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Deplin Side Effects

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Common Deplin Side Effects


The most commonly reported Deplin side effects (click to view or check a box to report):

Contusion (2)
Dyspnoea (2)
Convulsion (1)
Crying (1)
Constipation (1)
Dehydration (1)
Depressed Mood (1)
Nasopharyngitis (1)
Eczema (1)
Diarrhoea (1)
Oral Herpes (1)
Anxiety Disorder (1)
Postmenopausal Haemorrhage (1)
Pneumonia (1)
Cholecystitis Chronic (1)
Abdominal Pain Lower (1)
Affective Disorder (1)
Anxiety (1)
Agranulocytosis (1)
Palpitations (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Deplin Side Effects Reported to FDA



Deplin Side Effect Report#9735394
Trigeminal Neuralgia
This is a report of a 59-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: unevaluable event, who was treated with Deplin (dosage: 7.5 Mg 1 Pill Daily By Mouth, start time:
Oct 11, 2013), combined with:
  • Simvastatin
  • Testosterone
and developed a serious reaction and side effect(s): Trigeminal Neuralgia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Deplin treatment in male patients, resulting in Trigeminal Neuralgia side effect.
Deplin Side Effect Report#9579949
Contusion, Contusion
This report suggests a potential Deplin Contusion side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Deplin (dosage: One Pill; Once Daily) starting NS. After starting Deplin the patient began experiencing various side effects, including: Contusion, ContusionAdditional drugs used concurrently: NA. Although Deplin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Contusion, may still occur.
Deplin Side Effect Report#8223773-9
Gallbladder Disorder, Cholecystitis Chronic
This Gallbladder Disorder problem was reported by a consumer or non-health professional from United States. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: depression,gastrooesophageal reflux disease,vitamin supplementation,anxiety. On
Feb 01, 2009 this consumer started treatment with Deplin (methylfolate) (dosage: 7.5 Mg, Once Daily). The following drugs were being taken at the same time:
  • Magnesium Hydroxide Tab (Unk)
  • Vitamin D2 (5000 Units Every Week)
When using Deplin (methylfolate), the patient experienced the following unwanted symptoms/side effects: Gallbladder Disorder, Cholecystitis ChronicThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gallbladder Disorder, may become evident only after a product is in use by the general population.
Deplin Side Effect Report#8132109-3
Aspiration, Diarrhoea, Pneumonia
This Aspiration side effect was reported by a consumer or non-health professional from United States. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Deplin (calcium Levomefolate) (calcium Levomefolate) (drug dosage: NA), which was initiated on
Jan 01, 2011. Concurrently used drugs:
  • Xanax
  • Avelox
  • Vitamin D3 (colecalciferol) (colecalciferol)
  • Ambien
  • Protonix (pantoprazole Sodium Sesquihydrate) (pantoprazole Sodium Sesq
  • Viibryd (10 Mg (10 Mg, 1 In 1 D), Oral, 20 Mg (20 Mg, 1 In 1 D), Oral, 40 Mg (40 Mg, 1 In 1 D), Oral)
  • Viibryd (10 Mg (10 Mg, 1 In 1 D), Oral, 20 Mg (20 Mg, 1 In 1 D), Oral, 40 Mg (40 Mg, 1 In 1 D), Oral)
  • Viibryd (10 Mg (10 Mg, 1 In 1 D), Oral, 20 Mg (20 Mg, 1 In 1 D), Oral, 40 Mg (40 Mg, 1 In 1 D), Oral)
.After starting to take Deplin (calcium Levomefolate) (calcium Levomefolate) the consumer reported adverse symptoms, such as: Aspiration, Diarrhoea, PneumoniaThese side effects may potentially be related to Deplin (calcium Levomefolate) (calcium Levomefolate).
Deplin Side Effect Report#8095045-7
Dyspnoea
This is a report of a 61-year-old male patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Deplin (dosage: NA, start time:
Jun 13, 2011), combined with:
  • Rapaflo (8 Mg)
  • Meloxicam
  • Viagra
  • Wellbutrin
  • Pantoprazole
  • Lipitor
