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DRY MOUTH AND THROAT (198)
Weight Gain (136)
Drowsiness (80)
Fatigued (70)
Wieght Gain (64)
Constipation (59)
Diarrhea (14)
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Endep Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Hypoaesthesia Oral, Rash Erythematous, Hypersensitivity, Pruritus, Oedema Mouth (8336263-X)
on Apr 30, 2012 Male from AUSTRALIA , 63 years of age, was treated with Endep. Directly after, patient experienced the unwanted or unexpected Endep side effects: hypoaesthesia oral, rash erythematous, hypersensitivity, pruritus, oedema mouth. Endep dosage: N/A.
Associated medications used:
  • Cartia Xt
  • Karvea
  • Zydol - Slow Release (100 Mg, As Needed)
  • Zyloprim
  • Atorvastatin Calcium (40 Mg, 1x/day)
  • Spiriva
Patient was hospitalized.

Cerebrovascular Accident (8175709-7)
Patient was taking Endep. Patient felt the following Endep side effects: cerebrovascular accident on Feb 20, 2012 from AUSTRALIA Additional patient health information: Female , 46 years of age, . Endep dosage: Unk.
Multiple prescriptions taken:
  • Botulinum Toxin Type A (Unk)
  • Inderal /00030001/ (Unk)


Mantle Cell Lymphoma (7843065-7)
Adverse event was reported on Oct 19, 2011 by a Female taking Endep (Dosage: N/A) was diagnosed with
  • anxiety
and. Location: AUSTRALIA , 82 years of age, weighting 132.3 lb, After Endep was administered, patient encountered several Endep side effects: mantle cell lymphoma.
Multiple concurrent drugs taken:
  • Panamax
  • Prolia (60 Mg, Unk)
  • Lyrica
  • Temazepam
  • Ezetimibe (10 Mg, Qd)
  • Coveram (5 Mg, Qd)
  • Dexamethasone
Patient was hospitalized.

Vulval Cellulitis (7636222-6)
on Jul 15, 2011 Female from AUSTRALIA , weighting 260.1 lb, was treated with Endep. Directly after, patient experienced the unwanted or unexpected Endep side effects: vulval cellulitis. Endep dosage: N/A.
Associated medications used:
  • Prednisone
  • Clotrimazole
  • Estradiol
  • Golimumab
  • Temaze
  • Irbesartan + Hydrochlorothiazide
  • Spiriva
  • Rabeprazole Sodium
Patient was hospitalized.


Product Quality Issue (7246742-4)
on Jan 20, 2011 Male from AUSTRALIA , 58 years of age, was treated with Endep. Patient felt the following Endep side effects: product quality issue. Endep dosage: N/A.
Multiple prescriptions taken:
  • Mobic
  • Duragesic-100
  • Zoloft
  • Duragesic-100
  • Emadine Se
  • Xanax


Iiird Nerve Paralysis (6659527-4)
Patient was taking Endep. After Endep was administered, patient encountered several Endep side effects: iiird nerve paralysis on Mar 16, 2010 from AUSTRALIA Additional patient health information: Female , 76 years of age, weighting 132.3 lb, was diagnosed with
  • post herpetic neuralgia
and. Endep dosage: N/A.
Multiple concurrent drugs taken:
  • Lyrica
  • Lyrica
  • Prednisolone
Patient was hospitalized.

Breast Cancer, Chest Pain, Palpitations, Pulmonary Embolism, Tremor (6347734-X)
Adverse event was reported on Aug 27, 2009 by a Female taking Endep (Dosage: N/A) was diagnosed with
  • pain
and. Location: AUSTRALIA , 49 years of age, Directly after, patient experienced the unwanted or unexpected Endep side effects: breast cancer, chest pain, palpitations, pulmonary embolism, tremor. Patient was hospitalized.

Pulmonary Embolism (6125957-2)
on Mar 03, 2009 Female from AUSTRALIA , 49 years of age, was diagnosed with
  • pain
and was treated with Endep. Patient felt the following Endep side effects: pulmonary embolism. Endep dosage: 10 Mg;daily; Oral. Patient was hospitalized.

