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Depakote Side Effects

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Common Depakote Side Effects


The most commonly reported Depakote side effects (click to view or check a box to report):

Convulsion (327)
Weight Increased (181)
Alopecia (171)
Tremor (152)
Somnolence (149)
Fall (118)
Nausea (110)
Dizziness (105)
Vomiting (102)
Headache (102)
Depression (92)
Fatigue (91)
Confusional State (86)
Abnormal Behaviour (83)
Thrombocytopenia (82)
Diarrhoea (79)
Pancreatitis (77)
Product Substitution Issue (74)
Aggression (73)
Insomnia (71)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Depakote Side Effects Reported to FDA



Depakote Side Effect Report#9972676
Panic Attack, Anxiety, Mental Disorder, Condition Aggravated, Depression
This is a report of a 57-year-old male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: bipolar disorder, who was treated with Depakote (dosage: NA, start time:
Feb 18, 2012), combined with:
  • Cipramil
  • Prednisolone
  • Prednisolone
  • Diazepam
  • Zopiclone
and developed a serious reaction and side effect(s): Panic Attack, Anxiety, Mental Disorder, Condition Aggravated, Depression after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in male patients, resulting in Panic Attack side effect.
Depakote Side Effect Report#9960643
Thrombocytopenia, No Therapeutic Response, Product Substitution Issue
This report suggests a potential Depakote Er Thrombocytopenia side effect(s) that can have serious consequences. A 13-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: epilepsy and used Depakote Er (dosage: NA) starting NS. After starting Depakote Er the patient began experiencing various side effects, including: Thrombocytopenia, No Therapeutic Response, Product Substitution IssueAdditional drugs used concurrently: NA. Although Depakote Er demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Thrombocytopenia, may still occur.
Depakote Side Effect Report#9940378
Aura, Convulsion, Vomiting, Product Solubility Abnormal, Blepharospasm, Migraine
This Aura problem was reported by a physician from US. A 18-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: convulsion,baltic myoclonic epilepsy. On 201307 this consumer started treatment with Depakote (dosage: 3 Tabs In Am And Noc And 2 Tabs In Pm). The following drugs were being taken at the same time: NA. When using Depakote, the patient experienced the following unwanted symptoms/side effects: Aura, Convulsion, Vomiting, Product Solubility Abnormal, Blepharospasm, MigraineAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Aura, may become evident only after a product is in use by the general population.
Depakote Side Effect Report#9927730
Scoliosis, Convulsion, Back Pain
This Scoliosis side effect was reported by a consumer or non-health professional from US. A 20-year-old male patient (weight:NA) experienced the following symptoms/conditions: convulsion.The patient was prescribed Depakote Er (drug dosage: NA), which was initiated on
Feb 01, 2014. Concurrently used drugs:
  • Divalproex Sodium
.After starting to take Depakote Er the consumer reported adverse symptoms, such as: Scoliosis, Convulsion, Back PainThese side effects may potentially be related to Depakote Er.
Depakote Side Effect Report#9924489
Hepatic Failure
This is a report of a 43-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Depakote (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Hepatic Failure after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in male patients, resulting in Hepatic Failure side effect.
Depakote Side Effect Report#9904794
Interstitial Lung Disease, Alveolitis, Dyspnoea
This report suggests a potential Depakote Er Interstitial Lung Disease side effect(s) that can have serious consequences. A 73-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: NA and used Depakote Er (dosage: NA) starting 2010. After starting Depakote Er the patient began experiencing various side effects, including: Interstitial Lung Disease, Alveolitis, DyspnoeaAdditional drugs used concurrently:
  • Mianserine
  • Kardegic
  • Inexium
  • Vesicare
  • Temesta
  • Lovenox
  • Mianserine
Although Depakote Er demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Interstitial Lung Disease, may still occur.
Depakote Side Effect Report#9903579
Mood Swings
This Mood Swings problem was reported by a consumer or non-health professional from Country Not Specified. A 25-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: convulsion. On 201312 this consumer started treatment with Depakote (dosage: NA). The following drugs were being taken at the same time: NA. When using Depakote, the patient experienced the following unwanted symptoms/side effects: Mood SwingsThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Mood Swings, may become evident only after a product is in use by the general population.
Depakote Side Effect Report#9899354
Hypertensive Crisis, Hypertensive Crisis, Increased Appetite
This Hypertensive Crisis side effect was reported by a physician from BR. A 70-year-old female patient (weight:NA) experienced the following symptoms/conditions: bipolar disorder.The patient was prescribed Depakote Er (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Depakote Er the consumer reported adverse symptoms, such as: Hypertensive Crisis, Hypertensive Crisis, Increased AppetiteThese side effects may potentially be related to Depakote Er. The patient was hospitalized.
