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Depakote Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 2502 

Retinal Toxicity, Visual Field Defect (8409599-1)
on May 17, 2012 Male from UNITED STATES , 27 years of age, was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: retinal toxicity, visual field defect. Depakote dosage: N/A.
Associated medications used:
  • Dilantin
  • Neurontin
  • Tegretol
  • Lamictal
  • Sabril (1000 Mg Milligram(s), Every Morning, Oral ; 1500 Mg Milligram(s), Every Evening, Oral)
  • Sabril (1000 Mg Milligram(s), Every Morning, Oral ; 1500 Mg Milligram(s), Every Evening, Oral)
  • Felbatol


Hepatic Steatosis, Weight Loss Poor, Obesity, Weight Increased, Insomnia, Sexual Relationship Change, Tremor, Dizziness, Partner Stress (8402803-5)
Patient was taking Depakote. Patient felt the following Depakote side effects: hepatic steatosis, weight loss poor, obesity, weight increased, insomnia, sexual relationship change, tremor, dizziness, partner stress on May 23, 2012 from UNITED STATES Additional patient health information: Female , weighting 145.1 lb, was diagnosed with
  • bipolar disorder
and. Depakote dosage: N/A. Patient was hospitalized.

Gastrostomy, Pneumonia Aspiration (8400476-9)
Adverse event was reported on May 22, 2012 by a Female taking Depakote (Dosage: N/A) was diagnosed with
  • schinzel-giedion syndrome
  • convulsion prophylaxis
and. Location: BRAZIL , weighting 22.05 lb, After Depakote was administered, patient encountered several Depakote side effects: gastrostomy, pneumonia aspiration.
Multiple concurrent drugs taken:
  • Clonazepam
  • Topiramate
Patient was hospitalized.

(8399654-7)
on May 29, 2012 Female from UNITED STATES , 36 years of age, was treated with Depakote. . Depakote dosage: N/A.
Associated medications used:
  • Opioids
  • Lithium Carbonate
  • Butrans (20 Mcg/hr, Unk)



Incontinence, Abasia, Pain, Overdose (8396365-9)
on May 24, 2012 Female from UNITED STATES , 50 years of age, was treated with Depakote. Patient felt the following Depakote side effects: incontinence, abasia, pain, overdose. Depakote dosage: N/A.
Multiple prescriptions taken:
  • Citalopram
  • Sinemet


Intervertebral Disc Protrusion (8393612-4)
Patient was taking Depakote. After Depakote was administered, patient encountered several Depakote side effects: intervertebral disc protrusion on May 21, 2012 from FRANCE Additional patient health information: Female , 32 years of age, . Depakote dosage: N/A.
Multiple concurrent drugs taken:
  • Citalopram Hydrobromide
  • Tysabri
Patient was hospitalized and became disabled.

Haemorrhage, Nervousness, Bleeding Time Prolonged (8391283-4)
Adverse event was reported on Nov 18, 2011 by a Female taking Depakote (Dosage: N/A) was diagnosed with
  • bipolar disorder
  • anxiety
  • hyperparathyroidism
  • hypertension
  • hypothyroidism
and. Location: UNITED STATES , weighting 240.2 lb, Directly after, patient experienced the unwanted or unexpected Depakote side effects: haemorrhage, nervousness, bleeding time prolonged.
Associated medications used:
  • Klonopin
  • Zemplar
  • Losartan Potassium
  • Synthroid
  • Lamictal
  • Verapamil Hcl
  • Zemplar


Myocardial Infarction (8390436-9)
on May 17, 2012 Male from UNITED STATES , 51 years of age, was treated with Depakote. Patient felt the following Depakote side effects: myocardial infarction. Depakote dosage: N/A.
Multiple prescriptions taken:
  • Zyprexa
  • Saphris (Sl)


Overdose, Mania, Aggression, Psychiatric Decompensation (8384869-4)
on May 11, 2012 Male from FRANCE , 40 years of age, was treated with Depakote. After Depakote was administered, patient encountered several Depakote side effects: overdose, mania, aggression, psychiatric decompensation. Depakote dosage: Unk.
Multiple concurrent drugs taken:
  • Zyprexa (40 Mg, Qd)
Patient was hospitalized.

