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Imipramine Side Effects

Common Imipramine Side Effects


The most commonly reported Imipramine side effects (click to view or check a box to report):

Completed Suicide (40)
Overdose (22)
Cardio-respiratory Arrest (17)
Suicide Attempt (15)
Depression (11)
Death (10)
Anxiety (9)
Headache (9)
Asthenia (7)
Dizziness (7)
Fatigue (7)
Suicidal Ideation (7)
Somnolence (7)
Toxicity To Various Agents (7)
Ventricular Tachycardia (6)
Memory Impairment (6)
Confusional State (6)
Convulsion (6)
Cardiac Arrest (6)
Dysarthria (6)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Imipramine Side Effects Reported to FDA

The following Imipramine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Imipramine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

This is a report of a 79-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Imipramine Pamoate (dosage: Unk, start time: NS), combined with:
  • Fluoxetine (Unk)
and developed a serious reaction and side effect(s). The consumer presented with:
    which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Imipramine Pamoate treatment in female patients, resulting in death side effect.

    Completed Suicide
    This report suggests a potential Imipramine Pamoate Completed Suicide side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Imipramine Pamoate (dosage: NA) starting NS. Soon after starting Imipramine Pamoate the patient began experiencing various side effects, including:
    • Completed Suicide
    Drugs used concurrently:
    • Hydrocodone/acetaminophen
    • Atropine W/diphenoxylate
    Although Imipramine Pamoate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as completed suicide, may still occur.

    Cardio-respiratory Arrest
    This Cardio-respiratory Arrest problem was reported by a pharmacist from US. A 29-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Imipramine Pamoate (dosage: NA). The following drugs were being taken at the same time:
    • Cocaine
    • Ethanol
    • Lisdexamfetamine
    • Risperidone
    • Acetaminophen
    • Cephalexin
    When commencing Imipramine Pamoate, the patient experienced the following unwanted symptoms/side effects:
    • Cardio-respiratory Arrest
    Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as cardio-respiratory arrest, may become evident only after a product is in use by the general population.


    This is a report of a 79-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED. The patient developed the following symptoms/conditions: NA and was treated with Imipramine (dosage: NA) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
      This opens a possibility that Imipramine treatment could cause the above reactions, including death, and some female subjects may be more susceptible.


      Nausea
      A 67-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED with the following symptoms/conditions: pain started Imipramine Pamoate treatment (dosage: 20 Mg) on NS. Soon after starting Imipramine Pamoate treatment, the subject experienced various side effects, including:
      • Nausea
      Concurrently used drugs:
      • Oxycodone
      • Gabapentin
      This finding indicates that some female patients could be more vulnerable to Imipramine Pamoate.

      Nausea
      A 68-year-old male patient from COUNTRY NOT SPECIFIED (weight: NA) experienced symptoms, such as: pain and was treated with Imipramine Pamoate(dosage: 20 Mg). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
      • Nausea
      Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Imipramine Pamoate efficacy:
      • Oxycodone
      • Gabapentin



      In this report, Imipramine was administered for the following condition: NA.A 53-year-old female consumer from US (weight: NA) started Imipramine treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
        A possible interaction with other drugs could have contributed to this reaction:
        • Diazepam
        Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Imipramine treatment could be related to the listed above side effect(s).

        Cardio-respiratory Arrest
        This is a report of the following Imipramine side effect(s):
        • Cardio-respiratory Arrest
        A 29-year-old female patient from US (weight: NA) presented with the following condition: NA and received a treatment with Imipramine (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions:
        • Risperidone
        • Cocaine
        • Ethanol
        • Lisdexamfetamine
        • Acetaminophen
        • Vitamins(multiple)
        • Cephalexin /00145501/
        This report suggests that a Imipramine treatment could be associated with the listed above side effect(s).

        Toxicity To Various Agents
        This Imipramine report was submitted by a 79-year-old female consumer from US (weight: NA). The patient was diagnosed with: NA and Imipramine was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
        • Toxicity To Various Agents
        Other drugs used simultaneously:
        • Fluoxetine
        Those unexpected symptoms could be linked to a Imipramine treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

        Completed Suicide
        This is a report of a possible correlation between Imipramine use and the following symptoms/side effect(s):
        • Completed Suicide
        which could contribute to an assessment of Imipramine risk profile.A 64-year-old female consumer from US (weight: NA) was suffering from NA and was treated with Imipramine (dosage: NA) starting NS.Other concurrent medications:
        • Zolpidem Tartrate Er
        • Diphenoxylate Hci + Atropine Sulfate
        • Acetaminophen W/hydrocodone


        Stupor, Memory Impairment, Vision Blurred, Somnolence, Dizziness, Paraesthesia, Tinnitus, Constipation, Confusional State
        A 85-year-old female patient from US (weight: NA) presented with the following symptoms: incontinence and after a treatment with Imipramine (dosage: NA) experienced the following side effect(s):
        • Stupor
        • Memory Impairment
        • Vision Blurred
        • Somnolence
        • Dizziness
        • Paraesthesia
        • Tinnitus
        • Constipation
        • Confusional State
        The treatment was started on NS. Imipramine was used in combination with the following drugs: NA.This report could alert potential Imipramine consumers.

