Gleevec Safety Questions, Gleevec Answers
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Gleevec Safety Reports
Total Gleevec reports: 1116.Gleevec FDA safety alerts: 2006 .
Reported deaths: 200 Reported hospitalizations: 506.
Take Gleevec Side Effects Survey or Share Your Gleevec Story.
Reported Gleevec Side Effects: oedema peripheral, nausea, cardiac failure congestive, haemoglobin decreased, fatigue, malignant neoplasm progression, blood creatinine increased, pyrexia, dyspnoea exertional, dyspnoea, asthenia.
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< Previous Showing 101-150 of 1116 Next >
Gleevec Side Effects Report #5247857-2Physician from RUSSIAN FEDERATION reported GLEEVEC problem on Jan 31, 2007. Female patient, 29 years of age, was diagnosed with chronic myeloid leukaemia, post procedural hypothyroidism and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: abortion induced, foetal growth retardation. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with LEVOTHYROXINE. Patient recovered.
Gleevec Side Effects Report #5247858-4
GLEEVEC problem was reported by a Physician from KOREA, REPUBLIC OF on Feb 15, 2007. Male patient, 56 years of age, weighting 123.2 lb, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: pyrexia, septic shock. GLEEVEC dosage: 600 MG, QD. During the same period patient was treated with VINCRISTINE, DAUNORUBICIN, PREDNISOLONE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5247933-4
Health Professional from UNITED STATES reported GLEEVEC problem on Feb 26, 2007. Male patient was diagnosed with prostate cancer and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: disease progression, pain, refusal of treatment by patient, spinal compression fracture. GLEEVEC dosage: 300 MG QD PO. During the same period patient was treated with SORAFENIB. Patient was hospitalized. Patient died on 02/22/2007.
Gleevec Side Effects Report #5249309-2
GLEEVEC problem was reported by a Physician from GERMANY on Feb 15, 2007. Male patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: visual acuity reduced. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5249310-9
Physician from SPAIN reported GLEEVEC problem on Feb 15, 2007. Female patient, 66 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: articular calcification, calcification of muscle, tendon calcification. GLEEVEC dosage: 400 MG/DAY. Patient recovered.
Gleevec Side Effects Report #5249313-4
GLEEVEC problem was reported by a Physician from GERMANY on Feb 15, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: acute myocardial infarction, cardiac failure, ejection fraction decreased, pleural effusion. GLEEVEC dosage: 400 MG, QD. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5253175-9
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Feb 16, 2007. Female patient, 40 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased, constipation, diarrhoea, diastolic hypotension, dizziness, tachyarrhythmia, vomiting. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5253176-0
GLEEVEC problem was reported by a Physician from ITALY on Feb 15, 2007. Male patient, 75 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: arthralgia, osteonecrosis, prostate cancer, prostatic operation. GLEEVEC dosage: 400 MG/DAY. Patient recovered.
Gleevec Side Effects Report #5253178-4
Consumer or non-health professional from JAPAN reported GLEEVEC problem on Feb 23, 2007. Male patient, 31 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: blast crisis in myelogenous leukaemia, graft versus host disease, sepsis, stem cell transplant. GLEEVEC dosage: 400 MG/DAY. Patient was hospitalized. Patient died on 08/01/2005.
Gleevec Side Effects Report #5254117-2
GLEEVEC problem was reported by a Physician from SWITZERLAND on Feb 16, 2007. Female patient was diagnosed with chronic myeloid leukaemia, anaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: hearing impaired. GLEEVEC dosage: 600 MG/DAY. During the same period patient was treated with FOLVITE, VITAMIN B. Patient recovered.
Gleevec Side Effects Report #5254119-6
Physician from FRANCE reported GLEEVEC problem on Feb 16, 2007. Female patient, 58 years of age, weighting 121.3 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: metastases to liver, metastases to peritoneum, ovarian cancer metastatic. GLEEVEC dosage: 400 MG PER DAY. Patient recovered.
Gleevec Side Effects Report #5255429-9
GLEEVEC problem was reported by a Physician from SWITZERLAND on Feb 20, 2007. Male patient, 36 years of age, weighting 224.9 lb, was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: arthralgia, chondropathy, meniscus lesion, muscle spasms, myalgia. GLEEVEC dosage: 400 MG/DAY. During the same period patient was treated with ALLOPURINOL. Patient recovered.
