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Daptomycin Side Effects

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Common Daptomycin Side Effects


The most commonly reported Daptomycin side effects (click to view or check a box to report):

Blood Creatine Phosphokinase Increased (52)
Rhabdomyolysis (37)
Eosinophilic Pneumonia (34)
Pyrexia (18)
Dyspnoea (17)
Rash (11)
Myalgia (11)
Eosinophilia (11)
Renal Failure Acute (10)
Blood Creatinine Increased (9)
Lung Infiltration (8)
Pruritus (8)
Pain (6)
Pneumonitis (6)
Nausea (6)
Respiratory Distress (6)
Infection (6)
Aspartate Aminotransferase Increased (6)
Eosinophil Count Increased (6)
Renal Failure (6)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Daptomycin Side Effects Reported to FDA



Daptomycin Side Effect Report#9862780
Necrotising Fasciitis, Staphylococcal Infection, Limb Discomfort, Joint Swelling, Chest Pain, Staphylococcal Sepsis
This is a report of a male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: endocarditis staphylococcal,off label use, who was treated with Daptomycin (dosage: 8 Mg/kg, Daily, start time:
Nov 17, 2013), combined with: NA. and developed a serious reaction and side effect(s): Necrotising Fasciitis, Staphylococcal Infection, Limb Discomfort, Joint Swelling, Chest Pain, Staphylococcal Sepsis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Daptomycin treatment in male patients, resulting in Necrotising Fasciitis side effect. The patient was hospitalized.
Daptomycin Side Effect Report#9861717
Osteomyelitis, Pneumonia
This report suggests a potential Daptomycin Osteomyelitis side effect(s) that can have serious consequences. A 27-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: decubitus ulcer and used Daptomycin (dosage: NA) starting
Sep 30, 2013. After starting Daptomycin the patient began experiencing various side effects, including: Osteomyelitis, PneumoniaAdditional drugs used concurrently:
  • Imipenem
The patient was hospitalized. Although Daptomycin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Osteomyelitis, may still occur.
Daptomycin Side Effect Report#9849222
Blood Creatine Phosphokinase Increased, Myalgia
This Blood Creatine Phosphokinase Increased problem was reported by a consumer or non-health professional from US. A 66-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: osteomyelitis. On NS this consumer started treatment with Daptomycin (dosage: NA). The following drugs were being taken at the same time: NA. When using Daptomycin, the patient experienced the following unwanted symptoms/side effects: Blood Creatine Phosphokinase Increased, MyalgiaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Blood Creatine Phosphokinase Increased, may become evident only after a product is in use by the general population.
Daptomycin Side Effect Report#9848146
Diabetes Mellitus Inadequate Control, Oliguria
This Diabetes Mellitus Inadequate Control side effect was reported by a pharmacist from US. A 64-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Daptomycin (drug dosage: NA), which was initiated on
Aug 16, 2013. Concurrently used drugs: NA..After starting to take Daptomycin the consumer reported adverse symptoms, such as: Diabetes Mellitus Inadequate Control, OliguriaThese side effects may potentially be related to Daptomycin. The patient was hospitalized.
Daptomycin Side Effect Report#9848040
Necrotising Fasciitis
This is a report of a 69-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Daptomycin (dosage: NA, start time:
May 08, 2013), combined with: NA. and developed a serious reaction and side effect(s): Necrotising Fasciitis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Daptomycin treatment in male patients, resulting in Necrotising Fasciitis side effect.
Daptomycin Side Effect Report#9813698
Renal Failure Acute, Hepatitis Acute, Rhabdomyolysis, Haemodialysis
This report suggests a potential Daptomycin Renal Failure Acute side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: arthritis bacterial,staphylococcal infection and used Daptomycin (dosage: NA) starting NS. After starting Daptomycin the patient began experiencing various side effects, including: Renal Failure Acute, Hepatitis Acute, Rhabdomyolysis, HaemodialysisAdditional drugs used concurrently: NA.The patient was hospitalized. Although Daptomycin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure Acute, may still occur.
Daptomycin Side Effect Report#9748785
Pyrexia, Mental Status Changes, Dyspnoea, Traumatic Lung Injury, Lung Infiltration
This Pyrexia problem was reported by a pharmacist from US. A 76-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: osteomyelitis. On
Nov 14, 2013 this consumer started treatment with Daptomycin (cubicin) (dosage: NA). The following drugs were being taken at the same time: NA. When using Daptomycin (cubicin), the patient experienced the following unwanted symptoms/side effects: Pyrexia, Mental Status Changes, Dyspnoea, Traumatic Lung Injury, Lung InfiltrationThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pyrexia, may become evident only after a product is in use by the general population.
Daptomycin Side Effect Report#9729223
Rhabdomyolysis
This Rhabdomyolysis side effect was reported by a pharmacist from US. A 63-year-old male patient (weight:NA) experienced the following symptoms/conditions: infection.The patient was prescribed Daptomycin (drug dosage: 900 Mg, Other, Iv), which was initiated on