        Hyperaesthesia, Depression, Apathy, Fatigue, Dyskinesia
        In this report, a 51-year-old male patient from JP (weight: NA) was affected by a possible Imipramine side effect.The patient was diagnosed with depression. After a treatment with Imipramine (dosage: 150 Mg/day For 4 Years, start date: NS), the patient experienced the following side effect(s):
        • Hyperaesthesia
        • Depression
        • Apathy
        • Fatigue
        • Dyskinesia
        The following simultaneously used drugs could have led to this reaction: NA.The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Imipramine treatment.

        Tinnitus, Product Substitution Issue
        This is a report of a 67-year-old female patient from US (weight: NA), who used Imipramine (dosage: 4 Pills At Bedtime Taken By Mouth) for a treatment of depression. After starting a treatment on Apr 23, 2013, the patient experienced the following side effect(s):
        • Tinnitus
        • Product Substitution Issue
        The following drugs could possibly have interacted with the Imipramine treatment NA.Taken together, these observations suggest that a Imipramine treatment could be related to side effect(s), such as Tinnitus, Product Substitution Issue.

        Neuroleptic Malignant Syndrome, Respiratory Failure
        This neuroleptic malignant syndrome side effect was reported by a health professional from COUNTRY NOT SPECIFIED. A 57-year-old male patient (weight:NA) experienced the following symptoms/conditions: frontotemporal dementia. The patient was prescribed Imipramine Pamoate (dosage: 75 Mg), which was started on NS. Concurrently used drugs:
        • Lorazepam (15 Mg)
        • Aripiprazole (15 Mg)
        • Lormetazepam (2 Mg)
        When starting to take Imipramine Pamoate the consumer reported the following symptoms:
        • Neuroleptic Malignant Syndrome
        • Respiratory Failure
        The patient was hospitalized. These side effects may potentially be related to Imipramine Pamoate.

        Memory Impairment, Dysarthria, Headache, Muscular Weakness, Balance Disorder
        This is a Imipramine side effect report of a 44-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: hypertonic bladder, who was treated with Imipramine (dosage:1 Tablet, Three Times Daily, Taken By Mouth, start time: Oct 22, 2013), combined with: NA., and developed a serious reaction and a memory impairment side effect. The patient presented with:
        • Memory Impairment
        • Dysarthria
        • Headache
        • Muscular Weakness
        • Balance Disorder
        which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Imipramine treatment in female patients suffering from hypertonic bladder, resulting in memory impairment.

        Dystonia
        This report suggests a potential Imipramine Pamoate dystonia side effect(s) that can have serious consequences. A 8-year-old male patient from COUNTRY NOT SPECIFIED (weight:NA) was diagnosed with the following health condition(s): enuresis and used Imipramine Pamoate (dosage: 10 Mg) starting NS. Soon after starting Imipramine Pamoate the patient began experiencing various side effects, including:
        • Dystonia
        Drugs used concurrently:NA. Although Imipramine Pamoate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as dystonia, may still occur.

        Dry Mouth, Dental Caries, Weight Increased, Memory Impairment
        This dry mouth problem was reported by a consumer or non-health professional from US. A 35-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): depression.On NS a consumer started treatment with Imipramine Hydrochloride (dosage: 300 Mg (50 Mg, Daily), Per Oral). The following drugs/medications were being taken at the same time: NA. When commencing Imipramine Hydrochloride, the patient experienced the following unwanted symptoms /side effects:
        • Dry Mouth
        • Dental Caries
        • Weight Increased
        • Memory Impairment
        Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as dry mouth, may become evident only after a product is in use by the general population.

        Dyspnoea, Chest Pain, Dysarthria, Jaw Disorder, Feeling Abnormal
        This is a Imipramine side effect report of a 49-year-old patient (weight: NA) from US. The patient developed the following symptoms/conditions: anxiety and was treated with Imipramine (dosage: NA) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
        • Dyspnoea
        • Chest Pain
        • Dysarthria
        • Jaw Disorder
        • Feeling Abnormal
        This opens a possibility that Imipramine could cause dyspnoea and that some patients may be more susceptible.

        Dystonia
        A 8-year-old male patient (weight: NA) from COUNTRY NOT SPECIFIED with the following symptoms: major depression started Imipramine Pamoate treatment (dosage: 25 Mg) on NS. Soon after starting Imipramine Pamoate treatment, the consumer experienced several side effects, including:
        • Dystonia
        . Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Imipramine Pamoate side effects, such as dystonia.

