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Ifosfamide Side Effects

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Common Ifosfamide Side Effects


The most commonly reported Ifosfamide side effects (click to view or check a box to report):

Encephalopathy (70)
Febrile Neutropenia (61)
Confusional State (42)
Neurotoxicity (36)
Neutropenia (32)
Nausea (31)
Thrombocytopenia (28)
Vomiting (23)
Tremor (23)
Epistaxis (22)
Myoclonus (22)
Mental Status Changes (22)
Pyrexia (21)
Anaemia (20)
Disorientation (20)
Convulsion (20)
Bone Marrow Failure (19)
Renal Failure Acute (19)
Mucosal Inflammation (19)
Alopecia (18)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Ifosfamide Side Effects Reported to FDA



Ifosfamide Side Effect Report#9976097
Pleural Effusion, Pericardial Effusion, Pain, Back Pain, Paresis, Abasia, Metastases To Lung, Respiratory Disorder, Malignant Neoplasm Progression
This is a report of a 25-year-old female patient (weight: NA) from ES, suffering from the following health symptoms/conditions: metastases to lung,malignant fibrous histiocytoma, who was treated with Ifosfamide (dosage: NA, start time: NS), combined with:
  • Carboplatin
  • Etoposide
  • Doxorubicin
  • Docetaxel
  • Gemcitabine
  • Enalapril (20 Mg, Per Day)
and developed a serious reaction and side effect(s): Pleural Effusion, Pericardial Effusion, Pain, Back Pain, Paresis, Abasia, Metastases To Lung, Respiratory Disorder, Malignant Neoplasm Progression after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Ifosfamide treatment in female patients, resulting in Pleural Effusion side effect.
Ifosfamide Side Effect Report#9962015
Pain In Jaw, Odynophagia, Malnutrition, Abdominal Pain, Febrile Neutropenia, Sinusitis, Stomatitis, Chest Pain
This report suggests a potential Ifosfamide Pain In Jaw side effect(s) that can have serious consequences. A 53-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: rhabdomyosarcoma and used Ifosfamide (dosage: NA) starting
Jan 29, 2014. After starting Ifosfamide the patient began experiencing various side effects, including: Pain In Jaw, Odynophagia, Malnutrition, Abdominal Pain, Febrile Neutropenia, Sinusitis, Stomatitis, Chest PainAdditional drugs used concurrently:
  • Etoposide
The patient was hospitalized. Although Ifosfamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pain In Jaw, may still occur.
Ifosfamide Side Effect Report#9875716
Neutrophil Count Decreased, White Blood Cell Count Decreased
This Neutrophil Count Decreased problem was reported by a physician from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Ifosfamide (dosage: NA). The following drugs were being taken at the same time:
  • Paclitaxel (taxol)
When using Ifosfamide, the patient experienced the following unwanted symptoms/side effects: Neutrophil Count Decreased, White Blood Cell Count DecreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Neutrophil Count Decreased, may become evident only after a product is in use by the general population.
Ifosfamide Side Effect Report#9849073
Anaemia, Hyponatraemia, Hypomagnesaemia, Hypoalbuminaemia, Hypophosphataemia, Diabetes Mellitus Inadequate Control, Hypotension, Cellulitis, Wound Infection Staphylococcal
This Anaemia side effect was reported by a physician from US. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Ifosfamide (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Taxol
  • Dexamethasone 4mg/ml Injection
  • Lovenox 150mg/ml Sq
.After starting to take Ifosfamide the consumer reported adverse symptoms, such as: Anaemia, Hyponatraemia, Hypomagnesaemia, Hypoalbuminaemia, Hypophosphataemia, Diabetes Mellitus Inadequate Control, Hypotension, Cellulitis, Wound Infection StaphylococcalThese side effects may potentially be related to Ifosfamide. The patient was hospitalized.
Ifosfamide Side Effect Report#9803474
Post Procedural Cellulitis, Postoperative Wound Infection, Wound Infection Bacterial
This is a report of a 55-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Ifosfamide (dosage: NA, start time: NS), combined with:
  • Paclitaxel (taxol)
  • Dexamethasone
and developed a serious reaction and side effect(s): Post Procedural Cellulitis, Postoperative Wound Infection, Wound Infection Bacterial after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Ifosfamide treatment in female patients, resulting in Post Procedural Cellulitis side effect. The patient was hospitalized.
Ifosfamide Side Effect Report#9799446
Asthenia, Dysstasia, Hypophagia, Fluid Intake Reduced, Hallucination, Disorientation, Paranoia, Fear, Atelectasis
This report suggests a potential Ifosfamide Asthenia side effect(s) that can have serious consequences. A 65-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Ifosfamide (dosage: NA) starting NS. After starting Ifosfamide the patient began experiencing various side effects, including: Asthenia, Dysstasia, Hypophagia, Fluid Intake Reduced, Hallucination, Disorientation, Paranoia, Fear, AtelectasisAdditional drugs used concurrently:
  • Paclitaxel (taxol)
The patient was hospitalized. Although Ifosfamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Asthenia, may still occur.
Ifosfamide Side Effect Report#9799444
Klebsiella Infection, Culture Urine Positive, Pyrexia
This Klebsiella Infection problem was reported by a health professional from US. A 67-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Ifosfamide (dosage: NA). The following drugs were being taken at the same time:
  • Paclitaxel (taxol)
  • Asa
  • Mesna
When using Ifosfamide, the patient experienced the following unwanted symptoms/side effects: Klebsiella Infection, Culture Urine Positive, PyrexiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Klebsiella Infection, may become evident only after a product is in use by the general population.
