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Dacarbazine Side Effects

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Common Dacarbazine Side Effects


The most commonly reported Dacarbazine side effects (click to view or check a box to report):

Pyrexia (41)
Disease Progression (33)
Dyspnoea (32)
Dehydration (30)
Metastatic Malignant Melanoma (27)
Fatigue (21)
Febrile Neutropenia (19)
Thrombocytopenia (19)
Hypotension (19)
Anaemia (18)
Nausea (18)
Diarrhoea (17)
Malignant Neoplasm Progression (17)
Neutropenia (16)
Abdominal Pain (15)
Vomiting (15)
Pleural Effusion (14)
Back Pain (14)
Chills (14)
Pulmonary Toxicity (14)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Dacarbazine Side Effects Reported to FDA



Dacarbazine Side Effect Report#9891503
Chills, Pyrexia, Tachycardia, Wheezing, Investigation
This is a report of a 56-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: hodgkin^s disease, who was treated with Dacarbazine (dosage: NA, start time:
Oct 04, 2013), combined with: NA. and developed a serious reaction and side effect(s): Chills, Pyrexia, Tachycardia, Wheezing, Investigation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dacarbazine treatment in male patients, resulting in Chills side effect.
Dacarbazine Side Effect Report#9885310
Myelodysplastic Syndrome
This report suggests a potential Dacarbazine Myelodysplastic Syndrome side effect(s) that can have serious consequences. A 44-year-old male patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: malignant melanoma and used Dacarbazine (dosage: 5000 Mg) starting NS. After starting Dacarbazine the patient began experiencing various side effects, including: Myelodysplastic SyndromeAdditional drugs used concurrently: NA. Although Dacarbazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Myelodysplastic Syndrome, may still occur.
Dacarbazine Side Effect Report#9761229
Clostridium Difficile Infection, Clostridium Difficile Colitis, Pancytopenia
This Clostridium Difficile Infection problem was reported by a physician from US. A 43-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hodgkin^s disease. On NS this consumer started treatment with Dacarbazine (dosage: NA). The following drugs were being taken at the same time:
  • Doxorubicin
  • Vinblastine
  • Bleomycin
  • Oxycodone W/paracetamol
When using Dacarbazine, the patient experienced the following unwanted symptoms/side effects: Clostridium Difficile Infection, Clostridium Difficile Colitis, PancytopeniaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Clostridium Difficile Infection, may become evident only after a product is in use by the general population.
Dacarbazine Side Effect Report#9735174
Abscess, Cellulitis, Malignant Melanoma Stage Iv, Malignant Neoplasm Progression
This Abscess side effect was reported by a physician from GB. A 47-year-old male patient (weight:NA) experienced the following symptoms/conditions: malignant melanoma.The patient was prescribed Dacarbazine (drug dosage: NA), which was initiated on
Aug 09, 2011. Concurrently used drugs: NA..After starting to take Dacarbazine the consumer reported adverse symptoms, such as: Abscess, Cellulitis, Malignant Melanoma Stage Iv, Malignant Neoplasm ProgressionThese side effects may potentially be related to Dacarbazine. The patient was hospitalized.
Dacarbazine Side Effect Report#9683505
Hypoglycaemia, Fatigue, Chills, Hypotension
This is a report of a 84-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: malignant melanoma, who was treated with Dacarbazine (dosage: 1820mg Cyclical, start time:
Aug 26, 2013), combined with: NA. and developed a serious reaction and side effect(s): Hypoglycaemia, Fatigue, Chills, Hypotension after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dacarbazine treatment in male patients, resulting in Hypoglycaemia side effect.
Dacarbazine Side Effect Report#9531313
Thrombocytopenia
This report suggests a potential Dacarbazine Thrombocytopenia side effect(s) that can have serious consequences. A 34-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: metastatic malignant melanoma and used Dacarbazine (dosage: 1 Cycle) starting NS. After starting Dacarbazine the patient began experiencing various side effects, including: ThrombocytopeniaAdditional drugs used concurrently: NA. Although Dacarbazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Thrombocytopenia, may still occur.
Dacarbazine Side Effect Report#9463785
Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
This Alanine Aminotransferase Increased problem was reported by a consumer or non-health professional from US. A 55-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: metastatic malignant melanoma. On
