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Gleevec Side Effects

PatientsVille

Common Gleevec Side Effects


The most commonly reported Gleevec side effects (click to view or check a box to report):

Nausea (514)
Death (469)
Diarrhoea (431)
Anaemia (418)
Dyspnoea (382)
Vomiting (312)
Fatigue (310)
Pyrexia (284)
Rash (268)
Haemoglobin Decreased (261)
Malignant Neoplasm Progression (260)
Asthenia (226)
Oedema Peripheral (226)
Muscle Spasms (223)
Abdominal Pain (222)
Neoplasm Malignant (214)
Platelet Count Decreased (212)
Pleural Effusion (195)
Blood Creatinine Increased (176)
Oedema (170)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Gleevec Side Effects Reported to FDA



Gleevec Side Effect Report#9983309
This is a report of a 56-year-old patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Gleevec (dosage: Unk Ukn, Unk, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Gleevec treatment in patients, resulting in Death side effect.
Gleevec Side Effect Report#9971116
This report suggests a potential Gleevec Death side effect(s) that can have serious consequences. A 46-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Gleevec (dosage: Unk Ukn, Unk) starting NS. After starting Gleevec the patient began experiencing various side effects, including:Additional drugs used concurrently: NA. Although Gleevec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Gleevec Side Effect Report#9961291
Pain, Thrombocytopenia, Nausea, Night Sweats, Skin Hypopigmentation, Therapeutic Response Unexpected
This Pain problem was reported by a health professional from US. A 29-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: chronic myeloid leukaemia. On NS this consumer started treatment with Gleevec (dosage: NA). The following drugs were being taken at the same time:
  • Morphine (15 Mg, Bid)
  • Morphine (30 Mg, Daily)
  • Oxycodone Hydrochloride (5 Mg, Q4h)
  • Oxycodone Hydrochloride (10 Mg, Q4h)
  • Hydroxyurea
When using Gleevec, the patient experienced the following unwanted symptoms/side effects: Pain, Thrombocytopenia, Nausea, Night Sweats, Skin Hypopigmentation, Therapeutic Response UnexpectedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pain, may become evident only after a product is in use by the general population.
Gleevec Side Effect Report#9943436
This Death side effect was reported by a health professional from US. A 82-year-old male patient (weight:NA) experienced the following symptoms/conditions: chronic myeloid leukaemia.The patient was prescribed Gleevec (drug dosage: 400 Mg, Daily), which was initiated on
Feb 18, 2011. Concurrently used drugs: NA..After starting to take Gleevec the consumer reported adverse symptoms, such as: These side effects may potentially be related to Gleevec.
Gleevec Side Effect Report#9931059
Thrombocytosis, Urinary Tract Infection, Pyrexia, Fall, Upper Limb Fracture, Wrist Fracture, Erythropoiesis Abnormal, Thyroid Disorder
This is a report of a 59-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: chronic myeloid leukaemia, who was treated with Gleevec (dosage: 400 Mg, Unk, start time:
Jul 25, 2012), combined with:
  • Tasigna (Unk Ukn, Unk)
  • Tasigna (Unk Ukn, Unk)
  • Hydrea
  • Bosutinib (500 Mg, Daily)
  • Bosutinib (500 Mg, Daily)
  • Keppra (500 Mg, 6qd (3 Tablets In The Morning And 3 Tablets In The Evening))
  • Levothroid (150 Ug, Daily)
  • Bupropion Hcl (300 Mg, Daily)
and developed a serious reaction and side effect(s): Thrombocytosis, Urinary Tract Infection, Pyrexia, Fall, Upper Limb Fracture, Wrist Fracture, Erythropoiesis Abnormal, Thyroid Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Gleevec treatment in female patients, resulting in Thrombocytosis side effect. The patient was hospitalized.
Gleevec Side Effect Report#9927306
Fall, Gait Disturbance, Abasia, Concomitant Disease Progression, Fatigue, Arthritis, Back Pain
This report suggests a potential Gleevec Fall side effect(s) that can have serious consequences. A 73-year-old male patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: chronic myeloid leukaemia and used Gleevec (dosage: 400 Mg, Qd) starting 201211. After starting Gleevec the patient began experiencing various side effects, including: Fall, Gait Disturbance, Abasia, Concomitant Disease Progression, Fatigue, Arthritis, Back PainAdditional drugs used concurrently:
  • Ativan (Unk Ukn, Prn)
  • Celexa (10 Mg, Qd)
  • Salmon Oil (3 Df, Qd)
The patient was hospitalized. Although Gleevec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Fall, may still occur.
Gleevec Side Effect Report#9926057
Oesophageal Carcinoma, Second Primary Malignancy
This Oesophageal Carcinoma problem was reported by a consumer or non-health professional from Country Not Specified. A 49-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: chronic myeloid leukaemia. On 201011 this consumer started treatment with Gleevec (dosage: 400 Mg, Qd). The following drugs were being taken at the same time: NA. When using Gleevec, the patient experienced the following unwanted symptoms/side effects: Oesophageal Carcinoma, Second Primary MalignancyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Oesophageal Carcinoma, may become evident only after a product is in use by the general population.