Apr 04, 2013. Concurrently used drugs:
  • Atorvastatin (10 Mg, Every Day, Po)
.After starting to take Daptomycin the consumer reported adverse symptoms, such as: RhabdomyolysisThese side effects may potentially be related to Daptomycin. The patient was hospitalized.
Daptomycin Side Effect Report#9716783
Blood Creatine Phosphokinase Increased
This is a report of a 64-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: abdominal abscess, who was treated with Daptomycin (cubicin) (dosage: NA, start time:
Oct 23, 2013), combined with: NA. and developed a serious reaction and side effect(s): Blood Creatine Phosphokinase Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Daptomycin (cubicin) treatment in female patients, resulting in Blood Creatine Phosphokinase Increased side effect. The patient was hospitalized.
Daptomycin Side Effect Report#9713774
Respiratory Distress, Blood Creatinine Increased
This report suggests a potential Daptomycin Respiratory Distress side effect(s) that can have serious consequences. A 35-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: diabetic foot,osteomyelitis and used Daptomycin (dosage: NA) starting
Oct 15, 2013. After starting Daptomycin the patient began experiencing various side effects, including: Respiratory Distress, Blood Creatinine IncreasedAdditional drugs used concurrently: NA.The patient was hospitalized. Although Daptomycin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Respiratory Distress, may still occur.
Daptomycin Side Effect Report#9695529
Blood Creatine Phosphokinase Increased
This Blood Creatine Phosphokinase Increased problem was reported by a pharmacist from US. A 60-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: staphylococcal bacteraemia. On
Oct 22, 2013 this consumer started treatment with Daptomycin (dosage: NA). The following drugs were being taken at the same time:
  • Linezolid
  • Merrem
  • Flagyl
  • Micafungin
  • Oxacillin
  • Zosyn
  • Rifampin
  • Tygacil
When using Daptomycin, the patient experienced the following unwanted symptoms/side effects: Blood Creatine Phosphokinase IncreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Blood Creatine Phosphokinase Increased, may become evident only after a product is in use by the general population.
Daptomycin Side Effect Report#9680883
Pruritus, Infusion Site Pruritus, Infusion Site Urticaria
This Pruritus side effect was reported by a pharmacist from US. A 22-year-old male patient (weight:NA) experienced the following symptoms/conditions: localised infection.The patient was prescribed Daptomycin (drug dosage: NA), which was initiated on
Sep 30, 2013. Concurrently used drugs: NA..After starting to take Daptomycin the consumer reported adverse symptoms, such as: Pruritus, Infusion Site Pruritus, Infusion Site UrticariaThese side effects may potentially be related to Daptomycin.
Daptomycin Side Effect Report#9666709
Blood Creatine Phosphokinase Increased
This is a report of a 54-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Daptomycin (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Blood Creatine Phosphokinase Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Daptomycin treatment in male patients, resulting in Blood Creatine Phosphokinase Increased side effect.
Daptomycin Side Effect Report#9641343
Blood Creatine Phosphokinase Abnormal
This report suggests a potential Daptomycin Blood Creatine Phosphokinase Abnormal side effect(s) that can have serious consequences. A 36-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: sepsis and used Daptomycin (dosage: NA) starting NS. After starting Daptomycin the patient began experiencing various side effects, including: Blood Creatine Phosphokinase AbnormalAdditional drugs used concurrently: NA. Although Daptomycin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Blood Creatine Phosphokinase Abnormal, may still occur.
Daptomycin Side Effect Report#9633218
Erythema Multiforme
This Erythema Multiforme problem was reported by a pharmacist from US. A 80-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: cellulitis. On
Aug 20, 2013 this consumer started treatment with Daptomycin (dosage: NA). The following drugs were being taken at the same time: NA. When using Daptomycin, the patient experienced the following unwanted symptoms/side effects: Erythema MultiformeThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Erythema Multiforme, may become evident only after a product is in use by the general population.
Daptomycin Side Effect Report#9632366
Tendon Rupture, Muscle Spasms
This Tendon Rupture side effect was reported by a physician from US. A 57-year-old male patient (weight:NA) experienced the following symptoms/conditions: post procedural infection.The patient was prescribed Daptomycin (drug dosage: NA), which was initiated on
Jul 01, 2013. Concurrently used drugs:
  • Rocephin
.After starting to take Daptomycin the consumer reported adverse symptoms, such as: Tendon Rupture, Muscle SpasmsThese side effects may potentially be related to Daptomycin.
Daptomycin Side Effect Report#9609648
Eosinophilic Pneumonia Acute, Respiratory Failure, Wound Infection Bacterial, Klebsiella Infection, Escherichia Infection