May 31, 2013 this consumer started treatment with Dacarbazine (dosage: 1539 Mg, Unk). The following drugs were being taken at the same time:
  • Monoclonal Antibodies (680 Mg, Unk)
  • Zolpidem (Unk)
  • Palonosetron (Unk)
  • Hydroxyzine Hcl (Unk)
  • Aprepitant (Unk)
  • Difluprednate
  • Loxoprofen (Unk)
  • Rebamipide (Unk)
When using Dacarbazine, the patient experienced the following unwanted symptoms/side effects: Alanine Aminotransferase Increased, Aspartate Aminotransferase IncreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Alanine Aminotransferase Increased, may become evident only after a product is in use by the general population.
Dacarbazine Side Effect Report#9424428
Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
This Alanine Aminotransferase Increased side effect was reported by a consumer or non-health professional from US. A 62-year-old male patient (weight:NA) experienced the following symptoms/conditions: metastatic malignant melanoma.The patient was prescribed Dacarbazine (drug dosage: 1343 Mg, Q3wk), which was initiated on
May 08, 2013. Concurrently used drugs:
  • Ipilimumab (547 Mg Every 3 Weeks)
  • Sucrose (Unk)
  • Betamethasone (Unk)
  • Fexofenadine Hydrochloride (Unk)
.After starting to take Dacarbazine the consumer reported adverse symptoms, such as: Alanine Aminotransferase Increased, Aspartate Aminotransferase IncreasedThese side effects may potentially be related to Dacarbazine. The patient was hospitalized.
Dacarbazine Side Effect Report#9372234
Radiation Pneumonitis, Cough, Dyspnoea Exertional, Radiation Fibrosis, Lung Disorder
This is a report of a 24-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: hodgkin^s disease nodular sclerosis stage ii, who was treated with Dacarbazine (dosage: NA, start time: NS), combined with:
  • Adriamycin
  • Bleomycin
  • Vinblastine
  • Bicnu
  • Etoposide
  • Cytosine Arabinoside
  • Melphalan
and developed a serious reaction and side effect(s): Radiation Pneumonitis, Cough, Dyspnoea Exertional, Radiation Fibrosis, Lung Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dacarbazine treatment in male patients, resulting in Radiation Pneumonitis side effect.
Dacarbazine Side Effect Report#9324433
Diffuse Large B-cell Lymphoma
This report suggests a potential Dacarbazine Diffuse Large B-cell Lymphoma side effect(s) that can have serious consequences. A 62-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hodgkin^s disease and used Dacarbazine (dosage: 6 Cycles) starting NS. After starting Dacarbazine the patient began experiencing various side effects, including: Diffuse Large B-cell LymphomaAdditional drugs used concurrently:
  • Doxorubicin (6 Cycles)
  • Doxorubicin
  • Bleomycin (6 Cycles)
  • Vinblastine (6 Cycles)
  • Ifosfamide (2 Cycles)
  • Carboplatin (6 Cycles)
  • Etoposide (6 Cycles)
  • Etoposide (Treatment Of Event)
Although Dacarbazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Diffuse Large B-cell Lymphoma, may still occur.
Dacarbazine Side Effect Report#9311861
Blood Alkaline Phosphatase Increased, Gamma-glutamyltransferase Increased, Hepatic Failure, Sepsis, Acute Respiratory Distress Syndrome, Malaise, C-reactive Protein Increased, Paronychia, Rash
This Blood Alkaline Phosphatase Increased problem was reported by a health professional from JP. A 31-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pancreatic neuroendocrine tumour. On
Feb 23, 2012 this consumer started treatment with Dacarbazine (dosage: NA). The following drugs were being taken at the same time:
  • Epirubicin Hydrochloride
  • Xeloda
  • Temodal
  • Aroglycem (225 Mg)
  • Sutent (25 Mg)
  • Amino Acid (1000 Ml)
  • Sosegon (15 Mg)
  • Azunol /00517002/
When using Dacarbazine, the patient experienced the following unwanted symptoms/side effects: Blood Alkaline Phosphatase Increased, Gamma-glutamyltransferase Increased, Hepatic Failure, Sepsis, Acute Respiratory Distress Syndrome, Malaise, C-reactive Protein Increased, Paronychia, RashThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Blood Alkaline Phosphatase Increased, may become evident only after a product is in use by the general population.
Dacarbazine Side Effect Report#9240298
Vascular Occlusion, Vasospasm, Raynaud^s Phenomenon
This Vascular Occlusion side effect was reported by a health professional from GB. A 61-year-old male patient (weight:NA) experienced the following symptoms/conditions: hodgkin^s disease stage iv.The patient was prescribed Dacarbazine (drug dosage: Cyclical), which was initiated on NS. Concurrently used drugs:
  • Vincristine Sulfate (Cyclical)
  • Doxorubicin Hydrochloride (Cyclical)
  • Bleomycin
