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Definity Side Effects

Report Definity Side Effects

If you experienced any harmful or unwanted effects of Definity, please share your experience. This could help to raise awareness about Definity side effects, identify uknown risks and inform health professionals and patients taking Definity.

Examples: headache, dizziness


The most commonly reported Definity side effects are:
Diarrhea (1 reports)

If you have experienced a side effect listed above, you can check a box to report it.


To view a complete list of submitted side effects, please follow the link Definity side effects . You can also compare Definity side effects or view FDA reports.

Definity Side Effects reported to FDA

The following Definity reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
The FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Definity on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has identified a causal relationship between the drug and the listed risk.

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Dyspnoea, Unresponsive To Stimuli, Laryngeal Oedema, Endotracheal Intubation Complication, Pulmonary Oedema
on Feb 28, 2013 Male from US , 57 years of age, weighting 312.0 lb, was diagnosed with and was treated with Definity. Directly after, patient experienced the unwanted or unexpected Definity side effects: dyspnoea, unresponsive to stimuli, laryngeal oedema, endotracheal intubation complication, pulmonary oedema. Definity dosage: N/A.

Hypersensitivity, Myocardial Infarction, Hypotension, Tachycardia
Patient was taking Definity. Patient felt the following Definity side effects: hypersensitivity, myocardial infarction, hypotension, tachycardia on Mar 07, 2013 from US Additional patient health information: Male , 60 years of age, weighting 294.0 lb, was diagnosed with and. Definity dosage: 1.7 Ml Of Defintiy Dilutated With 8.3 Ml Normal Saline (1 Ml).
Multiple prescriptions taken:
  • Tylenol (paracetamol)
  • Ibuprofen (ibuprofen)
  • Heparin (heparin)
  • Zofran (ondansetron)
  • Coreg (carvedilol)
  • Lasix (furosemide)
  • Lisinopril (lisinopril)
  • Pepcid (famotidine)
Patient was hospitalized.

Anaphylactic Reaction
Adverse event was reported on Dec 27, 2012 by a Male taking Definity (Dosage: N/A) was diagnosed with and. Location: US , 57 years of age, weighting 308.6 lb, After Definity was administered, patient encountered several Definity side effects: anaphylactic reaction.

Anaphylactic Shock, Post Procedural Complication, Pulse Absent
on Jan 07, 2013 Male from US , 57 years of age, weighting 308.0 lb, was diagnosed with and was treated with Definity. Directly after, patient experienced the unwanted or unexpected Definity side effects: anaphylactic shock, post procedural complication, pulse absent. Definity dosage: 1.5 Ml Of Definity Diluted With 8 Ml Normal Saline.
Associated medications used:
  • Albuterol (salbutamol)
  • Diltiazem
  • Allegra
  • Indomethacin (indometacin)
  • Lasix (furosemide)
  • Metformin
  • Nexium (esomeprazole Magnesium)
  • Pravastatin



Dyspnoea, Oxygen Saturation Decreased, Cyanosis
on Nov 28, 2012 Female from US , 53 years of age, was treated with Definity. Patient felt the following Definity side effects: dyspnoea, oxygen saturation decreased, cyanosis. Definity dosage: 1 Vial Of Definity Diluted In 9 Ml Normal Saline.

Dizziness, Eye Movement Disorder, Unresponsive To Stimuli, Blood Pressure Decreased, Heart Rate Decreased, Blood Glucose Increased, Fatigue
Patient was taking Definity. After Definity was administered, patient encountered several Definity side effects: dizziness, eye movement disorder, unresponsive to stimuli, blood pressure decreased, heart rate decreased, blood glucose increased, fatigue on Nov 21, 2012 from US Additional patient health information: Male , 54 years of age, weighting 150.0 lb, was diagnosed with and. Definity dosage: Diluted As Directed (1.5 Ml), Intravenous.
Multiple concurrent drugs taken:
  • Lasix (furosemide)
  • Zaroxolyn (metolazone)
  • Zocor (simvastatin)
  • Carvedilol (carvedilol)
  • Lisinopril (lisinopril)
  • Spironolactone (spironolactone)
  • Plavix (clopidogrel Bisulfate)
  • Coumadin (warfarin Sodium)


Hypertension, Back Pain, Pain In Extremity, Chest Pain, Dyspnoea
Adverse event was reported on Nov 16, 2012 by a Female taking Definity (Dosage: 1 Ml Definity Diluted In 10 Ml Normal Saline (3 Ml)) was diagnosed with and. Location: US , 67 years of age, weighting 256.0 lb, Directly after, patient experienced the unwanted or unexpected Definity side effects: hypertension, back pain, pain in extremity, chest pain, dyspnoea.
Associated medications used:
  • Aspirin (acetylsalicylic Acid) (tablet)
  • Losartan (losartan) (tablet)
  • Bystolic (nebivolol Hydrochloride) (tablet)
  • Clonidine (clonidine) (tablet)
  • Pantoprazole Sodium (pantroprazole Sodium Sesquihydrate) (tablet)
  • Pravastatin (pravastatin) (tablet)
  • Metformin Hcl (metformin Hydrochloride) (tablet)
  • Magnesium Oxide (magnesium Oxide) (tablet)
Patient was hospitalized.

