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MEMORY LOSS (42)
Hair Loss (19)
Erectile Disfunction (15)
Dekapine (11)
Nervous (8)
Weight Gain (8)
Amenorrhoea (5)
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Depakine Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 45 

Erythema, Rash Macular, Epilepsy (8310769-1)
on Apr 19, 2012 Male from SPAIN , 49 years of age, was diagnosed with
  • epilepsy
and was treated with Depakine 500. Directly after, patient experienced the unwanted or unexpected Depakine side effects: erythema, rash macular, epilepsy. Depakine 500 dosage: N/A.
Associated medications used:
  • Topamax
  • Humira


Motor Dysfunction, Hepatitis, Stupor, Pancreatitis (7829018-3)
Patient was taking Depakine Chronosphere. Patient felt the following Depakine side effects: motor dysfunction, hepatitis, stupor, pancreatitis on Oct 13, 2011 from RUSSIAN FEDERATION Additional patient health information: Male , 26 years of age, was diagnosed with
  • myoclonic epilepsy
and. Depakine Chronosphere dosage: N/A.
Multiple prescriptions taken:
  • Thiopental Sodium


Psychomotor Retardation (7722554-X)
Adverse event was reported on Aug 24, 2011 by a Female taking Depakine Chrono Tablets Extended Release (Dosage: N/A) was diagnosed with
  • self injurious behaviour
and. Location: ITALY , 46 years of age, After Depakine was administered, patient encountered several Depakine side effects: psychomotor retardation.
Multiple concurrent drugs taken:
  • Haldol
  • Disipal
  • Clonazepam


Product Counterfeit, Hypotension, Presyncope, Asthenia (7459474-4)
on Apr 29, 2011 Female from RUSSIAN FEDERATION , 14 years of age, was diagnosed with
  • epilepsy
  • constipation
and was treated with Depakine Enteric. Directly after, patient experienced the unwanted or unexpected Depakine side effects: product counterfeit, hypotension, presyncope, asthenia. Depakine Enteric dosage: 150 Mg Daily.
Associated medications used:
  • Bisacodyl



Thrombosis (7315617-4)
on Feb 23, 2011 Male from SWITZERLAND , 61 years of age, was diagnosed with
  • mental disability
  • depression
and was treated with Depakine Tablets. Patient felt the following Depakine side effects: thrombosis. Depakine Tablets dosage: N/A.
Multiple prescriptions taken:
  • Remeron
  • Pantozol
Patient was hospitalized.

Ear Malformation, Congenital Renal Disorder (7305345-3)
Patient was taking Depakine Chrono /01294701/ (depakine Chrono) (not Specified). After Depakine was administered, patient encountered several Depakine side effects: ear malformation, congenital renal disorder on Jan 27, 2011 from FRANCE Additional patient health information: Male , weighting 5.95 lb, was diagnosed with
  • epilepsy
and. Depakine Chrono /01294701/ (depakine Chrono) (not Specified) dosage: 500 Mg Bid Transplacental.
Multiple concurrent drugs taken:
  • Ciprofloxacin Hcl
  • Keppra ((transplacental) (transplacental))
  • Keppra ((transplacental) (transplacental))
  • Urbanyl (urbanyl) (not Specified) (500 Mg Transplacental)
  • Donormyl /00886901/ (donormyl) (150 Mg Transplacental)


Dermatitis (6960591-3)
Adverse event was reported on Aug 25, 2010 by a Male taking Depakine Enteric (Dosage: N/A) was diagnosed with
  • affective disorder
and. Location: RUSSIAN FEDERATION , 23 years of age, Directly after, patient experienced the unwanted or unexpected Depakine side effects: dermatitis.
Associated medications used:
  • Zyprexa
  • Sibazon
  • Haloperidol


Pancreatic Necrosis, Pleural Effusion (6827031-6)
on Jun 30, 2010 Female from RUSSIAN FEDERATION , 25 years of age, was diagnosed with
  • epilepsy
and was treated with Depakine Chronosphere. Patient felt the following Depakine side effects: pancreatic necrosis, pleural effusion. Depakine Chronosphere dosage: Prolonged Release Granules. Patient was hospitalized.

