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Dilantin Side Effects

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Common Dilantin Side Effects


The most commonly reported Dilantin side effects (click to view or check a box to report):

Convulsion (951)
Stevens-johnson Syndrome (462)
Dizziness (223)
Grand Mal Convulsion (144)
Fall (135)
Balance Disorder (126)
Headache (121)
Toxic Epidermal Necrolysis (114)
Fatigue (114)
Feeling Abnormal (110)
Rash (96)
Malaise (95)
Gait Disturbance (91)
Asthenia (90)
Nausea (88)
Confusional State (82)
Somnolence (81)
Condition Aggravated (81)
Cerebrovascular Accident (80)
Tremor (80)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Dilantin Side Effects Reported to FDA



Dilantin Side Effect Report#9997683
Bone Density Decreased, Weight Decreased, Ligament Rupture, Muscle Atrophy
This is a report of a 61-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: convulsion, who was treated with Dilantin (dosage: 400 Mg, 1x/day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Bone Density Decreased, Weight Decreased, Ligament Rupture, Muscle Atrophy after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dilantin treatment in male patients, resulting in Bone Density Decreased side effect.
Dilantin Side Effect Report#9935074
Loss Of Consciousness, Fall, Fatigue, Somnolence, Confusional State, Nervousness, Tremor, Constipation, Asthenia
This report suggests a potential Dilantin-125 Loss Of Consciousness side effect(s) that can have serious consequences. A 92-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: grand mal convulsion and used Dilantin-125 (dosage: 260 Mg, 1x/day (at Night)) starting NS. After starting Dilantin-125 the patient began experiencing various side effects, including: Loss Of Consciousness, Fall, Fatigue, Somnolence, Confusional State, Nervousness, Tremor, Constipation, AstheniaAdditional drugs used concurrently: NA. Although Dilantin-125 demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Loss Of Consciousness, may still occur.
Dilantin Side Effect Report#9927918
Rash
This Rash problem was reported by a consumer or non-health professional from US. A 71-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Dilantin (dosage: Unk). The following drugs were being taken at the same time: NA. When using Dilantin, the patient experienced the following unwanted symptoms/side effects: RashAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Rash, may become evident only after a product is in use by the general population.
Dilantin Side Effect Report#9919846
Convulsion
This Convulsion side effect was reported by a consumer or non-health professional from US. A male patient (weight:NA) experienced the following symptoms/conditions: convulsion,loss of consciousness.The patient was prescribed Dilantin-125 (drug dosage: 100 Mg Two Times During Day And 30 Mg At Night,3x/day), which was initiated on NS. Concurrently used drugs: NA..After starting to take Dilantin-125 the consumer reported adverse symptoms, such as: ConvulsionThese side effects may potentially be related to Dilantin-125.
Dilantin Side Effect Report#9909783
Balance Disorder, Ataxia
This is a report of a 51-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: epilepsy, who was treated with Dilantin (dosage: Unk, start time:
Dec 09, 2013), combined with: NA. and developed a serious reaction and side effect(s): Balance Disorder, Ataxia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dilantin treatment in male patients, resulting in Balance Disorder side effect.
Dilantin Side Effect Report#9908459
Encephalopathy, Lethargy, Toxicity To Various Agents
This report suggests a potential Dilantin Encephalopathy side effect(s) that can have serious consequences. A 59-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: convulsion and used Dilantin (dosage: NA) starting NS. After starting Dilantin the patient began experiencing various side effects, including: Encephalopathy, Lethargy, Toxicity To Various AgentsAdditional drugs used concurrently:
  • Neurontin
  • Valium
  • Effexor
The patient was hospitalized. Although Dilantin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Encephalopathy, may still occur.
Dilantin Side Effect Report#9907120
Off Label Use, Loss Of Consciousness, Oxygen Saturation Decreased
This Off Label Use problem was reported by a consumer or non-health professional from US. A 73-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pain. On
Feb 11, 2014 this consumer started treatment with Dilantin (dosage: 2 G (only Received Once)). The following drugs were being taken at the same time: NA. When using Dilantin, the patient experienced the following unwanted symptoms/side effects: Off Label Use, Loss Of Consciousness, Oxygen Saturation DecreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Off Label Use, may become evident only after a product is in use by the general population.
Dilantin Side Effect Report#9901086
Tremor
This Tremor side effect was reported by a consumer or non-health professional from US. A 59-year-old female patient (weight:NA) experienced the following symptoms/conditions: convulsion.The patient was prescribed Dilantin-125 (drug dosage: Unk), which was initiated on 201401. Concurrently used drugs:
  • Roxicodone (Unk)
  • Provigil (Unk)
  • Tapazole (2.5 Mg, 1x/day)
  • Duragesic (Unk)
  • Tylenol (Unk)
  • Lyrica (75 Mg, 2x/day)
.After starting to take Dilantin-125 the consumer reported adverse symptoms, such as: TremorThese side effects may potentially be related to Dilantin-125.
