Common Effexor Side Effects


The most commonly reported Effexor side effects (click to view or check a box to report):

Dizziness (702)
Anxiety (595)
Nausea (594)
Depression (503)
Headache (495)
Feeling Abnormal (492)
Suicidal Ideation (449)
Condition Aggravated (436)
Paraesthesia (372)
Malaise (353)
Insomnia (349)
Fatigue (286)
Crying (285)
Confusional State (269)
Agitation (265)
Hyperhidrosis (263)
Asthenia (249)
Tremor (236)
Diarrhoea (236)
Convulsion (235)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Effexor Side Effects Reported to FDA



Effexor Side Effect Report#9999317
Suicidal Ideation, Nausea, Tremor, Pain
This is a report of a 39-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: anxiety,panic attack, who was treated with Effexor (dosage: 1 Once Daily, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Suicidal Ideation, Nausea, Tremor, Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Effexor treatment in female patients, resulting in Suicidal Ideation side effect.
Effexor Side Effect Report#9999290
Pregnancy, Talipes, Heart Disease Congenital, Dandy-walker Syndrome, Abortion Induced, Emotional Disorder, Exposure During Pregnancy
This report suggests a potential Effexor Xr Pregnancy side effect(s) that can have serious consequences. A 28-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: bipolar disorder and used Effexor Xr (dosage: 75 Mg --1 Cap) starting NS. After starting Effexor Xr the patient began experiencing various side effects, including: Pregnancy, Talipes, Heart Disease Congenital, Dandy-walker Syndrome, Abortion Induced, Emotional Disorder, Exposure During PregnancyAdditional drugs used concurrently: NA. Although Effexor Xr demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pregnancy, may still occur.
Effexor Side Effect Report#9999173
Palpitations, Paraesthesia, Dizziness, Vertigo, Impaired Driving Ability
This Palpitations problem was reported by a consumer or non-health professional from US. A 34-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On
Jan 14, 2014 this consumer started treatment with Effexor (dosage: 2 Pills Twice Daily Taken By Mouth). The following drugs were being taken at the same time: NA. When using Effexor, the patient experienced the following unwanted symptoms/side effects: Palpitations, Paraesthesia, Dizziness, Vertigo, Impaired Driving AbilityAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Palpitations, may become evident only after a product is in use by the general population.
Effexor Side Effect Report#9999159
Muscle Spasms
This Muscle Spasms side effect was reported by a consumer or non-health professional from US. A 20-year-old patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Effexor (drug dosage: Taken By Mouth), which was initiated on NS. Concurrently used drugs: NA..After starting to take Effexor the consumer reported adverse symptoms, such as: Muscle SpasmsThese side effects may potentially be related to Effexor.
Effexor Side Effect Report#9998968
Product Substitution Issue, Condition Aggravated
This is a report of a 54-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: depression,anxiety, who was treated with Effexor Xr 75mg (dosage: 3 Capsule Daily, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Product Substitution Issue, Condition Aggravated after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Effexor Xr 75mg treatment in female patients, resulting in Product Substitution Issue side effect.
Effexor Side Effect Report#9997676
Dizziness
This report suggests a potential Effexor Xr Dizziness side effect(s) that can have serious consequences. A 27-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: depression and used Effexor Xr (dosage: 37.5 Mg, 1x/day) starting 201402. After starting Effexor Xr the patient began experiencing various side effects, including: DizzinessAdditional drugs used concurrently: NA. Although Effexor Xr demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dizziness, may still occur.
Effexor Side Effect Report#9993534
Mania, Respiratory Tract Infection, Pleurisy, Agitation, Poor Quality Sleep, Weight Decreased, Decreased Appetite, Throat Irritation, Feeling Abnormal
This Mania problem was reported by a consumer or non-health professional from US. A 24-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On 2009 this consumer started treatment with Effexor (dosage: Unk). The following drugs were being taken at the same time:
  • Lithium Carbonate (Unk)
  • Dayquil (Unk)
  • Nyquil (Unk)
  • Abilify (10 Mg, Unk)
  • Abilify (5 Mg, Unk)
  • Abilify (2 Mg, Daily)
  • Abilify (1 Mg, Daily)
  • Abilify (Unk)
When using Effexor, the patient experienced the following unwanted symptoms/side effects: Mania, Respiratory Tract Infection, Pleurisy, Agitation, Poor Quality Sleep, Weight Decreased, Decreased Appetite, Throat Irritation, Feeling AbnormalThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Mania, may become evident only after a product is in use by the general population.
Effexor Side Effect Report#9992776
Weight Increased
