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Depakine Side Effects

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Common Depakine Side Effects


The most commonly reported Depakine side effects (click to view or check a box to report):

Epilepsy (80)
Convulsion (68)
Loss Of Consciousness (31)
Fall (31)
Foaming At Mouth (26)
Product Counterfeit (22)
Confusional State (21)
Trismus (20)
Tremor (17)
Pyrexia (14)
Asthenia (14)
Thrombocytopenia (14)
Somnolence (14)
Eye Movement Disorder (11)
Encephalopathy (10)
Grand Mal Convulsion (10)
Alopecia (10)
Intentional Overdose (10)
Sopor (9)
Abnormal Behaviour (9)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Depakine Side Effects Reported to FDA



Depakine Side Effect Report#9995434
Coma Scale Abnormal, Coma
This is a report of a 44-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: bipolar disorder, who was treated with Depakine (dosage: NA, start time:
Nov 05, 2013), combined with: NA. and developed a serious reaction and side effect(s): Coma Scale Abnormal, Coma after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine treatment in male patients, resulting in Coma Scale Abnormal side effect.
Depakine Side Effect Report#9994593
Delirium
This report suggests a potential Depakine Chrono Delirium side effect(s) that can have serious consequences. A 47-year-old male patient (weight: NA) from AT was diagnosed with the following symptoms/conditions: NA and used Depakine Chrono (dosage: NA) starting
Oct 09, 2013. After starting Depakine Chrono the patient began experiencing various side effects, including: DeliriumAdditional drugs used concurrently:
  • Lorazepam
  • Lorazepam
  • Abilify
  • Seroquel (Extended Release)
  • Seroquel (Extended Release)
The patient was hospitalized. Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Delirium, may still occur.
Depakine Side Effect Report#9985801
Fatigue, Hyponatraemia, Confusional State
This Fatigue problem was reported by a physician from AT. A 74-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jul 01, 2013 this consumer started treatment with Depakine Chrono (dosage: NA). The following drugs were being taken at the same time: NA. When using Depakine Chrono, the patient experienced the following unwanted symptoms/side effects: Fatigue, Hyponatraemia, Confusional StateAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Fatigue, may become evident only after a product is in use by the general population.
Depakine Side Effect Report#9985720
Lip Blister, Dry Mouth
This Lip Blister side effect was reported by a physician from AT. A 73-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Depakine Chrono (drug dosage: NA), which was initiated on
May 18, 2013. Concurrently used drugs: NA..After starting to take Depakine Chrono the consumer reported adverse symptoms, such as: Lip Blister, Dry MouthThese side effects may potentially be related to Depakine Chrono.
Depakine Side Effect Report#9985312
Foaming At Mouth, Staring, Epilepsy, Unevaluable Event, Dyskinesia, Convulsion
This is a report of a 75-year-old male patient (weight: NA) from CN, suffering from the following health symptoms/conditions: epilepsy, who was treated with Depakine Chrono (dosage: Extended Release, start time: 201310), combined with: NA. and developed a serious reaction and side effect(s): Foaming At Mouth, Staring, Epilepsy, Unevaluable Event, Dyskinesia, Convulsion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine Chrono treatment in male patients, resulting in Foaming At Mouth side effect.
Depakine Side Effect Report#9980752
Head Titubation, Product Counterfeit, Epilepsy, Tremor
This report suggests a potential Depakine Chrono Head Titubation side effect(s) that can have serious consequences. A 21-year-old male patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: epilepsy and used Depakine Chrono (dosage: Extended Release) starting 201402. After starting Depakine Chrono the patient began experiencing various side effects, including: Head Titubation, Product Counterfeit, Epilepsy, TremorAdditional drugs used concurrently: NA. Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Head Titubation, may still occur.
Depakine Side Effect Report#9955734
Gamma-glutamyltransferase Increased
This Gamma-glutamyltransferase Increased problem was reported by a health professional from FR. A 44-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On 2012 this consumer started treatment with Depakine Chrono (dosage: NA). The following drugs were being taken at the same time:
  • Trinordiol (Every Three Weeks)
  • Ethinylestradiol W/levonorgestrel (Every Three Weeks)
