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Flexeril Side Effects

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Common Flexeril Side Effects


The most commonly reported Flexeril side effects (click to view or check a box to report):

Pain (39)
Depression (23)
Anxiety (23)
Pulmonary Embolism (22)
Fatigue (21)
Nausea (20)
Dyspnoea (19)
Dizziness (18)
Fall (17)
Asthenia (17)
Pain In Extremity (16)
Confusional State (16)
Deep Vein Thrombosis (15)
Feeling Abnormal (15)
Somnolence (14)
Oedema Peripheral (14)
Convulsion (14)
Muscle Spasms (14)
Headache (14)
Overdose (13)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Flexeril Side Effects Reported to FDA



Flexeril Side Effect Report#9785138
Pulmonary Embolism, Heart Rate Increased
This is a report of a 67-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Flexeril (dosage: NA, start time:
Dec 05, 2012), combined with:
  • Hctz
  • Xarelto
  • Xarelto
  • Vitamin D
  • Trospium
  • Rapaflo
  • Aspirin
  • Metformin
and developed a serious reaction and side effect(s): Pulmonary Embolism, Heart Rate Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Flexeril treatment in male patients, resulting in Pulmonary Embolism side effect. The patient was hospitalized.
Flexeril Side Effect Report#9630630
Somnolence, Decreased Appetite, Vision Blurred, Coordination Abnormal, Lethargy, Loss Of Libido, Muscular Weakness, Disturbance In Attention, Nightmare
This report suggests a potential Flexeril Somnolence side effect(s) that can have serious consequences. A 32-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: muscle strain and used Flexeril (dosage: NA) starting
Sep 14, 2013. After starting Flexeril the patient began experiencing various side effects, including: Somnolence, Decreased Appetite, Vision Blurred, Coordination Abnormal, Lethargy, Loss Of Libido, Muscular Weakness, Disturbance In Attention, NightmareAdditional drugs used concurrently: NA. Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Somnolence, may still occur.
Flexeril Side Effect Report#9615320
Amnesia
This Amnesia problem was reported by a consumer or non-health professional from US. A 62-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: back pain. On
Sep 11, 2013 this consumer started treatment with Flexeril (dosage: NA). The following drugs were being taken at the same time:
  • Paxil
  • Lipitor
When using Flexeril, the patient experienced the following unwanted symptoms/side effects: AmnesiaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Amnesia, may become evident only after a product is in use by the general population.
Flexeril Side Effect Report#9586274
Vertigo, Headache
This Vertigo side effect was reported by a consumer or non-health professional from US. A 72-year-old female patient (weight:NA) experienced the following symptoms/conditions: muscle spasms.The patient was prescribed Flexeril (drug dosage: 1 Pill Three Times Daily Taken By Mouth?), which was initiated on NS. Concurrently used drugs:
  • Avapro
  • Avalide
  • Acidophilus
  • Maalox
  • Ibuprofen
  • Ranitidine
.After starting to take Flexeril the consumer reported adverse symptoms, such as: Vertigo, HeadacheThese side effects may potentially be related to Flexeril.
Flexeril Side Effect Report#9341458
Viith Nerve Paralysis
This is a report of a 60-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: fibromyalgia, who was treated with Flexeril (dosage: NA, start time:
Jan 15, 2013), combined with: NA. and developed a serious reaction and side effect(s): Viith Nerve Paralysis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Flexeril treatment in female patients, resulting in Viith Nerve Paralysis side effect.
Flexeril Side Effect Report#9312909
Application Site Pain
This report suggests a potential Flexeril Application Site Pain side effect(s) that can have serious consequences. A male patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: muscle spasms,hypertension,blood cholesterol increased,diabetes mellitus,pain and used Flexeril (dosage: NA) starting 201302. After starting Flexeril the patient began experiencing various side effects, including: Application Site PainAdditional drugs used concurrently:
  • Losartan Hct
  • Simvastatin
  • Metformin
  • Tylenol
  • Levomire
  • Androgel
  • Bengay
  • Salonpas
Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Application Site Pain, may still occur.
Flexeril Side Effect Report#9299948
Cognitive Disorder, Disturbance In Attention, Depressed Level Of Consciousness
This Cognitive Disorder problem was reported by a consumer or non-health professional from US. A 60-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 20, 2012 this consumer started treatment with Flexeril (cyclobenzaprine Hydrochloride) (dosage: NA). The following drugs were being taken at the same time:
  • Neurontin (gabapentin)
  • Drisdol (ergocalciferol)
  • Adderall Xr (amfetamine Asparate, Amfetamine Sulfate, Dexamfetamine Saccharate, Dexamfetamine Sulfat
  • Remeron (mirtazapine)
  • Robaxin (methocarbamol)
  • Gilenya
  • Cymbalta (duloxetine Hydrochloride)
  • Vitamin B12 (cyanocobalamin)
When using Flexeril (cyclobenzaprine Hydrochloride), the patient experienced the following unwanted symptoms/side effects: Cognitive Disorder, Disturbance In Attention, Depressed Level Of ConsciousnessAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cognitive Disorder, may become evident only after a product is in use by the general population.
Flexeril Side Effect Report#9251737
Plantar Fasciitis
This Plantar Fasciitis side effect was reported by a health professional from US. A 71-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Flexeril (cyclobenzaprine Hydrochloride) (drug dosage: NA), which was initiated on
Apr 09, 2009. Concurrently used drugs:
  • Lisinopril (lisinopril)
  • Vitamins
  • Pantoprazole (pantoprazole)
  • Pravastatin (pravastatin)
  • Vitamin D (ergocalciferol)
  • Revlimid (lenalidomide) (25 Milligram, Capsules)
  • Acyclovir (aciclovir)
  • Celebrex (celecoxib)
.After starting to take Flexeril (cyclobenzaprine Hydrochloride) the consumer reported adverse symptoms, such as: Plantar FasciitisThese side effects may potentially be related to Flexeril (cyclobenzaprine Hydrochloride).
Flexeril Side Effect Report#9080716
Serotonin Syndrome, Erectile Dysfunction, Increased Tendency To Bruise
This is a report of a 65-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Flexeril (dosage: NA, start time: 201210), combined with:
  • Cymbalta
  • Cymbalta
  • Cymbalta
  • Lisinopril
  • Celebrex
  • Xanax
  • Fosamax
  • Halothane
and developed a serious reaction and side effect(s): Serotonin Syndrome, Erectile Dysfunction, Increased Tendency To Bruise after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Flexeril treatment in male patients, resulting in Serotonin Syndrome side effect.
Flexeril Side Effect Report#9027054
Adenocarcinoma Of Colon, Streptococcal Bacteraemia, Spinal Cord Compression
This report suggests a potential Flexeril Adenocarcinoma Of Colon side effect(s) that can have serious consequences. A 60-year-old male patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: adverse event and used Flexeril (dosage: NA) starting
Dec 02, 2012. After starting Flexeril the patient began experiencing various side effects, including: Adenocarcinoma Of Colon, Streptococcal Bacteraemia, Spinal Cord CompressionAdditional drugs used concurrently: NA.The patient was hospitalized. Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Adenocarcinoma Of Colon, may still occur.
Flexeril Side Effect Report#9002115
Adverse Event, Unevaluable Event, Injury
This Adverse Event problem was reported by a consumer or non-health professional from US. A 47-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: rotator cuff syndrome,wrist fracture. On
Feb 03, 2010 this consumer started treatment with Flexeril (dosage: NA). The following drugs were being taken at the same time: NA. When using Flexeril, the patient experienced the following unwanted symptoms/side effects: Adverse Event, Unevaluable Event, InjuryAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Adverse Event, may become evident only after a product is in use by the general population.
Flexeril Side Effect Report#8974132
Confusional State, Mental Status Changes
This Confusional State side effect was reported by a pharmacist from US. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Flexeril (drug dosage: 5 Mg Po Tid Prn), which was initiated on
Sep 19, 2012. Concurrently used drugs: NA..After starting to take Flexeril the consumer reported adverse symptoms, such as: Confusional State, Mental Status ChangesThese side effects may potentially be related to Flexeril. The patient was hospitalized.
Flexeril Side Effect Report#8935484
Encephalopathy, Sleep Disorder
This is a report of a 55-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: pain, who was treated with Flexeril (dosage: NA, start time: NS), combined with:
  • Zoloft
  • Savella
  • Naprosyn
and developed a serious reaction and side effect(s): Encephalopathy, Sleep Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Flexeril treatment in male patients, resulting in Encephalopathy side effect. The patient was hospitalized.
Flexeril Side Effect Report#8912870
Renal Failure Acute, Intervertebral Disc Protrusion, Intervertebral Disc Injury, Feeling Abnormal, Somnolence, Nausea, Vomiting