and developed a serious reaction and side effect(s): Dyspnoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Deplin treatment in male patients, resulting in Dyspnoea side effect.
Deplin Side Effect Report#8001176-X
Tremor, Asthenia, Vomiting, Dehydration
This report suggests a potential Deplin Tremor side effect(s) that can have serious consequences. A 57-year-old female patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Deplin (dosage: NA) starting
Sep 20, 2011. After starting Deplin the patient began experiencing various side effects, including: Tremor, Asthenia, Vomiting, DehydrationAdditional drugs used concurrently:
  • Valtrex
  • Rebetol (2 Df;qam;po)
  • Ibuprofen
  • Peginterferon Alfa-2b (4 Df;tid;po)
  • Wellbutrin
  • Lysine
  • Peg-intron (0.4 Ml;qw;sc)
The patient was hospitalized. Although Deplin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Tremor, may still occur.
Deplin Side Effect Report#7987105-3
Agranulocytosis
This Agranulocytosis problem was reported by a consumer or non-health professional from United States. A 40-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 01, 2010 this consumer started treatment with Deplin (dosage: NA). The following drugs were being taken at the same time:
  • Anafranil
  • Abilify
When using Deplin, the patient experienced the following unwanted symptoms/side effects: AgranulocytosisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Agranulocytosis, may become evident only after a product is in use by the general population.
Deplin Side Effect Report#7842407-6
Constipation, Sedation, Nasopharyngitis
This Constipation side effect was reported by a consumer or non-health professional from United States. A female patient (weight:NA) experienced the following symptoms/conditions: anxiety,hypersomnia,feeling hot,depression,pain.The patient was prescribed Deplin (drug dosage: Once A Day), which was initiated on
Feb 05, 2011. Concurrently used drugs:
  • Trazodone Hydrochloride (Once Daily)
  • Clonidine
  • Pristiq (Once Daily)
  • Tramadol Hcl (As Needed)
  • Nucynta (Once Every 6 Hours)
  • Zyrtec (Once Daily)
  • Fentanyl-100 (100 Ug/hr+50 Ug/hr)
  • Ferrous Sulfate Tab
.After starting to take Deplin the consumer reported adverse symptoms, such as: Constipation, Sedation, NasopharyngitisThese side effects may potentially be related to Deplin.
Deplin Side Effect Report#7588139-3
Loss Of Consciousness, Postmenopausal Haemorrhage, Convulsion
This is a report of a female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Deplin (dosage: NA, start time:
Dec 21, 2010), combined with:
  • Aplenzin ((348 Mg Qd Oral) (522 Mg Qd Oral))
  • Aplenzin ((348 Mg Qd Oral) (522 Mg Qd Oral))
  • Folic Acid
  • B-12 Vitamin
and developed a serious reaction and side effect(s): Loss Of Consciousness, Postmenopausal Haemorrhage, Convulsion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Deplin treatment in female patients, resulting in Loss Of Consciousness side effect. The patient was hospitalized.
Deplin Side Effect Report#7327340-0
Affective Disorder, Asperger's Disorder, Suicide Attempt, Anxiety Disorder
This report suggests a potential Deplin Affective Disorder side effect(s) that can have serious consequences. A 16-year-old male patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Deplin (dosage: NA) starting NS. After starting Deplin the patient began experiencing various side effects, including: Affective Disorder, Asperger's Disorder, Suicide Attempt, Anxiety DisorderAdditional drugs used concurrently:
  • Saphris
  • Zonegran
  • Prilosec
  • Celebrex
  • Lamictal
  • Enbrel
The patient was hospitalized. Although Deplin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Affective Disorder, may still occur.
Deplin Side Effect Report#7295824-X
Hepatic Enzyme Increased, Back Disorder
This Hepatic Enzyme Increased problem was reported by a consumer or non-health professional from United States. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 25, 2011 this consumer started treatment with Deplin (dosage: NA). The following drugs were being taken at the same time:
  • Vitamin B-12
  • Simcor (Every Night)
  • Xyzal
  • Lunesta
  • Xyzal
  • Prestique
  • Allergy
  • Plavix
When using Deplin, the patient experienced the following unwanted symptoms/side effects: Hepatic Enzyme Increased, Back DisorderAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hepatic Enzyme Increased, may become evident only after a product is in use by the general population.
Deplin Side Effect Report#7251689-3
Palpitations, Headache, Flushing, Throat Tightness, Anxiety, Sensation Of Foreign Body, Dyspnoea, Blood Pressure Increased, Hypersensitivity
This Palpitations side effect was reported by a health professional from United States. A female patient (weight:NA) experienced the following symptoms/conditions: folate deficiency,asthenia,asthma.The patient was prescribed Deplin (drug dosage: 7.5 Mg, Unk), which was initiated on
Mar 01, 2009. Concurrently used drugs:
  • Nuvigil (150 Mg, Unk)
  • Alvesco (160 A?g, Bid)
  • Vitamin D (Unk)
  • Estropipate (1.25 Mg, Unk)
  • Singulair (10 Mg, Unk)
  • Foradil (2 A?g, Bid)
  • Asmanex Twisthaler (440 Mg, Bid)
  • Alpha Lipoic Acid (600 A?g, Qd)
.After starting to take Deplin the consumer reported adverse symptoms, such as: Palpitations, Headache, Flushing, Throat Tightness, Anxiety, Sensation Of Foreign Body, Dyspnoea, Blood Pressure Increased, HypersensitivityThese side effects may potentially be related to Deplin.
Deplin Side Effect Report#7138398-6
Abdominal Pain Lower, Chest Discomfort, Eczema, Glossitis, Irritable Bowel Syndrome, Muscle Contracture, Oral Herpes, Tinnitus
This is a report of a 64-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: bipolar disorder, who was treated with Deplin 15 Mg Not On Label (dosage: 15 Mg Once Per Day Po, start time: NS), combined with:
  • Geodon (20 Mg Once Per Day Po)
and developed a serious reaction and side effect(s): Abdominal Pain Lower, Chest Discomfort, Eczema, Glossitis, Irritable Bowel Syndrome, Muscle Contracture, Oral Herpes, Tinnitus after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Deplin 15 Mg Not On Label treatment in female patients, resulting in Abdominal Pain Lower side effect. The patient was hospitalized.
Deplin Side Effect Report#6757778-1
No Adverse Event
This report suggests a potential Deplin 7.5 Famlab No Adverse Event side effect(s) that can have serious consequences. A male patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Deplin 7.5 Famlab (dosage: NA) starting NS. After starting Deplin 7.5 Famlab the patient began experiencing various side effects, including: No Adverse EventAdditional drugs used concurrently: NA. Although Deplin 7.5 Famlab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as No Adverse Event, may still occur.
Deplin Side Effect Report#5321260-9
Crying, Depressed Mood
This Crying problem was reported by a consumer or non-health professional from United States. A 47-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On
Apr 22, 2007 this consumer started treatment with Deplin 7.5 Mg Pamlab (dosage: 7.5 Mg One Per Day Po). The following drugs were being taken at the same time: NA. When using Deplin 7.5 Mg Pamlab, the patient experienced the following unwanted symptoms/side effects: Crying, Depressed MoodAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Crying, may become evident only after a product is in use by the general population.



The appearance of Deplin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Deplin Side Effects for Men?

Men Side EffectsReports
Affective Disorder 1
Anxiety Disorder 1
Asperger's Disorder 1
Dyspnoea 1
No Adverse Event 1
Suicide Attempt 1
Trigeminal Neuralgia 1

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Deplin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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