        Myocardial Infarction, Heart Rate Increased, Dizziness, Vomiting
        This myocardial infarction side effect was reported by a consumer or non-health professional from US. A 68-year-old male patient (weight:NA) experienced the following symptoms/conditions: parkinson^s disease.The patient was prescribed Imipramine Hydrochloride (dosage: 50mg, Bedtime, Oral), which was started on 201205. Concurrently used drugs:
        • Avodart (dutasteride) Capsules
        • Flomax
        • Ditropan (oxybutynin Hydrochloride)
        • Sinemet (carbidpa, Levodopa)
        .When starting to take Imipramine Hydrochloride the consumer reported symptoms, such as:
        • Myocardial Infarction
        • Heart Rate Increased
        • Dizziness
        • Vomiting
        These side effects may potentially be related to Imipramine Hydrochloride. The patient was hospitalized.

        Myocardial Infarction, Heart Rate Increased, Dizziness, Vomiting
        This is a report of a 68-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: parkinson^s disease, who was treated with Imipramine Hydrochloride (dosage: 50mg, Bedtime, Oral, start time: 201205), combined with:
        • Avodart (dutasteride) Capsules
        • Flomax
        • Ditropan (oxybutynin Hydrochloride)
        • Sinemet (carbidpa, Levodopa)
        and developed a serious reaction and side effect(s). The consumer presented with:
        • Myocardial Infarction
        • Heart Rate Increased
        • Dizziness
        • Vomiting
        which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Imipramine Hydrochloride treatment in male patients, resulting in myocardial infarction side effect. The patient was hospitalized.

        Major Depression
        This report suggests a potential Imipramine Hydrochloride Major Depression side effect(s) that can have serious consequences. A 50-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: depression and used Imipramine Hydrochloride (dosage: NA) starting Mar 19, 2012. Soon after starting Imipramine Hydrochloride the patient began experiencing various side effects, including:
        • Major Depression
        Drugs used concurrently:
        • Fexofenadine (allegra) (tablets)
        • Conjugated Estrogens And Medroxyprogesterone (prempro) (tablets)
        • Gabapentin (capsules)
        Although Imipramine Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as major depression, may still occur.

        Dystonia, Musculoskeletal Discomfort, Facial Paresis, Pain
        This Dystonia, Musculoskeletal Discomfort, Facial Paresis, Pain problem was reported by a health professional from BR. A 8-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On NS this consumer started treatment with Imipramine (dosage: 25 Mg, Daily). The following drugs were being taken at the same time: NA. When commencing Imipramine, the patient experienced the following unwanted symptoms/side effects:
        • Dystonia
        • Musculoskeletal Discomfort
        • Facial Paresis
        • Pain
        Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as dystonia, may become evident only after a product is in use by the general population.

        Completed Suicide
        This is a report of a 51-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Imipramine (dosage: NA) starting NS. Concurrently used drugs:
        • Methadone
        • Methamphetamine
        Soon after that, the consumer experienced the following side effects:
        • Completed Suicide
        This opens a possibility that Imipramine treatment could cause the above reactions, including completed suicide, and some female subjects may be more susceptible.

        Completed Suicide
        A 51-year-old female patient (weight: NA) from US with the following symptoms/conditions: NA started Imipramine treatment (dosage: NA) on NS. Soon after starting Imipramine treatment, the subject experienced various side effects, including:
        • Completed Suicide
        Concurrently used drugs:
        • Desipramine
        • Methadone
        • Amphetamine
        • Methamphetamine
        This finding indicates that some female patients could be more vulnerable to Imipramine.

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        Keep Track of Side Effects

        Note Your Observations

        It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

        Why Your Notes are Important

        Your notes could be helpful in several ways:

      • You can use them to remind you of details that may alert your health care professional(s) to a problem
      • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

      • Log Form

        You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

        Medicine Name and Dosage:
        Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
        Scale: 1 = very mild to 10 = very bad

        You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


        Discuss Imipramine Side Effects

        Did You Have a Imipramine Side Effect?

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        Yes, Moderate
        Yes, Minor
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        How Effective is Imipramine for You?

        Exceeded Expectations
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        Imipramine Safety Alerts, Active Ingredients, Usage Information

        NDC0054-0273
        TypeHUMAN PRESCRIPTION DRUG
        Proprietary NameImipramine Pamoate
        NameImipramine Pamoate
        Dosage FormCAPSULE
        RouteORAL
        On market since20100419
        LabelerRoxane Laboratories, Inc
        Active Ingredient(s)IMIPRAMINE PAMOATE
        Strength(s)75
        Unit(s)mg/1
        Pharma ClassTricyclic Antidepressant [EPC]

        More About Imipramine

        Side Effects reported to FDA: 207

        Imipramine safety alerts: No

        Reported deaths: 52

        Reported hospitalizations: 39

        Latest Imipramine clinical trials