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Depakine Side Effects

Common Depakine Side Effects


The most commonly reported Depakine side effects (click to view or check a box to report):

Epilepsy (80)
Convulsion (68)
Loss Of Consciousness (31)
Fall (31)
Foaming At Mouth (26)
Product Counterfeit (22)
Confusional State (21)
Trismus (20)
Tremor (17)
Pyrexia (14)
Asthenia (14)
Thrombocytopenia (14)
Somnolence (14)
Eye Movement Disorder (11)
Encephalopathy (10)
Grand Mal Convulsion (10)
Alopecia (10)
Intentional Overdose (10)
Sopor (9)
Abnormal Behaviour (9)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Depakine Side Effects Reported to FDA

The following Depakine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Depakine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Coma Scale Abnormal
This is a report of a 44-year-old male patient (weight: NA) from FR, suffering from the following symptoms/conditions: bipolar disorder, who was treated with Depakine (dosage: NA, start time: Nov 05, 2013), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Coma Scale Abnormal
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine treatment in male patients, resulting in coma scale abnormal side effect.

Delirium
This report suggests a potential Depakine Chrono Delirium side effect(s) that can have serious consequences. A 47-year-old male patient (weight: NA) from AT was diagnosed with the following symptoms/conditions: NA and used Depakine Chrono (dosage: NA) starting Oct 09, 2013. Soon after starting Depakine Chrono the patient began experiencing various side effects, including:
  • Delirium
Drugs used concurrently:
  • Lorazepam
  • Lorazepam
  • Abilify
  • Seroquel (Extended Release)
  • Seroquel (Extended Release)
The patient was hospitalized. Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as delirium, may still occur.

Fatigue, Hyponatraemia, Confusional State
This Fatigue, Hyponatraemia, Confusional State problem was reported by a physician from AT. A 74-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Jul 01, 2013 this consumer started treatment with Depakine Chrono (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Depakine Chrono, the patient experienced the following unwanted symptoms/side effects:
  • Fatigue
  • Hyponatraemia
  • Confusional State
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as fatigue, may become evident only after a product is in use by the general population.

Lip Blister, Dry Mouth
This is a report of a 73-year-old female patient (weight: NA) from AT. The patient developed the following symptoms/conditions: NA and was treated with Depakine Chrono (dosage: NA) starting May 18, 2013. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Lip Blister
  • Dry Mouth
This opens a possibility that Depakine Chrono treatment could cause the above reactions, including lip blister, and some female subjects may be more susceptible.


Foaming At Mouth, Staring, Epilepsy, Unevaluable Event, Dyskinesia, Convulsion
A 75-year-old male patient (weight: NA) from CN with the following symptoms/conditions: epilepsy started Depakine Chrono treatment (dosage: Extended Release) on 201310. Soon after starting Depakine Chrono treatment, the subject experienced various side effects, including:
  • Foaming At Mouth
  • Staring
  • Epilepsy
  • Unevaluable Event
  • Dyskinesia
  • Convulsion
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Depakine Chrono.

Head Titubation, Product Counterfeit, Epilepsy, Tremor
A 21-year-old male patient from CN (weight: NA) experienced symptoms, such as: epilepsy and was treated with Depakine Chrono(dosage: Extended Release). The treatment was initiated on 201402. After that a consumer reported the following side effect(s):
  • Head Titubation
  • Product Counterfeit
  • Epilepsy
  • Tremor
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Depakine Chrono efficacy: NA.

Gamma-glutamyltransferase Increased
In this report, Depakine Chrono was administered for the following condition: NA.A 44-year-old female consumer from FR (weight: NA) started Depakine Chrono treatment (dosage: NA) on 2012.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Gamma-glutamyltransferase Increased
A possible interaction with other drugs could have contributed to this reaction:
  • Trinordiol (Every Three Weeks)
  • Ethinylestradiol W/levonorgestrel (Every Three Weeks)
  • Contraceptives (Every Three Weeks)
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Depakine Chrono treatment could be related to the listed above side effect(s).

