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Hydrocortisone Side Effects

Common Hydrocortisone Side Effects


The most commonly reported Hydrocortisone side effects (click to view or check a box to report):

Malaise (45)
Pyrexia (41)
Nausea (36)
Infusion Related Reaction (32)
Rash (31)
Dyspnoea (30)
Headache (28)
Fatigue (26)
Abdominal Pain (24)
Asthenia (22)
Vomiting (21)
Erythema (20)
Blood Glucose Increased (20)
Product Substitution Issue (19)
Tachycardia (19)
Hypotension (18)
Hypertension (18)
Hyperglycaemia (18)
Condition Aggravated (18)
Urticaria (17)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Hydrocortisone Side Effects Reported to FDA

The following Hydrocortisone reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Hydrocortisone on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Pyrexia, Renal Infarct, Coagulation Factor Viii Level Increased, Anaemia, Embolism Arterial
This is a report of a 31-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: colitis ulcerative,condition aggravated,sepsis, who was treated with Hydrocortisone (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Pyrexia
  • Renal Infarct
  • Coagulation Factor Viii Level Increased
  • Anaemia
  • Embolism Arterial
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydrocortisone treatment in male patients, resulting in pyrexia side effect.

Haemorrhoids, Abdominal Discomfort, Haematochezia, Full Blood Count Abnormal, Thrombosis, Constipation
This report suggests a potential Hydrocortisone Haemorrhoids, Abdominal Discomfort, Haematochezia, Full Blood Count Abnormal, Thrombosis, Constipation side effect(s) that can have serious consequences. A 69-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED was diagnosed with the following symptoms/conditions: NA and used Hydrocortisone (dosage: At Night) starting 2008. Soon after starting Hydrocortisone the patient began experiencing various side effects, including:
  • Haemorrhoids
  • Abdominal Discomfort
  • Haematochezia
  • Full Blood Count Abnormal
  • Thrombosis
  • Constipation
Drugs used concurrently:
  • Calcium (500mg Daily)
  • Vitamin D
  • Centrum Silver (Daily)
  • Humira (Loading Dose)
  • Humira (Loading Dose)
  • Apriso
  • Synthroid (125mcg Daily)
  • Plaquenil (200mg Daily)
Although Hydrocortisone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as haemorrhoids, may still occur.

Cell-mediated Immune Deficiency, Superinfection, Candida Sepsis
This Cell-mediated Immune Deficiency, Superinfection, Candida Sepsis problem was reported by a pharmacist from JP. A 83-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: multi-organ failure,septic shock,pneumonia. On NS this consumer started treatment with Hydrocortisone Sodium Phosphate (dosage: Unk). The following drugs were being taken at the same time:
  • Doripenem
  • Doripenem
  • Globulin, Immune
When commencing Hydrocortisone Sodium Phosphate, the patient experienced the following unwanted symptoms/side effects:
  • Cell-mediated Immune Deficiency
  • Superinfection
  • Candida Sepsis
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as cell-mediated immune deficiency, may become evident only after a product is in use by the general population.

Cerebrovascular Disorder, Vasculitis
This is a report of a 79-year-old female patient (weight: NA) from CH. The patient developed the following symptoms/conditions: hypothalamo-pituitary disorder and was treated with Hydrocortisone (dosage: NA) starting NS. Concurrently used drugs:
  • Dexamethasone (3 X 8 Mg Iv)
Soon after that, the consumer experienced the following side effects:
  • Cerebrovascular Disorder
  • Vasculitis
This opens a possibility that Hydrocortisone treatment could cause the above reactions, including cerebrovascular disorder, and some female subjects may be more susceptible.


Swelling Face, Eye Swelling
A 70-year-old female patient (weight: NA) from US with the following symptoms/conditions: skin burning sensation started Hydrocortisone treatment (dosage: Apply Twice Daily Smear On Skin-burned) on Jan 24, 2014. Soon after starting Hydrocortisone treatment, the subject experienced various side effects, including:
  • Swelling Face
  • Eye Swelling
Concurrently used drugs:
  • Benadrly + Silver Sulfadine
  • Multi-vit
  • Calcium
  • D3
  • Niacin
  • Omega
This finding indicates that some female patients could be more vulnerable to Hydrocortisone.