Ifosfamide Side Effect Report#9799442
Ventricular Tachycardia, Unresponsive To Stimuli, Cardiac Arrest
This Ventricular Tachycardia side effect was reported by a physician from US. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Ifosfamide (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Paclitaxel (taxol)
  • Pegfilgrastim (neulasta)
.After starting to take Ifosfamide the consumer reported adverse symptoms, such as: Ventricular Tachycardia, Unresponsive To Stimuli, Cardiac ArrestThese side effects may potentially be related to Ifosfamide. The patient was hospitalized.
Ifosfamide Side Effect Report#9798135
Asthenia, Dysstasia, Hypophagia, Fluid Intake Reduced, Atelectasis, Lung Infiltration, Deep Vein Thrombosis, Confusional State, Psychotic Disorder
This is a report of a 65-year-old female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: NA, who was treated with Ifosfamide (dosage: NA, start time: NS), combined with:
  • Paclitaxel (taxol)
and developed a serious reaction and side effect(s): Asthenia, Dysstasia, Hypophagia, Fluid Intake Reduced, Atelectasis, Lung Infiltration, Deep Vein Thrombosis, Confusional State, Psychotic Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Ifosfamide treatment in female patients, resulting in Asthenia side effect. The patient was hospitalized.
Ifosfamide Side Effect Report#9793091
This report suggests a potential Ifosfamide Death side effect(s) that can have serious consequences. A 65-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Ifosfamide (dosage: NA) starting NS. After starting Ifosfamide the patient began experiencing various side effects, including:Additional drugs used concurrently:
  • Paclitaxel
  • Pegfilgrastim
Although Ifosfamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Ifosfamide Side Effect Report#9787714
Encephalopathy, Tinnitus, Dizziness, Deafness Bilateral, Cerebellar Syndrome, Neurotoxicity
This Encephalopathy problem was reported by a health professional from Country Not Specified. A 17-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: osteosarcoma. On NS this consumer started treatment with Ifosfamide (dosage: 3000 Mg/m2, 1 D). The following drugs were being taken at the same time:
  • Methotrexate (methotrexate) (methotrexate) (12000 Mg/m2)
  • Folinic Acid (folinic Acid)
  • Uromitexan (mesna)
When using Ifosfamide, the patient experienced the following unwanted symptoms/side effects: Encephalopathy, Tinnitus, Dizziness, Deafness Bilateral, Cerebellar Syndrome, NeurotoxicityAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Encephalopathy, may become evident only after a product is in use by the general population.
Ifosfamide Side Effect Report#9781366
Toxicity To Various Agents, Confusional State, Dysarthria, Eating Disorder, Nervous System Disorder
This Toxicity To Various Agents side effect was reported by a pharmacist from US. A 72-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Ifosfamide (drug dosage: NA), which was initiated on
Dec 08, 2013. Concurrently used drugs: NA..After starting to take Ifosfamide the consumer reported adverse symptoms, such as: Toxicity To Various Agents, Confusional State, Dysarthria, Eating Disorder, Nervous System DisorderThese side effects may potentially be related to Ifosfamide.
Ifosfamide Side Effect Report#9733368
Myocardial Infarction
This is a report of a 60-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Ifosfamide (dosage: NA, start time: NS), combined with:
  • Paclitaxel (taxol)
  • Pegfilgrastim (neulasta)
and developed a serious reaction and side effect(s): Myocardial Infarction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Ifosfamide treatment in female patients, resulting in Myocardial Infarction side effect. The patient was hospitalized.
Ifosfamide Side Effect Report#9733335
Blood Count Abnormal
This report suggests a potential Ifosfamide Blood Count Abnormal side effect(s) that can have serious consequences. A 65-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Ifosfamide (dosage: NA) starting NS. After starting Ifosfamide the patient began experiencing various side effects, including: Blood Count AbnormalAdditional drugs used concurrently:
  • Paclitaxel (taxol)
  • Pegfilgrastim (neulasta)
Although Ifosfamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Blood Count Abnormal, may still occur.
Ifosfamide Side Effect Report#9716359
Nausea, Vomiting, Diarrhoea, Asthenia, Abdominal Pain Upper
This Nausea problem was reported by a consumer or non-health professional from US. A 67-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Ifosfamide (dosage: NA). The following drugs were being taken at the same time:
  • Paclitaxel (taxol)
  • Pegfilgrastim (neulasta)
  • Asa
  • Mesna
  • Metoprolol
When using Ifosfamide, the patient experienced the following unwanted symptoms/side effects: Nausea, Vomiting, Diarrhoea, Asthenia, Abdominal Pain UpperThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Nausea, may become evident only after a product is in use by the general population.
Ifosfamide Side Effect Report#9690390
Anaemia, Hypotension, Renal Failure Acute, Hypovolaemia
This Anaemia side effect was reported by a consumer or non-health professional from Country Not Specified. A 57-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Ifosfamide (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Paclitaxel
.After starting to take Ifosfamide the consumer reported adverse symptoms, such as: Anaemia, Hypotension, Renal Failure Acute, HypovolaemiaThese side effects may potentially be related to Ifosfamide. The patient was hospitalized.
Ifosfamide Side Effect Report#9688900