This report suggests a potential Flexeril Renal Failure Acute side effect(s) that can have serious consequences. A female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: myalgia,muscle spasms and used Flexeril (dosage: NA) starting 2000. After starting Flexeril the patient began experiencing various side effects, including: Renal Failure Acute, Intervertebral Disc Protrusion, Intervertebral Disc Injury, Feeling Abnormal, Somnolence, Nausea, VomitingAdditional drugs used concurrently:
  • Tylenol 3
  • Cyclobenzaprine Hydrochloride
  • Voltaren
  • Lyrica
  • Celebrex
  • Amrix
The patient was hospitalized. Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure Acute, may still occur.
Flexeril Side Effect Report#8886750
Fatigue, Rash Erythematous, Dysgeusia, Decreased Appetite
This Fatigue problem was reported by a consumer or non-health professional from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Oct 14, 2012 this consumer started treatment with Flexeril /00428402/ (dosage: 1 Df, Prn). The following drugs were being taken at the same time:
  • Vx-950 (750 Mg, Tid)
  • Pegintron /01543001/ (120 ?g, Unk)
  • Ribasphere (600 Mg, Bid)
  • Vitamin D /00107901/ (1 Df, Qd)
When using Flexeril /00428402/, the patient experienced the following unwanted symptoms/side effects: Fatigue, Rash Erythematous, Dysgeusia, Decreased AppetiteAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Fatigue, may become evident only after a product is in use by the general population.
Flexeril Side Effect Report#8819696
Cystitis Interstitial
This Cystitis Interstitial side effect was reported by a consumer or non-health professional from US. A 33-year-old female patient (weight:NA) experienced the following symptoms/conditions: bladder disorder.The patient was prescribed Flexeril (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Heparin
  • Bicarbonate
  • Lidocaine
  • Xanax
  • Zofran
  • Valium
  • Phenobarbital
  • Bactrim Ds
.After starting to take Flexeril the consumer reported adverse symptoms, such as: Cystitis InterstitialThese side effects may potentially be related to Flexeril. The patient was hospitalized.
Flexeril Side Effect Report#8771856
Osteoarthritis, Haemorrhage, Fibromyalgia, Epstein-barr Virus Infection, Immune System Disorder, Weight Increased, Nasopharyngitis, Hypersomnia
This is a report of a female patient (weight: NA) from US, suffering from the following health symptoms/conditions: muscle spasms, who was treated with Flexeril (dosage: NA, start time: 2011), combined with: NA. and developed a serious reaction and side effect(s): Osteoarthritis, Haemorrhage, Fibromyalgia, Epstein-barr Virus Infection, Immune System Disorder, Weight Increased, Nasopharyngitis, Hypersomnia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Flexeril treatment in female patients, resulting in Osteoarthritis side effect.
Flexeril Side Effect Report#8499109-5
Muscle Spasms, Pain In Extremity, Dysphagia, Musculoskeletal Pain, Blood Calcium Decreased, Movement Disorder
This report suggests a potential Flexeril Muscle Spasms side effect(s) that can have serious consequences. A 75-year-old female patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Flexeril (dosage: NA) starting
Jan 25, 2010. After starting Flexeril the patient began experiencing various side effects, including: Muscle Spasms, Pain In Extremity, Dysphagia, Musculoskeletal Pain, Blood Calcium Decreased, Movement DisorderAdditional drugs used concurrently:
  • Omeprazole
  • Adavan (lorazepam)
  • Reclast (Infusion)
  • Lorazepam
  • Calcium Carbonate
  • Cardil (diltiazem Hydrochloride)
  • Ranitidine Hydrochloride
  • Vitamin D
The patient was hospitalized. Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Muscle Spasms, may still occur.
Flexeril Side Effect Report#8462126-5
Product Quality Issue
This Product Quality Issue problem was reported by a consumer or non-health professional from United States. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: neck pain. On
Jan 01, 2011 this consumer started treatment with Flexeril (dosage: NA). The following drugs were being taken at the same time:
  • Duragesic-100
  • Ultram
When using Flexeril, the patient experienced the following unwanted symptoms/side effects: Product Quality IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Product Quality Issue, may become evident only after a product is in use by the general population.
Flexeril Side Effect Report#8461853-3
Oesophageal Varices Haemorrhage, Peroneal Nerve Palsy, Sepsis, Haemorrhage, Pain, Neuropathy Peripheral, Surgery, Sensory Loss