Dilantin Side Effect Report#9898864
White Blood Cell Count Decreased, Lipids Decreased
This is a report of a 68-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: epilepsy, who was treated with Dilantin (dosage: 200 Mg, 2x/day (by Taking 100mg Two Capsule In Morning And Two Capsules At Night), start time: NS), combined with:
  • Vitamin D (50000 Iu, Unk)
  • Synthroid (Unk)
and developed a serious reaction and side effect(s): White Blood Cell Count Decreased, Lipids Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dilantin treatment in female patients, resulting in White Blood Cell Count Decreased side effect.
Dilantin Side Effect Report#9890591
Product Substitution Issue
This report suggests a potential Dilantin Product Substitution Issue side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: convulsion and used Dilantin (dosage: 100 Mg 4 Caps Po At Bedtime Daily) starting 201102. After starting Dilantin the patient began experiencing various side effects, including: Product Substitution IssueAdditional drugs used concurrently: NA. Although Dilantin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Product Substitution Issue, may still occur.
Dilantin Side Effect Report#9888416
Convulsion
This Convulsion problem was reported by a consumer or non-health professional from US. A 46-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: convulsion,diabetes mellitus,hypertension. On NS this consumer started treatment with Dilantin (dosage: 300 Mg (three100mg Capsules) , 2x/day). The following drugs were being taken at the same time:
  • Metformin (1000 Mg, Unk)
  • Metoprolol (Unk)
  • Phenobarbital (Unk)
When using Dilantin, the patient experienced the following unwanted symptoms/side effects: ConvulsionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Convulsion, may become evident only after a product is in use by the general population.
Dilantin Side Effect Report#9886136
Convulsion
This Convulsion side effect was reported by a consumer or non-health professional from US. A 49-year-old female patient (weight:NA) experienced the following symptoms/conditions: convulsion,diabetes mellitus,hypertension.The patient was prescribed Dilantin (drug dosage: 300 Mg (three 100mg Oral Capsules), 2x/day), which was initiated on 2002. Concurrently used drugs:
  • Metformin (1000 Mg, Unk)
  • Metoprolol (Unk)
  • Phenobarbital (Unk)
.After starting to take Dilantin the consumer reported adverse symptoms, such as: ConvulsionThese side effects may potentially be related to Dilantin. The patient was hospitalized.
Dilantin Side Effect Report#9881854
Nasopharyngitis
This is a report of a 57-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: convulsion, who was treated with Dilantin-125 (dosage: 200 Mg, 2x/day, start time: 1990), combined with: NA. and developed a serious reaction and side effect(s): Nasopharyngitis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dilantin-125 treatment in male patients, resulting in Nasopharyngitis side effect. The patient was hospitalized.
Dilantin Side Effect Report#9863053
Toxicity To Various Agents, Cerebrovascular Accident, Convulsion, Hemiplegia, Hypokinesia, Musculoskeletal Stiffness, Neck Pain, Mobility Decreased, White Blood Cell Count Increased
This report suggests a potential Dilantin-125 Toxicity To Various Agents side effect(s) that can have serious consequences. A 38-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Dilantin-125 (dosage: Unk) starting
Jun 14, 2011. After starting Dilantin-125 the patient began experiencing various side effects, including: Toxicity To Various Agents, Cerebrovascular Accident, Convulsion, Hemiplegia, Hypokinesia, Musculoskeletal Stiffness, Neck Pain, Mobility Decreased, White Blood Cell Count IncreasedAdditional drugs used concurrently:
  • Tysabri (300 Mg, Qm)
  • Tysabri (Unk)
The patient was hospitalized. Although Dilantin-125 demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Toxicity To Various Agents, may still occur.
Dilantin Side Effect Report#9862307
Toxicity To Various Agents, Agranulocytosis, Phagocytosis
This Toxicity To Various Agents problem was reported by a physician from US. A 15-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Dilantin (dosage: 300 Mg, Daily). The following drugs were being taken at the same time: NA. When using Dilantin, the patient experienced the following unwanted symptoms/side effects: Toxicity To Various Agents, Agranulocytosis, PhagocytosisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Toxicity To Various Agents, may become evident only after a product is in use by the general population.
Dilantin Side Effect Report#9857394
Fall, Head Injury, Epilepsy, Convulsion, Urinary Incontinence, Faecal Incontinence, Learning Disability, Reading Disorder
This Fall side effect was reported by a consumer or non-health professional from US. A 21-year-old male patient (weight:NA) experienced the following symptoms/conditions: convulsion,epilepsy.The patient was prescribed Dilantin (drug dosage: 1 Df, 1x/day), which was initiated on NS. Concurrently used drugs: NA..After starting to take Dilantin the consumer reported adverse symptoms, such as: Fall, Head Injury, Epilepsy, Convulsion, Urinary Incontinence, Faecal Incontinence, Learning Disability, Reading DisorderThese side effects may potentially be related to Dilantin. The patient was hospitalized.
Dilantin Side Effect Report#9850880
Epilepsy, Neoplasm, Neoplasm Recurrence