Rash, Renal Failure Acute
on Nov 01, 2012 Female from US , 73 years of age, weighting 164.0 lb, was treated with Definity. Patient felt the following Definity side effects: rash, renal failure acute. Definity dosage: N/A. Patient was hospitalized.

Hypertensive Crisis, Back Pain
on Oct 19, 2012 Female from US , 55 years of age, weighting 228.0 lb, was diagnosed with and was treated with Definity. After Definity was administered, patient encountered several Definity side effects: hypertensive crisis, back pain. Definity dosage: 1 Vial Definity Diluted With 8 Ml Normal Saline (1 In 1 D),intravenous Bolus.
Multiple concurrent drugs taken:
  • Aspirin
  • Baclofen (baclofen)
  • Diovan (valsartan)
  • Lipitor (atorvastatin Calcium)
  • Glipizide (glipizide)
  • Lopressor (metoprolol Tartrate)
  • Metformin (metformin)
  • Plavix (clopidogrel Bisulfate)


Ventricular Tachycardia, Ventricular Fibrillation, Acute Myocardial Infarction, Mitral Valve Incompetence
Patient was taking Definity. Directly after, patient experienced the unwanted or unexpected Definity side effects: ventricular tachycardia, ventricular fibrillation, acute myocardial infarction, mitral valve incompetence on Oct 17, 2012 from US Additional patient health information: Male , 50 years of age, weighting 310.0 lb, was diagnosed with and. Definity dosage: Injection. Patient was hospitalized.

Dyspnoea, Oxygen Saturation Decreased, Anxiety
Adverse event was reported on Nov 21, 2012 by a Female taking Definity (Dosage: N/A) was diagnosed with and. Location: US , 91 years of age, weighting 250.0 lb, Patient felt the following Definity side effects: dyspnoea, oxygen saturation decreased, anxiety. Patient was hospitalized.

Unresponsive To Stimuli, Myoclonus, Temporal Lobe Epilepsy, Tardive Dyskinesia
on Jun 27, 2012 Female from UNITED STATES , 58 years of age, weighting 280.0 lb, was diagnosed with and was treated with Definity. After Definity was administered, patient encountered several Definity side effects: unresponsive to stimuli, myoclonus, temporal lobe epilepsy, tardive dyskinesia. Definity dosage: N/A.

Back Pain, Injection Related Reaction
on May 31, 2012 Female from UNITED STATES , weighting 220.5 lb, was diagnosed with and was treated with Definity. Directly after, patient experienced the unwanted or unexpected Definity side effects: back pain, injection related reaction. Definity dosage: 1.5 Ml Once Iv.

Back Pain, Anxiety, Acute Myocardial Infarction
Patient was taking Definity. Patient felt the following Definity side effects: back pain, anxiety, acute myocardial infarction on May 01, 2012 from UNITED STATES Additional patient health information: Female , 67 years of age, weighting 264.6 lb, was diagnosed with and. Definity dosage: 2 Ml Definity Diluted With 8 Ml Normal Saline (1 Ml), Intravenous Bolus.

Acute Pulmonary Oedema, Pruritus, Sinus Tachycardia, Delirium, Hypokalaemia, Angioedema, Rales, Agitation, Wheezing
Adverse event was reported on Apr 24, 2012 by a Male taking Definity (Dosage: 1.5 Ml Definity Diluted With 8.5 Ml Normal Saline (0.5 Ml), Intravenous Bolus) was diagnosed with and. Location: UNITED STATES , 78 years of age, weighting 189.0 lb, After Definity was administered, patient encountered several Definity side effects: acute pulmonary oedema, pruritus, sinus tachycardia, delirium, hypokalaemia, angioedema, rales, agitation, wheezing. Patient was hospitalized.

Syncope, Bundle Branch Block Left, Ejection Fraction Decreased
on Apr 04, 2012 Male from GERMANY , 63 years of age, was treated with Definity. Directly after, patient experienced the unwanted or unexpected Definity side effects: syncope, bundle branch block left, ejection fraction decreased. Definity dosage: N/A. Patient was hospitalized.

Pain In Extremity, Back Pain
on Apr 10, 2012 Male from UNITED STATES , 68 years of age, weighting 215.0 lb, was treated with Definity. Patient felt the following Definity side effects: pain in extremity, back pain. Definity dosage: N/A.

Back Pain, Tremor, Anxiety, Dyspnoea, Fatigue, Chest Pain, Screaming
Patient was taking Definity. After Definity was administered, patient encountered several Definity side effects: back pain, tremor, anxiety, dyspnoea, fatigue, chest pain, screaming on Mar 02, 2012 from UNITED STATES Additional patient health information: Female , weighting 227.3 lb, was diagnosed with and. Definity dosage: 3ml -1.5ml Vial In 8.5ml Ns-.

