PatientsVille.com Logo

PatientsVille

Depakote Side Effects

Common Depakote Side Effects


The most commonly reported Depakote side effects (click to view or check a box to report):

Convulsion (327)
Weight Increased (181)
Alopecia (171)
Tremor (152)
Somnolence (149)
Fall (118)
Nausea (110)
Dizziness (105)
Vomiting (102)
Headache (102)
Depression (92)
Fatigue (91)
Confusional State (86)
Abnormal Behaviour (83)
Thrombocytopenia (82)
Diarrhoea (79)
Pancreatitis (77)
Product Substitution Issue (74)
Aggression (73)
Insomnia (71)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Depakote Side Effects Reported to FDA

The following Depakote reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Depakote on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Panic Attack, Anxiety, Mental Disorder, Condition Aggravated, Depression
This is a report of a 57-year-old male patient (weight: NA) from GB, suffering from the following symptoms/conditions: bipolar disorder, who was treated with Depakote (dosage: NA, start time: Feb 18, 2012), combined with:
  • Cipramil
  • Prednisolone
  • Prednisolone
  • Diazepam
  • Zopiclone
and developed a serious reaction and side effect(s). The consumer presented with:
  • Panic Attack
  • Anxiety
  • Mental Disorder
  • Condition Aggravated
  • Depression
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in male patients, resulting in panic attack side effect.

Thrombocytopenia, No Therapeutic Response, Product Substitution Issue
This report suggests a potential Depakote Er Thrombocytopenia, No Therapeutic Response, Product Substitution Issue side effect(s) that can have serious consequences. A 13-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: epilepsy and used Depakote Er (dosage: NA) starting NS. Soon after starting Depakote Er the patient began experiencing various side effects, including:
  • Thrombocytopenia
  • No Therapeutic Response
  • Product Substitution Issue
Drugs used concurrently: NA. Although Depakote Er demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as thrombocytopenia, may still occur.

Aura, Convulsion, Vomiting, Product Solubility Abnormal, Blepharospasm, Migraine
This Aura, Convulsion, Vomiting, Product Solubility Abnormal, Blepharospasm, Migraine problem was reported by a physician from US. A 18-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: convulsion,baltic myoclonic epilepsy. On 201307 this consumer started treatment with Depakote (dosage: 3 Tabs In Am And Noc And 2 Tabs In Pm). The following drugs were being taken at the same time: NA. When commencing Depakote, the patient experienced the following unwanted symptoms/side effects:
  • Aura
  • Convulsion
  • Vomiting
  • Product Solubility Abnormal
  • Blepharospasm
  • Migraine
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as aura, may become evident only after a product is in use by the general population.

Scoliosis, Convulsion, Back Pain
This is a report of a 20-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: convulsion and was treated with Depakote Er (dosage: NA) starting Feb 01, 2014. Concurrently used drugs:
  • Divalproex Sodium
Soon after that, the consumer experienced the following side effects:
  • Scoliosis
  • Convulsion
  • Back Pain
This opens a possibility that Depakote Er treatment could cause the above reactions, including scoliosis, and some male subjects may be more susceptible.


Hepatic Failure
A 43-year-old male patient (weight: NA) from US with the following symptoms/conditions: NA started Depakote treatment (dosage: NA) on NS. Soon after starting Depakote treatment, the subject experienced various side effects, including:
  • Hepatic Failure
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Depakote.

Interstitial Lung Disease, Alveolitis, Dyspnoea
A 73-year-old male patient from FR (weight: NA) experienced symptoms, such as: NA and was treated with Depakote Er(dosage: NA). The treatment was initiated on 2010. After that a consumer reported the following side effect(s):
  • Interstitial Lung Disease
  • Alveolitis
  • Dyspnoea
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Depakote Er efficacy:
  • Mianserine
  • Kardegic
  • Inexium
  • Vesicare
  • Temesta
  • Lovenox
  • Mianserine


Mood Swings
In this report, Depakote was administered for the following condition: convulsion.A 25-year-old male consumer from COUNTRY NOT SPECIFIED (weight: NA) started Depakote treatment (dosage: NA) on 201312.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Mood Swings
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Depakote treatment could be related to the listed above side effect(s).