Depakote Side Effect Report#9893771
Altered State Of Consciousness, Hyponatraemia, Disorientation, Confusional State
This is a report of a 61-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: bipolar disorder,schizophrenia, who was treated with Depakote (dosage: NA, start time: NS), combined with:
  • Risperdal (Daily)
  • Keppra
  • Effexor
  • Valium (Daily)
  • Levothyrox
  • Mopral
and developed a serious reaction and side effect(s): Altered State Of Consciousness, Hyponatraemia, Disorientation, Confusional State after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in female patients, resulting in Altered State Of Consciousness side effect. The patient was hospitalized.
Depakote Side Effect Report#9890963
Epilepsy
This report suggests a potential Depakote Epilepsy side effect(s) that can have serious consequences. A 4-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: convulsion and used Depakote (dosage: NA) starting NS. After starting Depakote the patient began experiencing various side effects, including: EpilepsyAdditional drugs used concurrently:
  • Keppra
  • Phenobarbital
  • Lamictal
  • Topamax
  • Trileptal
  • Vimpat
  • Carbatrol
  • Valium
Although Depakote demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Epilepsy, may still occur.
Depakote Side Effect Report#9890480
Somnolence, Hypophagia, Dehydration, Renal Failure Acute
This Somnolence problem was reported by a pharmacist from US. A 58-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: convulsion. On NS this consumer started treatment with Depakote (dosage: 3 Pills Bid Oral). The following drugs were being taken at the same time:
  • Advair
  • Albuterol
  • Metoprolol
  • Hctz
  • Nexium
  • Kcl
  • Detrol La
  • Asa
When using Depakote, the patient experienced the following unwanted symptoms/side effects: Somnolence, Hypophagia, Dehydration, Renal Failure AcuteThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Somnolence, may become evident only after a product is in use by the general population.
Depakote Side Effect Report#9856830
Affective Disorder, Affective Disorder, Agitation, Aggression, Suicidal Ideation, Treatment Noncompliance, Hospitalisation, Aggression, Aggression
This Affective Disorder side effect was reported by a physician from US. A 12-year-old male patient (weight:NA) experienced the following symptoms/conditions: affective disorder.The patient was prescribed Depakote Er (drug dosage: NA), which was initiated on
Jun 17, 2013. Concurrently used drugs: NA..After starting to take Depakote Er the consumer reported adverse symptoms, such as: Affective Disorder, Affective Disorder, Agitation, Aggression, Suicidal Ideation, Treatment Noncompliance, Hospitalisation, Aggression, AggressionThese side effects may potentially be related to Depakote Er. The patient was hospitalized.
Depakote Side Effect Report#9853246
Psychiatric Symptom, Decreased Interest, Apathy, Depression, Hunger, Weight Increased, Incorrect Dose Administered
This is a report of a 46-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: bipolar disorder, who was treated with Depakote (dosage: NA, start time: NS), combined with:
  • Seroquel
and developed a serious reaction and side effect(s): Psychiatric Symptom, Decreased Interest, Apathy, Depression, Hunger, Weight Increased, Incorrect Dose Administered after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in female patients, resulting in Psychiatric Symptom side effect. The patient was hospitalized.
Depakote Side Effect Report#9852741
Alopecia, Abdominal Pain Upper, Depression, Anxiety, Asthenia, Confusional State, Somnolence, Ataxia, Back Pain
This report suggests a potential Depakote Alopecia side effect(s) that can have serious consequences. A 80-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: headache,prophylaxis and used Depakote (dosage: 1 Tablet, 2x Daily, By Mouth) starting
Jun 01, 2009. After starting Depakote the patient began experiencing various side effects, including: Alopecia, Abdominal Pain Upper, Depression, Anxiety, Asthenia, Confusional State, Somnolence, Ataxia, Back PainAdditional drugs used concurrently: NA. Although Depakote demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Alopecia, may still occur.
Depakote Side Effect Report#9848613
Convulsion, Product Substitution Issue
This Convulsion problem was reported by a health professional from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: epilepsy. On NS this consumer started treatment with Depakote (dosage: 2 Qam 3 Qhs). The following drugs were being taken at the same time: NA. When using Depakote, the patient experienced the following unwanted symptoms/side effects: Convulsion, Product Substitution IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Convulsion, may become evident only after a product is in use by the general population.
Depakote Side Effect Report#9833232
Hypersensitivity, Abasia, Balance Disorder, Feeling Drunk, Dizziness, Dizziness, Fall, Off Label Use
This Hypersensitivity side effect was reported by a consumer or non-health professional from US. A patient (weight:NA) experienced the following symptoms/conditions: bipolar disorder.The patient was prescribed Depakote (drug dosage: NA), which was initiated on 2009. Concurrently used drugs:
  • Ziprasidone
  • Tegretol
  • Invega
  • Klonopin
