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Imipram Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 172 

Cellulitis, Injection Site Pain (8075379-2)
on Jan 25, 2012 Female from UNITED STATES , 57 years of age, was treated with Imipramine Hcl. Directly after, patient experienced the unwanted or unexpected Imipram side effects: cellulitis, injection site pain. Imipramine Hcl dosage: 50 Mg, Unk.
Associated medications used:
  • Gabapentin (100 Mg, Unk)
  • Vitamin D (5000 Iu, Unk)
  • Ascorbic Acid (100 Mg, Unk)
  • Calcium (600 Tab)
  • Vitamin D
  • Betaseron (.3 Mg, Unk)
  • Fosamax (10 Mg, Unk)
  • Nitrofurantoin (100 Mg, Unk)


Cardio-respiratory Arrest (8063180-5)
Patient was taking Imipramine. Patient felt the following Imipram side effects: cardio-respiratory arrest on Jan 03, 2012 from UNITED STATES Additional patient health information: Female , 62 years of age, . Imipramine dosage: Oral.
Multiple prescriptions taken:
  • Bupropion Hydrochloride (Oral)
  • Diphenhydramine Hydrochloride (Oral)


Cardiac Arrest, Poisoning, Respiratory Arrest (8060050-3)
Adverse event was reported on Dec 27, 2011 by a Female taking Imipramine (Dosage: (df Oral)) . Location: UNITED STATES , 62 years of age, After Imipram was administered, patient encountered several Imipram side effects: cardiac arrest, poisoning, respiratory arrest.
Multiple concurrent drugs taken:
  • Bupropion Hydrochloride ((df Oral))
  • Diphenhydramine Hcl ((df Oral))
  • Temazepam ((df Oral))
  • Trazodone Hcl ((df Oral))
  • Laxative (not Specified) ((df Oral))
  • Muscle Relaxants ((df Oral))


Completed Suicide, Cardio-respiratory Arrest (8058391-9)
on Jan 04, 2012 Male from UNITED STATES , 39 years of age, was treated with Imipramine Pamoate. Directly after, patient experienced the unwanted or unexpected Imipram side effects: completed suicide, cardio-respiratory arrest. Imipramine Pamoate dosage: N/A.
Associated medications used:
  • Zolpidem



Psychotic Disorder, Paranoia, Hallucination, Auditory (8058147-7)
on Jan 09, 2012 Female from CANADA , 54 years of age, was treated with Imipramine Hcl Tab. Patient felt the following Imipram side effects: psychotic disorder, paranoia, hallucination, auditory. Imipramine Hcl Tab dosage: 25.0 Mg/bid Po.
Multiple prescriptions taken:
  • Plavix (75.0 Mg/daily Po)
  • Tab Domperidone (10 Mg/bid Po)
  • Mavik (2.0 Mg/daily Po)
  • Pantoprazole (40.0 Mg/daily Unk)
  • Sucralfate (1000.0 Mg/bid Unk)
  • Desloratadine (5.0 Mg/daily Unk)
  • Zetia (10 Mg/daily Po)
  • Crestor (20 Mg/daily Po)
Patient was hospitalized.

Nausea, Somnolence, Hallucination, Asthenia, Fatigue (8053052-4)
Patient was taking Imipramine Hcl. After Imipram was administered, patient encountered several Imipram side effects: nausea, somnolence, hallucination, asthenia, fatigue on Oct 21, 2010 from UNITED STATES Additional patient health information: Female , 53 years of age, was diagnosed with
  • narcolepsy
  • cataplexy
and. Imipramine Hcl dosage: 10 Mg, At Night, Oral 5mg At 9:30am, 30mg At 12:30pm And 25mg At 3:30pm, Oral.