Hypertensive Crisis, Increased Appetite
This is a report of the following Depakote Er side effect(s):
  • Hypertensive Crisis
  • Increased Appetite
A 70-year-old female patient from BR (weight: NA) presented with the following condition: bipolar disorder and received a treatment with Depakote Er (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions: NA.The patient was hospitalized.This report suggests that a Depakote Er treatment could be associated with the listed above side effect(s).

Altered State Of Consciousness, Hyponatraemia, Disorientation, Confusional State
This Depakote report was submitted by a 61-year-old female consumer from FR (weight: NA). The patient was diagnosed with: bipolar disorder,schizophrenia and Depakote was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Altered State Of Consciousness
  • Hyponatraemia
  • Disorientation
  • Confusional State
Other drugs used simultaneously:
  • Risperdal (Daily)
  • Keppra
  • Effexor
  • Valium (Daily)
  • Levothyrox
  • Mopral
The patient was hospitalized.Those unexpected symptoms could be linked to a Depakote treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Epilepsy
This is a report of a possible correlation between Depakote use and the following symptoms/side effect(s):
  • Epilepsy
which could contribute to an assessment of Depakote risk profile.A 4-year-old female consumer from US (weight: NA) was suffering from convulsion and was treated with Depakote (dosage: NA) starting NS.Other concurrent medications:
  • Keppra
  • Phenobarbital
  • Lamictal
  • Topamax
  • Trileptal
  • Vimpat
  • Carbatrol
  • Valium


Somnolence, Hypophagia, Dehydration, Renal Failure Acute
A 58-year-old female patient from US (weight: NA) presented with the following symptoms: convulsion and after a treatment with Depakote (dosage: 3 Pills Bid Oral) experienced the following side effect(s):
  • Somnolence
  • Hypophagia
  • Dehydration
  • Renal Failure Acute
The treatment was started on NS. Depakote was used in combination with the following drugs:
  • Advair
  • Albuterol
  • Metoprolol
  • Hctz
  • Nexium
  • Kcl
  • Detrol La
  • Asa
The patient was hospitalized.This report could alert potential Depakote consumers.

Affective Disorder, Agitation, Aggression, Suicidal Ideation, Treatment Noncompliance, Hospitalisation
In this report, a 12-year-old male patient from US (weight: NA) was affected by a possible Depakote Er side effect.The patient was diagnosed with affective disorder. After a treatment with Depakote Er (dosage: NA, start date: Jun 17, 2013), the patient experienced the following side effect(s):
  • Affective Disorder
  • Agitation
  • Aggression
  • Suicidal Ideation
  • Treatment Noncompliance
  • Hospitalisation
The following simultaneously used drugs could have led to this reaction: NA.The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Depakote Er treatment.

Psychiatric Symptom, Decreased Interest, Apathy, Depression, Hunger, Weight Increased, Incorrect Dose Administered
This is a report of a 46-year-old female patient from US (weight: NA), who used Depakote (dosage: NA) for a treatment of bipolar disorder. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Psychiatric Symptom
  • Decreased Interest
  • Apathy
  • Depression
  • Hunger
  • Weight Increased
  • Incorrect Dose Administered
The following drugs could possibly have interacted with the Depakote treatment
  • Seroquel
The patient was hospitalized.Taken together, these observations suggest that a Depakote treatment could be related to side effect(s), such as Psychiatric Symptom, Decreased Interest, Apathy, Depression, Hunger, Weight Increased, Incorrect Dose Administered.

Alopecia, Abdominal Pain Upper, Depression, Anxiety, Asthenia, Confusional State, Somnolence, Ataxia, Back Pain
This alopecia side effect was reported by a consumer or non-health professional from US. A 80-year-old female patient (weight:NA) experienced the following symptoms/conditions: headache,prophylaxis. The patient was prescribed Depakote (dosage: 1 Tablet, 2x Daily, By Mouth), which was started on Jun 01, 2009. Concurrently used drugs: NA. When starting to take Depakote the consumer reported the following symptoms:
  • Alopecia
  • Abdominal Pain Upper
  • Depression
  • Anxiety
  • Asthenia
  • Confusional State
  • Somnolence
  • Ataxia
  • Back Pain
These side effects may potentially be related to Depakote.