.After starting to take Depakote the consumer reported adverse symptoms, such as: Hypersensitivity, Abasia, Balance Disorder, Feeling Drunk, Dizziness, Dizziness, Fall, Off Label UseThese side effects may potentially be related to Depakote.
Depakote Side Effect Report#9832757
Neutropenia
This is a report of a 43-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Depakote (dosage: NA, start time: 201207), combined with:
  • Olanzapine
  • Lysanxia
and developed a serious reaction and side effect(s): Neutropenia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in male patients, resulting in Neutropenia side effect. The patient was hospitalized.
Depakote Side Effect Report#9832740
Neutropenia
This report suggests a potential Depakote Neutropenia side effect(s) that can have serious consequences. A 73-year-old female patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: schizoaffective disorder and used Depakote (dosage: NA) starting 2011. After starting Depakote the patient began experiencing various side effects, including: NeutropeniaAdditional drugs used concurrently:
  • Clozapine
The patient was hospitalized. Although Depakote demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Neutropenia, may still occur.
Depakote Side Effect Report#9827407
Paraesthesia, Convulsion, Convulsion, Drooling, Product Physical Issue
This Paraesthesia problem was reported by a consumer or non-health professional from BR. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: epilepsy. On 2008 this consumer started treatment with Depakote Sprinkle (dosage: NA). The following drugs were being taken at the same time:
  • Trileptal
When using Depakote Sprinkle, the patient experienced the following unwanted symptoms/side effects: Paraesthesia, Convulsion, Convulsion, Drooling, Product Physical IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Paraesthesia, may become evident only after a product is in use by the general population.
Depakote Side Effect Report#9819234
Hypokalaemia
This Hypokalaemia side effect was reported by a physician from Country Not Specified. A 60-year-old male patient (weight:NA) experienced the following symptoms/conditions: bipolar disorder.The patient was prescribed Depakote (drug dosage: NA), which was initiated on
Oct 11, 2012. Concurrently used drugs:
  • Lurasidone
.After starting to take Depakote the consumer reported adverse symptoms, such as: HypokalaemiaThese side effects may potentially be related to Depakote.
Depakote Side Effect Report#9816499
Inappropriate Antidiuretic Hormone Secretion
This is a report of a 65-year-old female patient (weight: NA) from GB, suffering from the following health symptoms/conditions: mania, who was treated with Depakote (dosage: NA, start time:
Nov 27, 2013), combined with:
  • Olanzapine
and developed a serious reaction and side effect(s): Inappropriate Antidiuretic Hormone Secretion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in female patients, resulting in Inappropriate Antidiuretic Hormone Secretion side effect.
Depakote Side Effect Report#9816391
Convulsion, Coma, Intentional Overdose
This report suggests a potential Depakote Convulsion side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: bipolar disorder and used Depakote (dosage: NA) starting
Jun 26, 2013. After starting Depakote the patient began experiencing various side effects, including: Convulsion, Coma, Intentional OverdoseAdditional drugs used concurrently: NA.The patient was hospitalized. Although Depakote demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Convulsion, may still occur.
Depakote Side Effect Report#9816069
Diverticulum, Irritable Bowel Syndrome, Large Intestinal Haemorrhage, Vascular Rupture, Weight Increased, Hypertension, Blood Cholesterol Increased, Glucose Tolerance Impaired, Oedema
This Diverticulum problem was reported by a consumer or non-health professional from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: bipolar disorder,anxiety,depression. On 2000 this consumer started treatment with Depakote (dosage: NA). The following drugs were being taken at the same time: NA. When using Depakote, the patient experienced the following unwanted symptoms/side effects: Diverticulum, Irritable Bowel Syndrome, Large Intestinal Haemorrhage, Vascular Rupture, Weight Increased, Hypertension, Blood Cholesterol Increased, Glucose Tolerance Impaired, OedemaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Diverticulum, may become evident only after a product is in use by the general population.
Depakote Side Effect Report#9813940
This Death side effect was reported by a health professional from Country Not Specified. A 23-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Depakote Er (drug dosage: NA), which was initiated on
Jul 18, 2013. Concurrently used drugs:
  • Buspirone
  • Neurontin
  • Prozac
  • Seroquel (Every Night)
  • Vistaril (As Needed)
  • Remeron (Every Night)
  • Risperdal (1 In Am 2 Qhs)
.After starting to take Depakote Er the consumer reported adverse symptoms, such as: These side effects may potentially be related to Depakote Er.
Depakote Side Effect Report#9813121
Wheelchair User, Incoherent, Dysarthria, Lethargy
This is a report of a 71-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: dementia,aggression, who was treated with Depakote (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Wheelchair User, Incoherent, Dysarthria, Lethargy after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in male patients, resulting in Wheelchair User side effect.