This is a report of a 50-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: convulsion, who was treated with Dilantin (dosage: 300 Mg, 2x/day (taking Of 3 Capsules Of 100mg In The Morning And 3 Capsules Of 100mg In The Night), start time: 200712), combined with:
  • Vimpat (Unk)
and developed a serious reaction and side effect(s): Epilepsy, Neoplasm, Neoplasm Recurrence after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dilantin treatment in male patients, resulting in Epilepsy side effect.
Dilantin Side Effect Report#9847059
Pyrexia, Rash Maculo-papular, Rash Erythematous
This report suggests a potential Dilantin Pyrexia side effect(s) that can have serious consequences. A 63-year-old male patient (weight: NA) from MY was diagnosed with the following symptoms/conditions: convulsion,blood phosphorus,hypertension and used Dilantin (dosage: 300 Mg, Daily) starting NS. After starting Dilantin the patient began experiencing various side effects, including: Pyrexia, Rash Maculo-papular, Rash ErythematousAdditional drugs used concurrently:
  • Calcium Carbonate (1 G, 3x/day)
  • Amlodipine (10 Mg, 1x/day)
  • Atenolol (25 Mg, 1x/day)
  • Simvastatin (40 Mg, 1x/day)
  • Ranitidine (150 Mg, 2x/day)
Although Dilantin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pyrexia, may still occur.
Dilantin Side Effect Report#9845895
Liver Injury
This Liver Injury problem was reported by a consumer or non-health professional from US. A 34-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: epilepsy. On 1990 this consumer started treatment with Dilantin-125 (dosage: 300 Mg, Unk). The following drugs were being taken at the same time: NA. When using Dilantin-125, the patient experienced the following unwanted symptoms/side effects: Liver InjuryAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Liver Injury, may become evident only after a product is in use by the general population.
Dilantin Side Effect Report#9845708
Oral Disorder, Gingival Disorder, Infection
This Oral Disorder side effect was reported by a consumer or non-health professional from US. A 29-year-old female patient (weight:NA) experienced the following symptoms/conditions: epilepsy.The patient was prescribed Dilantin-125 (drug dosage: 300 Mg, Unk), which was initiated on 1990. Concurrently used drugs: NA..After starting to take Dilantin-125 the consumer reported adverse symptoms, such as: Oral Disorder, Gingival Disorder, InfectionThese side effects may potentially be related to Dilantin-125.
Dilantin Side Effect Report#9842115
Skin Swelling, Pruritus
This is a report of a 27-year-old female patient (weight: NA) from MY, suffering from the following health symptoms/conditions: NA, who was treated with Dilantin (dosage: 200 Mg, 2x/day, start time:
Jan 11, 2012), combined with:
  • Amoxicillin (500 Mg, 3x/day)
  • Neomycin (Unk)
  • Folic Acid (1/1 Od)
and developed a serious reaction and side effect(s): Skin Swelling, Pruritus after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dilantin treatment in female patients, resulting in Skin Swelling side effect.
Dilantin Side Effect Report#9841909
Neutropenia, Thrombocytopenia, Rash, Hepatitis
This report suggests a potential Dilantin Neutropenia side effect(s) that can have serious consequences. A 20-year-old male patient (weight: NA) from MY was diagnosed with the following symptoms/conditions: epilepsy and used Dilantin (dosage: 100 Mg, 3x/day) starting
Sep 06, 2012. After starting Dilantin the patient began experiencing various side effects, including: Neutropenia, Thrombocytopenia, Rash, HepatitisAdditional drugs used concurrently: NA. Although Dilantin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Neutropenia, may still occur.
Dilantin Side Effect Report#9841901
Rash Maculo-papular, Petechiae, Erythema, Scab
This Rash Maculo-papular problem was reported by a health professional from MY. A 45-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: convulsion,aortic valve replacement,rash. On
Jun 11, 2012 this consumer started treatment with Dilantin (dosage: 300 Mg, Daily). The following drugs were being taken at the same time:
  • Warfarin (5 Mg, Daily)
  • Piriton (4 Mg, 3x/day)
When using Dilantin, the patient experienced the following unwanted symptoms/side effects: Rash Maculo-papular, Petechiae, Erythema, ScabAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Rash Maculo-papular, may become evident only after a product is in use by the general population.
Dilantin Side Effect Report#9840641
Off Label Use, Convulsion
This Off Label Use side effect was reported by a consumer or non-health professional from US. A 49-year-old female patient (weight:NA) experienced the following symptoms/conditions: convulsion,panic attack.The patient was prescribed Dilantin (drug dosage: Unk), which was initiated on NS. Concurrently used drugs: NA..After starting to take Dilantin the consumer reported adverse symptoms, such as: Off Label Use, ConvulsionThese side effects may potentially be related to Dilantin.
Dilantin Side Effect Report#9838582
Coma
This is a report of a 36-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Dilantin-125 (dosage: Unk, 3x/day (300mg In Morning, 200mg In Noon And 200mg In Night), start time: 200401), combined with:
  • Coumadine (Unk)
  • Amlodipine (5 Mg, Daily)
and developed a serious reaction and side effect(s): Coma after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dilantin-125 treatment in male patients, resulting in Coma side effect. The patient was hospitalized.