Off Label Use, Nausea, Vomiting (8384522-7)
Patient was taking Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: off label use, nausea, vomiting on May 22, 2012 from UNITED STATES Additional patient health information: Female , weighting 190.2 lb, was diagnosed with
  • convulsion
  • post coital contraception
and. Depakote dosage: N/A.
Associated medications used:
  • Plan B One-step (1.5 Milligram;)


Dizziness, Obesity, Body Mass Index Increased, Tremor, Alopecia, Insomnia, Hepatic Steatosis, Depression, Neoplasm Malignant (8383576-1)
Adverse event was reported on May 17, 2012 by a Female taking Depakote (Dosage: N/A) was diagnosed with
  • bipolar disorder
and. Location: UNITED STATES , weighting 145.1 lb, Patient felt the following Depakote side effects: dizziness, obesity, body mass index increased, tremor, alopecia, insomnia, hepatic steatosis, depression, neoplasm malignant. Patient was hospitalized.

Tremor, Cardiorenal Syndrome, Ill-defined Disorder, Moaning, Facial Pain, Convulsion (8382547-9)
on May 17, 2012 Male from BRAZIL , weighting 176.4 lb, was treated with Depakote Er. After Depakote was administered, patient encountered several Depakote side effects: tremor, cardiorenal syndrome, ill-defined disorder, moaning, facial pain, convulsion. Depakote Er dosage: After Dinner.

Cholestasis, Pancreatic Enzymes Increased (8378508-6)
on May 15, 2012 Female from FRANCE , 66 years of age, was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: cholestasis, pancreatic enzymes increased. Depakote dosage: N/A.

Retching, Vomiting, Product Taste Abnormal (8374880-1)
Patient was taking Depakote. Patient felt the following Depakote side effects: retching, vomiting, product taste abnormal on May 15, 2012 from UNITED STATES Additional patient health information: Female , weighting 37.99 lb, was diagnosed with
  • epilepsy
  • pneumonia
and. Depakote dosage: Unk.
Multiple prescriptions taken:
  • Azithromycin (125 Mg, 1x/day)


Completed Suicide (8374025-8)
Adverse event was reported on May 16, 2012 by a Male taking Depakote (Dosage: N/A) was diagnosed with
  • bipolar disorder
  • mania
and. Location: FRANCE , weighting 152.1 lb, After Depakote was administered, patient encountered several Depakote side effects: completed suicide.
Multiple concurrent drugs taken:
  • Quetiapine Fumarate


Renal Failure, Pain In Extremity, Loss Of Consciousness, Myocardial Calcification, Herpes Zoster, Micturition Urgency, Walking Aid User, Hepatic Failure, Mental Disorder (8365140-3)
on May 08, 2012 Female from UNITED STATES , weighting 175.2 lb, was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: renal failure, pain in extremity, loss of consciousness, myocardial calcification, herpes zoster, micturition urgency, walking aid user, hepatic failure, mental disorder. Depakote dosage: N/A.
Associated medications used:
  • Diovan
  • Coq10
  • Lithium Carbonate
  • Diovan
  • Aspirin (325mg Up To Tid Daily Prn)
  • Humira
  • Pravastatin
  • Klonopin


Atrial Fibrillation, Hypertension, Coronary Artery Disease (8364956-7)
on May 10, 2012 Male from UNITED STATES , 43 years of age, was treated with Depakote. Patient felt the following Depakote side effects: atrial fibrillation, hypertension, coronary artery disease. Depakote dosage: N/A.
Multiple prescriptions taken:
  • Metoprolol Tartrate
  • Seroquel
  • Abilify
  • Avandia (8mg Per Day)
  • Lisinopril
  • Simvastatin
Patient was hospitalized.