Acute Pulmonary Oedema, Pruritus
Adverse event was reported on Feb 09, 2012 by a Male taking Definity (Dosage: 1.5 Ml Definity Diluted With 8.5 Ml Normal Saline (0.5 Ml) Intravenous Bolus) was diagnosed with and. Location: UNITED STATES , 78 years of age, weighting 189.0 lb, Directly after, patient experienced the unwanted or unexpected Definity side effects: acute pulmonary oedema, pruritus. Patient was hospitalized.

Atrial Fibrillation, Oxygen Saturation Decreased, Tachycardia, Unresponsive To Stimuli, Pulse Absent
on Oct 12, 2011 Male from UNITED STATES , 69 years of age, weighting 274.5 lb, was diagnosed with and was treated with Definity. Patient felt the following Definity side effects: atrial fibrillation, oxygen saturation decreased, tachycardia, unresponsive to stimuli, pulse absent. Definity dosage: 0.4mg.

Back Pain
on Aug 24, 2011 Male from UNITED STATES , 87 years of age, was diagnosed with and was treated with Definity. After Definity was administered, patient encountered several Definity side effects: back pain. Definity dosage: 3ml.

Bradycardia, Cardiac Arrest, Hypoxia
Patient was taking Definity. Directly after, patient experienced the unwanted or unexpected Definity side effects: bradycardia, cardiac arrest, hypoxia on Aug 24, 2011 from UNITED STATES Additional patient health information: Female , 76 years of age, weighting 196.0 lb, was diagnosed with and. Definity dosage: 1 Vial.

Neck Pain, Unresponsive To Stimuli, Ventricular Extrasystoles, Dyspnoea, Hypertension
Adverse event was reported on Jun 22, 2011 by a Male taking Definity (Dosage: See Image) was diagnosed with and. Location: UNITED STATES , 64 years of age, weighting 248.0 lb, Patient felt the following Definity side effects: neck pain, unresponsive to stimuli, ventricular extrasystoles, dyspnoea, hypertension.

Feeling Hot, Malaise, Erythema, Dizziness, Dyspnoea, Nausea, Hypotension
on Jun 16, 2011 Male from UNITED STATES , weighting 450.0 lb, was diagnosed with and was treated with Definity. After Definity was administered, patient encountered several Definity side effects: feeling hot, malaise, erythema, dizziness, dyspnoea, nausea, hypotension. Definity dosage: 5 Cc Of Diluted Definity In Ns Prn Iv Bolus (slow Ivp One Dose). Patient was hospitalized.

Feeling Hot, Erythema, Dyspnoea, Malaise, Hypotension, Nausea, Dizziness
on May 31, 2011 Male from UNITED STATES , weighting 450.0 lb, was diagnosed with and was treated with Definity. Directly after, patient experienced the unwanted or unexpected Definity side effects: feeling hot, erythema, dyspnoea, malaise, hypotension, nausea, dizziness. Definity dosage: Cc Of Diluted Definity In Ns Prn Intravenous Bolus. Patient was hospitalized.

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Record and Track Your Side Effects

It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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JustAnswer.com

Safety Alerts, Active Ingredients, Usage Information

Alternative DEFINITY Names:PERFLUTRE

Active Ingredient: PERFLUTRE

More About Definity

Side Effects reported to FDA: 1251

Definity safety alerts: 2008 2007

Reported deaths: 42

Reported hospitalizations: 140

Micro-bubble Contrast Agents (marketed as Definity (Perflutren Lipid Microsphere) Injectable Suspension and Optison (Perflutren Protein-Type A Microspheres for Injection)

Audience: Radiological healthcare professionals, cardiologists, hospital risk managers 

[Posted 07/17/2008] FDA is updating healthcare professionals about recent changes made to the Boxed Warning, Warnings, and Contraindications sections of the prescribing information for micro-bubble contrast agents, a sterile suspension of perflutren gas microspheres, indicated for use in certain patients with suboptimal echocardiograms, to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border.These changes reflect conclusions of FDA reviews of information received following the addition of new Contraindications and Warnings in October 2007. The revised Boxed Warning and Warnings highlight the risk of serious cardiopulmonary reactions during or within 30 minutes following the administration of these products and recommend that high risk patients with pulmonary hypertension or unstable cardiopulmonary conditions be closely monitored during and for at least 30 minutes post administration of these contrast agents. In addition, several of the Contraindications that were added to the labeling in October, 2007 were removed because FDA determined that, in some patients, the benefits from the diagnostic information obtained through the use of Definity or Optison may outweigh the risk for serious cardiopulmonary reactions, even among some patients at particularly high risk for these reactions.

[July 17, 2008 - Information for Healthcare Professionals - FDA] 
[June 2008 - Dear Healthcare Professional Letter - GE] 
[May 2008 - Dear Healthcare Professional Letter - Lantheus Medical Imaging]

Latest Definity clinical trials

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