Gleevec Side Effects Report #5255430-5
Pharmacist from UNITED KINGDOM reported GLEEVEC problem on Feb 20, 2007. Male patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: erythema nodosum, no therapeutic response. GLEEVEC dosage: 600 MG, QD. Patient recovered.
Gleevec Side Effects Report #5256127-8
GLEEVEC problem was reported by a Health Professional from UNITED KINGDOM on Mar 01, 2007. Male patient, 58 years of age, weighting 207.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: arteriosclerosis coronary artery, circulatory collapse, left ventricular failure, vomiting. GLEEVEC dosage: 600MG/DAY. Patient was hospitalized. Patient died on 12/10/2006.
Gleevec Side Effects Report #5256128-X
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Feb 21, 2007. Female patient, 69 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, contusion, eyelid oedema, oedema peripheral, rash. GLEEVEC dosage: 400 MG, QD. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5257631-9
GLEEVEC problem was reported by a Health Professional from ITALY on Feb 28, 2007. Male patient, 50 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: asthenia, blast cells present, blast crisis in myelogenous leukaemia, cerebral haemorrhage, disseminated intravascular coagulation, haemoglobin decreased, platelet count decreased, white blood cell count decreased. GLEEVEC dosage: 400 MG/D. Patient died.
Gleevec Side Effects Report #5257632-0
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Feb 22, 2007. Male patient, 76 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: abdominal distension, abdominal pain, chills, diarrhoea, dizziness, flatulence, headache, nuclear magnetic resonance imaging abnormal, oedema peripheral. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with DIOVAN, LIPITOR, LASIX, ATENOLOL, HYDROCODONE. Patient recovered.
Gleevec Side Effects Report #5257640-X
GLEEVEC problem was reported by a Physician from SPAIN on Feb 23, 2007. Male patient, 74 years of age, was diagnosed with chronic myeloid leukaemia, anxiety and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac failure, escherichia urinary tract infection, hypertensive cardiomyopathy, respiratory tract infection. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with FUROSEMIDE, CAPTOPRIL, OMEPRAZOLE, ALOPURINOL, METAMIZOLE, ALPRAZOLAM, PIRACETAM, RAMIPRIL. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5261835-9
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Feb 26, 2007. Male patient, 79 years of age, weighting 169.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: amnesia, asthenia, confusional state, dementia alzheimer's type, diarrhoea, disorientation, haematochezia, mental status changes. GLEEVEC dosage: unknown. During the same period patient was treated with COREG, ALLOPURINOL, FLOMAX, DIGITEK. Patient recovered.
Gleevec Side Effects Report #5261859-1
GLEEVEC problem was reported by a Physician from FRANCE on Mar 02, 2007. Male patient, 79 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: rectosigmoid cancer, surgery. GLEEVEC dosage: 400 MG PER DAY. Patient recovered.
Gleevec Side Effects Report #5262300-5
Physician from UNITED STATES reported GLEEVEC problem on Feb 27, 2007. Female patient, 20 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cervical dysplasia. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5262315-7
GLEEVEC problem was reported by a Physician from UNITED STATES on Feb 26, 2007. Female patient, 50 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: eye inflammation, uveitis. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with ALLEGRA, ZYRTEC, ATENOLOL, ESTRACE, VITAMIN CAP, CALTRATE. Patient recovered.
Gleevec Side Effects Report #5262525-9
Health Professional from ECUADOR reported GLEEVEC problem on Feb 26, 2007. Male patient, 50 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: arthralgia, conjunctival hyperaemia, dry mouth, dry skin, eyelid oedema, face oedema, fatigue, muscle spasms, muscular weakness. GLEEVEC dosage: 600 MG, QD. Patient recovered.
Gleevec Side Effects Report #5262584-3
GLEEVEC problem was reported by a Physician from SPAIN on Feb 27, 2007. Female patient, 68 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: colon cancer metastatic, colon cancer stage iv. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5264757-2
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Feb 26, 2007. Male patient, 79 years of age, weighting 169.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: amnesia, asthenia, confusional state, dementia alzheimer's type, diarrhoea, disorientation, haematochezia, mental status changes. GLEEVEC dosage: unknown. During the same period patient was treated with COREG, ALLOPURINOL, FLOMAX, DIGITEK. Patient recovered.