Feeling Hot, Nausea, Syncope (6112267-2)
on Dec 02, 2008 Female from AUSTRALIA , 64 years of age, was diagnosed with
  • depression
and was treated with Endep. After Endep was administered, patient encountered several Endep side effects: feeling hot, nausea, syncope. Endep dosage: 25 Mg, Daily, Oral.
Multiple concurrent drugs taken:
  • Zomig


Depression (6012622-5)
Patient was taking Endep. Directly after, patient experienced the unwanted or unexpected Endep side effects: depression on Dec 03, 2008 from AUSTRALIA Additional patient health information: Female , 73 years of age, was diagnosed with
  • anxiety
and. Endep dosage: 5 Mg;at Bedtime; Oral.
Associated medications used:
  • Xanax
  • Cardizem
  • Nexium


Open Angle Glaucoma (5920419-7)
Adverse event was reported on Sep 29, 2008 by a Female taking Endep (Dosage: 50 Mg;at Bedtime; Oral) was diagnosed with
  • insomnia
  • tension headache
and. Location: AUSTRALIA , 53 years of age, Patient felt the following Endep side effects: open angle glaucoma.

Abnormal Sleep-related Event, Dry Mouth, Gingivitis, Oral Candidiasis, Pollakiuria, Sensitivity Of Teeth, Urinary Retention (5844603-6)
on Jul 29, 2008 Female from AUSTRALIA , 43 years of age, was diagnosed with
  • neuralgia
and was treated with Endep. After Endep was administered, patient encountered several Endep side effects: abnormal sleep-related event, dry mouth, gingivitis, oral candidiasis, pollakiuria, sensitivity of teeth, urinary retention. Endep dosage: 150 Mg; At Bedtime; Oral, 125 Mg; At Bedtime; Oral, 100 Mg; At Bedtime; Oral.

Dry Mouth, Dysgeusia, Hallucination, Hyperhidrosis, Illusion, Lip Dry (5811075-7)
on Jun 25, 2008 Female from AUSTRALIA , 69 years of age, was diagnosed with
  • anxiety
and was treated with Endep. Directly after, patient experienced the unwanted or unexpected Endep side effects: dry mouth, dysgeusia, hallucination, hyperhidrosis, illusion, lip dry. Endep dosage: 50 Mg; At Bedtime; Oral.
Associated medications used:
  • Protos(con.)
  • Brufen /00109201/ (con.)
  • Rani (con.)
  • Aratac (con.)
  • Avapro (con.)
  • Warfarin (con.)
  • Zocor (con.)


Bladder Disorder, Dry Mouth, Dysuria, Gingivitis, Oral Candidiasis, Sensitivity Of Teeth, Sleep Disorder, Urinary Retention (5754127-2)
Patient was taking Endep. Patient felt the following Endep side effects: bladder disorder, dry mouth, dysuria, gingivitis, oral candidiasis, sensitivity of teeth, sleep disorder, urinary retention on May 07, 2008 from AUSTRALIA Additional patient health information: Female , 43 years of age, was diagnosed with
  • neuralgia
and. Endep dosage: 150 Mg; At Bedtime; Oral.
Multiple prescriptions taken:
  • Trifeme
  • Lyrica
  • Neurontin
  • Ditropan
  • Panadeine
  • Vesicare
  • Coloxyl With Senna
  • Avanza


Condition Aggravated, Dry Mouth, Dysgeusia, Hallucination, Hyperhidrosis, Lip Dry (5753052-0)
Adverse event was reported on May 08, 2008 by a Female taking Endep (Dosage: 50 Mg; At Bedtime; Oral) was diagnosed with
  • anxiety
and. Location: AUSTRALIA , 69 years of age, After Endep was administered, patient encountered several Endep side effects: condition aggravated, dry mouth, dysgeusia, hallucination, hyperhidrosis, lip dry.
Multiple concurrent drugs taken:
  • Protos
  • Brufen
  • Rani
  • Aratac
  • Avapro
  • Warfarin Sodium
  • Zocor