Convulsion, Depression, Stress (8361793-4)
Patient was taking Depakote. After Depakote was administered, patient encountered several Depakote side effects: convulsion, depression, stress on May 08, 2012 from UNITED STATES Additional patient health information: Female , 49 years of age, . Depakote dosage: N/A.
Multiple concurrent drugs taken:
  • Vitamin Tab
  • Lamictal (100mg Twice Per Day)
  • Celexa


Parkinson's Disease, Sexual Relationship Change, Partner Stress, Neoplasm Malignant, Tremor, Weight Loss Poor, Hepatic Steatosis, Bedridden, Alopecia (8361049-X)
Adverse event was reported on May 07, 2012 by a Female taking Depakote (Dosage: N/A) was diagnosed with
  • bipolar disorder
and. Location: UNITED STATES , weighting 145.1 lb, Directly after, patient experienced the unwanted or unexpected Depakote side effects: parkinson's disease, sexual relationship change, partner stress, neoplasm malignant, tremor, weight loss poor, hepatic steatosis, bedridden, alopecia. Patient was hospitalized.

Incorrect Dose Administered (8357323-3)
on May 03, 2012 Male from UNITED KINGDOM , 31 years of age, was treated with Depakote. Patient felt the following Depakote side effects: incorrect dose administered. Depakote dosage: N/A.
Multiple prescriptions taken:
  • Haldol
  • Haldol
  • Haloperidol
  • Zopiclone
  • Diazepam


(8354373-8)
on May 09, 2012 Female from UNITED STATES , weighting 75.07 lb, was treated with Depakote. . Depakote dosage: N/A.

Cystitis, Palpitations, Arteriosclerosis Coronary Artery, Blood Count Abnormal, Abdominal Distension, Cholecystectomy, Ingrowing Nail, Loss Of Consciousness, Weight Decreased (8353375-5)
Patient was taking Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: cystitis, palpitations, arteriosclerosis coronary artery, blood count abnormal, abdominal distension, cholecystectomy, ingrowing nail, loss of consciousness, weight decreased on May 07, 2012 from UNITED STATES Additional patient health information: Female , 75 years of age, . Depakote dosage: N/A.
Associated medications used:
  • Amlodipine Besylate
  • Xanax
  • Atacand
  • Furosemide
  • Amlodipine Besylate
  • Lisinopril
  • Nebivolol
  • Metoclopramide
Patient was hospitalized.

Myoclonus, Tremor (8350007-7)
Adverse event was reported on May 02, 2012 by a Female taking Depakote (Dosage: N/A) was diagnosed with
  • tremor
  • myoclonus
and. Location: BRAZIL , weighting 154.3 lb, Patient felt the following Depakote side effects: myoclonus, tremor.

Thrombophlebitis (8349074-6)
on Apr 30, 2012 Female from FRANCE , 64 years of age, was treated with Depakote. After Depakote was administered, patient encountered several Depakote side effects: thrombophlebitis. Depakote dosage: N/A.
Multiple concurrent drugs taken:
  • Risperdal (Introduced 15days Before Report)
  • Valium
Patient was hospitalized.

Abnormal Dreams, Cough, Night Sweats, Vomiting (8342105-9)
on May 02, 2012 Female from UNITED STATES , weighting 131.0 lb, was diagnosed with
  • bipolar disorder
and was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: abnormal dreams, cough, night sweats, vomiting. Depakote dosage: 500 Mg, Daily.
Associated medications used:
  • Geodon (40 Mg, Daily)
  • Geodon (40 Mg, Daily)


Showing 1-25 of 2502 

Depakote Health Episodes

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It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Depakote Information

Alternative DEPAKOTE Names:DIVALPROE

Active Ingredient: DIVALPROE

Depakote Dosage, Warnings, Usage.

Side Effects reported to FDA: 2502. View Depakote Adverse Reports

Depakote safety alerts: 2002 2000

Reported deaths: 114

Reported hospitalizations: 699

Depakote / Depakene / Depacon (divalproex sodium / valproic acid / valproate sodium)

Audience: Neuropsychiatric healthcare professionals

FDA and Abbott strengthened the CONTRAINDICATIONS, WARNINGS and PRECAUTIONS sections of the label for Depakote Tablets, Depakote ER Tablets, Depakote Sprinkle Capsules, Depakene Capsules and Syrup and Depacon for Injection. Healthcare professionals were informed that hyperammonemic encephalopathy, sometimes fatal, has been reported following initiation of valproate therapy in patients with urea cycle disorders [UCD], a group of uncommon genetic abnormalities. Patient criteria to consider in evaluation for UCD prior to initiation of valproate therapy are offered.

[June, 2002 - Letter - Abbott]

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