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Headache (21)
Delay Mensuration (18)
Stomach Pains (11)
Tinnitus (7)
Menorrhagia (6)
Eosinophilia (5)
Pimples (5)
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Daflon Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Pruritus, Rash Maculo-papular, Rash Erythematous, Urticaria, Idiopathic Urticaria (8400563-5)
on May 25, 2012 Female from FRANCE , 71 years of age, was treated with Daflon. Directly after, patient experienced the unwanted or unexpected Daflon side effects: pruritus, rash maculo-papular, rash erythematous, urticaria, idiopathic urticaria. Daflon dosage: Unk.
Associated medications used:
  • Metformin Hcl (500 Mg, Tid, Unk)
  • Heparin (Unk)
  • Visipaque (Unk)
  • Ebastine (Unk)
  • Loprazolam Mesilate (Unk)
  • Macrogol (Unk)
  • Betadine (Unk)
  • Repaglinide (0.5 Mg, Tid , Unk)
Patient was hospitalized.

Neutropenia (8250959-X)
Patient was taking Daflon. Patient felt the following Daflon side effects: neutropenia on Mar 23, 2012 from FRANCE Additional patient health information: Female , 65 years of age, . Daflon dosage: N/A.
Multiple prescriptions taken:
  • Mycophenolate Mofetil (cellcept)
  • Levothyroxine Sodium
  • Lopressor
  • Plaquenil
  • Corticosteroids
  • Lasix
  • Potassium Chloride
  • Eupressyl
Patient was hospitalized.

Glaucoma (8220766-2)
Adverse event was reported on Mar 15, 2012 by a Male taking Daflon (Dosage: N/A) . Location: BRAZIL , 77 years of age, weighting 163.1 lb, After Daflon was administered, patient encountered several Daflon side effects: glaucoma.
Multiple concurrent drugs taken:
  • Vitamin B Complex Cap
  • Autopen 24
  • Warfarin Sodium (1/4 Tablet Daily)
  • Lantus
  • Multivitamin
  • Humalog (Dose: According To Glycemia)
  • Sertraline Hydrochloride


Burning Sensation, Adverse Reaction, Pruritus, Gingivitis, Erythema, Gingival Oedema (8173399-0)
on Feb 22, 2012 Female from PORTUGAL , 81 years of age, weighting 156.5 lb, was treated with Daflon 500. Directly after, patient experienced the unwanted or unexpected Daflon side effects: burning sensation, adverse reaction, pruritus, gingivitis, erythema, gingival oedema. Daflon 500 dosage: N/A.
Associated medications used:
  • Trental
  • Clopidogrel



Myocardial Infarction (8171994-6)
on Feb 24, 2012 Female from VENEZUELA , 92 years of age, was treated with Daflon. Patient felt the following Daflon side effects: myocardial infarction. Daflon dosage: N/A.
Multiple prescriptions taken:
  • Lipitor (20 Mg, 1x/day)
  • Levothyroxine Sodium
  • Omeprazole (20 Mg, 1x/day)


Nicotine Dependence, Cough, Adverse Event (8153702-8)
Patient was taking Daflon. After Daflon was administered, patient encountered several Daflon side effects: nicotine dependence, cough, adverse event on Feb 13, 2012 from BRAZIL Additional patient health information: Female , weighting 176.4 lb, was diagnosed with
  • cardiovascular disorder
  • blood cholesterol increased
  • arthritis
and. Daflon dosage: N/A.
Multiple concurrent drugs taken:
  • Crestor
  • Glucocorticoid
  • Arava
  • Procoralan
  • Synthroid
  • Nicorette (6gum Per Day)
  • Diovan Hct
  • Omega 3-6-9
Patient was hospitalized.

Gingivitis, Pruritus, Abasia, Burning Sensation, Erythema, Insomnia, Gingival Oedema (8111641-2)
Adverse event was reported on Jan 25, 2012 by a Female taking Daflon 500 (Dosage: N/A) . Location: PORTUGAL , 81 years of age, weighting 156.5 lb, Directly after, patient experienced the unwanted or unexpected Daflon side effects: gingivitis, pruritus, abasia, burning sensation, erythema, insomnia, gingival oedema.
Associated medications used:
  • Trental
  • Clopidogrel


Urinary Tract Infection, Nephrolithiasis, Oedema Peripheral, Wrist Fracture, Pain In Extremity, Fall, Dysgeusia, Hunger (7794583-1)
on Sep 22, 2011 Female from BRAZIL , weighting 147.7 lb, was treated with Daflon. Patient felt the following Daflon side effects: urinary tract infection, nephrolithiasis, oedema peripheral, wrist fracture, pain in extremity, fall, dysgeusia, hunger. Daflon dosage: N/A.
Multiple prescriptions taken:
  • Enalapril Maleate
  • Forteo (20 Ug, Qd)
  • Sinvastatina
Patient was hospitalized.

