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Doxycycline Side Effects

Common Doxycycline Side Effects


The most commonly reported Doxycycline side effects (click to view or check a box to report):

Headache (127)
Nausea (125)
Rash (81)
Dyspnoea (80)
Dizziness (80)
Pain (80)
Vomiting (80)
Diarrhoea (67)
Haemorrhage (66)
Malaise (64)
Abortion Incomplete (63)
Chest Pain (60)
Anxiety (57)
Oesophageal Ulcer (52)
Pyrexia (50)
Asthenia (48)
Fatigue (47)
Abdominal Pain Upper (45)
Pruritus (44)
Photosensitivity Reaction (43)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Doxycycline Side Effects Reported to FDA

The following Doxycycline reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Doxycycline on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Vascular Injury, Oesophageal Ulcer, Oesophagitis
This is a report of a 27-year-old female patient (weight: NA) from CA, suffering from the following symptoms/conditions: urinary tract infection, who was treated with Doxycycline (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Vascular Injury
  • Oesophageal Ulcer
  • Oesophagitis
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Doxycycline treatment in female patients, resulting in vascular injury side effect.

Pancreatitis
This report suggests a potential Doxycycline Pancreatitis side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: atypical pneumonia and used Doxycycline (dosage: Daily Dose: 200 Mg Millgram(s) Every Days) starting NS. Soon after starting Doxycycline the patient began experiencing various side effects, including:
  • Pancreatitis
Drugs used concurrently:
  • Cefuroxime (Daily Dose: 2 Df Dosage Form Every Days)
  • Caprelsa (Daily Dose: 300 Mg Millgram(s) Every Days)
The patient was hospitalized. Although Doxycycline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pancreatitis, may still occur.

Nausea, Headache, Disinhibition, Affect Lability, Irritability, Anxiety, Depressed Mood, Social Avoidant Behaviour, Indifference
This Nausea, Headache, Disinhibition, Affect Lability, Irritability, Anxiety, Depressed Mood, Social Avoidant Behaviour, Indifference problem was reported by a physician from GB. A 33-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: acne. On NS this consumer started treatment with Doxycycline Hyclate (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Doxycycline Hyclate, the patient experienced the following unwanted symptoms/side effects:
  • Nausea
  • Headache
  • Disinhibition
  • Affect Lability
  • Irritability
  • Anxiety
  • Depressed Mood
  • Social Avoidant Behaviour
  • Indifference
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as nausea, may become evident only after a product is in use by the general population.

Suicidal Ideation, Mood Swings, Disinhibition, Irritability, Depressed Mood, Mental Status Changes, Nausea
This is a report of a 33-year-old female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: acne and was treated with Doxycycline (dosage: One Time) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Suicidal Ideation
  • Mood Swings
  • Disinhibition
  • Irritability
  • Depressed Mood
  • Mental Status Changes
  • Nausea
This opens a possibility that Doxycycline treatment could cause the above reactions, including suicidal ideation, and some female subjects may be more susceptible.


Haemoglobin Decreased, Gastrointestinal Haemorrhage
A 81-year-old female patient (weight: NA) from GB with the following symptoms/conditions: pneumonia started Doxycycline treatment (dosage: 100 Milligram Daily; Morning) on Feb 05, 2014. Soon after starting Doxycycline treatment, the subject experienced various side effects, including:
  • Haemoglobin Decreased
  • Gastrointestinal Haemorrhage
Concurrently used drugs:
  • Prednisolone (Morning)
  • Amlodipine
  • Aspirin (Witheld)
  • Co-codamol
  • Ferrous Fumarate
  • Folic Acid
  • Lansoprazole (15 Milligram Daily;)
  • Lansoprazole (30 Milligram Daily;)
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Doxycycline.

Suicidal Ideation, Completed Suicide
A 19-year-old male patient from GB (weight: NA) experienced symptoms, such as: dermatitis and was treated with Doxycycline(dosage: NA). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Suicidal Ideation
  • Completed Suicide
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Doxycycline efficacy: NA.