This Weight Increased side effect was reported by a consumer or non-health professional from US. A 40-year-old female patient (weight:NA) experienced the following symptoms/conditions: anxiety,affective disorder,hypertension.The patient was prescribed Effexor Xr (drug dosage: 150 Mg, Daily), which was initiated on 2007. Concurrently used drugs: NA..After starting to take Effexor Xr the consumer reported adverse symptoms, such as: Weight IncreasedThese side effects may potentially be related to Effexor Xr.
Effexor Side Effect Report#9992613
Convulsion
This is a report of a 23-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: depression, who was treated with Effexor Xr (dosage: 75 Mg, 2x/day, start time: 2005), combined with: NA. and developed a serious reaction and side effect(s): Convulsion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Effexor Xr treatment in male patients, resulting in Convulsion side effect.
Effexor Side Effect Report#9992589
Blood Cholesterol Abnormal
This report suggests a potential Effexor Xr Blood Cholesterol Abnormal side effect(s) that can have serious consequences. A 43-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: anxiety,affective disorder,hypertension and used Effexor Xr (dosage: 150 Mg, Daily) starting 2007. After starting Effexor Xr the patient began experiencing various side effects, including: Blood Cholesterol AbnormalAdditional drugs used concurrently: NA. Although Effexor Xr demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Blood Cholesterol Abnormal, may still occur.
Effexor Side Effect Report#9992378
Convulsion
This Convulsion problem was reported by a consumer or non-health professional from US. A 23-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: depression,anxiety. On NS this consumer started treatment with Effexor (dosage: Unk). The following drugs were being taken at the same time: NA. When using Effexor, the patient experienced the following unwanted symptoms/side effects: ConvulsionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Convulsion, may become evident only after a product is in use by the general population.
Effexor Side Effect Report#9991620
Limb Injury, Weight Increased, Neuralgia
This Limb Injury side effect was reported by a consumer or non-health professional from US. A 31-year-old male patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Effexor Xr (drug dosage: 75 Mg, 2x/day), which was initiated on 2003. Concurrently used drugs: NA..After starting to take Effexor Xr the consumer reported adverse symptoms, such as: Limb Injury, Weight Increased, NeuralgiaThese side effects may potentially be related to Effexor Xr. The patient was hospitalized.
Effexor Side Effect Report#9991232
Depression, Headache, Neck Pain, Back Pain
This is a report of a 38-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: depression, who was treated with Effexor (dosage: Unk, Once A Day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Depression, Headache, Neck Pain, Back Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Effexor treatment in male patients, resulting in Depression side effect.
Effexor Side Effect Report#9990754
Hearing Impaired
This report suggests a potential Effexor Xr Hearing Impaired side effect(s) that can have serious consequences. A 72-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: depression,hypothyroidism and used Effexor Xr (dosage: 225 Mg, Daily) starting 2008. After starting Effexor Xr the patient began experiencing various side effects, including: Hearing ImpairedAdditional drugs used concurrently:
  • Synthroid (0.1 Mg, Daily)
Although Effexor Xr demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hearing Impaired, may still occur.
Effexor Side Effect Report#9973837
Paranoia, Hallucination, Delusion, Anxiety, Thinking Abnormal, Burning Sensation
This Paranoia problem was reported by a consumer or non-health professional from US. A 20-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On
Jan 27, 2014 this consumer started treatment with Effexor (dosage: 75 Mg, Daily). The following drugs were being taken at the same time:
  • Effexor Xr (Unk)
  • 3, 4-methylenedioxy-n-methylamphetamine (mdma)./ (Unk, Single)
When using Effexor, the patient experienced the following unwanted symptoms/side effects: Paranoia, Hallucination, Delusion, Anxiety, Thinking Abnormal, Burning SensationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Paranoia, may become evident only after a product is in use by the general population.
Effexor Side Effect Report#9972990
Anger, Screaming, Crying, Palpitations, Headache, Decreased Appetite, Gait Disturbance, Eye Disorder
This Anger side effect was reported by a consumer or non-health professional from US. A 58-year-old female patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Effexor Xr (drug dosage: 75 Mg, Daily), which was initiated on 2000. Concurrently used drugs: NA..After starting to take Effexor Xr the consumer reported adverse symptoms, such as: Anger, Screaming, Crying, Palpitations, Headache, Decreased Appetite, Gait Disturbance, Eye DisorderThese side effects may potentially be related to Effexor Xr.