Respiratory Alkalosis, Pco2 Decreased, Blood Lactic Acid Increased, Hypokalaemia, Hepatocellular Injury, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased
This is a report of the following Depakine side effect(s):
  • Respiratory Alkalosis
  • Pco2 Decreased
  • Blood Lactic Acid Increased
  • Hypokalaemia
  • Hepatocellular Injury
  • Aspartate Aminotransferase Increased
  • Alanine Aminotransferase Increased
A 27-year-old female patient from FR (weight: NA) presented with the following condition: epilepsy and received a treatment with Depakine (dosage: NA) starting: 201312.The following concurrently used drugs could have generated interactions:
  • Epitomax
  • Urbanyl
  • Gabacet
  • Keppra
The patient was hospitalized.This report suggests that a Depakine treatment could be associated with the listed above side effect(s).

Spinal Compression Fracture, Osteoporosis
This Depakine Chrono report was submitted by a 51-year-old male consumer from FR (weight: NA). The patient was diagnosed with: epilepsy and Depakine Chrono was administered (dosage: Extended Release) starting: NS. The consumer developed a set of symptoms:
  • Spinal Compression Fracture
  • Osteoporosis
Other drugs used simultaneously: NA.The patient was hospitalized.Those unexpected symptoms could be linked to a Depakine Chrono treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Hypoaesthesia, Convulsion, Muscular Weakness
This is a report of a possible correlation between Depakine Chrono use and the following symptoms/side effect(s):
  • Hypoaesthesia
  • Convulsion
  • Muscular Weakness
which could contribute to an assessment of Depakine Chrono risk profile.A 37-year-old male consumer from CN (weight: NA) was suffering from epilepsy and was treated with Depakine Chrono (dosage: Extended Release) starting 201310.Other concurrent medications: NA.

Carotid Artery Thrombosis, Dysgeusia, Cerebral Atrophy, Dry Mouth, Nausea, Bacterial Vaginosis, Vaginal Discharge, Cerebral Microangiopathy, Atrophic Vulvovaginitis
A 65-year-old female patient from AT (weight: NA) presented with the following symptoms: NA and after a treatment with Depakine Chrono Retard (dosage: NA) experienced the following side effect(s):
  • Carotid Artery Thrombosis
  • Dysgeusia
  • Cerebral Atrophy
  • Dry Mouth
  • Nausea
  • Bacterial Vaginosis
  • Vaginal Discharge
  • Cerebral Microangiopathy
  • Atrophic Vulvovaginitis
The treatment was started on Mar 18, 2013. Depakine Chrono Retard was used in combination with the following drugs: NA.This report could alert potential Depakine Chrono Retard consumers.

Sopor, Somnolence
In this report, a 88-year-old female patient from IT (weight: NA) was affected by a possible Depakine side effect.The patient was diagnosed with psychotic disorder. After a treatment with Depakine (dosage: NA, start date: Dec 01, 2013), the patient experienced the following side effect(s):
  • Sopor
  • Somnolence
The following simultaneously used drugs could have led to this reaction:
  • Talofen (Drops)
  • Paracodina (Drops)
  • Pantoprazole
  • Lasix
  • Congescor
  • Ranexa
  • Ascriptin
  • Plavix
The findings here stress that side effects should be taken into consideration when evaluating a Depakine treatment.

Product Counterfeit, Epilepsy, Fall, Syncope, Convulsion, Pyrexia
This is a report of a 4-year-old female patient from CN (weight: NA), who used Depakine (dosage: NA) for a treatment of epilepsy. After starting a treatment on Feb 12, 2014, the patient experienced the following side effect(s):
  • Product Counterfeit
  • Epilepsy
  • Fall
  • Syncope
  • Convulsion
  • Pyrexia
The following drugs could possibly have interacted with the Depakine treatment NA.Taken together, these observations suggest that a Depakine treatment could be related to side effect(s), such as Product Counterfeit, Epilepsy, Fall, Syncope, Convulsion, Pyrexia.

Trismus, Foaming At Mouth, Convulsion, Eye Disorder, Epilepsy
This trismus side effect was reported by a consumer or non-health professional from CN. A 8-year-old female patient (weight:NA) experienced the following symptoms/conditions: epilepsy. The patient was prescribed Depakine Chrono (dosage: Time To Onset: Few Months), which was started on 201306. Concurrently used drugs:
  • Multivitamins
When starting to take Depakine Chrono the consumer reported the following symptoms:
  • Trismus
  • Foaming At Mouth
  • Convulsion
  • Eye Disorder
  • Epilepsy
These side effects may potentially be related to Depakine Chrono.