Cholecystitis, Anxiety, Deep Vein Thrombosis, Pulmonary Embolism, Fear, Pain, Anhedonia, Injury, Quality Of Life Decreased (8048239-0)
Adverse event was reported on Jan 09, 2012 by a Female taking Imipramine (Dosage: N/A) . Location: UNITED STATES , 24 years of age, weighting 165.3 lb, Directly after, patient experienced the unwanted or unexpected Imipram side effects: cholecystitis, anxiety, deep vein thrombosis, pulmonary embolism, fear, pain, anhedonia, injury, quality of life decreased.
Associated medications used:
  • Nasalide
  • Yasmin (Unk)
  • Guaifen-pse
  • Wellbutrin
Patient was hospitalized.

Toxicity To Various Agents (8037732-2)
on Jan 02, 2012 Female from UNITED STATES , 62 years of age, was treated with Imipramine. Patient felt the following Imipram side effects: toxicity to various agents. Imipramine dosage: Unk.
Multiple prescriptions taken:
  • Bupropion Hydrochloride (Unk)
  • Diphenhydramine Hcl (Unk)
  • Trazodone Hcl (Unk)
  • Laxative (Unk)
  • Muscle Relaxants (Unk)


Cardiac Failure Congestive, Coronary Artery Disease, Cardiomyopathy, Dehydration, Acute Myocardial Infarction, Asthenia, Hypotension (8027282-1)
on Jan 05, 2012 Female from UNITED STATES , 75 years of age, was treated with Imipramine. After Imipram was administered, patient encountered several Imipram side effects: cardiac failure congestive, coronary artery disease, cardiomyopathy, dehydration, acute myocardial infarction, asthenia, hypotension. Imipramine dosage: N/A.
Multiple concurrent drugs taken:
  • Premarin
  • Acyclovir
  • Alendronate Sodium
  • Omeprazole
  • Revlimid (15 Mg Every Other Day Orally 2-3 Days)
  • Hydrocodone Bitartrate And Acetaminophen
  • Aspirin
  • Medroxyprogesterone
Patient was hospitalized.

Hallucination, Visual, Fear, Stress, Depression (8011257-2)
Patient was taking Imipramine. Directly after, patient experienced the unwanted or unexpected Imipram side effects: hallucination, visual, fear, stress, depression on Dec 27, 2011 from UNITED STATES Additional patient health information: Male , 13 years of age, weighting 130.0 lb, was diagnosed with
  • enuresis
and. Imipramine dosage: N/A.

Completed Suicide, Toxicity To Various Agents (7996469-6)
Adverse event was reported on Dec 16, 2011 by a Male taking Imipramine (Dosage: N/A) . Location: UNITED STATES , 38 years of age, Patient felt the following Imipram side effects: completed suicide, toxicity to various agents.
Multiple prescriptions taken:
  • Atenolol
  • Amlodipine
  • Lisinopril
  • Ethanol


Cerebellar Syndrome, Fall, Salivary Hypersecretion, Dysarthria, Speech Disorder, Aphasia, Dysphagia, Asthenia, Weight Decreased (7964151-7)
on Nov 18, 2011 Male from UNITED KINGDOM , 50 years of age, was treated with Imipramine. After Imipram was administered, patient encountered several Imipram side effects: cerebellar syndrome, fall, salivary hypersecretion, dysarthria, speech disorder, aphasia, dysphagia, asthenia, weight decreased. Imipramine dosage: N/A.
Multiple concurrent drugs taken:
  • Fluoxetine (fuoxetine)
  • Olanzapine
  • Effexor (37.5 Mg;qd 75 Mg;qd 112.5 Mg;qd 187.5 Mg;qd)
  • Effexor (37.5 Mg;qd 75 Mg;qd 112.5 Mg;qd 187.5 Mg;qd)
  • Effexor (37.5 Mg;qd 75 Mg;qd 112.5 Mg;qd 187.5 Mg;qd)
  • Effexor (37.5 Mg;qd 75 Mg;qd 112.5 Mg;qd 187.5 Mg;qd)
  • Effexor (37.5 Mg;qd 75 Mg;qd 112.5 Mg;qd 187.5 Mg;qd)
  • Effexor (37.5 Mg;qd 75 Mg;qd 112.5 Mg;qd 187.5 Mg;qd)
Patient was hospitalized.