Asthenia, Dizziness, Nausea, Malaise, Constipation
In this report, Doxycycline was administered for the following condition: sinusitis.A 73-year-old male consumer from US (weight: NA) started Doxycycline treatment (dosage: NA) on Jan 23, 2014.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Asthenia
  • Dizziness
  • Nausea
  • Malaise
  • Constipation
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Doxycycline treatment could be related to the listed above side effect(s).

Haemoglobin Decreased
This is a report of the following Doxycycline Monohydrate side effect(s):
  • Haemoglobin Decreased
A 81-year-old female patient from GB (weight: NA) presented with the following condition: pneumonia and received a treatment with Doxycycline Monohydrate (dosage: 100 Mg, 1x/day) starting: Feb 05, 2014.The following concurrently used drugs could have generated interactions:
  • Prednisolone (Morning)
  • Amlodipine
  • Acetylsalicylic Acid (Witheld)
  • Co-codamol
  • Ferrous Fumarate
  • Folic Acid
  • Lansoprazole (15 Mg, 1x/day)
  • Ramipril
The patient was hospitalized.This report suggests that a Doxycycline Monohydrate treatment could be associated with the listed above side effect(s).

Headache, Dizziness
This Doxycycline report was submitted by a 51-year-old female consumer from GB (weight: NA). The patient was diagnosed with: NA and Doxycycline was administered (dosage: NA) starting: Jan 29, 2014. The consumer developed a set of symptoms:
  • Headache
  • Dizziness
Other drugs used simultaneously: NA.Those unexpected symptoms could be linked to a Doxycycline treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Suicidal Ideation, Panic Attack, Depressed Mood
This is a report of a possible correlation between Doxycycline Hyclate use and the following symptoms/side effect(s):
  • Suicidal Ideation
  • Panic Attack
  • Depressed Mood
which could contribute to an assessment of Doxycycline Hyclate risk profile.A 15-year-old male consumer from NL (weight: NA) was suffering from chlamydial infection and was treated with Doxycycline Hyclate (dosage: 100 Mg, 2x/day) starting 2011.Other concurrent medications:
  • Venlafaxine (150 Mg, 1x/day)


Headache, Dizziness
A 51-year-old female patient from GB (weight: NA) presented with the following symptoms: NA and after a treatment with Doxycycline (dosage: NA) experienced the following side effect(s):
  • Headache
  • Dizziness
The treatment was started on Jan 29, 2014. Doxycycline was used in combination with the following drugs: NA.This report could alert potential Doxycycline consumers.

Lupus-like Syndrome, Musculoskeletal Stiffness, Arthralgia, Movement Disorder, Gait Disturbance, Nausea, Headache, Confusional State
In this report, a 59-year-old female patient from US (weight: NA) was affected by a possible Doxycycline side effect.The patient was diagnosed with acne. After a treatment with Doxycycline (dosage: 1 Pill Twice Daily, start date: Oct 30, 2013), the patient experienced the following side effect(s):
  • Lupus-like Syndrome
  • Musculoskeletal Stiffness
  • Arthralgia
  • Movement Disorder
  • Gait Disturbance
  • Nausea
  • Headache
  • Confusional State
The following simultaneously used drugs could have led to this reaction: NA.The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Doxycycline treatment.

Deafness, Hypoacusis, Autophony
This is a report of a 78-year-old female patient from GB (weight: NA), who used Doxycycline Hyclate (dosage: 199 Mg, Daily) for a treatment of infection. After starting a treatment on Apr 23, 2012, the patient experienced the following side effect(s):
  • Deafness
  • Hypoacusis
  • Autophony
The following drugs could possibly have interacted with the Doxycycline Hyclate treatment NA.Taken together, these observations suggest that a Doxycycline Hyclate treatment could be related to side effect(s), such as Deafness, Hypoacusis, Autophony.