Malaise, Product Quality Issue, Feeling Abnormal
A 38-year-old female patient from US (weight: NA) experienced symptoms, such as: addison^s disease and was treated with Hydrocortisone(dosage: 6 Pills A Day Three Times Daily). The treatment was initiated on Jan 01, 2014. After that a consumer reported the following side effect(s):
  • Malaise
  • Product Quality Issue
  • Feeling Abnormal
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Hydrocortisone efficacy: NA.

Pallor, Headache, Palpitations, Hypotension, Tachycardia, Nausea, Vomiting, Abdominal Pain
In this report, Hydrocortisone was administered for the following condition: asthma.A 10-year-old male consumer from PK (weight: NA) started Hydrocortisone treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Pallor
  • Headache
  • Palpitations
  • Hypotension
  • Tachycardia
  • Nausea
  • Vomiting
  • Abdominal Pain
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Hydrocortisone treatment could be related to the listed above side effect(s).

Erythema, Oedema, Wound Secretion, Conjunctivitis Bacterial, Fatigue, Steroid Withdrawal Syndrome
This is a report of the following Hydrocortisone side effect(s):
  • Erythema
  • Oedema
  • Wound Secretion
  • Conjunctivitis Bacterial
  • Fatigue
  • Steroid Withdrawal Syndrome
A 21-year-old female patient from GB (weight: NA) presented with the following condition: rash and received a treatment with Hydrocortisone (dosage: Sporadic For Problem Areas) starting: Apr 10, 2013.The following concurrently used drugs could have generated interactions:
  • Eumovate (Sporadic.)
This report suggests that a Hydrocortisone treatment could be associated with the listed above side effect(s).

Erythema, Oedema, Wound Secretion, Conjunctivitis Bacterial, Fatigue, Steroid Withdrawal Syndrome
This Hydrocortisone Sodium Succinate report was submitted by a 21-year-old female consumer from GB (weight: NA). The patient was diagnosed with: rash and Hydrocortisone Sodium Succinate was administered (dosage: Sporadic For Problem Areas) starting: Apr 10, 2013. The consumer developed a set of symptoms:
  • Erythema
  • Oedema
  • Wound Secretion
  • Conjunctivitis Bacterial
  • Fatigue
  • Steroid Withdrawal Syndrome
Other drugs used simultaneously:
  • Eumovate (Sporadic.)
Those unexpected symptoms could be linked to a Hydrocortisone Sodium Succinate treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Fatigue, Migraine, Loss Of Consciousness, Road Traffic Accident, Feeling Abnormal, Adrenocortical Insufficiency Acute
This is a report of a possible correlation between Hydrocortisone use and the following symptoms/side effect(s):
  • Fatigue
  • Migraine
  • Loss Of Consciousness
  • Road Traffic Accident
  • Feeling Abnormal
  • Adrenocortical Insufficiency Acute
which could contribute to an assessment of Hydrocortisone risk profile.A 52-year-old female consumer from US (weight: NA) was suffering from addison^s disease and was treated with Hydrocortisone (dosage: NA) starting NS.Other concurrent medications: NA.

Respiratory Arrest, Bronchospasm
A 57-year-old male patient from ZA (weight: NA) presented with the following symptoms: bronchospasm,asthma and after a treatment with Hydrocortisone Sodium Succinate (dosage: Unk) experienced the following side effect(s):
  • Respiratory Arrest
  • Bronchospasm
The treatment was started on NS. Hydrocortisone Sodium Succinate was used in combination with the following drugs:
  • Theophylline (Unk)
  • Salbutamol (Inhaler)
The patient was hospitalized.This report could alert potential Hydrocortisone Sodium Succinate consumers.

Respiratory Arrest, Bronchospasm
In this report, a 48-year-old male patient from ZA (weight: NA) was affected by a possible Hydrocortisone Sodium Succinate side effect.The patient was diagnosed with bronchospasm. After a treatment with Hydrocortisone Sodium Succinate (dosage: 400 Mg, Unk, start date: NS), the patient experienced the following side effect(s):
  • Respiratory Arrest
  • Bronchospasm
The following simultaneously used drugs could have led to this reaction:
  • Hexoprenaline
  • Theophylline (Unk)
The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Hydrocortisone Sodium Succinate treatment.