Insomnia, Irritability (7962086-7)
on Sep 20, 2011 Female from UNITED STATES , 48 years of age, was treated with Imipramine. Directly after, patient experienced the unwanted or unexpected Imipram side effects: insomnia, irritability. Imipramine dosage: N/A.
Associated medications used:
  • Ambien
  • Viibryd (10 Mg (10 Mg, 1 In 1 D), Oral)
  • Neurontin


Suicidal Ideation, Withdrawal Syndrome, Homicidal Ideation (7959079-2)
Patient was taking Imipramine. Patient felt the following Imipram side effects: suicidal ideation, withdrawal syndrome, homicidal ideation on Dec 06, 2011 from UNITED STATES Additional patient health information: Female , 34 years of age, weighting 118.0 lb, was diagnosed with
  • anxiety
and. Imipramine dosage: 75 Mg. Patient was hospitalized.

Coordination Abnormal, Muscle Spasms, Salivary Hypersecretion, Weight Decreased, Clumsiness, Cerebellar Syndrome, Balance Disorder, Dysarthria, Speech Disorder (7953286-0)
Adverse event was reported on Nov 18, 2011 by a Male taking Imipramine (Dosage: N/A) was diagnosed with
  • anxiety
  • depression
and. Location: UNITED KINGDOM , 50 years of age, After Imipram was administered, patient encountered several Imipram side effects: coordination abnormal, muscle spasms, salivary hypersecretion, weight decreased, clumsiness, cerebellar syndrome, balance disorder, dysarthria, speech disorder. Patient was hospitalized.

Overdose, Ventricular Tachycardia, Somnolence (7905432-2)
on Oct 27, 2011 Female from JAPAN , 32 years of age, was treated with Imipramine. Directly after, patient experienced the unwanted or unexpected Imipram side effects: overdose, ventricular tachycardia, somnolence. Imipramine dosage: Total Dose 3650mg (146 Tablets).
Associated medications used:
  • Flunitrazepam (Total Dose 20mg (10 Tablets))
  • Triazolam (Total Dose 3.25mg (13 Tablets))
  • Cloxazolam (Total Dose 172mg (172 Tablets))
  • Bromazepam (Total Dose 50mg (10 Tablets))
Patient was hospitalized.

Left Ventricular Hypertrophy (7878035-6)
on Oct 18, 2011 Patient from UNITED STATES , child 11 years of age, was treated with Imipramine. Patient felt the following Imipram side effects: left ventricular hypertrophy. Imipramine dosage: Unk, Unk.
Multiple prescriptions taken:
  • Risperidone (Unk, Unk)
  • Sertraline Hydrochloride (Unk ,unk)


Completed Suicide (7829685-4)
Patient was taking Imipramine. After Imipram was administered, patient encountered several Imipram side effects: completed suicide on Oct 10, 2011 from UNITED STATES Additional patient health information: Patient , 38 years of age, . Imipramine dosage: Unk, Unk.
Multiple concurrent drugs taken:
  • Naproxen (Unk, Unk)
  • Trazodone Hydrochloride (Unk, Unk)


Angle Closure Glaucoma, Headache, Anxiety Disorder (7826997-5)
Adverse event was reported on Oct 06, 2011 by a Female taking Imipramine (Dosage: 25 Mg (25 Mg,1 In 1 D)) was diagnosed with
  • anxiety disorder
  • depression
and. Location: , 55 years of age, Directly after, patient experienced the unwanted or unexpected Imipram side effects: angle closure glaucoma, headache, anxiety disorder. Patient was hospitalized.

