Epirubicin Safety Questions, Epirubicin Answers
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Epirubicin Safety Reports
Total Epirubicin reports: 130.Epirubicin FDA safety alerts: 2007 .
Reported deaths: 34 Reported hospitalizations: 58.
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Reported Epirubicin Side Effects: interstitial lung disease, febrile neutropenia, respiratory failure, cardiac failure, white blood cell count decreased, erythema multiforme, acute myeloid leukaemia, pain in extremity, pneumonitis, odynophagia, dysphasia.
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Epirubicin Side Effects Report #5382167-4Pharmacist from JAPAN reported EPIRUBICIN problem on June 27, 2007. Female patient, 66 years of age, was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: angiopathy, phlebitis, pigmentation disorder. EPIRUBICIN dosage: DAILY DOSE:100MG. During the same period patient was treated with CYCLOPHOSPHAMIDE, FLUOROURACIL. Patient recovered.
Epirubicin Side Effects Report #5384701-7
EPIRUBICIN problem was reported by a Health Professional from GREECE on June 29, 2007. Male patient, 65 years of age, weighting 143.3 lb, was diagnosed with bladder cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: cystitis interstitial. EPIRUBICIN dosage: unknown. Patient recovered.
Epirubicin Side Effects Report #5389598-7
Health Professional from UNITED KINGDOM reported EPIRUBICIN problem on July 06, 2007. Female patient, child 6 years of age, was diagnosed with rhabdomyosarcoma and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease. EPIRUBICIN dosage: unknown. During the same period patient was treated with CARBOPLATIN, VINCRISTINE, ETOPOSIDE, IFOSFAMIDE, ACTINOMYCIN D. Patient died.
Epirubicin Side Effects Report #5390005-9
EPIRUBICIN problem was reported by a Health Professional from GERMANY on July 17, 2007. Female patient, 45 years of age, weighting 165.3 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: oesophagitis. EPIRUBICIN dosage: unknown. Patient was hospitalized and became disabled. Patient recovered.
Epirubicin Side Effects Report #5395845-8
Consumer or non-health professional from UNITED KINGDOM reported EPIRUBICIN problem on July 12, 2007. Female patient, child 6 years of age, was diagnosed with rhabdomyosarcoma and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: pneumonitis. EPIRUBICIN dosage: unknown. During the same period patient was treated with CARBOPLATIN, DACTINOMYCIN, ETOPOSIDE, IFOSFAMIDE, VINCRISTINE. Patient was hospitalized. Patient died.
Epirubicin Side Effects Report #5400708-5
EPIRUBICIN problem was reported by a Consumer or non-health professional from SPAIN on July 19, 2007. Male patient, weighting 158.7 lb, was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: asthenia, neutropenia. EPIRUBICIN dosage: unknown. During the same period patient was treated with OXALIPLATIN, CAPECITABINE, HIPOARTEL. Patient was hospitalized. Patient recovered.
Epirubicin Side Effects Report #5400737-1
Consumer or non-health professional from ITALY reported EPIRUBICIN problem on July 24, 2007. Female patient, 50 years of age, was diagnosed with breast cancer and was treated with EPIRUBICIN. EPIRUBICIN dosage: DAILY DOSE:75MG/M*2. During the same period patient was treated with DOCETAXEL, NEUPOGEN. Patient died on 07/15/2007.
Epirubicin Side Effects Report #5403231-7
EPIRUBICIN problem was reported by a Consumer or non-health professional from UNITED KINGDOM on July 20, 2007. Male patient was diagnosed with rhabdomyosarcoma and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: febrile neutropenia, interstitial lung disease, ototoxicity, recall phenomenon, respiratory failure. EPIRUBICIN dosage: DAILY DOSE:150MG/M*2. During the same period patient was treated with CARBOPLATIN, VINCRISTINE SULPHATE, ETOPOSIDE, IFOSFAMIDE, DACTINOMYCIN. Patient was hospitalized. Patient died.
Epirubicin Side Effects Report #5404383-5
Health Professional from GREECE reported EPIRUBICIN problem on July 24, 2007. Male patient, 65 years of age, weighting 143.3 lb, was diagnosed with bladder cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: cystitis interstitial. EPIRUBICIN dosage: unknown. Patient recovered.
Epirubicin Side Effects Report #5405443-5
EPIRUBICIN problem was reported by a Consumer or non-health professional from ITALY on July 24, 2007. Female patient, 50 years of age, was diagnosed with breast cancer and was treated with EPIRUBICIN. EPIRUBICIN dosage: DAILY DOSE:75MG/M*2. During the same period patient was treated with DOCETAXEL, NEUPOGEN. Patient died on 07/15/2007.
Epirubicin Side Effects Report #5407559-6
Consumer or non-health professional from UNITED KINGDOM reported EPIRUBICIN problem on July 24, 2007. Female patient, child 6 years of age, was diagnosed with rhabdomyosarcoma and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: beta haemolytic streptococcal infection, blood culture positive, candidiasis, febrile neutropenia, mucosal inflammation, pneumonitis. EPIRUBICIN dosage: unknown. During the same period patient was treated with CARBOPLATIN, DACTINOMYCIN, ETOPOSIDE, IFOSFAMIDE, VINCRISTINE. Patient was hospitalized. Patient died.