This Oesophageal Varices Haemorrhage side effect was reported by a consumer or non-health professional from United States. A female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Flexeril (drug dosage: 2 Mg, Tid), which was initiated on
Dec 01, 1999. Concurrently used drugs:
  • Colace (100 Mg, Uid/qd)
  • Gabapentin (600 Mg, Tid)
  • Oxycodone Hcl (30 Mg Every 4 Hours)
  • Cyclobenzaprine (10 Mg, Tid)
  • Proair Hfa (Unk)
  • Fosamax (70 Mg, Weekly)
  • Ativan (1 Mg, Tid)
  • Prograf (3 Mg, Bid)
.After starting to take Flexeril the consumer reported adverse symptoms, such as: Oesophageal Varices Haemorrhage, Peroneal Nerve Palsy, Sepsis, Haemorrhage, Pain, Neuropathy Peripheral, Surgery, Sensory LossThese side effects may potentially be related to Flexeril. The patient was hospitalized.
Flexeril Side Effect Report#8451263-7
Dyspepsia, Chromaturia, Nausea, Headache
This is a report of a 58-year-old male patient (weight: NA) from United States, suffering from the following health symptoms/conditions: muscle tightness,hepatitis c,hypertension, who was treated with Flexeril (dosage: NA, start time:
Jan 30, 2012), combined with:
  • Peg-intron
  • Lisinopril And Hydrochlorothiazide
  • Copegus
  • Incivek
  • Naproxen
and developed a serious reaction and side effect(s): Dyspepsia, Chromaturia, Nausea, Headache after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Flexeril treatment in male patients, resulting in Dyspepsia side effect.
Flexeril Side Effect Report#8445555-5
Full Blood Count Decreased
This report suggests a potential Flexeril Full Blood Count Decreased side effect(s) that can have serious consequences. A 43-year-old male patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Flexeril (dosage: NA) starting
May 03, 2011. After starting Flexeril the patient began experiencing various side effects, including: Full Blood Count DecreasedAdditional drugs used concurrently:
  • Multivitamin
  • Norvasc
  • Gabapentin
  • Revlimid (5 Mg, Daily For 21 Days, Po)
  • Aspirin
  • Robaxin
Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Full Blood Count Decreased, may still occur.
Flexeril Side Effect Report#8440595-4
Oedema Peripheral
This Oedema Peripheral problem was reported by a consumer or non-health professional from United States. A 82-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Apr 12, 2011 this consumer started treatment with Flexeril (dosage: NA). The following drugs were being taken at the same time:
  • Toprol-xl
  • Dexamethasone
When using Flexeril, the patient experienced the following unwanted symptoms/side effects: Oedema PeripheralThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Oedema Peripheral, may become evident only after a product is in use by the general population.
Flexeril Side Effect Report#8439611-5
Oesophagitis Haemorrhagic, Fungaemia, Upper Gastrointestinal Haemorrhage, Pancytopenia, Pneumonia
This Oesophagitis Haemorrhagic side effect was reported by a physician from United States. A 51-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Flexeril (drug dosage: NA), which was initiated on
Feb 10, 2011. Concurrently used drugs:
  • Amitriptyline Hcl
  • Carafate
.After starting to take Flexeril the consumer reported adverse symptoms, such as: Oesophagitis Haemorrhagic, Fungaemia, Upper Gastrointestinal Haemorrhage, Pancytopenia, PneumoniaThese side effects may potentially be related to Flexeril. The patient was hospitalized.
Flexeril Side Effect Report#8437341-7
Neuralgia, Malaise, Abdominal Discomfort, Alopecia, Herpes Zoster
This is a report of a 46-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Flexeril (dosage: NA, start time:
Jul 01, 2004), combined with:
  • Gabapentin
  • Zoloft
  • Copaxone (20 Milligram;)
  • Tizanidine Hydrochloride
  • Ambien
  • Biotin
  • Acyclovir
and developed a serious reaction and side effect(s): Neuralgia, Malaise, Abdominal Discomfort, Alopecia, Herpes Zoster after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Flexeril treatment in female patients, resulting in Neuralgia side effect.


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The appearance of Flexeril on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Flexeril Side Effects for Women?

Women Side EffectsReports
Pain 33
Pulmonary Embolism 20
Fatigue 17
Asthenia 16
Deep Vein Thrombosis 15
Dyspnoea 15
Nausea 15
Pain In Extremity 15
Anxiety 14
Confusional State 14

What are common Flexeril Side Effects for Men?

Men Side EffectsReports
Anxiety 9
Cardiac Failure 9
Depression 9
Bladder Cancer 7
Liver Disorder 7
Rhabdomyolysis 7
Fall 6
Pain 6
Feeling Abnormal 5
Headache 5

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Flexeril reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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