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The appearance of Dilantin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Dilantin Side Effects for Women?

Women Side EffectsReports
Convulsion 477
Stevens-johnson Syndrome 246
Dizziness 123
Fatigue 72
Fall 71
Headache 69
Balance Disorder 65
Grand Mal Convulsion 64
Malaise 62
Toxic Epidermal Necrolysis 59

What are common Dilantin Side Effects for Men?

Men Side EffectsReports
Convulsion 463
Stevens-johnson Syndrome 171
Dizziness 99
Grand Mal Convulsion 79
Fall 64
Balance Disorder 61
Feeling Abnormal 55
Toxic Epidermal Necrolysis 54
Headache 52
Condition Aggravated 48

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Dilantin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Dilantin Side Effects

    Did You Have a Dilantin Side Effect?

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    How Effective is Dilantin for You?

    Exceeded Expectations
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    Dilantin Safety Alerts, Active Ingredients, Usage Information

    NDC0071-0007
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameDilantin Infatabs
    NamePhenytoin
    Dosage FormTABLET, CHEWABLE
    RouteORAL
    On market since19790226
    LabelerParke-Davis Div of Pfizer Inc
    Active Ingredient(s)PHENYTOIN
    Strength(s)50
    Unit(s)mg/1
    Pharma ClassAnti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE]

    More About Dilantin

    Side Effects reported to FDA: 3054

    Dilantin safety alerts: 2008

    Reported deaths: 143

    Reported hospitalizations: 888

    Phenytoin (marketed as Dilantin, Phenytek and generics) and Fosphenytoin Sodium (marketed as Cerebyx and generics)

    Audience: Neurological healthcare professionals 

    [Posted 11/24/2008] FDA is investigating new preliminary data regarding a potential increased risk of serious skin reactions including Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from phenytoin therapy in Asian patients positive for human leukocyte antigen (HLA) allele, HLA-B*1502. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including Han Chinese, Filipinos, Malaysians, South Asian Indians, and Thais. Until the FDA evaluation is completed, healthcare providers who are considering the use of phenytoin or fosphenytoin should be aware of the risks and benefits described in the current prescribing information for this drug. Healthcare providers should consider avoiding phenytoin and fosphenytoin as alternatives for carbamazepine in patients who test positive for HLA-B*1502. A summary of the data currently being analyzed by FDA, and information for patients and healthcare professionals to consider, can be found in the links provided below.

    [November 24, 2008 - Drug Information Page - FDA]
    [November 24, 2008 - Information for Healthcare Professionals - FDA]

    Latest Dilantin clinical trials