Epirubicin Side Effects Report #5409028-6
EPIRUBICIN problem was reported by a Health Professional from UNITED STATES on July 26, 2007. Male patient, 74 years of age, was diagnosed with oesophageal adenocarcinoma and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: anaemia, bone marrow failure, rash pruritic, thrombocytopenia, white blood cell count decreased. EPIRUBICIN dosage: unknown. During the same period patient was treated with METHOTREXATE, MITOMYCIN, ETOPOSIDE, FLUOROURACIL, PROLEUKIN, LEUCOVORIN CALCIUM. Patient recovered.
Epirubicin Side Effects Report #5409612-X
Health Professional from UNITED STATES reported EPIRUBICIN problem on Aug 07, 2007. Female patient, 38 years of age, weighting 149.0 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: febrile neutropenia, jugular vein thrombosis. EPIRUBICIN dosage: 149MG Q3WK IV BOLUS. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.
Epirubicin Side Effects Report #5411693-4
EPIRUBICIN problem was reported by a Consumer or non-health professional from JAPAN on Aug 01, 2007. Female patient, 59 years of age, was diagnosed with bladder cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: anorexia, fatigue, hepatitis b. EPIRUBICIN dosage: unknown. During the same period patient was treated with CISPLATIN, METHOTREXATE. Patient recovered.
Epirubicin Side Effects Report #5414125-5
Physician from JAPAN reported EPIRUBICIN problem on Aug 03, 2007. Male patient, weighting 169.8 lb, was diagnosed with bladder neoplasm and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: toxic skin eruption. EPIRUBICIN dosage: unknown. During the same period patient was treated with PANSPORIN, ADONA, TRANSAMIN. Patient recovered.
Epirubicin Side Effects Report #5418955-5
EPIRUBICIN problem was reported by a Consumer or non-health professional from JAPAN on Aug 09, 2007. Female patient, 59 years of age, was diagnosed with bladder cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: anorexia, fatigue, hepatitis b. EPIRUBICIN dosage: unknown. During the same period patient was treated with CISPLATIN, METHOTREXATE, DEXAMETHASONE. Patient recovered.
Epirubicin Side Effects Report #5418975-0
Health Professional from FRANCE reported EPIRUBICIN problem on Aug 07, 2007. Female patient was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: chronic lymphocytic leukaemia, neoplasm malignant. EPIRUBICIN dosage: DAILY DOSE:85MG-FREQ:CYCLIC. During the same period patient was treated with FLUOROURACIL, ENDOXAN, TAMOXIFEN CITRATE. Patient was hospitalized. Patient recovered.
Epirubicin Side Effects Report #5420224-4
EPIRUBICIN problem was reported by a Physician from FINLAND on Aug 06, 2007. Female patient, 35 years of age, was diagnosed with malignant histiocytosis and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: acute promyelocytic leukaemia. EPIRUBICIN dosage: unknown. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE, PREDNISOLONE. Patient died.
Epirubicin Side Effects Report #5421669-9
Physician from JAPAN reported EPIRUBICIN problem on Aug 09, 2007. Female patient, weighting 97.00 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: acute respiratory distress syndrome, sepsis. EPIRUBICIN dosage: unknown. During the same period patient was treated with FLUOROURACIL, ENDOXAN. Patient was hospitalized. Patient died on 07/25/2007.
Epirubicin Side Effects Report #5425687-6
EPIRUBICIN problem was reported by a Consumer or non-health professional from NETHERLANDS on Aug 13, 2007. Female patient, weighting 136.7 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: breast cancer. EPIRUBICIN dosage: unknown. During the same period patient was treated with DOCETAXEL, TAMOXIFEN CITRATE. Patient recovered.
Epirubicin Side Effects Report #5427417-0
Health Professional from UNITED STATES reported EPIRUBICIN problem on Aug 24, 2007. Female patient, 58 years of age, weighting 130.0 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: asthma, chronic obstructive pulmonary disease, dyspnoea, neutropenia. EPIRUBICIN dosage: 90 MG/M2 Q3WK X 4 IV BOLUS. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.
Epirubicin Side Effects Report #5428007-6
EPIRUBICIN problem was reported by a Physician from JAPAN on Aug 21, 2007. Female patient, weighting 97.00 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: acute respiratory distress syndrome, neutropenia, sepsis. EPIRUBICIN dosage: unknown. During the same period patient was treated with ENDOXAN. Patient was hospitalized. Patient died on 07/25/2007.
Epirubicin Side Effects Report #5440979-2
Physician from JAPAN reported EPIRUBICIN problem on Aug 23, 2007. Male patient, weighting 169.8 lb, was diagnosed with bladder neoplasm and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: toxic skin eruption. EPIRUBICIN dosage: unknown. During the same period patient was treated with PANSPORIN, ADONA, TRANSAMIN. Patient recovered.