This is a report of a 53-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: endocarditis staphylococcal, who was treated with Daptomycin (dosage: NA, start time:
Aug 23, 2013), combined with:
  • Ceftaroline
and developed a serious reaction and side effect(s): Eosinophilic Pneumonia Acute, Respiratory Failure, Wound Infection Bacterial, Klebsiella Infection, Escherichia Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Daptomycin treatment in female patients, resulting in Eosinophilic Pneumonia Acute side effect. The patient was hospitalized.
Daptomycin Side Effect Report#9592494
Liver Function Test Abnormal
This report suggests a potential Daptomycin Liver Function Test Abnormal side effect(s) that can have serious consequences. A 31-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: osteomyelitis and used Daptomycin (dosage: NA) starting
Sep 19, 2013. After starting Daptomycin the patient began experiencing various side effects, including: Liver Function Test AbnormalAdditional drugs used concurrently: NA. Although Daptomycin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Liver Function Test Abnormal, may still occur.
Daptomycin Side Effect Report#9586130
Eosinophilic Pneumonia
This Eosinophilic Pneumonia problem was reported by a pharmacist from US. A 55-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: osteomyelitis. On
Apr 29, 2013 this consumer started treatment with Daptomycin (dosage: NA). The following drugs were being taken at the same time: NA. When using Daptomycin, the patient experienced the following unwanted symptoms/side effects: Eosinophilic PneumoniaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eosinophilic Pneumonia, may become evident only after a product is in use by the general population.
Daptomycin Side Effect Report#9573302
Thrombocytopenia
This Thrombocytopenia side effect was reported by a pharmacist from US. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: pneumonia.The patient was prescribed Daptomycin (drug dosage: NA), which was initiated on
Aug 19, 2013. Concurrently used drugs:
  • Allopurinol
  • Atenolol
  • Azithromycin
  • Chlorthalidone
  • Clonidine
  • Glipizide
  • Methylprednisone
  • Warfarin
.After starting to take Daptomycin the consumer reported adverse symptoms, such as: ThrombocytopeniaThese side effects may potentially be related to Daptomycin.
Daptomycin Side Effect Report#9541544
Dyspnoea, Eosinophilic Pneumonia
This is a report of a 67-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: abscess,spinal disorder,enterococcal infection, who was treated with Daptomycin (dosage: 750 Mg Qd Intravenous, start time:
Jul 02, 2013), combined with: NA. and developed a serious reaction and side effect(s): Dyspnoea, Eosinophilic Pneumonia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Daptomycin treatment in male patients, resulting in Dyspnoea side effect. The patient was hospitalized.
Daptomycin Side Effect Report#9506967
Alveolitis Allergic, Pyrexia, Respiratory Depression
This report suggests a potential Daptomycin Alveolitis Allergic side effect(s) that can have serious consequences. A 61-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: pyrexia,arthritis bacterial and used Daptomycin (dosage: Daptomycin 450mg Iv Daily) starting
Jul 20, 2013. After starting Daptomycin the patient began experiencing various side effects, including: Alveolitis Allergic, Pyrexia, Respiratory DepressionAdditional drugs used concurrently: NA.The patient was hospitalized. Although Daptomycin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Alveolitis Allergic, may still occur.
Daptomycin Side Effect Report#9485775
Renal Failure Acute, Rhabdomyolysis
This Renal Failure Acute problem was reported by a pharmacist from US. A 55-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: renal failure acute,rhabdomyolysis. On
Apr 25, 2013 this consumer started treatment with Daptomycin (dosage: 390mg, Other, Iv). The following drugs were being taken at the same time: NA. When using Daptomycin, the patient experienced the following unwanted symptoms/side effects: Renal Failure Acute, RhabdomyolysisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Failure Acute, may become evident only after a product is in use by the general population.
Daptomycin Side Effect Report#9476226
Rash Erythematous, Urticaria
This Rash Erythematous side effect was reported by a pharmacist from US. A 61-year-old male patient (weight:NA) experienced the following symptoms/conditions: infection.The patient was prescribed Daptomycin (drug dosage: NA), which was initiated on
Oct 24, 2012. Concurrently used drugs: NA..After starting to take Daptomycin the consumer reported adverse symptoms, such as: Rash Erythematous, UrticariaThese side effects may potentially be related to Daptomycin. The patient was hospitalized.
Daptomycin Side Effect Report#9454003
Rash
This is a report of a 51-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: febrile neutropenia, who was treated with Daptomycin (dosage: 2 G, Q8h, start time:
Sep 26, 2011), combined with:
  • Vancomycin (1 Unk, Q12h)
  • Doryx /00055701/ (100 Mg, Q12h)
and developed a serious reaction and side effect(s): Rash after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Daptomycin treatment in female patients, resulting in Rash side effect. The patient was hospitalized.