Gleevec Side Effect Report#9915867
Glaucoma, Confusional State, Amnesia
This Glaucoma side effect was reported by a consumer or non-health professional from US. A 45-year-old female patient (weight:NA) experienced the following symptoms/conditions: neoplasm.The patient was prescribed Gleevec (drug dosage: NA), which was initiated on
Sep 20, 2013. Concurrently used drugs: NA..After starting to take Gleevec the consumer reported adverse symptoms, such as: Glaucoma, Confusional State, AmnesiaThese side effects may potentially be related to Gleevec.
Gleevec Side Effect Report#9914802
Fall, Gastrooesophageal Reflux Disease, Arthralgia, Chest Pain, Asthenia
This is a report of a 86-year-old female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: chronic myeloid leukaemia, who was treated with Gleevec (dosage: 100 Mg, Daily, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Fall, Gastrooesophageal Reflux Disease, Arthralgia, Chest Pain, Asthenia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Gleevec treatment in female patients, resulting in Fall side effect. The patient was hospitalized.
Gleevec Side Effect Report#9902928
Fall, Dysphagia, Chest Pain, Scar, Hepatic Failure, Gastrointestinal Stromal Tumour, Malignant Neoplasm Progression
This report suggests a potential Gleevec Death side effect(s) that can have serious consequences. A 35-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: gastrointestinal stromal tumour and used Gleevec (dosage: Unk Ukn, Unk) starting 2006. After starting Gleevec the patient began experiencing various side effects, including: Fall, Dysphagia, Chest Pain, Scar, Hepatic Failure, Gastrointestinal Stromal Tumour, Malignant Neoplasm ProgressionAdditional drugs used concurrently: NA.The patient was hospitalized. Although Gleevec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Gleevec Side Effect Report#9901671
This Death problem was reported by a consumer or non-health professional from Country Not Specified. A 80-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: myeloid leukaemia. On
Sep 29, 2011 this consumer started treatment with Gleevec (dosage: 400 Mg, Every Day). The following drugs were being taken at the same time:
  • Plavix (75 U, Daily)
  • Colace (100 U, Daily)
  • Ferrous Sulfate (325 U, Daily)
  • Hydrochlorothiazide (25 U, Daily)
  • Lansoprazole (30 U, Daily)
When using Gleevec, the patient experienced the following unwanted symptoms/side effects:Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Gleevec Side Effect Report#9893504
Lung Infection, Tinea Pedis, Fungal Skin Infection, Erythema, Dry Skin
This Lung Infection side effect was reported by a physician from CA. A 62-year-old female patient (weight:NA) experienced the following symptoms/conditions: chronic myeloid leukaemia.The patient was prescribed Gleevec (drug dosage: 400 Mg, Qd), which was initiated on 201212. Concurrently used drugs:
  • Crestor (Unk Ukn, Unk)
.After starting to take Gleevec the consumer reported adverse symptoms, such as: Lung Infection, Tinea Pedis, Fungal Skin Infection, Erythema, Dry SkinThese side effects may potentially be related to Gleevec.
Gleevec Side Effect Report#9893233
This is a report of a 82-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: chronic myeloid leukaemia,acute myeloid leukaemia (in remission), who was treated with Gleevec (dosage: 400 Mg, Qd, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Gleevec treatment in female patients, resulting in Death side effect.
Gleevec Side Effect Report#9893219
Sepsis, Skin Ulcer, Renal Failure
This report suggests a potential Gleevec Sepsis side effect(s) that can have serious consequences. A 84-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: chronic myeloid leukaemia and used Gleevec (dosage: 400 Mg, Qd) starting NS. After starting Gleevec the patient began experiencing various side effects, including: Sepsis, Skin Ulcer, Renal FailureAdditional drugs used concurrently: NA.The patient was hospitalized. Although Gleevec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Sepsis, may still occur.
Gleevec Side Effect Report#9890422
Disease Progression
This Disease Progression problem was reported by a consumer or non-health professional from US. A 90-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: chronic myeloid leukaemia. On NS this consumer started treatment with Gleevec, 400 Mg, Novartis (dosage: 11/08/2014-01/08/2014). The following drugs were being taken at the same time: NA. When using Gleevec, 400 Mg, Novartis, the patient experienced the following unwanted symptoms/side effects: Disease ProgressionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Disease Progression, may become evident only after a product is in use by the general population.
Gleevec Side Effect Report#9890419
Disease Progression
This Disease Progression side effect was reported by a pharmacist from US. A 90-year-old male patient (weight:NA) experienced the following symptoms/conditions: chronic myeloid leukaemia.The patient was prescribed Gleevec (drug dosage: 400 Mg Qday Oral), which was initiated on
Oct 09, 2013. Concurrently used drugs: NA..After starting to take Gleevec the consumer reported adverse symptoms, such as: Disease ProgressionThese side effects may potentially be related to Gleevec.
