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Intron Side Effects

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Common Intron Side Effects


The most commonly reported Intron side effects (click to view or check a box to report):

Nausea (81)
Fatigue (79)
Asthenia (75)
Anaemia (64)
Diarrhoea (55)
Pyrexia (51)
Headache (49)
Depression (48)
Anorexia (45)
Vomiting (40)
Dehydration (40)
Abdominal Pain (39)
Anxiety (37)
Condition Aggravated (37)
Confusional State (36)
Decreased Appetite (35)
Chills (32)
Weight Decreased (32)
Influenza Like Illness (30)
Dyspnoea (29)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Intron Side Effects Reported to FDA



Intron Side Effect Report#9982383
Lymphadenopathy, Metastatic Malignant Melanoma, Chills, Headache, Pain, Nausea, Vomiting
This is a report of a 62-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Intron A (dosage: 235 Million Iu, start time: NS), combined with:
  • Acetaminophen
  • Amitriptyline
  • Multivitamin
  • Esomeprazole
  • Ibuprofen
  • Prochlorperazine
  • Salmeterol
and developed a serious reaction and side effect(s): Lymphadenopathy, Metastatic Malignant Melanoma, Chills, Headache, Pain, Nausea, Vomiting after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Intron A treatment in male patients, resulting in Lymphadenopathy side effect.
Intron Side Effect Report#9969626
Pulmonary Arterial Hypertension
This report suggests a potential Introna Pulmonary Arterial Hypertension side effect(s) that can have serious consequences. A 40-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: hepatitis c and used Introna (dosage: Unk) starting 200107. After starting Introna the patient began experiencing various side effects, including: Pulmonary Arterial HypertensionAdditional drugs used concurrently: NA. Although Introna demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pulmonary Arterial Hypertension, may still occur.
Intron Side Effect Report#9925569
Dehydration
This Dehydration problem was reported by a consumer or non-health professional from Country Not Specified. A 48-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 14, 2013 this consumer started treatment with Intron-a (interferon Alfa-2b) (dosage: 20 Mu). The following drugs were being taken at the same time: NA. When using Intron-a (interferon Alfa-2b), the patient experienced the following unwanted symptoms/side effects: DehydrationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dehydration, may become evident only after a product is in use by the general population.
Intron Side Effect Report#9922482
Metastases To Kidney, Metastases To Lung
This Metastases To Kidney side effect was reported by a health professional from CA. A male patient (weight:NA) experienced the following symptoms/conditions: malignant melanoma,pyrexia.The patient was prescribed Intron A (drug dosage: 18 Million Iu, Q3w), which was initiated on
Jul 01, 2013. Concurrently used drugs:
  • Tylenol (Unk, Prn)
.After starting to take Intron A the consumer reported adverse symptoms, such as: Metastases To Kidney, Metastases To LungThese side effects may potentially be related to Intron A.
Intron Side Effect Report#9921946
Erythema
This is a report of a 28-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: malignant melanoma, who was treated with Introna (dosage: Unk Unk, Tiw, start time: 201312), combined with: NA. and developed a serious reaction and side effect(s): Erythema after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Introna treatment in female patients, resulting in Erythema side effect.
Intron Side Effect Report#9908780
Depression
This report suggests a potential Introna Depression side effect(s) that can have serious consequences. A 24-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: t-cell lymphoma and used Introna (dosage: 0.5 Ml, Three Times Weekly) starting
Feb 03, 2014. After starting Introna the patient began experiencing various side effects, including: DepressionAdditional drugs used concurrently: NA. Although Introna demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Depression, may still occur.
Intron Side Effect Report#9889748
Coronary Artery Bypass, Weight Increased, Fatigue
This Coronary Artery Bypass problem was reported by a physician from US. A 72-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: mycosis fungoides. On 200702 this consumer started treatment with Introna (dosage: 1.0 (measurement Not Confirmed) Injection Taken 3 Times Per Week At 9:30pm). The following drugs were being taken at the same time: NA. When using Introna, the patient experienced the following unwanted symptoms/side effects: Coronary Artery Bypass, Weight Increased, FatigueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Coronary Artery Bypass, may become evident only after a product is in use by the general population.
Intron Side Effect Report#9887396
Lung Disorder
This Lung Disorder side effect was reported by a health professional from FR. A 60-year-old female patient (weight:NA) experienced the following symptoms/conditions: hepatitis c.The patient was prescribed Introna (drug dosage: 1 Df, Tiw), which was initiated on 201112. Concurrently used drugs:
  • Ribavirin
.After starting to take Introna the consumer reported adverse symptoms, such as: Lung DisorderThese side effects may potentially be related to Introna.