Electrocardiogram Q Wave Abnormal, Somnolence, Adjustment Disorder, Haemorrhoids, Lower Gastrointestinal Haemorrhage, Ventricular Extrasystoles, Diverticulum Intestinal, Decreased Appetite, Scoliosis (7720908-9)
on Aug 05, 2011 Male from SINGAPORE , 86 years of age, was treated with Daflon (diosmin). After Daflon was administered, patient encountered several Daflon side effects: electrocardiogram q wave abnormal, somnolence, adjustment disorder, haemorrhoids, lower gastrointestinal haemorrhage, ventricular extrasystoles, diverticulum intestinal, decreased appetite, scoliosis. Daflon (diosmin) dosage: N/A.
Multiple concurrent drugs taken:
  • Enalapril Maleate
Patient was hospitalized.

Decreased Appetite, Hypothyroidism, Disorientation (7658758-4)
Patient was taking Daflon. Directly after, patient experienced the unwanted or unexpected Daflon side effects: decreased appetite, hypothyroidism, disorientation on Aug 02, 2011 from SPAIN Additional patient health information: Female , 56 years of age, weighting 209.4 lb, . Daflon dosage: N/A.
Associated medications used:
  • Espidifen
  • Nolotil /spa/
  • Seroxat ^ciba-geigy^
  • Zolpidem
  • Aldactone
  • Pantoprazole
  • Sutent (50 Mg, 1x/day)
  • Norvasc


Fall (7584682-1)
Adverse event was reported on Jun 29, 2011 by a Male taking Daflon (Dosage: 500 Mg, 2x/day) was diagnosed with
  • haemorrhoids
and. Location: EGYPT , 66 years of age, Patient felt the following Daflon side effects: fall.
Multiple prescriptions taken:
  • Isosorbide Dinitrate (5 Mg, 1x/day)
  • Cardura (4 Mg, 1x/day)
  • Procto-glyvenol (Unk)


Respiratory Disorder (7525767-5)
on Jun 03, 2011 Male from BRAZIL , weighting 176.4 lb, was treated with Daflon. After Daflon was administered, patient encountered several Daflon side effects: respiratory disorder. Daflon dosage: 500, Unk.
Multiple concurrent drugs taken:
  • Exelon (Unk)
Patient was hospitalized.

Carpal Tunnel Syndrome, Limb Injury (7484151-3)
on May 04, 2011 Female from BRAZIL , weighting 198.4 lb, was diagnosed with
  • varicose vein
  • osteoarthritis
and was treated with Daflon. Directly after, patient experienced the unwanted or unexpected Daflon side effects: carpal tunnel syndrome, limb injury. Daflon dosage: Unk, Qd.
Associated medications used:
  • Glucosamine Sulfate (Unk, Qd)
  • Natrilix (10 Mg, Qd)
  • Cymbalta (60 Mg, Qd)
  • Diovan (80 Mg, Qd)
Patient was hospitalized.

Lymphoedema, Aortic Aneurysm (7419158-5)
Patient was taking Daflon. Patient felt the following Daflon side effects: lymphoedema, aortic aneurysm on Apr 12, 2011 from BELGIUM Additional patient health information: Male , 87 years of age, weighting 176.4 lb, . Daflon dosage: Unk.
Multiple prescriptions taken:
  • Cymbalta (Unk)
  • Zocor (20 Mg, 1x/day)
  • Bisoprolol (10 Mg, 1x/day)
  • Sintrom (Unk)
  • Lyrica (150 Mg, 2x/day)
  • Lasix (Unk)


Femur Fracture, Fall (7328166-4)
Adverse event was reported on Feb 23, 2011 by a Female taking Daflon (Dosage: 500 Mg, Daily (1/d)) . Location: SPAIN , weighting 207.2 lb, After Daflon was administered, patient encountered several Daflon side effects: femur fracture, fall.
Multiple concurrent drugs taken:
  • Forteo (20 Ug, Daily (1/d))
  • Omeprazole (20 Mg, Daily (1/d))
  • Atorvastatina (40 Mg, Daily (1/d))
  • Micardis
Patient was hospitalized.