Iiird Nerve Injury, Diplopia, Vith Nerve Paralysis
This iiird nerve injury side effect was reported by a physician from GB. A 52-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Doxycycline (dosage: NA), which was started on Jan 09, 2014. Concurrently used drugs: NA. When starting to take Doxycycline the consumer reported the following symptoms:
  • Iiird Nerve Injury
  • Diplopia
  • Vith Nerve Paralysis
These side effects may potentially be related to Doxycycline.

Night Sweats, Palpitations, Migraine, Diarrhoea, Nausea, Decreased Appetite, Hypoaesthesia, Anxiety, Paranoia
This is a Doxycycline Hyclate side effect report of a 30-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: rosacea, who was treated with Doxycycline Hyclate (dosage:2.5 Weeks , 18 Days, start time: NS), combined with: NA., and developed a serious reaction and a night sweats side effect. The patient presented with:
  • Night Sweats
  • Palpitations
  • Migraine
  • Diarrhoea
  • Nausea
  • Decreased Appetite
  • Hypoaesthesia
  • Anxiety
  • Paranoia
which developed after the beginning of treatment. The patient was hospitalized and became disabled. This side effect report can indicate a possible existence of increased vulnerability to Doxycycline Hyclate treatment in female patients suffering from rosacea, resulting in night sweats.

Idiopathic Angioedema, Deformity, Mass, Flushing, Idiopathic Urticaria, Skin Discolouration, Pyrexia, Oropharyngeal Pain
This report suggests a potential Doxycycline Tablets idiopathic angioedema side effect(s) that can have serious consequences. A female patient from US (weight:NA) was diagnosed with the following health condition(s): idiopathic angioedema,deformity,mass,flushing,idiopathic urticaria,skin discolouration,off label use and used Doxycycline Tablets (dosage: NA) starting NS. Soon after starting Doxycycline Tablets the patient began experiencing various side effects, including:
  • Idiopathic Angioedema
  • Deformity
  • Mass
  • Flushing
  • Idiopathic Urticaria
  • Skin Discolouration
  • Pyrexia
  • Oropharyngeal Pain
Drugs used concurrently:NA. Although Doxycycline Tablets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as idiopathic angioedema, may still occur.

Iiird Nerve Injury, Diplopia, Vith Nerve Paralysis
This iiird nerve injury problem was reported by a physician from GB. A 52-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Jan 09, 2014 a consumer started treatment with Doxycycline (dosage: NA). The following drugs/medications were being taken at the same time: NA. When commencing Doxycycline, the patient experienced the following unwanted symptoms /side effects:
  • Iiird Nerve Injury
  • Diplopia
  • Vith Nerve Paralysis
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as iiird nerve injury, may become evident only after a product is in use by the general population.

Dizziness, Headache
This is a Doxycycline side effect report of a 51-year-old female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: NA and was treated with Doxycycline (dosage: 100 Mg, Unk) starting Jan 29, 2014. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Dizziness
  • Headache
This opens a possibility that Doxycycline could cause dizziness and that some female patients may be more susceptible.

Headache, Dizziness
A 51-year-old female patient (weight: NA) from GB with the following symptoms: NA started Doxycycline Monohydrate treatment (dosage: 100 Mg, Unk) on Jan 29, 2014. Soon after starting Doxycycline Monohydrate treatment, the consumer experienced several side effects, including:
  • Headache
  • Dizziness
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Doxycycline Monohydrate side effects, such as headache.

Suicidal Ideation, Completed Suicide, Malaise, Depressed Mood
This suicidal ideation side effect was reported by a health professional from GB. A 18-year-old male patient (weight:NA) experienced the following symptoms/conditions: acne.The patient was prescribed Doxycycline (dosage: 50 Mg/day For 1y), which was started on 201202. Concurrently used drugs: NA..When starting to take Doxycycline the consumer reported symptoms, such as:
  • Suicidal Ideation
  • Completed Suicide
  • Malaise
  • Depressed Mood
These side effects may potentially be related to Doxycycline.