Intron Side Effect Report#9860514
Depression, Fatigue, Family Stress, Mood Swings
This is a report of a 38-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: malignant melanoma, who was treated with Introna (dosage: 10 Million Units, Three Times Per Week, start time:
Aug 26, 2013), combined with: NA. and developed a serious reaction and side effect(s): Depression, Fatigue, Family Stress, Mood Swings after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Introna treatment in female patients, resulting in Depression side effect. The patient was hospitalized.
Intron Side Effect Report#9851392
Limb Operation, Musculoskeletal Stiffness, Neutrophil Count Decreased, White Blood Cell Count Decreased, Chills, Fatigue, Headache, Nausea
This report suggests a potential Introna Limb Operation side effect(s) that can have serious consequences. A 70-year-old male patient (weight: NA) from FI was diagnosed with the following symptoms/conditions: melanoma recurrent and used Introna (dosage: Strength 60 Miu) starting
Jan 15, 2014. After starting Introna the patient began experiencing various side effects, including: Limb Operation, Musculoskeletal Stiffness, Neutrophil Count Decreased, White Blood Cell Count Decreased, Chills, Fatigue, Headache, NauseaAdditional drugs used concurrently: NA. Although Introna demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Limb Operation, may still occur.
Intron Side Effect Report#9851388
Liver Injury
This Liver Injury problem was reported by a consumer or non-health professional from IN. A 48-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Introna (dosage: 18 Miu, Had Taken 22 Injections). The following drugs were being taken at the same time:
  • Rebetol (Unk)
When using Introna, the patient experienced the following unwanted symptoms/side effects: Liver InjuryAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Liver Injury, may become evident only after a product is in use by the general population.
Intron Side Effect Report#9848535
Tremor
This Tremor side effect was reported by a pharmacist from US. A 66-year-old male patient (weight:NA) experienced the following symptoms/conditions: malignant melanoma.The patient was prescribed Intron-a (interferon Alfa-2b) (drug dosage: NA), which was initiated on
Jan 03, 2014. Concurrently used drugs: NA..After starting to take Intron-a (interferon Alfa-2b) the consumer reported adverse symptoms, such as: TremorThese side effects may potentially be related to Intron-a (interferon Alfa-2b).
Intron Side Effect Report#9842696
Blood Urine, Chest Discomfort, Palpitations, Headache, Dyspnoea, Dizziness, Fatigue, Palpitations
This is a report of a 66-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: skin cancer,lymphoma, who was treated with Introna (dosage: 1.5 Million Iu, Tiw, start time: 200301), combined with: NA. and developed a serious reaction and side effect(s): Blood Urine, Chest Discomfort, Palpitations, Headache, Dyspnoea, Dizziness, Fatigue, Palpitations after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Introna treatment in male patients, resulting in Blood Urine side effect.
Intron Side Effect Report#9830186
Vomiting, Nausea, Off Label Use
This report suggests a potential Introna Vomiting side effect(s) that can have serious consequences. A 13-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: craniopharyngioma and used Introna (dosage: 1 Microgram Per Kilogram Per Week) starting NS. After starting Introna the patient began experiencing various side effects, including: Vomiting, Nausea, Off Label UseAdditional drugs used concurrently:
  • Acetaminophen (15 Mg/kg, Once; 30 Minutes Before First Dose)
  • Acetaminophen (15 Mg/kg, Every 4-6 Hours, Prn)
Although Introna demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Vomiting, may still occur.
Intron Side Effect Report#9830185
Fatigue, Pyrexia, Off Label Use
This Fatigue problem was reported by a physician from US. A 14-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: craniopharyngioma. On NS this consumer started treatment with Introna (dosage: 3 Microgram Per Kilogram, Unk). The following drugs were being taken at the same time:
  • Acetaminophen (15 Mg/kg, Once; 30 Minutes Before First Dose)
  • Acetaminophen (15 Mg/kg, Every 4-6 Hours, Prn)
When using Introna, the patient experienced the following unwanted symptoms/side effects: Fatigue, Pyrexia, Off Label UseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Fatigue, may become evident only after a product is in use by the general population.
Intron Side Effect Report#9830157
Transaminases Increased, Thrombocytopenia, Cachexia, Off Label Use
This Transaminases Increased side effect was reported by a physician from US. A 14-year-old male patient (weight:NA) experienced the following symptoms/conditions: craniopharyngioma.The patient was prescribed Introna (drug dosage: 3 Microgram Per Kilogram Per Week), which was initiated on NS. Concurrently used drugs: NA..After starting to take Introna the consumer reported adverse symptoms, such as: Transaminases Increased, Thrombocytopenia, Cachexia, Off Label UseThese side effects may potentially be related to Introna.
Intron Side Effect Report#9830150
Cachexia, Nausea, Off Label Use
This is a report of a 9-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: craniopharyngioma, who was treated with Introna (dosage: 3 Microgram Per Kilogram, Unk, start time: NS), combined with:
  • Acetaminophen (15 Mg/kg, Once; 30 Minutes Before First Dose)
  • Acetaminophen (15 Mg/kg, Every 4-6 Hours, Prn)
and developed a serious reaction and side effect(s): Cachexia, Nausea, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Introna treatment in female patients, resulting in Cachexia side effect.
Intron Side Effect Report#9825211
Dizziness, Vertigo, Dysstasia, Gait Disturbance, Retinopathy
This report suggests a potential Intron-a (interferon Alfa-2b) Dizziness side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Intron-a (interferon Alfa-2b) (dosage: NA) starting NS. After starting Intron-a (interferon Alfa-2b) the patient began experiencing various side effects, including: Dizziness, Vertigo, Dysstasia, Gait Disturbance, RetinopathyAdditional drugs used concurrently:
  • Diazepam
  • Levothyroxine
  • Prochlorperazine
  • Zofran
The patient was hospitalized. Although Intron-a (interferon Alfa-2b) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dizziness, may still occur.
Intron Side Effect Report#9817644
Abortion Induced, Exposure During Pregnancy, Off Label Use
This Abortion Induced problem was reported by a physician from HU. A 28-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: infection prophylaxis. On
Oct 30, 2013 this consumer started treatment with Introna (dosage: Total Daily Dose 5 Million Iu, Once). The following drugs were being taken at the same time: NA. When using Introna, the patient experienced the following unwanted symptoms/side effects: Abortion Induced, Exposure During Pregnancy, Off Label UseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Abortion Induced, may become evident only after a product is in use by the general population.
Intron Side Effect Report#9808127
Oropharyngeal Pain, Back Pain, Vomiting
This Oropharyngeal Pain side effect was reported by a health professional from US. A 63-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Introna (drug dosage: Unk), which was initiated on 201312. Concurrently used drugs: NA..After starting to take Introna the consumer reported adverse symptoms, such as: Oropharyngeal Pain, Back Pain, VomitingThese side effects may potentially be related to Introna.
Intron Side Effect Report#9798968
International Normalised Ratio Increased
This is a report of a 83-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: neoplasm malignant, who was treated with Intron A (dosage: Intradermally, start time:
Nov 29, 2013), combined with:
  • Coumadin
and developed a serious reaction and side effect(s): International Normalised Ratio Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Intron A treatment in female patients, resulting in International Normalised Ratio Increased side effect.
Intron Side Effect Report#9767084
Nightmare
This report suggests a potential Intron-a (interferon Alfa-2b) Nightmare side effect(s) that can have serious consequences. A 46-year-old female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: NA and used Intron-a (interferon Alfa-2b) (dosage: NA) starting
Mar 15, 2013. After starting Intron-a (interferon Alfa-2b) the patient began experiencing various side effects, including: NightmareAdditional drugs used concurrently: NA. Although Intron-a (interferon Alfa-2b) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Nightmare, may still occur.
Intron Side Effect Report#9758963
Acute Respiratory Distress Syndrome, Hepatic Necrosis, Renal Necrosis, Disseminated Intravascular Coagulation, Multi-organ Failure, Hypotension, Off Label Use, Coronary Artery Stenosis
This Death problem was reported by a consumer or non-health professional from GR. A 38-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: malignant melanoma stage ii. On
Nov 12, 2011 this consumer started treatment with Introna (dosage: 20000mil (5 Days A Week For 4 Weeks)). The following drugs were being taken at the same time: NA. When using Introna, the patient experienced the following unwanted symptoms/side effects: Acute Respiratory Distress Syndrome, Hepatic Necrosis, Renal Necrosis, Disseminated Intravascular Coagulation, Multi-organ Failure, Hypotension, Off Label Use, Coronary Artery StenosisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Intron Side Effect Report#9757376
Metastases To Liver, Gastritis, Nausea, Overdose, Liver Function Test Abnormal
This Metastases To Liver side effect was reported by a consumer or non-health professional from ZA. A 52-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Introna (drug dosage: 35 Miu), which was initiated on 2013. Concurrently used drugs: NA..After starting to take Introna the consumer reported adverse symptoms, such as: Metastases To Liver, Gastritis, Nausea, Overdose, Liver Function Test AbnormalThese side effects may potentially be related to Introna. The patient was hospitalized.
Intron Side Effect Report#9739512
Retinal Vein Occlusion
This is a report of a 65-year-old male patient (weight: NA) from JP, suffering from the following health symptoms/conditions: NA, who was treated with Introna (dosage: Unk, start time: NS), combined with:
  • Pegintron (Unk)
and developed a serious reaction and side effect(s): Retinal Vein Occlusion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Introna treatment in male patients, resulting in Retinal Vein Occlusion side effect.