Gleevec Side Effects Report #5264998-4
GLEEVEC problem was reported by a Physician from SPAIN on Mar 01, 2007. Female patient, 47 years of age, was diagnosed with chronic myeloid leukaemia, anxiety and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anxiety, diarrhoea, headache, hyperreflexia, hypokalaemia, tremor, weight decreased. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with ZOLPIDEM, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5264999-6
Consumer or non-health professional from TAIWAN, PROVINCE OF CHINA reported GLEEVEC problem on Mar 07, 2007. Female patient, 24 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: haemorrhagic ovarian cyst. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5266056-1
GLEEVEC problem was reported by a Physician from on Mar 02, 2007. Male patient, 75 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: myocardial infarction, plasmacytoma, surgery. GLEEVEC dosage: 300 MG DAILY. Patient recovered.
Gleevec Side Effects Report #5267142-2
Physician from PHILIPPINES reported GLEEVEC problem on Mar 05, 2007. Male patient, 56 years of age, weighting 157.9 lb, was diagnosed with gastrointestinal stromal tumour, arrhythmia, anaemia, diabetes mellitus and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: albuminuria, anaemia, blood creatinine increased, haematuria, melaena, nephrolithiasis, upper gastrointestinal haemorrhage. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with NEOBLOC, PERINDOPRIL ERBUMINE, FORTIFER, GLUCOVANCE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5268192-2
GLEEVEC problem was reported by a Health Professional from UNITED STATES on Mar 14, 2007. Male patient, 67 years of age, weighting 222.7 lb, was diagnosed with waldenstrom's macroglobulinaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anaemia, cardiomegaly, dyspnoea, platelet count decreased, pneumonia, pulmonary vascular disorder, pyrexia, supraventricular extrasystoles, ventricular hypertrophy. GLEEVEC dosage: 600 MG PO. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5269113-9
Physician from UNITED STATES reported GLEEVEC problem on Mar 06, 2007. Male patient, 40 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dizziness, dysphonia, gait disturbance, multiple sclerosis, muscular weakness, paraesthesia. GLEEVEC dosage: 400 MG, QD. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5269114-0
GLEEVEC problem was reported by a Physician from CHINA on Mar 06, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: blast cells present, lung infection, lymphadenopathy, pyrexia, white blood cell count increased. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5269986-X
Consumer or non-health professional from GERMANY reported GLEEVEC problem on Mar 06, 2007. Female patient was diagnosed with chronic myeloid leukaemia, hypertension and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: rash, swelling face, thrombocythaemia. GLEEVEC dosage: 200 MG/DAY. During the same period patient was treated with RAMIPRIL, BLOPRESS PLUS. Patient recovered.
Gleevec Side Effects Report #5269987-1
GLEEVEC problem was reported by a Physician from RUSSIAN FEDERATION on Mar 13, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia, anaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: gastric cancer, haemoglobin decreased, myocardial infarction, tumour haemorrhage. GLEEVEC dosage: 400 MG/DAY. During the same period patient was treated with SORBIFER DURULES, RECORMON. Patient died on 02/14/2007.
Gleevec Side Effects Report #5269990-1
Physician from FRANCE reported GLEEVEC problem on Mar 02, 2007. Female patient, 69 years of age, weighting 121.3 lb, was diagnosed with chronic myeloid leukaemia, lung neoplasm malignant and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bronchitis, conjunctival haemorrhage, dehydration, diarrhoea, erythema, gastric disorder, leukocytosis, lung neoplasm malignant. GLEEVEC dosage: 400 MG DAILY. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5269991-3
GLEEVEC problem was reported by a Consumer or non-health professional from UNITED STATES on Mar 16, 2007. Female patient, 37 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: eye haemorrhage, vitrectomy. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5269992-5
Consumer or non-health professional from JAPAN reported GLEEVEC problem on Mar 13, 2007. Female patient, child 8 years of age, was diagnosed with acute lymphocytic leukaemia recurrent and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: aspergillosis, blood beta-d-glucan increased, bronchopulmonary aspergillosis, cough, malignant neoplasm progression, multi-organ failure, neutropenia, pyrexia. GLEEVEC dosage: unknown. During the same period patient was treated with DEXAMETHASONE, VINCRISTINE SULPHATE, CYCLOPHOSPHAMIDE, CYTARABINE, IDARUBICIN, IFOSFAMIDE, FLUCONAZOLE, MICAFUNGIN. Patient died.