Agitation, Tonic Clonic Movements (6813711-5)
on Jun 21, 2010 Female from FRANCE , child 1 years of age, was diagnosed with
  • epilepsy
and was treated with Depakine Chrono Suspension. After Depakine was administered, patient encountered several Depakine side effects: agitation, tonic clonic movements. Depakine Chrono Suspension dosage: N/A.

Dizziness, Fall, Head Injury, Traumatic Haemorrhage (6764907-2)
Patient was taking Depakine Chrono Retard. Directly after, patient experienced the unwanted or unexpected Depakine side effects: dizziness, fall, head injury, traumatic haemorrhage on Jun 01, 2010 from FRANCE Additional patient health information: Female , 29 years of age, . Depakine Chrono Retard dosage: N/A.
Associated medications used:
  • Clozapine
  • Clozapine
  • Clozapine
  • Oxazepam
  • Oxazepam
  • Biperiden Hydrochloride Tab
  • Venlafaxine Hcl
Patient was hospitalized.

Abdominal Pain, C-reactive Protein Increased, Hyperlipasaemia, Leukocytosis, Neutrophil Count Increased, Pancreatitis, Pyrexia, Vomiting (6726635-9)
Adverse event was reported on May 04, 2010 by a Male taking Depakine Chrono (Dosage: 750 Mg Daily) was diagnosed with
  • convulsion
and. Location: FRANCE , 22 years of age, Patient felt the following Depakine side effects: abdominal pain, c-reactive protein increased, hyperlipasaemia, leukocytosis, neutrophil count increased, pancreatitis, pyrexia, vomiting.

Abortion Induced (6724729-5)
on Jun 05, 2009 Female from FRANCE , 29 years of age, was diagnosed with
  • epilepsy
and was treated with Depakine Chrono. After Depakine was administered, patient encountered several Depakine side effects: abortion induced. Depakine Chrono dosage: N/A.
Multiple concurrent drugs taken:
  • Zonisamide
  • Topamax
  • Lamictal
  • Rivotril
  • Nimesulide
  • Folic Acid


Hyperprolactinaemia (6715272-8)
on Apr 29, 2010 Female from FRANCE , child 6 years of age, was treated with Depakine Chrono. Directly after, patient experienced the unwanted or unexpected Depakine side effects: hyperprolactinaemia. Depakine Chrono dosage: N/A.

Catatonia, Encephalopathy, Mutism, Pyramidal Tract Syndrome (6715199-1)
Patient was taking Depakine Chrono. Patient felt the following Depakine side effects: catatonia, encephalopathy, mutism, pyramidal tract syndrome on Apr 28, 2010 from FRANCE Additional patient health information: Female , 71 years of age, was diagnosed with
  • epilepsy
and. Depakine Chrono dosage: Extended Release, 1 In 1 Day.
Multiple prescriptions taken:
  • Keppra
  • Kardegic
  • Stagid
  • Tahor
  • Lasix
  • Diffu K
  • Ferrous Sulfate Tab


Alopecia (6687332-1)
Adverse event was reported on Apr 09, 2010 by a Female taking Depakine Chrono (Dosage: N/A) . Location: FRANCE , 50 years of age, After Depakine was administered, patient encountered several Depakine side effects: alopecia.

Convulsion (6672472-3)
on Mar 31, 2010 Male from FRANCE , 45 years of age, was diagnosed with
  • convulsion
and was treated with Depakine Chrono. Directly after, patient experienced the unwanted or unexpected Depakine side effects: convulsion. Depakine Chrono dosage: N/A. Patient was hospitalized.

Convulsion, Pneumonia (6668049-6)
on Mar 26, 2010 Male from FRANCE , 45 years of age, was diagnosed with
  • epilepsy
  • convulsion
and was treated with Depakine Chrono. Patient felt the following Depakine side effects: convulsion, pneumonia. Depakine Chrono dosage: N/A. Patient was hospitalized.