  • Contraceptives (Every Three Weeks)
When using Depakine Chrono, the patient experienced the following unwanted symptoms/side effects: Gamma-glutamyltransferase IncreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gamma-glutamyltransferase Increased, may become evident only after a product is in use by the general population.
Depakine Side Effect Report#9929129
Respiratory Alkalosis, Pco2 Decreased, Blood Lactic Acid Increased, Hypokalaemia, Hepatocellular Injury, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased
This Respiratory Alkalosis side effect was reported by a health professional from FR. A 27-year-old female patient (weight:NA) experienced the following symptoms/conditions: epilepsy.The patient was prescribed Depakine (drug dosage: NA), which was initiated on 201312. Concurrently used drugs:
  • Epitomax
  • Urbanyl
  • Gabacet
  • Keppra
.After starting to take Depakine the consumer reported adverse symptoms, such as: Respiratory Alkalosis, Pco2 Decreased, Blood Lactic Acid Increased, Hypokalaemia, Hepatocellular Injury, Aspartate Aminotransferase Increased, Alanine Aminotransferase IncreasedThese side effects may potentially be related to Depakine. The patient was hospitalized.
Depakine Side Effect Report#9924003
Spinal Compression Fracture, Osteoporosis
This is a report of a 51-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: epilepsy, who was treated with Depakine Chrono (dosage: Extended Release, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Spinal Compression Fracture, Osteoporosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine Chrono treatment in male patients, resulting in Spinal Compression Fracture side effect. The patient was hospitalized.
Depakine Side Effect Report#9923999
Hypoaesthesia, Convulsion, Muscular Weakness
This report suggests a potential Depakine Chrono Hypoaesthesia side effect(s) that can have serious consequences. A 37-year-old male patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: epilepsy and used Depakine Chrono (dosage: Extended Release) starting 201310. After starting Depakine Chrono the patient began experiencing various side effects, including: Hypoaesthesia, Convulsion, Muscular WeaknessAdditional drugs used concurrently: NA. Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypoaesthesia, may still occur.
Depakine Side Effect Report#9922873
Carotid Artery Thrombosis, Dysgeusia, Cerebral Atrophy, Dry Mouth, Nausea, Bacterial Vaginosis, Vaginal Discharge, Cerebral Microangiopathy, Atrophic Vulvovaginitis
This Carotid Artery Thrombosis problem was reported by a health professional from AT. A 65-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Mar 18, 2013 this consumer started treatment with Depakine Chrono Retard (dosage: NA). The following drugs were being taken at the same time: NA. When using Depakine Chrono Retard, the patient experienced the following unwanted symptoms/side effects: Carotid Artery Thrombosis, Dysgeusia, Cerebral Atrophy, Dry Mouth, Nausea, Bacterial Vaginosis, Vaginal Discharge, Cerebral Microangiopathy, Atrophic VulvovaginitisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Carotid Artery Thrombosis, may become evident only after a product is in use by the general population.
Depakine Side Effect Report#9922419
Sopor, Somnolence
This Sopor side effect was reported by a physician from IT. A 88-year-old female patient (weight:NA) experienced the following symptoms/conditions: psychotic disorder.The patient was prescribed Depakine (drug dosage: NA), which was initiated on
Dec 01, 2013. Concurrently used drugs:
  • Talofen (Drops)
  • Paracodina (Drops)
  • Pantoprazole
  • Lasix
  • Congescor
  • Ranexa
  • Ascriptin
  • Plavix
.After starting to take Depakine the consumer reported adverse symptoms, such as: Sopor, SomnolenceThese side effects may potentially be related to Depakine.
Depakine Side Effect Report#9915008
Product Counterfeit, Epilepsy, Fall, Syncope, Convulsion, Pyrexia
This is a report of a 4-year-old female patient (weight: NA) from CN, suffering from the following health symptoms/conditions: epilepsy, who was treated with Depakine (dosage: NA, start time:
Feb 12, 2014), combined with: NA. and developed a serious reaction and side effect(s): Product Counterfeit, Epilepsy, Fall, Syncope, Convulsion, Pyrexia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine treatment in female patients, resulting in Product Counterfeit side effect.
Depakine Side Effect Report#9897972
Trismus, Foaming At Mouth, Convulsion, Eye Disorder, Epilepsy