Effexor Side Effect Report#9972982
Feeling Abnormal, Headache, Chills
This is a report of a 27-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: panic attack, who was treated with Effexor Xr (dosage: 75 Mg, 3x/day, start time: 201402), combined with: NA. and developed a serious reaction and side effect(s): Feeling Abnormal, Headache, Chills after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Effexor Xr treatment in female patients, resulting in Feeling Abnormal side effect.
Effexor Side Effect Report#9970526
Dry Mouth, Depression, Asthenia, Tooth Loss, Weight Decreased, Gingival Disorder, Impaired Work Ability, Economic Problem
This report suggests a potential Effexor Dry Mouth side effect(s) that can have serious consequences. A 51-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Effexor (dosage: 1 Pill Once Daily) starting NS. After starting Effexor the patient began experiencing various side effects, including: Dry Mouth, Depression, Asthenia, Tooth Loss, Weight Decreased, Gingival Disorder, Impaired Work Ability, Economic ProblemAdditional drugs used concurrently:
  • Ativan (1 Pill Twice Daily)
Although Effexor demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dry Mouth, may still occur.
Effexor Side Effect Report#9960555
Suicide Attempt, Paraesthesia
This Suicide Attempt problem was reported by a consumer or non-health professional from US. A 33-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: anxiety,depression,post-traumatic stress disorder. On
Dec 02, 2013 this consumer started treatment with Effexor (dosage: Effexor 3 75 Mg Pills, Once Daily Taken By Mouth). The following drugs were being taken at the same time: NA. When using Effexor, the patient experienced the following unwanted symptoms/side effects: Suicide Attempt, ParaesthesiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Suicide Attempt, may become evident only after a product is in use by the general population.
Effexor Side Effect Report#9949795
Nausea, Diarrhoea
This Nausea side effect was reported by a consumer or non-health professional from US. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Effexor Xr (drug dosage: Unk), which was initiated on NS. Concurrently used drugs: NA..After starting to take Effexor Xr the consumer reported adverse symptoms, such as: Nausea, DiarrhoeaThese side effects may potentially be related to Effexor Xr.
Effexor Side Effect Report#9943472
Malaise
This is a report of a 54-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Effexor Xr (dosage: Unk, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Malaise after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Effexor Xr treatment in female patients, resulting in Malaise side effect.
Effexor Side Effect Report#9935534
Nightmare
This report suggests a potential Effexor Xr Nightmare side effect(s) that can have serious consequences. A 61-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: depression and used Effexor Xr (dosage: 75mg In The Morning And 150mg In Evening) starting NS. After starting Effexor Xr the patient began experiencing various side effects, including: NightmareAdditional drugs used concurrently: NA. Although Effexor Xr demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Nightmare, may still occur.
Effexor Side Effect Report#9935515
Dizziness
This Dizziness problem was reported by a consumer or non-health professional from US. A 46-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Effexor Xr (dosage: Unk). The following drugs were being taken at the same time: NA. When using Effexor Xr, the patient experienced the following unwanted symptoms/side effects: DizzinessAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dizziness, may become evident only after a product is in use by the general population.
Effexor Side Effect Report#9935513
Off Label Use, Vitamin D Decreased, Malaise, Dizziness
This Off Label Use side effect was reported by a health professional from US. A 61-year-old female patient (weight:NA) experienced the following symptoms/conditions: hot flush.The patient was prescribed Effexor Xr (drug dosage: Unk), which was initiated on 201402. Concurrently used drugs: NA..After starting to take Effexor Xr the consumer reported adverse symptoms, such as: Off Label Use, Vitamin D Decreased, Malaise, DizzinessThese side effects may potentially be related to Effexor Xr.
Effexor Side Effect Report#9935123
Pancreatitis Acute
This is a report of a 37-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: depression,influenza like illness, who was treated with Effexor (dosage: 37.5 Mg, 1x/day, start time:
Jan 10, 2014), combined with:
  • Cefpodoxime (200 Mg, 2x/day)
  • Pulmodexane (Unk)
  • Paracetamol (1 G, 3x/day)
  • Nasonex (Unk)
  • Carbolevure (Unk)
and developed a serious reaction and side effect(s): Pancreatitis Acute after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Effexor treatment in male patients, resulting in Pancreatitis Acute side effect. The patient was hospitalized.