Gleevec Side Effect Report#9885725
Leukaemia Recurrent
This is a report of a female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: myeloid leukaemia,chronic lymphocytic leukaemia, who was treated with Gleevec (dosage: 400 Mg, Eod, start time:
Feb 16, 2012), combined with:
  • Ibrutinib (Unk Ukn, Unk)
  • Advair (Unk Ukn, Unk)
  • Dexilant (Unk Ukn, Unk)
  • Allopurinol (Unk Ukn, Unk)
  • Prednisone (Unk Ukn, Unk)
and developed a serious reaction and side effect(s): Leukaemia Recurrent after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Gleevec treatment in female patients, resulting in Death side effect.
Gleevec Side Effect Report#9885192
Myocardial Infarction
This report suggests a potential Gleevec Myocardial Infarction side effect(s) that can have serious consequences. A male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: leukaemia and used Gleevec (dosage: NA) starting 201206. After starting Gleevec the patient began experiencing various side effects, including: Myocardial InfarctionAdditional drugs used concurrently: NA. Although Gleevec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Myocardial Infarction, may still occur.
Gleevec Side Effect Report#9885059
Acute Lymphocytic Leukaemia, Second Primary Malignancy, Skin Discolouration, Neutrophil Count Decreased, Rash, Muscle Spasms, Fatigue, Leukocytosis
This Acute Lymphocytic Leukaemia problem was reported by a consumer or non-health professional from Country Not Specified. A 58-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: chronic myeloid leukaemia. On
Dec 17, 2013 this consumer started treatment with Gleevec (dosage: 400 Mg, Daily). The following drugs were being taken at the same time: NA. When using Gleevec, the patient experienced the following unwanted symptoms/side effects: Acute Lymphocytic Leukaemia, Second Primary Malignancy, Skin Discolouration, Neutrophil Count Decreased, Rash, Muscle Spasms, Fatigue, LeukocytosisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Acute Lymphocytic Leukaemia, may become evident only after a product is in use by the general population.
Gleevec Side Effect Report#9881585
This Death side effect was reported by a consumer or non-health professional from Country Not Specified. A 46-year-old male patient (weight:NA) experienced the following symptoms/conditions: soft tissue cancer.The patient was prescribed Gleevec (drug dosage: 400 Mg, Daily), which was initiated on
Jan 02, 2014. Concurrently used drugs:
  • Albuterol Sulfate (Unk Ukn, Unk)
  • Synthroid (Unk Ukn, Unk)
  • Dulera (Unk Ukn, Unk)
  • Singulair (Unk Ukn, Unk)
  • Lisinopril (Unk Ukn, Unk)
  • Miralax (Unk Ukn, Unk)
  • Docusate Sodium (Unk Ukn, Unk)
  • Mucinex (Unk Ukn, Unk)
.After starting to take Gleevec the consumer reported adverse symptoms, such as: These side effects may potentially be related to Gleevec.
Gleevec Side Effect Report#9875814
Fatigue
This is a report of a 73-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Gleevec (dosage: NA, start time:
Jul 24, 2013), combined with:
  • Paxil
  • Singulair
  • Coumadin
  • Imdur
  • Lopressor
  • Lipitor
  • Neurontin
  • Wellbutrin
and developed a serious reaction and side effect(s): Fatigue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Gleevec treatment in female patients, resulting in Fatigue side effect.
Gleevec Side Effect Report#9867490
Disease Progression, Unevaluable Event
This report suggests a potential Gleevec Disease Progression side effect(s) that can have serious consequences. A 75-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: white blood cell disorder and used Gleevec (dosage: NA) starting
Aug 16, 2013. After starting Gleevec the patient began experiencing various side effects, including: Disease Progression, Unevaluable EventAdditional drugs used concurrently: NA. Although Gleevec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Disease Progression, may still occur.
Gleevec Side Effect Report#9863858
This Death problem was reported by a consumer or non-health professional from Country Not Specified. A 78-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: small intestine carcinoma. On
Feb 21, 2013 this consumer started treatment with Gleevec (dosage: 400 Mg, Daily). The following drugs were being taken at the same time: NA. When using Gleevec, the patient experienced the following unwanted symptoms/side effects:Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Gleevec Side Effect Report#9861930
Convulsion
This Convulsion side effect was reported by a health professional from US. A 40-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Gleevec (drug dosage: NA), which was initiated on
Nov 13, 2009. Concurrently used drugs: NA..After starting to take Gleevec the consumer reported adverse symptoms, such as: ConvulsionThese side effects may potentially be related to Gleevec.
Gleevec Side Effect Report#9858477
Pericardial Effusion
This is a report of a male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Gleevec (dosage: NA, start time:
Dec 13, 2013), combined with: NA. and developed a serious reaction and side effect(s): Pericardial Effusion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Gleevec treatment in male patients, resulting in Pericardial Effusion side effect.