This report suggests a potential Depakine Chrono Trismus side effect(s) that can have serious consequences. A 8-year-old female patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: epilepsy and used Depakine Chrono (dosage: Time To Onset: Few Months) starting 201306. After starting Depakine Chrono the patient began experiencing various side effects, including: Trismus, Foaming At Mouth, Convulsion, Eye Disorder, EpilepsyAdditional drugs used concurrently:
  • Multivitamins
Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Trismus, may still occur.
Depakine Side Effect Report#9895227
Eye Movement Disorder, Grand Mal Convulsion, Loss Of Consciousness
This Eye Movement Disorder problem was reported by a health professional from IT. A 3-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: epilepsy. On
Feb 01, 2013 this consumer started treatment with Depakine (dosage: Modified-release Granules). The following drugs were being taken at the same time: NA. When using Depakine, the patient experienced the following unwanted symptoms/side effects: Eye Movement Disorder, Grand Mal Convulsion, Loss Of ConsciousnessThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eye Movement Disorder, may become evident only after a product is in use by the general population.
Depakine Side Effect Report#9894854
Psychomotor Retardation, Encephalopathy, Ammonia Increased, Confusional State
This Psychomotor Retardation side effect was reported by a health professional from FR. A 75-year-old male patient (weight:NA) experienced the following symptoms/conditions: epilepsy.The patient was prescribed Depakine Chrono (drug dosage: NA), which was initiated on 201312. Concurrently used drugs:
  • Antibiotics
  • Gardenal
  • Allopurinol
  • Fenofibrate
  • Ginkgo Biloba (ginkgo Biloba)
.After starting to take Depakine Chrono the consumer reported adverse symptoms, such as: Psychomotor Retardation, Encephalopathy, Ammonia Increased, Confusional StateThese side effects may potentially be related to Depakine Chrono. The patient was hospitalized.
Depakine Side Effect Report#9894168
Pyrexia, Diarrhoea, Pancytopenia, Hepatitis Cholestatic
This is a report of a 67-year-old male patient (weight: NA) from CH, suffering from the following health symptoms/conditions: epilepsy,polyuria,polymyalgia rheumatica, who was treated with Depakine Chrono (dosage: NA, start time:
Jul 15, 2013), combined with:
  • Ciprofloxacin (Few Day (s))
  • Arava
  • Aspirin Cardio
  • Nebilet
  • Amlodipine/hydrochlorothiazide/valsartan
  • Atorvastatin Calcium
  • Pantoprazole Sodium
  • Pantoprazole Sodium
and developed a serious reaction and side effect(s): Pyrexia, Diarrhoea, Pancytopenia, Hepatitis Cholestatic after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine Chrono treatment in male patients, resulting in Pyrexia side effect. The patient was hospitalized.
Depakine Side Effect Report#9882547
Hypersensitivity, Nausea, Dyspnoea, Oropharyngeal Swelling, Palpitations, Hypertension, Dehydration, Off Label Use
This report suggests a potential Depakine Chrono Hypersensitivity side effect(s) that can have serious consequences. A 51-year-old female patient (weight: NA) from NL was diagnosed with the following symptoms/conditions: migraine and used Depakine Chrono (dosage: Extended Release) starting
Jan 02, 1991. After starting Depakine Chrono the patient began experiencing various side effects, including: Hypersensitivity, Nausea, Dyspnoea, Oropharyngeal Swelling, Palpitations, Hypertension, Dehydration, Off Label UseAdditional drugs used concurrently:
  • Omeprazole
The patient was hospitalized. Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypersensitivity, may still occur.
Depakine Side Effect Report#9880726
Gait Disturbance, Hypophagia, Fluid Intake Reduced, Glomerular Filtration Rate Decreased, Hyponatraemia, Confusional State
This Gait Disturbance problem was reported by a health professional from NL. A 67-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: epilepsy. On 200501 this consumer started treatment with Depakine (dosage: NA). The following drugs were being taken at the same time:
  • Amlodipine
  • Aspirin
  • Fusidic Acid
  • Metoprolol
  • Olmesartan
  • Ranitidine
  • Thiamine
When using Depakine, the patient experienced the following unwanted symptoms/side effects: Gait Disturbance, Hypophagia, Fluid Intake Reduced, Glomerular Filtration Rate Decreased, Hyponatraemia, Confusional StateThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gait Disturbance, may become evident only after a product is in use by the general population.
Depakine Side Effect Report#9879824