.After starting to take Dacarbazine the consumer reported adverse symptoms, such as: Vascular Occlusion, Vasospasm, Raynaud^s PhenomenonThese side effects may potentially be related to Dacarbazine. The patient was hospitalized.
Dacarbazine Side Effect Report#9121387
Sarcoidosis
This is a report of a 33-year-old female patient (weight: NA) from ES, suffering from the following health symptoms/conditions: hodgkin^s disease, who was treated with Dacarbazine (dosage: NA, start time: NS), combined with:
  • Adriamycin
  • Bleomycin
  • Vinblastine
and developed a serious reaction and side effect(s): Sarcoidosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dacarbazine treatment in female patients, resulting in Sarcoidosis side effect.
Dacarbazine Side Effect Report#9121317
Bone Marrow Failure
This report suggests a potential Dacarbazine Bone Marrow Failure side effect(s) that can have serious consequences. A 47-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: metastatic malignant melanoma and used Dacarbazine (dosage: NA) starting
Dec 11, 2010. After starting Dacarbazine the patient began experiencing various side effects, including: Bone Marrow FailureAdditional drugs used concurrently:
  • Vemurafenib
  • Augmentin
  • Ciflox
  • Vancomycin
  • Tazocilline
  • Tazocilline
  • Amiklin
  • Amiklin
The patient was hospitalized. Although Dacarbazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Bone Marrow Failure, may still occur.
Dacarbazine Side Effect Report#9115757
Alanine Aminotransferase Increased
This Alanine Aminotransferase Increased problem was reported by a consumer or non-health professional from US. A 70-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: metastatic malignant melanoma. On
Feb 05, 2013 this consumer started treatment with Dacarbazine (dosage: 1513 Mg (every 3 Weeks)). The following drugs were being taken at the same time:
  • Mdx-010 (759 Mg (every 3 Weeks))
  • Amlodipine (Unk)
  • Olopatadine Hydrochloride (Unk)
  • Prednisolone (20 Mg Daily)
  • Prednisolone (15 Mg Daily)
  • Prednisolone (60 Mg Daily)
  • Prednisolone (50 Mg Daily)
  • Prednisolone (60 Mg Daily)
When using Dacarbazine, the patient experienced the following unwanted symptoms/side effects: Alanine Aminotransferase IncreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Alanine Aminotransferase Increased, may become evident only after a product is in use by the general population.
Dacarbazine Side Effect Report#9048323
Abdominal Pain, Neutropenia, Abdominal Distension, Intestinal Ischaemia, Gastrointestinal Necrosis
This Abdominal Pain side effect was reported by a consumer or non-health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Dacarbazine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Doxorubicin Hydrochloride
  • Vinblastine Sulfate
.After starting to take Dacarbazine the consumer reported adverse symptoms, such as: Abdominal Pain, Neutropenia, Abdominal Distension, Intestinal Ischaemia, Gastrointestinal NecrosisThese side effects may potentially be related to Dacarbazine. The patient was hospitalized.
Dacarbazine Side Effect Report#9028480
Malignant Fibrous Histiocytoma
This is a report of a 32-year-old male patient (weight: NA) from IN, suffering from the following health symptoms/conditions: hodgkin^s disease recurrent, who was treated with Dacarbazine (dosage: 6 Cycles Of Abvd (dosing Nos), start time: 1994), combined with:
  • Adriamycin (6 Cycles Of Abvd (dosing Nos))
  • Bleomycin (6 Cycles Of Abvd (dosing Nos))
  • Vinblastine (6 Cycles Of Abvd (dosing Nos))
and developed a serious reaction and side effect(s): Malignant Fibrous Histiocytoma after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dacarbazine treatment in male patients, resulting in Malignant Fibrous Histiocytoma side effect.
Dacarbazine Side Effect Report#8969157
Acute Lymphocytic Leukaemia
This report suggests a potential Dacarbazine Acute Lymphocytic Leukaemia side effect(s) that can have serious consequences. A 51-year-old female patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: hodgkin^s lymphoma and used Dacarbazine (dosage: NA) starting NS. After starting Dacarbazine the patient began experiencing various side effects, including: Acute Lymphocytic LeukaemiaAdditional drugs used concurrently:
  • Doxorubicin
  • Bleomycin
  • Vinblastine
Although Dacarbazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Acute Lymphocytic Leukaemia, may still occur.
Dacarbazine Side Effect Report#8960715
Respiratory Failure, Hypoxia
This Respiratory Failure problem was reported by a health professional from GB. A 54-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