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The appearance of Daptomycin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Daptomycin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Discuss Daptomycin Side Effects

    Did You Have a Daptomycin Side Effect?

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    Daptomycin Safety Alerts, Active Ingredients, Usage Information

    NDC0409-0106
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameDaptomycin
    NameDAPTOMYCIN
    Dosage FormINJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
    RouteINTRAVENOUS
    On market since20140912
    LabelerHospira, Inc.
    Active Ingredient(s)DAPTOMYCIN
    Strength(s)50
    Unit(s)mg/mL
    Pharma ClassLipopeptide Antibacterial [EPC],Lipopeptides [Chemical/Ingredient]

    More About Daptomycin

    Side Effects reported to FDA: 258

    Daptomycin safety alerts: 2013 2010 2008

    Reported deaths: 8

    Reported hospitalizations: 117

    Cubicin (daptomycin): Drug Safety Communication - Risk of Eosinophilic Pneumonia

    [Posted 07/29/2010]

    AUDIENCE: Infectious Disease, Pulmonology

    ISSUE:  FDA notified healthcare professionals and patients about the potential for developing eosinophilic pneumonia during treatment with Cubicin (daptomycin), an intravenous antibacterial drug indicated for use in treatment of serious skin infections and bloodstream infections. Eosinophilic pneumonia is a rare but serious condition where a type of white blood cell (eosinophil) fills the lungs. Symptoms of eosinophilic pneumonia include fever, cough, shortness of breath, and difficulty breathing. Eosinophilic pneumonia may lead to progressive respiratory failure and is potentially fatal if not quickly recognized and appropriately managed. 

    BACKGROUND: FDA has reviewed published case reports of Cubicin-associated eosinophilic pneumonia and conducted a review of post-marketing adverse event reports from the FDA's Adverse Event Reporting System. FDA's review identified 7 cases of eosinophilic pneumonia between 2004 and 2010 that were most likely associated with Cubicin. Based on these reviews, FDA determined that eosinophilic pneumonia can be associated with Cubicin use and requested that the manufacturer of Cubicin include this information in the Warnings and Precautions and Adverse Reactions, Post-Marketing Experience sections of the drug label.

    RECOMMENDATION: Healthcare professionals should closely monitor patients being treated with Cubicin for eosinophilic pneumonia. Patients receiving Cubicin should immediately contact their healthcare professional if they develop a new or worsening fever, cough, shortness of breath, or difficulty breathing.

    Additional information for Healthcare Professionals, Information for Patients, a Data Summary, and References are provided in the Drug Safety Communication at the link below.

    [07/29/2010 - Drug Safety Communication - FDA]
    [Jan 2010 - Cubicin (daptomycin) Prescribing Information - Cubist Pharmaceuticals]

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