Affect Lability, Hallucinations, Mixed, Mental Status Changes, Neurotoxicity
This is a report of a 41-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: sarcoma uterus, who was treated with Ifosfamide (dosage: 1500 Mg/m2, Daily Over 90 Min, start time: NS), combined with:
  • Cisplatin (20 Mg/m2)
  • Aprepitant
  • Mesna (mesna)
  • Dexamethasone (dexamethasone)
and developed a serious reaction and side effect(s): Affect Lability, Hallucinations, Mixed, Mental Status Changes, Neurotoxicity after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Ifosfamide treatment in female patients, resulting in Affect Lability side effect. The patient was hospitalized.
Ifosfamide Side Effect Report#9688898
Nausea, Vomiting, Febrile Neutropenia, Coma, Neurotoxicity
This report suggests a potential Ifosfamide Nausea side effect(s) that can have serious consequences. A 67-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: ovarian cancer and used Ifosfamide (dosage: 1500 Mg/m2, Daily Over 90 Min, Intravenous) starting NS. After starting Ifosfamide the patient began experiencing various side effects, including: Nausea, Vomiting, Febrile Neutropenia, Coma, NeurotoxicityAdditional drugs used concurrently:
  • Cisplatin (20 Mg/m2)
  • Aprepitant
  • Mesna (mesna)
  • Ondansetron (ondansetron)
  • Dexamethasone (desamethasone)
  • Metoclopramide (metoclopramide)
The patient was hospitalized. Although Ifosfamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Nausea, may still occur.
Ifosfamide Side Effect Report#9672238
Pulmonary Embolism, Bone Marrow Failure
This Pulmonary Embolism problem was reported by a consumer or non-health professional from CN. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: angiosarcoma. On
Nov 05, 2010 this consumer started treatment with Ifosfamide (dosage: Days 1-4). The following drugs were being taken at the same time:
  • Epirubicin
  • Bevacizumab (Day 1 Repeated Every 2)
  • Mesna (mesna)
  • Placitaxel (placitaxel)
  • Cisplatin (cisplatin)
When using Ifosfamide, the patient experienced the following unwanted symptoms/side effects: Pulmonary Embolism, Bone Marrow FailureAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pulmonary Embolism, may become evident only after a product is in use by the general population.
Ifosfamide Side Effect Report#9664763
Neutropenic Sepsis, Nail Disorder
This Neutropenic Sepsis side effect was reported by a health professional from TW. A 54-year-old female patient (weight:NA) experienced the following symptoms/conditions: uterine cancer,metastases to lung.The patient was prescribed Ifosfamide (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Ifosfamide the consumer reported adverse symptoms, such as: Neutropenic Sepsis, Nail DisorderThese side effects may potentially be related to Ifosfamide.
Ifosfamide Side Effect Report#9651472
Neutropenic Sepsis, Nail Ridging
This is a report of a 54-year-old female patient (weight: NA) from TW, suffering from the following health symptoms/conditions: uterine cancer,metastases to lung, who was treated with Ifosfamide (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Neutropenic Sepsis, Nail Ridging after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Ifosfamide treatment in female patients, resulting in Neutropenic Sepsis side effect.
Ifosfamide Side Effect Report#9649085
Neutropenic Sepsis, Nail Disorder
This report suggests a potential Ifosfamide Neutropenic Sepsis side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from TW was diagnosed with the following symptoms/conditions: uterine cancer and used Ifosfamide (dosage: NA) starting NS. After starting Ifosfamide the patient began experiencing various side effects, including: Neutropenic Sepsis, Nail DisorderAdditional drugs used concurrently:
  • Paclitaxel
Although Ifosfamide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Neutropenic Sepsis, may still occur.
Ifosfamide Side Effect Report#9648463
Tremor, Gait Disturbance, Mental Status Changes
This Tremor problem was reported by a physician from US. A 61-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: crohn^s disease. On NS this consumer started treatment with Ifosfamide (dosage: NA). The following drugs were being taken at the same time:
  • Doxorubicin
  • Calcium Carbonate
  • Vitamin D Nos
  • Ciprofloxacin
  • Dexamethasone
  • Docusate Sodium
  • Lorazepam
  • Mesna
When using Ifosfamide, the patient experienced the following unwanted symptoms/side effects: Tremor, Gait Disturbance, Mental Status ChangesThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Tremor, may become evident only after a product is in use by the general population.
Ifosfamide Side Effect Report#9614905
Hypotension, Syncope
This Hypotension side effect was reported by a consumer or non-health professional from Country Not Specified. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Ifosfamide (drug dosage: 9225 Mg), which was initiated on NS. Concurrently used drugs:
  • Paclitaxel (260mg)
  • Amlodipine
  • Diovan
.After starting to take Ifosfamide the consumer reported adverse symptoms, such as: Hypotension, SyncopeThese side effects may potentially be related to Ifosfamide. The patient was hospitalized.
Ifosfamide Side Effect Report#9608729
Abdominal Pain, Constipation, Asthenia, Tachycardia, Haemoglobin Decreased
This is a report of a 62-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Ifosfamide (dosage: NA, start time: NS), combined with:
  • Paclitaxel
and developed a serious reaction and side effect(s): Abdominal Pain, Constipation, Asthenia, Tachycardia, Haemoglobin Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Ifosfamide treatment in female patients, resulting in Abdominal Pain side effect. The patient was hospitalized.