Convulsion, Product Substitution Issue
This is a Depakote side effect report of a male patient (weight:NA) from US, suffering from the following symptoms/conditions: epilepsy, who was treated with Depakote (dosage:2 Qam 3 Qhs, start time: NS), combined with: NA., and developed a serious reaction and a convulsion side effect. The patient presented with:
  • Convulsion
  • Product Substitution Issue
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Depakote treatment in male patients suffering from epilepsy, resulting in convulsion.

Hypersensitivity, Abasia, Balance Disorder, Feeling Drunk, Dizziness, Fall, Off Label Use
This report suggests a potential Depakote hypersensitivity side effect(s) that can have serious consequences. A patient from US (weight:NA) was diagnosed with the following health condition(s): bipolar disorder and used Depakote (dosage: NA) starting 2009. Soon after starting Depakote the patient began experiencing various side effects, including:
  • Hypersensitivity
  • Abasia
  • Balance Disorder
  • Feeling Drunk
  • Dizziness
  • Fall
  • Off Label Use
Drugs used concurrently:
  • Ziprasidone
  • Tegretol
  • Invega
  • Klonopin
Although Depakote demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hypersensitivity, may still occur.

Neutropenia
This neutropenia problem was reported by a pharmacist from FR. A 43-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): NA.On 201207 a consumer started treatment with Depakote (dosage: NA). The following drugs/medications were being taken at the same time:
  • Olanzapine
  • Lysanxia
When commencing Depakote, the patient experienced the following unwanted symptoms /side effects:
  • Neutropenia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as neutropenia, may become evident only after a product is in use by the general population.

Neutropenia
This is a Depakote side effect report of a 73-year-old female patient (weight: NA) from FR. The patient developed the following symptoms/conditions: schizoaffective disorder and was treated with Depakote (dosage: NA) starting 2011. Concurrently used drugs:
  • Clozapine
Soon after that, the consumer experienced the following of symptoms:
  • Neutropenia
The patient was hospitalized. This opens a possibility that Depakote could cause neutropenia and that some female patients may be more susceptible.

Paraesthesia, Convulsion, Drooling, Product Physical Issue
A female patient (weight: NA) from BR with the following symptoms: epilepsy started Depakote Sprinkle treatment (dosage: NA) on 2008. Soon after starting Depakote Sprinkle treatment, the consumer experienced several side effects, including:
  • Paraesthesia
  • Convulsion
  • Drooling
  • Product Physical Issue
. Concurrently used drugs:
  • Trileptal
This finding indicates that some patients can be more vulnerable to developing Depakote Sprinkle side effects, such as paraesthesia.

Hypokalaemia
This hypokalaemia side effect was reported by a physician from COUNTRY NOT SPECIFIED. A 60-year-old male patient (weight:NA) experienced the following symptoms/conditions: bipolar disorder.The patient was prescribed Depakote (dosage: NA), which was started on Oct 11, 2012. Concurrently used drugs:
  • Lurasidone
.When starting to take Depakote the consumer reported symptoms, such as:
  • Hypokalaemia
These side effects may potentially be related to Depakote.

Inappropriate Antidiuretic Hormone Secretion
This is a report of a 65-year-old female patient (weight: NA) from GB, suffering from the following symptoms/conditions: mania, who was treated with Depakote (dosage: NA, start time: Nov 27, 2013), combined with:
  • Olanzapine
and developed a serious reaction and side effect(s). The consumer presented with:
  • Inappropriate Antidiuretic Hormone Secretion
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Depakote treatment in female patients, resulting in inappropriate antidiuretic hormone secretion side effect.

Convulsion, Coma, Intentional Overdose
This report suggests a potential Depakote Convulsion, Coma, Intentional Overdose side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: bipolar disorder and used Depakote (dosage: NA) starting Jun 26, 2013. Soon after starting Depakote the patient began experiencing various side effects, including:
  • Convulsion
  • Coma
  • Intentional Overdose
Drugs used concurrently: NA.The patient was hospitalized. Although Depakote demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as convulsion, may still occur.

