyclovir (Unk)
  • Dalteparin Sodium (Unk)
  • Mesna (Unk)
Patient was hospitalized.

Device Dislocation (8445031-X)
on Jun 13, 2012 Female from FRANCE , weighting 120.2 lb, was diagnosed with
  • neoplasm malignant
and was treated with Cyclophosphamide. After Cyclophospham was administered, patient encountered several Cyclophospham side effects: device dislocation. Cyclophosphamide dosage: Dosage Form: 17 Mg/m2, Date Of Last Dose: 14 May 2012.
Multiple concurrent drugs taken:
  • Vinorelbine Tartrate (Dosage Form: 17 Mg/m2, Date Of Last Dose: 14 May 2012)
  • Lutenyl
  • Avastin (Dosage Form: 5 Mg/kg, Date Of Last Dose: 14 May 2012, Temporarily Interrupted.)
Patient was hospitalized.

Neutropenia, Pyrexia, Rash Vesicular, Nausea, Dyspnoea, Shock, Circulatory Collapse, Hypotension, Tachycardia (8442932-3)
Patient was taking Cyclophosphamide. Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: neutropenia, pyrexia, rash vesicular, nausea, dyspnoea, shock, circulatory collapse, hypotension, tachycardia on Jun 04, 2012 from JAPAN Additional patient health information: Female , 68 years of age, weighting 87.96 lb, was diagnosed with
  • breast cancer
and. Cyclophosphamide dosage: N/A.
Associated medications used:
  • Epirubicin


Acute Lymphocytic Leukaemia (8440619-4)
Adverse event was reported on Jun 04, 2012 by a Female taking Cyclophosphamide (Dosage: Unk) was diagnosed with
  • acute lymphocytic leukaemia
and. Location: SPAIN , 74 years of age, Patient felt the following Cyclophospham side effects: acute lymphocytic leukaemia.
Multiple prescriptions taken:
  • Clofarabine (Unk)
  • Clofarabine (Unk)


Chronic Myeloid Leukaemia, Neoplasm Malignant, Graft Versus Host Disease (8439170-7)
on Jun 07, 2012 Male from CHINA , 26 years of age, was treated with Cyclophosphamide. After Cyclophospham was administered, patient encountered several Cyclophospham side effects: chronic myeloid leukaemia, neoplasm malignant, graft versus host disease. Cyclophosphamide dosage: 60 Mg/kg, Per Day.
Multiple concurrent drugs taken:
  • Imatinib Mesylate (400-800 Mg)
  • Busulfan (4 Mg/kg, Per Day)


Metal Poisoning (8439054-4)
on Jun 07, 2012 Female from TAIWAN, PROVINCE OF CHINA , 65 years of age, was diagnosed with
  • breast cancer
and was treated with Cyclophosphamide. Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: metal poisoning. Cyclophosphamide dosage: 600 Mg/m2, Four 3 Weekly Cycles.
Associated medications used:
  • Doxorubicin Hcl (60 Mg/m2, Four 3 Weekly Cycles)


Hypoxia, Atelectasis, Pneumonitis, Febrile Neutropenia, Pleural Effusion, Jugular Vein Thrombosis, Hypotension, Pneumonia, Pericardial Effusion (8438166-9)
Patient was taking Cyclophosphamide. Patient felt the following Cyclophospham side effects: hypoxia, atelectasis, pneumonitis, febrile neutropenia, pleural effusion, jugular vein thrombosis, hypotension, pneumonia, pericardial effusion on Jun 06, 2012 from UNITED STATES Additional patient health information: Female , 14 years of age, weighting 121.3 lb, was diagnosed with
  • rhabdomyosarcoma
and. Cyclophosphamide dosage: Day 1 Over 30-60 Minutes.
Multiple prescriptions taken:
  • Temsirolimus (Days 1, 8 And 15 Over 30-60 Minutes)
  • Vinorelbine (Days 1 And 8, Over 6-10 Minutes)
Patient was hospitalized.

Dehydration (8438051-2)
Adverse event was reported on Jun 11, 2012 by a Female taking Cyclophosphamide (Dosage: 1350 Mg, Unk) was diagnosed with
  • diffuse large b-cell lymphoma
and. Location: NETHERLANDS , 65 years of age, weighting 158.7 lb, After Cyclophospham was administered, patient encountered several Cyclophospham side effects: dehydration.
Multiple concurrent drugs taken:
  • Doxorubicin Hcl (90 Mg, Unk)
  • Pegfilgrastim (6 Mg, Unk)
  • Vincristine Sulfate (1 Mg, Unk)
  • Cotrim (960 Unk, Unk)
  • Metoclopramide (10 Mg, Unk)
  • Prednisone Tab (100 Mg, Unk)
  • Valaciclovir (500 Mg, Unk)
  • Rituximab (700 Mg, Unk)
Patient was hospitalized.

Renal Failure Acute, Stevens-johnson Syndrome (8436554-8)
on Jun 01, 2012 Female from UNITED KINGDOM , 72 years of age, was diagnosed with
  • multiple myeloma
and was treated with Cyclophosphamide. Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: renal failure acute, stevens-johnson syndrome. Cyclophosphamide dosage: 500 Milligram.
Associated medications used:
  • Dexamethasone (20 Milligram)
  • Allopurinol
  • Revlimid (25 Milligram)
  • Piperacillin And Tazobactam
  • Meropenem
Patient was hospitalized.