Hyperprolactinaemia (6666512-5)
Patient was taking Depakine Chrono Suspension. After Depakine was administered, patient encountered several Depakine side effects: hyperprolactinaemia on Mar 25, 2010 from FRANCE Additional patient health information: Female , child 4 years of age, was diagnosed with
  • epilepsy
and. Depakine Chrono Suspension dosage: N/A.
Multiple concurrent drugs taken:
  • Topamax


Disturbance In Attention, Stevens-johnson Syndrome (6663750-2)
Adverse event was reported on Mar 23, 2010 by a Male taking Depakine Chrono (Dosage: N/A) was diagnosed with
  • epilepsy
and. Location: FRANCE , child 9 years of age, Directly after, patient experienced the unwanted or unexpected Depakine side effects: disturbance in attention, stevens-johnson syndrome.
Associated medications used:
  • Lamotrigine


Convulsion, Product Substitution Issue (6644191-0)
on Mar 12, 2010 Male from FRANCE , child 10 years of age, was diagnosed with
  • epilepsy
and was treated with Depakine Chrono Suspension. Patient felt the following Depakine side effects: convulsion, product substitution issue. Depakine Chrono Suspension dosage: N/A.

Alanine Aminotransferase Increased, Ammonia Increased, Aspartate Aminotransferase Increased, Bronchitis, Gamma-glutamyltransferase Increased, Metabolic Encephalopathy (6640569-X)
on Mar 08, 2010 Male from FRANCE , 67 years of age, was diagnosed with
  • epilepsy
and was treated with Depakine Chrono. After Depakine was administered, patient encountered several Depakine side effects: alanine aminotransferase increased, ammonia increased, aspartate aminotransferase increased, bronchitis, gamma-glutamyltransferase increased, metabolic encephalopathy. Depakine Chrono dosage: N/A.
Multiple concurrent drugs taken:
  • Stilnox
  • Torental
  • Fenofibrate
  • Esomeprazole
  • Dafalgan
Patient was hospitalized.

Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Bronchitis, Gamma-glutamyltransferase Increased, Hyperammonaemic Encephalopathy (6571070-X)
Patient was taking Depakine Chrono. Directly after, patient experienced the unwanted or unexpected Depakine side effects: alanine aminotransferase increased, aspartate aminotransferase increased, bronchitis, gamma-glutamyltransferase increased, hyperammonaemic encephalopathy on Jan 27, 2010 from FRANCE Additional patient health information: Male , 67 years of age, was diagnosed with
  • epilepsy
and. Depakine Chrono dosage: N/A.
Associated medications used:
  • Stilnox
  • Torental
  • Fenofibrate
  • Esomeprazole
  • Dafalgan
Patient was hospitalized.

Aphthous Stomatitis, Leukopenia, Lichenoid Keratosis, Rash Erythematous, Rash Maculo-papular (6570602-5)
Adverse event was reported on Jan 25, 2010 by a Female taking Depakine Chrono (Dosage: 1500mg Daily) was diagnosed with
  • epilepsy
and. Location: FRANCE , 56 years of age, Patient felt the following Depakine side effects: aphthous stomatitis, leukopenia, lichenoid keratosis, rash erythematous, rash maculo-papular.
Multiple prescriptions taken:
  • Lamictal (At Bedtime)
  • Lamictal
  • Physiotens
Patient was hospitalized.

Dysmorphism, Gastrooesophageal Reflux Disease, Hypermobility Syndrome (5895358-0)
on Sep 18, 2008 Male from FRANCE , weighting 6.61 lb, was treated with Depakine Chrono Tablets 500 Mg. After Depakine was administered, patient encountered several Depakine side effects: dysmorphism, gastrooesophageal reflux disease, hypermobility syndrome. Depakine Chrono Tablets 500 Mg dosage: N/A.

Lymphoproliferative Disorder (5739604-2)
on May 05, 2008 Male from FRANCE , 17 years of age, was treated with Depakine Chronosphere Granule. Directly after, patient experienced the unwanted or unexpected Depakine side effects: lymphoproliferative disorder. Depakine Chronosphere Granule dosage: N/A.

Showing 1-25 of 45 

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Depakine Information

More About Depakine

Side Effects reported to FDA: 45. View Depakine Adverse Reports

Depakine safety alerts: No

Reported deaths: 2

Reported hospitalizations: 5

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