Anorexia, Chills, Dry Mouth, Gait Disturbance, Influenza, Myalgia, Nausea, Pharyngolaryngeal Pain, Pyrexia (5725069-3)
on Apr 14, 2008 Male from AUSTRALIA , 64 years of age, was diagnosed with
  • depression
and was treated with Endep. Directly after, patient experienced the unwanted or unexpected Endep side effects: anorexia, chills, dry mouth, gait disturbance, influenza, myalgia, nausea, pharyngolaryngeal pain, pyrexia. Endep dosage: 50 Mg; Daily; Oral.
Associated medications used:
  • Metformin Hcl
  • Prednisone Tab
  • Zocor
  • Pantoprazole Sodium
  • Myocrisin


Abnormal Behaviour, Anorexia, Anxiety, Convulsion, Mood Altered, Spousal Abuse, Stress, Suicidal Ideation (5706342-1)
on Mar 28, 2008 Female from AUSTRALIA , 29 years of age, was diagnosed with
  • depression
and was treated with Endep. Patient felt the following Endep side effects: abnormal behaviour, anorexia, anxiety, convulsion, mood altered, spousal abuse, stress, suicidal ideation. Endep dosage: Oral.
Multiple prescriptions taken:
  • Tramadol Hcl (Oral)
  • Restavit
  • Digesic


Blood Electrolytes Abnormal, Dizziness, Fall, Somnolence, Transient Ischaemic Attack, Upper Limb Fracture (5694191-2)
Patient was taking Endep (amitriptyline Hydrochloride) (50 Mg). After Endep was administered, patient encountered several Endep side effects: blood electrolytes abnormal, dizziness, fall, somnolence, transient ischaemic attack, upper limb fracture on Mar 18, 2008 from AUSTRALIA Additional patient health information: Female , 76 years of age, was diagnosed with
  • depression
and. Endep (amitriptyline Hydrochloride) (50 Mg) dosage: 50 Mg;at Bedtime;oral. Patient was hospitalized.

Dry Mouth, Dysuria, Eye Pain, Hallucination, Auditory, Insomnia, Paraesthesia, Sensation Of Heaviness (5670150-0)
Adverse event was reported on Feb 25, 2008 by a Female taking Endep (Dosage: 20 Mg; At Bedtime; Oral) was diagnosed with
  • depression
and. Location: AUSTRALIA , 55 years of age, Directly after, patient experienced the unwanted or unexpected Endep side effects: dry mouth, dysuria, eye pain, hallucination, auditory, insomnia, paraesthesia, sensation of heaviness.
Associated medications used:
  • Lipitor
  • Ural


Dry Mouth, Tardive Dyskinesia, Trismus, Vision Blurred (5614060-3)
on Jan 15, 2008 Female from AUSTRALIA , 75 years of age, was diagnosed with
  • fibromyalgia
and was treated with Endep. Patient felt the following Endep side effects: dry mouth, tardive dyskinesia, trismus, vision blurred. Endep dosage: 25 Mg;nocte;oral.

Agitation, Anxiety, Delusion, Nightmare, Paranoia, Urinary Retention (5503568-7)
on Oct 12, 2007 Male from UNITED STATES , 33 years of age, was diagnosed with
  • bone pain
  • neuralgia
and was treated with Endep. After Endep was administered, patient encountered several Endep side effects: agitation, anxiety, delusion, nightmare, paranoia, urinary retention. Endep dosage: 50 Mg; Hd; Oral; 10 Mg; Hd; Oral.

Aggression, Dry Mouth, Fatigue, Self-injurious Ideation, Tearfulness (5500099-5)
Patient was taking Endep (amitriptyline Hydrochloride) (25 Mg). Directly after, patient experienced the unwanted or unexpected Endep side effects: aggression, dry mouth, fatigue, self-injurious ideation, tearfulness on Oct 09, 2007 from Additional patient health information: Female , 57 years of age, was diagnosed with
  • burning sensation
and. Endep (amitriptyline Hydrochloride) (25 Mg) dosage: 25 Mg.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Endep Information

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