Epirubicin Side Effects Report #5441152-4
EPIRUBICIN problem was reported by a Consumer or non-health professional from NETHERLANDS on Aug 24, 2007. Female patient, weighting 136.7 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: breast cancer. EPIRUBICIN dosage: DAILY DOSE:80MG. During the same period patient was treated with DOCETAXEL, TAMOXIFEN CITRATE. Patient recovered.
Epirubicin Side Effects Report #5445152-X
Consumer or non-health professional from UNITED KINGDOM reported EPIRUBICIN problem on Aug 29, 2007. Female patient, weighting 191.8 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: disseminated intravascular coagulation, dysphasia, odynophagia. EPIRUBICIN dosage: unknown. During the same period patient was treated with DOCETAXEL, ENOXAPARIN, AUGMENTIN, DEXAMETHASONE, CITALOPRAM HYDROBROMIDE. Patient died on 03/10/2007.
Epirubicin Side Effects Report #5450240-8
EPIRUBICIN problem was reported by a Physician from GERMANY on Aug 31, 2007. Male patient was diagnosed with hepatic neoplasm malignant and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, hypertensive crisis. EPIRUBICIN dosage: DAILY DOSE:50MG. Patient was hospitalized. Patient recovered.
Epirubicin Side Effects Report #5450346-3
Pharmacist from GERMANY reported EPIRUBICIN problem on Aug 31, 2007. Male patient was diagnosed with hepatic neoplasm malignant and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: hypertensive crisis, nausea. EPIRUBICIN dosage: DAILY DOSE:40MG. Patient was hospitalized. Patient recovered.
Epirubicin Side Effects Report #5451355-0
EPIRUBICIN problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 11, 2007. Male patient, weighting 220.0 lb, was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, blood magnesium decreased, blood potassium decreased, blood pressure decreased, dizziness, dyspnoea, syncope. EPIRUBICIN dosage: 80 MG. Patient was hospitalized. Patient recovered.
Epirubicin Side Effects Report #5467429-4
Physician from GREECE reported EPIRUBICIN problem on Sept 14, 2007. Female patient was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: acute respiratory distress syndrome, sepsis. EPIRUBICIN dosage: DAILY DOSE:187MG. During the same period patient was treated with EPIRUBICIN HYDROCHLORIDE, EPIRUBICIN HYDROCHLORIDE, CYCLOPHOSPHAMIDE, METHOTREXATE. Patient died on 09/03/2007.
Epirubicin Side Effects Report #5469309-7
EPIRUBICIN problem was reported by a Health Professional from UNITED STATES on Sept 26, 2007. Female patient, 38 years of age, weighting 149.0 lb, was diagnosed with breast cancer and was treated with EPIRUBICIN. After drug was administered, patient experienced the following problems/side effects: febrile neutropenia, jugular vein thrombosis, staphylococcal infection, subclavian vein thrombosis. EPIRUBICIN dosage: 149MG IV Q3WK. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.
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Drug Information: Epirubicin Injection
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a603003.html
ep i roo' bi sinIMPORTANT WARNING:
| Epirubicin may cause severe heart damage, even months or years after you have stopped taking the drug. Epirubicin may also cause a decrease in the number of blood cells.Tell your doctor if you have ever had chemotherapy with daunorubicin (Cerubidine, DaunoXome), doxorubicin (Adriamycin, Doxil, Rubex), epirubicin, idarubicin (Idamycin), mitoxantrone (Novantrone), or valrubicin (Valstar) or radiation therapy to the chest and if you are taking calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan) or cyclophosphamide (Cytoxan, Neosar). Tell your doctor if you have or have ever had heart or liver disease.If you experience any of the following symptoms, call your doctor immediately: rapid heartbeat; shortness of breath; swelling of the hands, feet, ankles, or lower legs; swelling of the stomach; unusual bleeding or bruising; pale skin; lack of energy; or fever, sore throat, chills, and other signs of infection.Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before, during, and after your treatment to check your body's response to epirubicin.Epirubicin has been associated with the development of other types of cancer. Talk with your doctor about the risk of developing a new cancer. |
About your treatment
Your doctor has ordered the drug epirubicin to help treat your illness. The drug is given by injection into a vein.
This medication is used to treat:
- breast cancer
Epirubicin is in a class of drugs known as anthracyclines; it slows or stops the growth of cancer cells in your body. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Precautions
Before taking epirubicin,
- tell your doctor and pharmacist if you are allergic to epirubicin, daunorubicin (Cerubidine, DaunoXome), doxorubicin (Adriamycin, Doxil, Rubex), idarubicin (Idamycin), or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: cimetidine (Tagamet) and other chemotherapy drugs. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had gout or kidney disease.
- you should know that epirubicin may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Epirubicin may harm the fetus.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Epirubicin may make your skin sensitive to sunlight.
- do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.
Side effects
Epirubicin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- diarrhea
- swelling or bruising in the mouth
- hair loss
- hot flashes
- tiredness
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- vomiting
- dehydration
- pain at the site of injection
- hives
- difficulty breathing or swallowing
Epirubicin may cause other side effects. Call your doctor if you have any unusual problems while taking this drug.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Special instructions
- You should know that your urine may appear red for 1 to 2 days after a dose of epirubicin.
Brand name(s):
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