Gleevec Side Effects Report #5272285-3
GLEEVEC problem was reported by a Health Professional from UNITED STATES on Mar 20, 2007. Female patient, weighting 100.1 lb, was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: conjunctival haemorrhage, disseminated intravascular coagulation. GLEEVEC dosage: 9600 MG. Patient recovered.
Gleevec Side Effects Report #5272586-9
Physician from SPAIN reported GLEEVEC problem on Mar 09, 2007. Female patient, 66 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: articular calcification, calcification of muscle, tendon calcification. GLEEVEC dosage: 400 MG/DAY. Patient recovered.
Gleevec Side Effects Report #5272587-0
GLEEVEC problem was reported by a Consumer or non-health professional from UNITED STATES on Mar 09, 2007. Male patient, 60 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: alcoholism, amnesia, convulsion, depressed level of consciousness, laceration, loss of consciousness, mouth haemorrhage, musculoskeletal disorder. GLEEVEC dosage: unknown. During the same period patient was treated with ALCOHOL. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5272588-2
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Mar 09, 2007. Female patient, 31 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: chromosome analysis abnormal, multiple pregnancy. GLEEVEC dosage: unknown. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5272589-4
GLEEVEC problem was reported by a Physician from SLOVENIA on Mar 14, 2007. Female patient, 33 years of age, weighting 136.7 lb, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, chest x-ray abnormal, computerised tomogram abnormal, confusional state, cough, gamma-glutamyltransferase increased. GLEEVEC dosage: 400 MG, QD. Patient died on 12/26/2006.
Gleevec Side Effects Report #5273911-5
Physician from NETHERLANDS reported GLEEVEC problem on Mar 12, 2007. Female patient, 81 years of age, weighting 110.2 lb, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bleeding time prolonged, glaucoma, visual disturbance. GLEEVEC dosage: 400 MG/DAY. Patient recovered.
Gleevec Side Effects Report #5274169-3
GLEEVEC problem was reported by a Physician from JAPAN on Mar 12, 2007. Male patient, 87 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bronchiolitis, dyspnoea, pyrexia. GLEEVEC dosage: 200 MG/D. During the same period patient was treated with FAMOTIDINE, MUCOSTA, ASPIRIN, LASIX, CLEANAL, URALYT. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5275690-4
Physician from UNITED STATES reported GLEEVEC problem on Mar 12, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: blood creatine phosphokinase increased, osteonecrosis, rhabdomyolysis. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with CHOLESTEROL. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5275691-6
GLEEVEC problem was reported by a Consumer or non-health professional from UNITED STATES on Mar 13, 2007. Male patient, 76 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: artificial crown procedure, bone formation decreased, gingival pain, impaired healing, sensitivity of teeth, tooth abscess, tooth extraction. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5275693-X
Physician from UNITED KINGDOM reported GLEEVEC problem on Mar 13, 2007. Male patient, 24 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: ejaculation failure, erectile dysfunction, gynaecomastia, hypogonadism male, testicular disorder. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5278925-7
GLEEVEC problem was reported by a Physician from FRANCE on Mar 15, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: metastases to bone, metastases to liver. GLEEVEC dosage: unknown. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5278926-9
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Mar 15, 2007. Female patient, 54 years of age, weighting 141.1 lb, was diagnosed with chronic myeloid leukaemia, osteoporosis and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anaemia, arthralgia, bladder cancer, bladder neoplasm surgery, decreased appetite, diarrhoea, dry mouth, gastrointestinal disorder, gravitational oedema. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with ACTONEL, CALCIUM. Patient recovered.