Cardiac Arrest
This is a report of a 25-year-old male patient from US (weight: NA), who used Hydrocortisone (dosage: NA) for a treatment of NA. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Cardiac Arrest
The following drugs could possibly have interacted with the Hydrocortisone treatment
  • Cytarabine
  • Topotecan (Day 0-4)
  • Vinorelbine (Day 0)
  • Vinorelbine (Day 7)
  • Vinorelbine (Day 14)
  • Thiotepa (Day 2)
  • Clofarabine (Days 3-7)
  • Dexamethasone
Taken together, these observations suggest that a Hydrocortisone treatment could be related to side effect(s), such as Cardiac Arrest.

Adrenocortical Insufficiency Acute
This adrenocortical insufficiency acute side effect was reported by a consumer or non-health professional from US. A 18-year-old female patient (weight:NA) experienced the following symptoms/conditions: adrenocortical insufficiency acute. The patient was prescribed Hydrocortisone (dosage: Different Set Amots Three Times Daily Taken By Mouth), which was started on Oct 01, 2009. Concurrently used drugs: NA. When starting to take Hydrocortisone the consumer reported the following symptoms:
  • Adrenocortical Insufficiency Acute
These side effects may potentially be related to Hydrocortisone.

Nausea, Vomiting, Pallor, Abdominal Pain, Palpitations, Headache, Eyelid Oedema, Lip Swelling, Tachycardia
This is a Hydrocortisone side effect report of a 10-year-old male patient (weight:NA) from PK, suffering from the following symptoms/conditions: asthma, who was treated with Hydrocortisone (dosage:NA, start time: 201209), combined with:
  • Salbutamol
  • Ipratropium
  • Montelukast
, and developed a serious reaction and a nausea side effect. The patient presented with:
  • Nausea
  • Vomiting
  • Pallor
  • Abdominal Pain
  • Palpitations
  • Headache
  • Eyelid Oedema
  • Lip Swelling
  • Tachycardia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Hydrocortisone treatment in male patients suffering from asthma, resulting in nausea.

Adrenal Insufficiency, Condition Aggravated, Product Substitution Issue
This report suggests a potential Hydrocortisone adrenal insufficiency side effect(s) that can have serious consequences. A 52-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): addison^s disease and used Hydrocortisone (dosage: Up To 10 Tablets A Day 5 Does A Day Taken By Mouth) starting NS. Soon after starting Hydrocortisone the patient began experiencing various side effects, including:
  • Adrenal Insufficiency
  • Condition Aggravated
  • Product Substitution Issue
Drugs used concurrently:
  • Cytomel
  • Klor-con
  • Progesterone
  • Bi-est Cream
  • Testosterone
  • Clonazepam(for Sleep Only Am Currently Tapering Off Of)
  • Magnesium
  • Vitamin C
Although Hydrocortisone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as adrenal insufficiency, may still occur.

Nausea, Vomiting, Pallor, Abdominal Pain, Palpitations, Headache, Tachycardia, Lip Swelling, Eye Swelling
This nausea problem was reported by a health professional from PK. A 10-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): asthma.On 201209 a consumer started treatment with Hydrocortisone (dosage: NA). The following drugs/medications were being taken at the same time:
  • Salbutamol
  • Ipratropium
  • Montelukast
When commencing Hydrocortisone, the patient experienced the following unwanted symptoms /side effects:
  • Nausea
  • Vomiting
  • Pallor
  • Abdominal Pain
  • Palpitations
  • Headache
  • Tachycardia
  • Lip Swelling
  • Eye Swelling
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as nausea, may become evident only after a product is in use by the general population.

Discomfort, Anxiety
This is a Hydrocortisone Valerate side effect report of a 10-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: eczema and was treated with Hydrocortisone Valerate (dosage: NA) starting Jan 09, 2013. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Discomfort
  • Anxiety
This opens a possibility that Hydrocortisone Valerate could cause discomfort and that some male patients may be more susceptible.

Cushingoid, Erythema, Weight Increased, Oral Mucosal Discolouration, Dehydration, Skin Atrophy, Malaise, Influenza
A 45-year-old female patient (weight: NA) from US with the following symptoms: blood cortisol abnormal started Hydrocortisone treatment (dosage: 5 Mg, Unk) on NS. Soon after starting Hydrocortisone treatment, the consumer experienced several side effects, including:
  • Cushingoid
  • Erythema
  • Weight Increased
  • Oral Mucosal Discolouration
  • Dehydration
  • Skin Atrophy
  • Malaise
  • Influenza
. Concurrently used drugs:
  • Prednisone (Unk)
This finding indicates that some patients can be more vulnerable to developing Hydrocortisone side effects, such as cushingoid.