Diverticulum, Irritable Bowel Syndrome, Large Intestinal Haemorrhage, Vascular Rupture, Weight Increased, Hypertension, Blood Cholesterol Increased, Glucose Tolerance Impaired, Oedema
This Diverticulum, Irritable Bowel Syndrome, Large Intestinal Haemorrhage, Vascular Rupture, Weight Increased, Hypertension, Blood Cholesterol Increased, Glucose Tolerance Impaired, Oedema problem was reported by a consumer or non-health professional from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: bipolar disorder,anxiety,depression. On 2000 this consumer started treatment with Depakote (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Depakote, the patient experienced the following unwanted symptoms/side effects:
  • Diverticulum
  • Irritable Bowel Syndrome
  • Large Intestinal Haemorrhage
  • Vascular Rupture
  • Weight Increased
  • Hypertension
  • Blood Cholesterol Increased
  • Glucose Tolerance Impaired
  • Oedema
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as diverticulum, may become evident only after a product is in use by the general population.


This is a report of a 23-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED. The patient developed the following symptoms/conditions: NA and was treated with Depakote Er (dosage: NA) starting Jul 18, 2013. Concurrently used drugs:
  • Buspirone
  • Neurontin
  • Prozac
  • Seroquel (Every Night)
  • Vistaril (As Needed)
  • Remeron (Every Night)
  • Risperdal (1 In Am 2 Qhs)
Soon after that, the consumer experienced the following side effects:
    This opens a possibility that Depakote Er treatment could cause the above reactions, including death, and some female subjects may be more susceptible.

    Wheelchair User, Incoherent, Dysarthria, Lethargy
    A 71-year-old male patient (weight: NA) from US with the following symptoms/conditions: dementia,aggression started Depakote treatment (dosage: NA) on NS. Soon after starting Depakote treatment, the subject experienced various side effects, including:
    • Wheelchair User
    • Incoherent
    • Dysarthria
    • Lethargy
    Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Depakote.

    1 of 116 



    Top 10 Depakote Side Effects for Women

    Women Side EffectsReports
    Convulsion 149
    Alopecia 126
    Weight Increased 109
    Tremor 86
    Nausea 74
    Fall 64
    Dizziness 61
    Somnolence 58
    Depression 57
    Headache 53

    Top 10 Depakote Side Effects for Men

    Men Side EffectsReports
    Convulsion 171
    Somnolence 89
    Weight Increased 70
    Abnormal Behaviour 63
    Tremor 61
    Aggression 55
    Fall 52
    Vomiting 51
    Thrombocytopenia 50
    Headache 49

    Keep Track of Side Effects

    Note Your Observations

    It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

    Why Your Notes are Important

    Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Depakote Side Effects

    Did You Have a Depakote Side Effect?

    Yes, Severe
    Yes, Moderate
    Yes, Minor
    No

    How Effective is Depakote for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Depakote Safety Alerts, Active Ingredients, Usage Information

    NDC0074-3826
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameDepakote ER
    NameDivalproex Sodium
    Dosage FormTABLET, EXTENDED RELEASE
    RouteORAL
    On market since20000804
    LabelerAbbVie Inc.
    Active Ingredient(s)DIVALPROEX SODIUM
    Strength(s)250
    Unit(s)mg/1
    Pharma ClassAnti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE],Mo

    Depakote Dosage, Warnings, Usage.

    Side Effects reported to FDA: 2896

    Depakote safety alerts: 2002 2000

    Reported deaths: 164

    Reported hospitalizations: 907

    Depakote / Depakene / Depacon (divalproex sodium / valproic acid / valproate sodium)

    Audience: Neuropsychiatric healthcare professionals

    FDA and Abbott strengthened the CONTRAINDICATIONS, WARNINGS and PRECAUTIONS sections of the label for Depakote Tablets, Depakote ER Tablets, Depakote Sprinkle Capsules, Depakene Capsules and Syrup and Depacon for Injection. Healthcare professionals were informed that hyperammonemic encephalopathy, sometimes fatal, has been reported following initiation of valproate therapy in patients with urea cycle disorders [UCD], a group of uncommon genetic abnormalities. Patient criteria to consider in evaluation for UCD prior to initiation of valproate therapy are offered.

    [June, 2002 - Letter - Abbott]

    Latest Depakote clinical trials