Gleevec Side Effects Report #5278928-2
GLEEVEC problem was reported by a Pharmacist from JAPAN on Mar 14, 2007. Female patient, 76 years of age, weighting 99.21 lb, was diagnosed with chronic myeloid leukaemia, constipation, prophylaxis and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dry skin, eczema asteatotic, gastric cancer, hepatic failure, hepatitis b, liver disorder, pancytopenia, pyrexia, rash. GLEEVEC dosage: 200 MG/DAY. During the same period patient was treated with MAGNESIUM OXIDE HEAVY, MUCOSOLVAN, LAC B, HYDREA, CYMERIN, PREDONINE. Patient was hospitalized. Patient recovered.
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Drug Information: Imatinib
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a606018.html
(i mat' in ib)Why is this medication prescribed?
Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers of the blood cells. Imatinib is also used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body). Imatinib is also used to treat dermatofibrosarcoma protuberans (a tumor that forms under the top layer of skin) when the tumor cannot be removed surgically, has spread to other parts of the body, or has come back after surgery. Imatinib is in a class of medications called protein-tyrosine kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
How should this medicine be used?
Imatinib comes as a tablet to take by mouth. It is usually taken with a meal and a large glass of water once or twice a day. Take imatinib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take imatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are unable to swallow imatinib tablets, you may place all of the tablets that you need for one dose into a glass of water or apple juice. Use 50 mL (a little less than 2 ounces) of liquid for each 100 mg tablet and 100 mL (a little less than 4 ounces) of liquid for each 400 mg tablet. Stir with a spoon until the tablets crumble completely and drink the mixture immediately.
If your doctor has told you to take 800 mg of imatinib, you should take two of the 400 mg tablets. Do not take 8 of the 100 mg tablets. The tablet coating contains iron, and you will receive too much iron if you take 8 of the 100 mg tablets.
Your doctor may increase or decrease your dose of imatinib during your treatment. This depends on how well the medication works for you and on the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take imatinib even if you feel well. Do not stop taking imatinib without talking to your doctor.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking imatinib,
- tell your doctor and pharmacist if you are allergic to imatinib or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acetaminophen (Tylenol); certain antibiotics including erythromycin (E.E.S., E-Mycin, Erythrocin), clarithromycin (Biaxin), and rifampin (Rifadin, in Rifamate); anticoagulants ('blood thinners') such as warfarin (Coumadin); antifungals such as ketoconazole (Nizoral) and itraconazole (Sporanox); calcium channel blockers such as amlodipine (Norvasc, in Caduet), diltiazem (Cardizem, Tiazac), felodipine (Plendil), isradipine (Dynacirc), nicardipine (Cardene), nifedipine (Adalat, Procardia, others), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); cyclosporine (Neoral, Sandimmune); dexamethasone; hormonal contraceptives (birth control pills, patches, rings, injections or implants); pimozide (Orap); medications for anxiety; medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); sedatives; sleeping pills; and tranquilizers. Other medications may also interact with imatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had high blood pressure a heart attack; an irregular heartbeat; diabetes; or heart, lung, thyroid, or liver disease. Also tell your doctor if you smoke, if you use street drugs, and if you drink or have ever drunk large amounts of alcohol.
- tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking imatinib. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking imatinib, call your doctor. Imatinib may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breast-feed while you are taking imatinib.
- talk to your doctor about what you should do if you develop diarrhea during your treatment. Do not take any medications to treat diarrhea without talking to your doctor.
What special dietary instructions should I follow?
Talk to your doctor about drinking grapefruit juice or eating grapefruit while taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Imatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- constipation
- gas
- nausea
- vomiting
- loss of appetite
- indigestion
- joint pain
- muscle cramps
- depression
- anxiety
- night sweats
- teary eyes
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:
- puffiness under the eyes
- swelling of the hands, feet, ankles, or lower legs
- weight gain
- shortness of breath
- fast, irregular, or pounding heartbeat
- difficulty falling asleep or staying asleep
- fainting
- coughing up pink or bloody mucus
- increased urination, especially at night
- chest pain
- fever
- rash or blisters
- yellowing of the skin or eyes
- blood in the stool
- unusual bruising or bleeding
- sore throat, fever, chills, and other signs of infection
- excessive tiredness or weakness
- headache
- dizziness
Imatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- muscle cramps
- swollen or bloated stomach
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to imatinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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