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The appearance of Intron on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Intron Side Effects for Women?

Women Side EffectsReports
Anaemia 46
Asthenia 44
Anorexia 38
Nausea 38
Fatigue 37
Diarrhoea 34
Abdominal Pain 32
Abdominal Pain Upper 25
Depression 25
Anxiety 24

What are common Intron Side Effects for Men?

Men Side EffectsReports
Fatigue 41
Nausea 41
Pyrexia 32
Asthenia 31
Headache 27
Depression 23
Pneumonia 23
Condition Aggravated 21
Confusional State 21
Neutrophil Count Decreased 21

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Intron reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Intron Side Effects

    Did You Have a Intron Side Effect?

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    How Effective is Intron for You?

    Exceeded Expectations
    Effective
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    Intron Safety Alerts, Active Ingredients, Usage Information

    NDC0085-0539
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameINTRON A
    NameInterferon alfa-2b
    Dosage FormKIT
    Route
    On market since19860604
    LabelerMerck Sharp & Dohme Corp.
    Active Ingredient(s)
    Strength(s)
    Unit(s)
    Pharma Class

    More About Intron

    Side Effects reported to FDA: 1107

    Intron safety alerts: 2002

    Reported deaths: 177

    Reported hospitalizations: 492

    Alpha Interferons (Roferon-A, Intron A, Rebetron Combination Therapy)

    Intron A (Interferon alfa 2b, recombinant)
    Rebetron Combination Therapy (Rebetrol (Ribavirin, USP) Capsules and Intron A)
    Roferon-A (Interferon alfa-2a, recombinant)

    Audience: Oncologists and other Healthcare professionals

    Healthcare professionals are advised of important safety information for all alpha interferons. A BOXED WARNING has been added regarding the occurrence of neuropsychiatric, autoimmune, ischemic, and infectious disorders in patients taking alpha interferons; additional safety information and direction for patient monitoring is also provided in the WARNINGS section of the prescribing information.

    [March 14, 2002 - Letter - Roche]

    Latest Intron clinical trials