Fall
This Fall side effect was reported by a physician from CH. A 65-year-old male patient (weight:NA) experienced the following symptoms/conditions: grand mal convulsion,essential hypertension.The patient was prescribed Depakine Chrono (drug dosage: NA), which was initiated on
Nov 18, 2013. Concurrently used drugs:
  • Ramipril
  • Esidrex
  • Crestor
  • Janumet
  • Metfin
  • Rivotril
  • Aspirin Cardio
  • Amoxicillin/clavulanic Acid
.After starting to take Depakine Chrono the consumer reported adverse symptoms, such as: FallThese side effects may potentially be related to Depakine Chrono. The patient was hospitalized.
Depakine Side Effect Report#9871510
Suspected Counterfeit Product, Epilepsy, Syncope, Foaming At Mouth, Trismus, Tongue Biting, Fall, Convulsion
This is a report of a 17-year-old male patient (weight: NA) from CN, suffering from the following health symptoms/conditions: epilepsy, who was treated with Depakine Chrono (dosage: 2.5 Dosage Form Daily, start time: 201212), combined with: NA. and developed a serious reaction and side effect(s): Suspected Counterfeit Product, Epilepsy, Syncope, Foaming At Mouth, Trismus, Tongue Biting, Fall, Convulsion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine Chrono treatment in male patients, resulting in Suspected Counterfeit Product side effect. The patient was hospitalized.
Depakine Side Effect Report#9870444
Abortion Induced, Complication Of Pregnancy
This report suggests a potential Depakine Chrono Abortion Induced side effect(s) that can have serious consequences. A 45-year-old female patient (weight: NA) from CH was diagnosed with the following symptoms/conditions: epilepsy and used Depakine Chrono (dosage: NA) starting 2001. After starting Depakine Chrono the patient began experiencing various side effects, including: Abortion Induced, Complication Of PregnancyAdditional drugs used concurrently:
  • Fluctine
  • Tegretol
  • Carbamazepine ((prev.))
Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Abortion Induced, may still occur.
Depakine Side Effect Report#9870224
Neutropenia
This Neutropenia problem was reported by a physician from IT. A 50-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: mania. On
Dec 20, 2013 this consumer started treatment with Depakine Chrono (dosage: NA). The following drugs were being taken at the same time:
  • Clozapine
  • Abilify
  • Delorazepam
  • Inderal
  • Akineton
When using Depakine Chrono, the patient experienced the following unwanted symptoms/side effects: NeutropeniaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Neutropenia, may become evident only after a product is in use by the general population.
Depakine Side Effect Report#9869431
Pyrexia, Ocular Hyperaemia, Rhinitis, Fatigue, Nausea
This Pyrexia side effect was reported by a health professional from FR. A 17-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Depakine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Urbanyl
  • Lamictal (Once)
  • Risperdal
  • Tegretol
  • Sabril
  • Vimpat
.After starting to take Depakine the consumer reported adverse symptoms, such as: Pyrexia, Ocular Hyperaemia, Rhinitis, Fatigue, NauseaThese side effects may potentially be related to Depakine. The patient was hospitalized.
Depakine Side Effect Report#9863651
Extrapyramidal Disorder, Gait Disturbance, Tremor
This is a report of a 63-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: bipolar disorder, who was treated with Depakine (dosage: Extended Release, start time: 201208), combined with:
  • Theralene
  • Depakote
and developed a serious reaction and side effect(s): Extrapyramidal Disorder, Gait Disturbance, Tremor after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine treatment in female patients, resulting in Extrapyramidal Disorder side effect. The patient was hospitalized.


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The appearance of Depakine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Depakine Side Effects for Women?

Women Side EffectsReports
Epilepsy 25
Convulsion 23
Confusional State 14
Fall 12
Product Counterfeit 12
Thrombocytopenia 11
Asthenia 10
Loss Of Consciousness 9
Encephalopathy 8
Foaming At Mouth 8

What are common Depakine Side Effects for Men?

Men Side EffectsReports
Epilepsy 55
Convulsion 45
Loss Of Consciousness 22
Fall 19
Foaming At Mouth 18
Trismus 15
Tremor 11
Product Counterfeit 10
Grand Mal Convulsion 8
Confusional State 7

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Depakine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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