May 09, 2012 this consumer started treatment with Dacarbazine (dosage: (not Otherwise Specified)). The following drugs were being taken at the same time:
  • Vinblastine Sulfate ((not Otherwise Specified))
  • Doxorubicin Hydrochloride ((not Otherwise Specified))
  • Bleomycin ((not Otherwise Specified))
  • Truvada
  • Darunavir
  • (ritonavir)
When using Dacarbazine, the patient experienced the following unwanted symptoms/side effects: Respiratory Failure, HypoxiaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Respiratory Failure, may become evident only after a product is in use by the general population.
Dacarbazine Side Effect Report#8954892
Tuberculosis, Hodgkin^s Disease Stage Iv
This Tuberculosis side effect was reported by a physician from IT. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: hodgkin^s disease stage iii.The patient was prescribed Dacarbazine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Doxorubicin
  • Bleomycin
  • Vinblastine
  • Dexamethasone
  • Cisplatin
  • Cytarabine
.After starting to take Dacarbazine the consumer reported adverse symptoms, such as: Tuberculosis, Hodgkin^s Disease Stage IvThese side effects may potentially be related to Dacarbazine.
Dacarbazine Side Effect Report#8825931
Pleural Effusion, Decreased Appetite
This is a report of a 66-year-old male patient (weight: NA) from JP, suffering from the following health symptoms/conditions: malignant fibrous histiocytoma, who was treated with Dacarbazine (dosage: NA, start time: NS), combined with:
  • Pirarubicin
  • Ifosfamide
  • Warfarin
and developed a serious reaction and side effect(s): Pleural Effusion, Decreased Appetite after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dacarbazine treatment in male patients, resulting in Pleural Effusion side effect.
Dacarbazine Side Effect Report#8793938
This report suggests a potential Dacarbazine Foetal Death side effect(s) that can have serious consequences. A 33-year-old female patient (weight: NA) from TR was diagnosed with the following symptoms/conditions: hodgkin^s disease and used Dacarbazine (dosage: NA) starting NS. After starting Dacarbazine the patient began experiencing various side effects, including:Additional drugs used concurrently:
  • Adriamycin
  • Vinblastine
  • Bleomycin
Although Dacarbazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Foetal Death, may still occur.
Dacarbazine Side Effect Report#8433337-X
Metastatic Malignant Melanoma, Constipation, Neoplasm Progression, Convulsion, Intracranial Pressure Increased, Cerebral Haemorrhage
This Metastatic Malignant Melanoma problem was reported by a health professional from Brazil. A 74-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Apr 24, 2012 this consumer started treatment with Dacarbazine (dosage: NA). The following drugs were being taken at the same time:
  • Atenolol
  • Innohep (15000 Iu (15000 Iu, 1 In 1 D), Subcutaneous)
  • Dexamethasone
  • Gutalax (sodium Picosulfate)
When using Dacarbazine, the patient experienced the following unwanted symptoms/side effects: Metastatic Malignant Melanoma, Constipation, Neoplasm Progression, Convulsion, Intracranial Pressure Increased, Cerebral HaemorrhageAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Metastatic Malignant Melanoma, may become evident only after a product is in use by the general population.
Dacarbazine Side Effect Report#8429562-4
Glycosylated Haemoglobin Increased, Sclerodactylia, Interstitial Lung Disease, Scleroderma
This Glycosylated Haemoglobin Increased side effect was reported by a health professional from Japan. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: hodgkin's disease.The patient was prescribed Dacarbazine (drug dosage: 500 Mg), which was initiated on NS. Concurrently used drugs:
  • Adriamycin Pfs (35 Mg)
  • Vinblastine Sulfate (8 Mg)
  • Bleomycin Sulfate (26 Mg)
.After starting to take Dacarbazine the consumer reported adverse symptoms, such as: Glycosylated Haemoglobin Increased, Sclerodactylia, Interstitial Lung Disease, SclerodermaThese side effects may potentially be related to Dacarbazine.
Dacarbazine Side Effect Report#8374572-9
Respiratory Disorder
This is a report of a 33-year-old male patient (weight: NA) from Israel, suffering from the following health symptoms/conditions: hodgkin's disease, who was treated with Dacarbazine (dosage: 375 Mg/m2, start time: NS), combined with:
  • Doxorubicin Hcl (25 Mg/m2)
  • Vinblastine Sulfate (6 G/m2)
  • Dexamethasone (20mg)
  • Bleomycin (10 Mg/m2)
and developed a serious reaction and side effect(s): Respiratory Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dacarbazine treatment in male patients, resulting in Respiratory Disorder side effect.