Eye Movement Disorder, Grand Mal Convulsion, Loss Of Consciousness
This is a Depakine side effect report of a 3-year-old female patient (weight:NA) from IT, suffering from the following symptoms/conditions: epilepsy, who was treated with Depakine (dosage:Modified-release Granules, start time: Feb 01, 2013), combined with: NA., and developed a serious reaction and a eye movement disorder side effect. The patient presented with:
  • Eye Movement Disorder
  • Grand Mal Convulsion
  • Loss Of Consciousness
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Depakine treatment in female patients suffering from epilepsy, resulting in eye movement disorder.

Psychomotor Retardation, Encephalopathy, Ammonia Increased, Confusional State
This report suggests a potential Depakine Chrono psychomotor retardation side effect(s) that can have serious consequences. A 75-year-old male patient from FR (weight:NA) was diagnosed with the following health condition(s): epilepsy and used Depakine Chrono (dosage: NA) starting 201312. Soon after starting Depakine Chrono the patient began experiencing various side effects, including:
  • Psychomotor Retardation
  • Encephalopathy
  • Ammonia Increased
  • Confusional State
Drugs used concurrently:
  • Antibiotics
  • Gardenal
  • Allopurinol
  • Fenofibrate
  • Ginkgo Biloba (ginkgo Biloba)
The patient was hospitalized. Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as psychomotor retardation, may still occur.

Pyrexia, Diarrhoea, Pancytopenia, Hepatitis Cholestatic
This pyrexia problem was reported by a physician from CH. A 67-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): epilepsy,polyuria,polymyalgia rheumatica.On Jul 15, 2013 a consumer started treatment with Depakine Chrono (dosage: NA). The following drugs/medications were being taken at the same time:
  • Ciprofloxacin (Few Day (s))
  • Arava
  • Aspirin Cardio
  • Nebilet
  • Amlodipine/hydrochlorothiazide/valsartan
  • Atorvastatin Calcium
  • Pantoprazole Sodium
  • Pantoprazole Sodium
When commencing Depakine Chrono, the patient experienced the following unwanted symptoms /side effects:
  • Pyrexia
  • Diarrhoea
  • Pancytopenia
  • Hepatitis Cholestatic
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as pyrexia, may become evident only after a product is in use by the general population.

Hypersensitivity, Nausea, Dyspnoea, Oropharyngeal Swelling, Palpitations, Hypertension, Dehydration, Off Label Use
This is a Depakine Chrono side effect report of a 51-year-old female patient (weight: NA) from NL. The patient developed the following symptoms/conditions: migraine and was treated with Depakine Chrono (dosage: Extended Release) starting Jan 02, 1991. Concurrently used drugs:
  • Omeprazole
Soon after that, the consumer experienced the following of symptoms:
  • Hypersensitivity
  • Nausea
  • Dyspnoea
  • Oropharyngeal Swelling
  • Palpitations
  • Hypertension
  • Dehydration
  • Off Label Use
The patient was hospitalized. This opens a possibility that Depakine Chrono could cause hypersensitivity and that some female patients may be more susceptible.

Gait Disturbance, Hypophagia, Fluid Intake Reduced, Glomerular Filtration Rate Decreased, Hyponatraemia, Confusional State
A 67-year-old female patient (weight: NA) from NL with the following symptoms: epilepsy started Depakine treatment (dosage: NA) on 200501. Soon after starting Depakine treatment, the consumer experienced several side effects, including:
  • Gait Disturbance
  • Hypophagia
  • Fluid Intake Reduced
  • Glomerular Filtration Rate Decreased
  • Hyponatraemia
  • Confusional State
. Concurrently used drugs:
  • Amlodipine
  • Aspirin
  • Fusidic Acid
  • Metoprolol
  • Olmesartan
  • Ranitidine
  • Thiamine
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Depakine side effects, such as gait disturbance.