Suicidal Ideation, Completed Suicide
This is a report of a 19-year-old male patient (weight: NA) from GB, suffering from the following symptoms/conditions: dermatitis, who was treated with Doxycycline (dosage: 100 Milligram Daily;, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Suicidal Ideation
  • Completed Suicide
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Doxycycline treatment in male patients, resulting in suicidal ideation side effect.

Suicidal Ideation, Nausea, Headache, Mood Swings
This report suggests a potential Doxycycline Suicidal Ideation, Nausea, Headache, Mood Swings side effect(s) that can have serious consequences. A 33-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: acne and used Doxycycline (dosage: 200mg Stat; Then 100mg Once Daily) starting NS. Soon after starting Doxycycline the patient began experiencing various side effects, including:
  • Suicidal Ideation
  • Nausea
  • Headache
  • Mood Swings
Drugs used concurrently: NA. Although Doxycycline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as suicidal ideation, may still occur.

Iiird Nerve Injury, Diplopia, Vith Nerve Paralysis
This Iiird Nerve Injury, Diplopia, Vith Nerve Paralysis problem was reported by a physician from GB. A 52-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Jan 09, 2014 this consumer started treatment with Doxycycline Monohydrate (dosage: Unk). The following drugs were being taken at the same time: NA. When commencing Doxycycline Monohydrate, the patient experienced the following unwanted symptoms/side effects:
  • Iiird Nerve Injury
  • Diplopia
  • Vith Nerve Paralysis
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as iiird nerve injury, may become evident only after a product is in use by the general population.

Diplopia, Iiird Nerve Injury, Vith Nerve Paralysis
This is a report of a 52-year-old female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: NA and was treated with Doxycycline (dosage: NA) starting Jan 09, 2014. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Diplopia
  • Iiird Nerve Injury
  • Vith Nerve Paralysis
This opens a possibility that Doxycycline treatment could cause the above reactions, including diplopia, and some female subjects may be more susceptible.

Suicidal Ideation, Mood Swings, Nausea, Headache
A 33-year-old female patient (weight: NA) from GB with the following symptoms/conditions: acne started Doxycycline treatment (dosage: 200mg Stat; Then 100mg Once Daily) on NS. Soon after starting Doxycycline treatment, the subject experienced various side effects, including:
  • Suicidal Ideation
  • Mood Swings
  • Nausea
  • Headache
Concurrently used drugs: NA. This finding indicates that some female patients could be more vulnerable to Doxycycline.

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Top 10 Doxycycline Side Effects for Women

Women Side EffectsReports
Headache 95
Nausea 89
Haemorrhage 64
Pain 64
Vomiting 64
Abortion Incomplete 63
Dizziness 62
Rash 51
Dyspnoea 48
Diarrhoea 46

Top 10 Doxycycline Side Effects for Men

Men Side EffectsReports
Headache 32
Dyspnoea 31
Nausea 31
Rash 28
Anxiety 24
Malaise 23
Stevens-johnson Syndrome 22
Completed Suicide 20
Pyrexia 19
Renal Failure Acute 19

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Doxycycline Side Effects

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    How Effective is Doxycycline for You?

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    Doxycycline Safety Alerts, Active Ingredients, Usage Information

    NDC0069-0104
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameDoxycycline
    NameDOXYCYCLINE HYCLATE
    Dosage FormINJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
    RouteINTRAVENOUS
    On market since20120821
    LabelerPfizer Laboratories Div Pfizer Inc
    Active Ingredient(s)DOXYCYCLINE HYCLATE
    Strength(s)100
    Unit(s)mg/10mL
    Pharma Class

    Doxycycline Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1757

    Doxycycline safety alerts: 2001

    Reported deaths: 72

    Reported hospitalizations: 480

    Latest Doxycycline clinical trials