Anaemia, Salivary Hypersecretion, Quadriparesis, Enterobacter Infection, Monoparesis, Klebsiella Infection, Leukocyturia, Musculoskeletal Pain (7300434-1)
on Feb 14, 2011 Female from POLAND , weighting 103.6 lb, was diagnosed with
  • phlebitis
and was treated with Daflon (diosmin). Directly after, patient experienced the unwanted or unexpected Daflon side effects: anaemia, salivary hypersecretion, quadriparesis, enterobacter infection, monoparesis, klebsiella infection, leukocyturia, musculoskeletal pain. Daflon (diosmin) dosage: N/A.
Associated medications used:
  • Fraxiparina
  • Omeprazole
  • Mizodin
  • Fty 720 (No Treatment)
  • Tritace
  • Fty 720
  • Lactulose
  • Fty 720
Patient was hospitalized.

Oedema Peripheral, Cholecystitis, Cholelithiasis, Cyanosis, Erythema (7236456-9)
on Jan 10, 2011 Female from SPAIN , weighting 143.3 lb, was diagnosed with
  • cardiovascular insufficiency
  • hypersensitivity
  • osteoporosis
and was treated with Daflon. Patient felt the following Daflon side effects: oedema peripheral, cholecystitis, cholelithiasis, cyanosis, erythema. Daflon dosage: 1000 Mg, Daily (1/d).
Multiple prescriptions taken:
  • Ebastine (10 Mg, Daily (1/d))
  • Ideos (2 D/f, Daily (1/d))
  • Forteo (20 Ug, Daily (1/d))
  • Pariet (20 Mg, Daily (1/d))
  • Torsemide (5 Mg, Daily (1/d))
Patient was hospitalized.

Myocardial Infarction (5630110-2)
Patient was taking Daflon (diosmin). After Daflon was administered, patient encountered several Daflon side effects: myocardial infarction on Feb 08, 2008 from FRANCE Additional patient health information: Female , 56 years of age, weighting 157.6 lb, was diagnosed with
  • phlebitis
  • chronic myeloid leukaemia
and. Daflon (diosmin) dosage: N/A.
Multiple concurrent drugs taken:
  • Amn107 (400 Mg, Bid)
Patient was hospitalized.

Eosinophilia, Renal Failure Acute, Toxic Skin Eruption (5084996-3)
Adverse event was reported on Aug 11, 2006 by a Male taking Daflon (Dosage: N/A) was diagnosed with
  • ill-defined disorder
and. Location: FRANCE , 73 years of age, Directly after, patient experienced the unwanted or unexpected Daflon side effects: eosinophilia, renal failure acute, toxic skin eruption.
Associated medications used:
  • Coversyl (Daily Dose: 4 Milligram(s))
  • Allopurinol
  • Amlodipine Besylate (Daily Dose: 10 Milligram(s))
  • Asasantin
Patient was hospitalized.

Anorexia, Asthenia, Balance Disorder, Blood Creatinine Increased, Blood Pressure Decreased, Blood Urea Increased, Fall, Hypotension (4955315-5)
on Mar 17, 2006 Male from FRANCE , 50 years of age, weighting 134.5 lb, was treated with Daflon 500. Patient felt the following Daflon side effects: anorexia, asthenia, balance disorder, blood creatinine increased, blood pressure decreased, blood urea increased, fall, hypotension. Daflon 500 dosage: N/A.
Multiple prescriptions taken:
  • Motilium (30 Mg/day)
  • Equanil (750 Mg/day)
  • Vastarel (60 Mg/day)
  • Seresta (100 Mg/day)
  • Euphytose (3 Df/day)
  • Solian (200 Mg, Bid)
  • Cotareg (1 Df, Qd)
  • Vitamin B1 (+b6)
Patient was hospitalized.

Bullous Lung Disease, Dyspnoea Exertional, Interstitial Lung Disease, Pulmonary Eosinophilia (4852373-3)
on May 06, 2005 Male from FRANCE , weighting 145.5 lb, was treated with Daflon. After Daflon was administered, patient encountered several Daflon side effects: bullous lung disease, dyspnoea exertional, interstitial lung disease, pulmonary eosinophilia. Daflon dosage: Unk, Unk.
Multiple concurrent drugs taken:
  • Fractal (80 Mg, Qd)


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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Daflon Information

More About Daflon

Side Effects reported to FDA: 21. View Daflon Adverse Reports

Daflon safety alerts: No

Reported deaths: 2

Reported hospitalizations: 9

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