Hypersensitivity, Vomiting, Abdominal Pain, Headache, Palpitations, Pallor, Eyelid Oedema, Lip Swelling, Tachycardia
This hypersensitivity side effect was reported by a health professional from PK. A 10-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Hydrocortisone (dosage: 100 Mg, Unk), which was started on NS. Concurrently used drugs:
  • Salbutamol
.When starting to take Hydrocortisone the consumer reported symptoms, such as:
  • Hypersensitivity
  • Vomiting
  • Abdominal Pain
  • Headache
  • Palpitations
  • Pallor
  • Eyelid Oedema
  • Lip Swelling
  • Tachycardia
These side effects may potentially be related to Hydrocortisone. The patient was hospitalized.

Anaphylactic Reaction, Respiratory Arrest, Bronchospasm
This is a report of a 21-year-old female patient (weight: NA) from ZA, suffering from the following symptoms/conditions: asthma, who was treated with Hydrocortisone Sodium Succinate (dosage: Unk, start time: NS), combined with:
  • Salbutamol (Unk)
  • Aminophylline (Unk)
  • Hexoprenaline (Unk)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Anaphylactic Reaction
  • Respiratory Arrest
  • Bronchospasm
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydrocortisone Sodium Succinate treatment in female patients, resulting in anaphylactic reaction side effect. The patient was hospitalized.

Respiratory Arrest, Bronchospasm, Cough
This report suggests a potential Hydrocortisone Sodium Succinate Respiratory Arrest, Bronchospasm, Cough side effect(s) that can have serious consequences. A 21-year-old female patient (weight: NA) from ZA was diagnosed with the following symptoms/conditions: NA and used Hydrocortisone Sodium Succinate (dosage: Unk) starting NS. Soon after starting Hydrocortisone Sodium Succinate the patient began experiencing various side effects, including:
  • Respiratory Arrest
  • Bronchospasm
  • Cough
Drugs used concurrently: NA.The patient was hospitalized. Although Hydrocortisone Sodium Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as respiratory arrest, may still occur.

Respiratory Arrest, Anaphylactic Reaction, Bronchospasm
This Respiratory Arrest, Anaphylactic Reaction, Bronchospasm problem was reported by a health professional from ZA. A 21-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Hydrocortisone Sodium Succinate (dosage: NA). The following drugs were being taken at the same time:
  • Salbutamol
  • Theophylline
When commencing Hydrocortisone Sodium Succinate, the patient experienced the following unwanted symptoms/side effects:
  • Respiratory Arrest
  • Anaphylactic Reaction
  • Bronchospasm
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as respiratory arrest, may become evident only after a product is in use by the general population.

Abdominal Pain Upper, Burning Sensation, Anxiety, Depression, Feeling Abnormal, Sleep Disorder, Tremor, Dizziness, Chills
This is a report of a 52-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: adrenal insufficiency and was treated with Hydrocortisone (dosage: 4 Pills 3 In Am, 1 In Aftn Taken By Mouth) starting Dec 05, 2013. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Abdominal Pain Upper
  • Burning Sensation
  • Anxiety
  • Depression
  • Feeling Abnormal
  • Sleep Disorder
  • Tremor
  • Dizziness
  • Chills
This opens a possibility that Hydrocortisone treatment could cause the above reactions, including abdominal pain upper, and some female subjects may be more susceptible.

Product Quality Issue
A 15-year-old male patient (weight: NA) from US with the following symptoms/conditions: NA started Hydrocortisone treatment (dosage: 1 Pill) on Sep 16, 2013. Soon after starting Hydrocortisone treatment, the subject experienced various side effects, including:
  • Product Quality Issue
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Hydrocortisone.

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Top 10 Hydrocortisone Side Effects for Women

Women Side EffectsReports
Nausea 21
Dyspnoea 20
Headache 19
Rash 18
Fatigue 17
Infusion Related Reaction 17
Asthenia 15
Abdominal Pain 14
Malaise 14
Erythema 13

Top 10 Hydrocortisone Side Effects for Men

Men Side EffectsReports
Malaise 31
Pyrexia 29
Blood Glucose Increased 17
Food Poisoning 17
Infusion Related Reaction 15
Nausea 15
Hyperglycaemia 14
Cataract 13
Pneumonia 13
Rash 13

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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