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The appearance of Gleevec on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Gleevec Side Effects for Women?

Women Side EffectsReports
Nausea 313
Diarrhoea 235
Death 215
Anaemia 214
Dyspnoea 210
Vomiting 204
Fatigue 165
Rash 155
Pyrexia 127
Haemoglobin Decreased 121

What are common Gleevec Side Effects for Men?

Men Side EffectsReports
Death 251
Nausea 198
Anaemia 197
Diarrhoea 189
Dyspnoea 166
Pyrexia 154
Malignant Neoplasm Progression 150
Fatigue 141
Haemoglobin Decreased 136
Platelet Count Decreased 135

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Gleevec reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Gleevec Side Effects

    Did You Have a Gleevec Side Effect?

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    Yes, Moderate
    Yes, Minor
    No

    How Effective is Gleevec for You?

    Exceeded Expectations
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    Gleevec Safety Alerts, Active Ingredients, Usage Information

    NDC0078-0401
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameGleevec
    Nameimatinib mesylate
    Dosage FormTABLET
    RouteORAL
    On market since20010515
    LabelerNovartis Pharmaceuticals Corporation
    Active Ingredient(s)IMATINIB MESYLATE
    Strength(s)100
    Unit(s)mg/1
    Pharma ClassKinase Inhibitor [EPC],Protein Kinase Inhibitors [MoA]

    Gleevec Dosage, Warnings, Usage.

    Side Effects reported to FDA: 6380

    Gleevec safety alerts: 2006

    Reported deaths: 1949

    Reported hospitalizations: 2876

    Gleevec (imatinib mesylate)

    Audience: Oncology and cardiology healthcare professionals

    [Posted 10/19/2006] Novartis and FDA notified healthcare professionals about revisions to the PRECAUTIONS section of the prescribing information, describing the occasional occurrence of severe congestive heart failure and left ventricular dysfunction in patients taking Gleevec. Most of the patients with reported cardiac events had other co-morbidities and risk factors, including advanced age and previous medical history of cardiac disease. Patients with cardiac disease or risk factors for cardiac failure should be monitored carefully and any patients with signs or symptoms consistent with cardiac failure should be evaluated and treated.

    [October 19, 2006 - Letter - Norvartis]
    [September 2006 - Label - Novartis]

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