Prostate Cancer (8435927-7)
on Jun 12, 2012 Male from FRANCE , 74 years of age, was treated with Cyclophosphamide. Patient felt the following Cyclophospham side effects: prostate cancer. Cyclophosphamide dosage: N/A.
Multiple prescriptions taken:
  • Nplate
  • Mabthera
  • Phenoxymethyl Penicillin


Diffuse Large B-cell Lymphoma, Dysphagia, Asthenia, Aphagia, Periodontal Disease, Cachexia (8435846-6)
Patient was taking Cyclophosphamide. After Cyclophospham was administered, patient encountered several Cyclophospham side effects: diffuse large b-cell lymphoma, dysphagia, asthenia, aphagia, periodontal disease, cachexia on Jun 08, 2012 from UNITED STATES Additional patient health information: Male , weighting 143.3 lb, . Cyclophosphamide dosage: 1230 Mg.
Multiple concurrent drugs taken:
  • Prednisone Tab (1000 Mg)
  • Etoposide (328 Mg)
  • Rituximab (moab C2b8 Anti Cd20, Chimeric) (615 Mg)
  • Doxorubicin Hydrochloride (65.6 Mg)
  • Vincristine Sulfate (2,624 Mg)
Patient was hospitalized.

Pancytopenia (8435834-X)
Adverse event was reported on Jun 11, 2012 by a Female taking Cyclophosphamide (Dosage: 1400 Mg, Unk) was diagnosed with
  • diffuse large b-cell lymphoma
and. Location: NETHERLANDS , 61 years of age, Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: pancytopenia.
Associated medications used:
  • Prednisone Tab (100 Mg, Unk)
  • Ceftriaxone (200 Mg, Unk)
  • Rituximab (700 Mg, Unk)
  • Vincristine (2 Mg, Unk)
  • Pegfilgrastim (6 Mg, Unk)
  • Doxorubicin Hcl (95 Mg, Unk)
  • Tobramycin (Unk)


Vomiting, Headache, Nausea, White Blood Cell Count Decreased (8435512-7)
on Jun 07, 2012 Female from CHINA , 57 years of age, was diagnosed with
  • breast cancer female
and was treated with Cyclophosphamide. Patient felt the following Cyclophospham side effects: vomiting, headache, nausea, white blood cell count decreased. Cyclophosphamide dosage: Unk G, 1x/day.
Multiple prescriptions taken:
  • Fluorouracil (0.75g)
  • Epirubicin Hydrochloride (100 Mg, 1x/day)
Patient was hospitalized.

Respiratory Failure, Infection, Chills, Oxygen Saturation Decreased, Hyperpyrexia (8435434-1)
on Jun 04, 2012 Male from CHINA , weighting 135.1 lb, was diagnosed with
  • aplastic anaemia
and was treated with Cyclophosphamide. After Cyclophospham was administered, patient encountered several Cyclophospham side effects: respiratory failure, infection, chills, oxygen saturation decreased, hyperpyrexia. Cyclophosphamide dosage: 50 Mg/kg, Qd.
Multiple concurrent drugs taken:
  • Thymoglobulin (2.5 Mg/kg, Qd)


Tumour Lysis Syndrome (8433992-4)
Patient was taking Cyclophosphamide. Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: tumour lysis syndrome on Jun 06, 2012 from UNITED KINGDOM Additional patient health information: Female , 62 years of age, weighting 159.4 lb, . Cyclophosphamide dosage: N/A.
Associated medications used:
  • Prednisone Tab
  • Doxorubicin Hcl
  • Vincristine Sulfate
  • Rituximab
Patient was hospitalized.

Lymphoma (8432975-8)
Adverse event was reported on Jun 11, 2012 by a Male taking Cyclophosphamide (Dosage: N/A) was diagnosed with
  • diffuse large b-cell lymphoma
and. Location: CHINA , 44 years of age, weighting 121.3 lb, Patient felt the following Cyclophospham side effects: lymphoma.
Multiple prescriptions taken:
  • Mabthera
  • Vincristine
  • Prednisone
  • Doxorubicin Hcl


Ileus (8432946-1)
on Jun 01, 2012 Male from JAPAN , 59 years of age, was treated with Cyclophosphamide. After Cyclophospham was administered, patient encountered several Cyclophospham side effects: ileus. Cyclophosphamide dosage: Dosage Is Uncertain..
Multiple concurrent drugs taken:
  • Mabthera (Dosage Is Uncertain.)
  • Prednisolone (Dosage Is Uncertain.)
  • Mabthera (Dosage Is Uncertain.)
  • Vincristine (Dosage Is Uncertain.)
  • Prednisolone (Dosage Is Uncertain.)
  • Kytril (Dosage Is Uncertain.)
  • Kytril (Dosage Is Uncertain.)


Dizziness, Febrile Neutropenia, Orthostatic Hypotension, Chills, Asthenia, Syncope (8431833-2)
on Jun 07, 2012 Male from UNITED STATES , weighting 194.0 lb, was treated with Cyclophosphamide. Directly after, patient experienced the unwanted or unexpected Cyclophospham side effects: dizziness, febrile neutropenia, orthostatic hypotension, chills, asthenia, syncope. Cyclophosphamide dosage: 2095 Mg.
Associated medications used:
  • Doxorubicin Hcl (112 Mg)
  • Etoposide (560 Mg)
  • Vincristine Sulfate (3.12 Mg)
Patient was hospitalized.

Showing 1-25 of 4407 

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It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Cyclophospham Information

Alternative CYCLOPHOSPHAM Names:CYCLOPHOS

Active Ingredient: CYCLOPHOS

More About Cyclophospham

Side Effects reported to FDA: 4407. View Cyclophospham Adverse Reports

Cyclophospham safety alerts: No

Reported deaths: 858

Reported hospitalizations: 2386

Managing Your Medicines

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Before Taking Cyclophospham

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