Fall
This fall side effect was reported by a physician from CH. A 65-year-old male patient (weight:NA) experienced the following symptoms/conditions: grand mal convulsion,essential hypertension.The patient was prescribed Depakine Chrono (dosage: NA), which was started on Nov 18, 2013. Concurrently used drugs:
  • Ramipril
  • Esidrex
  • Crestor
  • Janumet
  • Metfin
  • Rivotril
  • Aspirin Cardio
  • Amoxicillin/clavulanic Acid
.When starting to take Depakine Chrono the consumer reported symptoms, such as:
  • Fall
These side effects may potentially be related to Depakine Chrono. The patient was hospitalized.

Suspected Counterfeit Product, Epilepsy, Syncope, Foaming At Mouth, Trismus, Tongue Biting, Fall, Convulsion
This is a report of a 17-year-old male patient (weight: NA) from CN, suffering from the following symptoms/conditions: epilepsy, who was treated with Depakine Chrono (dosage: 2.5 Dosage Form Daily, start time: 201212), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Suspected Counterfeit Product
  • Epilepsy
  • Syncope
  • Foaming At Mouth
  • Trismus
  • Tongue Biting
  • Fall
  • Convulsion
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakine Chrono treatment in male patients, resulting in suspected counterfeit product side effect. The patient was hospitalized.

Abortion Induced, Complication Of Pregnancy
This report suggests a potential Depakine Chrono Abortion Induced, Complication Of Pregnancy side effect(s) that can have serious consequences. A 45-year-old female patient (weight: NA) from CH was diagnosed with the following symptoms/conditions: epilepsy and used Depakine Chrono (dosage: NA) starting 2001. Soon after starting Depakine Chrono the patient began experiencing various side effects, including:
  • Abortion Induced
  • Complication Of Pregnancy
Drugs used concurrently:
  • Fluctine
  • Tegretol
  • Carbamazepine ((prev.))
Although Depakine Chrono demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as abortion induced, may still occur.

Neutropenia
This Neutropenia problem was reported by a physician from IT. A 50-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: mania. On Dec 20, 2013 this consumer started treatment with Depakine Chrono (dosage: NA). The following drugs were being taken at the same time:
  • Clozapine
  • Abilify
  • Delorazepam
  • Inderal
  • Akineton
When commencing Depakine Chrono, the patient experienced the following unwanted symptoms/side effects:
  • Neutropenia
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as neutropenia, may become evident only after a product is in use by the general population.

Pyrexia, Ocular Hyperaemia, Rhinitis, Fatigue, Nausea
This is a report of a 17-year-old male patient (weight: NA) from FR. The patient developed the following symptoms/conditions: NA and was treated with Depakine (dosage: NA) starting NS. Concurrently used drugs:
  • Urbanyl
  • Lamictal (Once)
  • Risperdal
  • Tegretol
  • Sabril
  • Vimpat
Soon after that, the consumer experienced the following side effects:
  • Pyrexia
  • Ocular Hyperaemia
  • Rhinitis
  • Fatigue
  • Nausea
The patient was hospitalized. This opens a possibility that Depakine treatment could cause the above reactions, including pyrexia, and some male subjects may be more susceptible.

Extrapyramidal Disorder, Gait Disturbance, Tremor
A 63-year-old female patient (weight: NA) from FR with the following symptoms/conditions: bipolar disorder started Depakine treatment (dosage: Extended Release) on 201208. Soon after starting Depakine treatment, the subject experienced various side effects, including:
  • Extrapyramidal Disorder
  • Gait Disturbance
  • Tremor
Concurrently used drugs:
  • Theralene
  • Depakote
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Depakine.

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Top 10 Depakine Side Effects for Women

Women Side EffectsReports
Epilepsy 25
Convulsion 23
Confusional State 14
Fall 12
Product Counterfeit 12
Thrombocytopenia 11
Asthenia 10
Loss Of Consciousness 9
Encephalopathy 8
Foaming At Mouth 8

Top 10 Depakine Side Effects for Men

Men Side EffectsReports
Epilepsy 55
Convulsion 45
Loss Of Consciousness 22
Fall 19
Foaming At Mouth 18
Trismus 15
Tremor 11
Product Counterfeit 10
Grand Mal Convulsion 8
Confusional State 7

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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