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The appearance of Effexor on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Effexor Side Effects for Women?

Women Side Effects Reports
Dizziness 563
Nausea 503
Anxiety 440
Headache 382
Feeling Abnormal 374
Depression 368
Condition Aggravated 298
Suicidal Ideation 297
Malaise 288
Paraesthesia 259

What are common Effexor Side Effects for Men?

Men Side Effects Reports
Anxiety 154
Completed Suicide 148
Suicidal Ideation 145
Dizziness 137
Condition Aggravated 136
Depression 132
Feeling Abnormal 117
Paraesthesia 110
Headache 109
Insomnia 103

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Effexor reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    How Effective is Effexor for You?

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    Effexor Safety Alerts, Active Ingredients, Usage Information

    NDC 0008-0833
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name Effexor XR
    Name VENLAFAXINE HYDROCHLORIDE
    Dosage Form CAPSULE, EXTENDED RELEASE
    Route ORAL
    On market since 19971101
    Labeler Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.
    Active Ingredient(s) VENLAFAXINE HYDROCHLORIDE
    Strength(s) 75
    Unit(s) mg/1
    Pharma Class Norepinephrine Uptake Inhibitors [MoA],Serotonin and Norepinephrine Reuptake Inhibitor [EPC],Seroton

    Effexor Dosage, Warnings, Usage.

    Side Effects reported to FDA: 7289

    Effexor safety alerts: 2013 2006 2005 2004

    Reported deaths: 309

    Reported hospitalizations: 1358

    Effexor XR (venlafaxine HCl) Extended-Release Capsules

    Effexor XR (venlafaxine HCl) Extended-Release Capsules
    Effexor (venlafaxine HCl) Tablets

    Audience: Neuropsychiatric and other healthcare professionals
    [Posted 10/25/2006] Wyeth and FDA notified healthcare professionals of revisions to the OVERDOSAGE/Human Experience section of the prescribing information for Effexor (venlafaxine HCl), indicated for treatment of major depressive disorder. In postmarketing experience, there have been reports of overdose with venlafaxine, occurring predominantly in combination with alcohol and/or other drugs. Published retrospective studies report that venlafaxine overdosage may be associated with an increased risk of fatal outcome compared to that observed with SSRI antidepressant products, but lower than that for tricyclic antidepressants. Healthcare professionals are advised to prescribe Effexor and Effexor XR in the smallest quantity of capsules consistent with good patient management to reduce the risk of overdose.

    [October 17, 2006 - Letter - Wyeth]
    [August, 2006 - Effexor Label - Wyeth]

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