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The appearance of Ifosfamide on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Ifosfamide Side Effects for Women?

Women Side EffectsReports
Encephalopathy 35
Febrile Neutropenia 32
Confusional State 23
Neurotoxicity 18
Neutropenia 18
Alopecia 17
Mental Status Changes 17
Nausea 17
Anaemia 14
Epistaxis 14

What are common Ifosfamide Side Effects for Men?

Men Side EffectsReports
Encephalopathy 35
Febrile Neutropenia 29
Confusional State 19
Thrombocytopenia 19
Neurotoxicity 17
Bone Marrow Failure 16
Pyrexia 15
Convulsion 14
Myoclonus 14
Nausea 14

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Ifosfamide reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Ifosfamide Safety Alerts, Active Ingredients, Usage Information

    NDC0069-4495
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameIfosfamide
    NameIfosfamide
    Dosage FormINJECTION, SOLUTION
    RouteINTRAVENOUS
    On market since20121127
    LabelerPfizer Laboratories Div Pfizer Inc.
    Active Ingredient(s)IFOSFAMIDE
    Strength(s)50
    Unit(s)mg/mL
    Pharma ClassAlkylating Activity [MoA],Alkylating Drug [EPC]

    More About Ifosfamide

    Side Effects reported to FDA: 570

    Ifosfamide safety alerts: No

    Reported deaths: 80

    Reported hospitalizations: 257

    Latest Ifosfamide clinical trials

    Ifosfamide Reviews

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