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The appearance of Dacarbazine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Dacarbazine Side Effects for Women?

Women Side EffectsReports
Disease Progression 19
Pyrexia 18
Dyspnoea 13
Dehydration 12
Vomiting 12
Abdominal Pain 11
Nausea 11
Metastatic Malignant Melanoma 9
Fatigue 8
Pneumonia 8

What are common Dacarbazine Side Effects for Men?

Men Side EffectsReports
Pyrexia 23
Dyspnoea 19
Dehydration 18
Metastatic Malignant Melanoma 18
Disease Progression 14
Hypotension 14
Malignant Neoplasm Progression 14
Fatigue 13
Pleural Effusion 13
Anaemia 12

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  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Dacarbazine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Dacarbazine Safety Alerts, Active Ingredients, Usage Information

    NDC0703-5075
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameDacarbazine
    NameDacarbazine
    Dosage FormINJECTION, POWDER, FOR SOLUTION
    RouteINTRAVENOUS
    On market since19980827
    LabelerTeva Parenteral Medicines, Inc.
    Active Ingredient(s)DACARBAZINE
    Strength(s)200
    Unit(s)mg/20mL
    Pharma ClassAlkylating Activity [MoA],Alkylating Drug [EPC]

    More About Dacarbazine

    Side Effects reported to FDA: 427

    Dacarbazine safety alerts: No

    Reported deaths: 84

    Reported hospitalizations: 284

    Latest Dacarbazine clinical trials

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