Impaired Healing, Fracture Displacement, Femur Fracture, Pathological Fracture, Anaemia Postoperative, Vomiting, Fall, Arthralgia, Emotional Distress (7815032-0)
on Sep 30, 2011 Female from UNITED STATES , 82 years of age, was treated with Imipramine. Patient felt the following Imipram side effects: impaired healing, fracture displacement, femur fracture, pathological fracture, anaemia postoperative, vomiting, fall, arthralgia, emotional distress. Imipramine dosage: N/A.
Multiple prescriptions taken:
  • Alprazolam
  • Actonel (35 Mg Once Weekly, Oral)
  • Fosamax (10 Mg Daily, Oral)
  • Aspirin
  • Cozaar
  • Glucosamine
  • Clobetasol 0.05% (clobetasol Propionate)
  • Detrol La
Patient was hospitalized.

Angle Closure Glaucoma, Pupillary Light Reflex Tests Abnormal, Vision Blurred, Intraocular Pressure Increased (7793428-3)
on Sep 23, 2011 Female from UNITED KINGDOM , 55 years of age, was treated with Imipramine. After Imipram was administered, patient encountered several Imipram side effects: angle closure glaucoma, pupillary light reflex tests abnormal, vision blurred, intraocular pressure increased. Imipramine dosage: 25 Mg, Qd.
Multiple concurrent drugs taken:
  • Levothyroxine Sodium
  • Citalopram Hydrobromide (20 Mg, Qd)
Patient was hospitalized.

Insomnia (7772536-7)
Patient was taking Imipramine Hcl. Directly after, patient experienced the unwanted or unexpected Imipram side effects: insomnia on Nov 04, 2010 from UNITED STATES Additional patient health information: Male , weighting 200.0 lb, . Imipramine Hcl dosage: N/A.
Associated medications used:
  • Lisinopril And Hydrochlorothiazide (10/12.5)
  • Alprazolam
  • Oxycodone Hcl
  • Seroquel Xr


Anaphylactic Shock, Cardio-respiratory Arrest (7763640-8)
Adverse event was reported on Sep 14, 2011 by a Female taking Imipramine (Dosage: N/A) . Location: UNITED STATES , 47 years of age, Patient felt the following Imipram side effects: anaphylactic shock, cardio-respiratory arrest.
Multiple prescriptions taken:
  • Tysabri
  • Vitamin D
  • Ultracet
  • Proventil
  • Proventil
  • Lunesta
  • Fosamax
  • Clonazepam


Angle Closure Glaucoma, Pupillary Reflex Impaired, Headache, Vision Blurred, Anxiety Disorder, Hyperthyroidism (7755584-2)
on Aug 18, 2011 Female from , 55 years of age, was diagnosed with
  • depression
  • anxiety disorder
and was treated with Imipramine. After Imipram was administered, patient encountered several Imipram side effects: angle closure glaucoma, pupillary reflex impaired, headache, vision blurred, anxiety disorder, hyperthyroidism. Imipramine dosage: 25 Mg (25 Mg, 1 In 1 D). Patient was hospitalized.

Hypercholesterolaemia, Sleep Paralysis, Fungal Infection, Back Pain, Myocardial Infarction, Abnormal Dreams, Hyperhidrosis, Phlebitis (7755370-3)
on Aug 25, 2011 Male from BELGIUM , 63 years of age, weighting 165.3 lb, was treated with Imipramine Hydrochloride. Directly after, patient experienced the unwanted or unexpected Imipram side effects: hypercholesterolaemia, sleep paralysis, fungal infection, back pain, myocardial infarction, abnormal dreams, hyperhidrosis, phlebitis. Imipramine Hydrochloride dosage: N/A.
Associated medications used:
  • Modafinil
  • Xyrem (See Image)
  • Xyrem (See Image)
  • Xyrem (See Image)
  • Xyrem (See Image)
  • Xyrem (See Image)
  • Clomipramine Hydrochloride
Patient was hospitalized.

Showing 1-25 of 172 

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Imipram Information

Alternative IMIPRAM Names:SURMONTIL TOFRANIL TOFRANIL-PM

Active Ingredient: IMIPRAMIN TRIMIPRAM

More About Imipram

Side Effects reported to FDA: 172. View Imipram Adverse Reports

Imipram safety alerts: No

Reported deaths: 40

Reported hospitalizations: 36

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