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The appearance of Depakote on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Depakote Side Effects for Women?

Women Side EffectsReports
Convulsion 149
Alopecia 126
Weight Increased 109
Tremor 86
Nausea 74
Fall 64
Dizziness 61
Somnolence 58
Depression 57
Headache 53

What are common Depakote Side Effects for Men?

Men Side EffectsReports
Convulsion 171
Somnolence 89
Weight Increased 70
Abnormal Behaviour 63
Tremor 61
Aggression 55
Fall 52
Vomiting 51
Thrombocytopenia 50
Headache 49

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Depakote reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Discuss Depakote Side Effects

    Did You Have a Depakote Side Effect?

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    Yes, Moderate
    Yes, Minor
    No

    How Effective is Depakote for You?

    Exceeded Expectations
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    Depakote Safety Alerts, Active Ingredients, Usage Information

    NDC0074-3826
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameDepakote ER
    NameDivalproex Sodium
    Dosage FormTABLET, EXTENDED RELEASE
    RouteORAL
    On market since20000804
    LabelerAbbVie Inc.
    Active Ingredient(s)DIVALPROEX SODIUM
    Strength(s)250
    Unit(s)mg/1
    Pharma ClassAnti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE],Mo

    Depakote Dosage, Warnings, Usage.

    Side Effects reported to FDA: 2896

    Depakote safety alerts: 2002 2000

    Reported deaths: 164

    Reported hospitalizations: 907

    Depakote / Depakene / Depacon (divalproex sodium / valproic acid / valproate sodium)

    Audience: Neuropsychiatric healthcare professionals

    FDA and Abbott strengthened the CONTRAINDICATIONS, WARNINGS and PRECAUTIONS sections of the label for Depakote Tablets, Depakote ER Tablets, Depakote Sprinkle Capsules, Depakene Capsules and Syrup and Depacon for Injection. Healthcare professionals were informed that hyperammonemic encephalopathy, sometimes fatal, has been reported following initiation of valproate therapy in patients with urea cycle disorders [UCD], a group of uncommon genetic abnormalities. Patient criteria to consider in evaluation for UCD prior to initiation of valproate therapy are offered.

    [June, 2002 - Letter - Abbott]

    Latest Depakote clinical trials