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Headache (7)
Heart Beat Increased (3)
Heart Beat Increased And Uneasiness (2)
Uneasiness (2)
Severe Headache (1)
Vomiting (1)
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Isoket Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Clostridium Difficile Colitis (7540054-7)
on May 30, 2011 Female from GERMANY , 90 years of age, weighting 123.5 lb, was diagnosed with
  • coronary artery disease
  • clostridium difficile colitis
  • bone pain
and was treated with Isoket 20. Directly after, patient experienced the unwanted or unexpected Isoket side effects: clostridium difficile colitis. Isoket 20 dosage: 40 Milligram;.
Associated medications used:
  • Metronidazole (1500 Milligram;)
  • Fentanyl (1.375 Milligram; Strength 25 Microg/h)
  • Corangin 40 Retard (80 Milligram;)
  • Ramipril (5 Milligram;)
  • Torem 10 (10 Milligram;)
  • Humalog (14 Iu (international Unit);)
  • Norvasc (10 Milligram;)
  • Rulid 300 Mg (300 Milligram;)
Patient was hospitalized.

Circulatory Collapse, Acute Myocardial Infarction (7332526-5)
Patient was taking Isoket (isosorbide Dinitrate). Patient felt the following Isoket side effects: circulatory collapse, acute myocardial infarction on Feb 07, 2011 from RUSSIAN FEDERATION Additional patient health information: Male , 40 years of age, was diagnosed with
  • acute myocardial infarction
and. Isoket (isosorbide Dinitrate) dosage: 1x;po. Patient was hospitalized.

Blood Pressure Abnormal, Dyspnoea, Heart Rate Increased, Ill-defined Disorder (7173287-2)
Adverse event was reported on Nov 13, 2010 by a Male taking Isoket (isosorbide Dinitrate) (Dosage: 40 Mg, Tid) . Location: GERMANY , 72 years of age, After Isoket was administered, patient encountered several Isoket side effects: blood pressure abnormal, dyspnoea, heart rate increased, ill-defined disorder.
Multiple concurrent drugs taken:
  • Bactrim
  • Torsemide
  • Acetylsalicylic Acid Srt
  • Allopurinol


Cardiac Failure, Diabetes Mellitus Inadequate Control, Malaise, Renal Failure (7125679-5)
on Nov 05, 2010 Female from UNITED KINGDOM , 59 years of age, was treated with Isoket (isoket). Directly after, patient experienced the unwanted or unexpected Isoket side effects: cardiac failure, diabetes mellitus inadequate control, malaise, renal failure. Isoket (isoket) dosage: (0.5mg/ml).


Cerebral Haemorrhage, Endotracheal Intubation Complication, Laryngeal Oedema, Stridor (6812325-0)
on Jun 17, 2010 Female from FINLAND , 65 years of age, was diagnosed with
  • blood pressure increased
and was treated with Isoket (isoket-spray) (not Specified). Patient felt the following Isoket side effects: cerebral haemorrhage, endotracheal intubation complication, laryngeal oedema, stridor. Isoket (isoket-spray) (not Specified) dosage: See Image.
Multiple prescriptions taken:
  • Nifedpine ((oral))


Suicide Attempt (6647748-6)
Patient was taking Isoket (isoket). After Isoket was administered, patient encountered several Isoket side effects: suicide attempt on Mar 05, 2010 from GERMANY Additional patient health information: Female , weighting 121.3 lb, . Isoket (isoket) dosage: (isoket 10 Mg, 30 Tablets Over A Period Op Several Hours, Total Amount 300mg).

Dysgeusia, Hyposmia, Parosmia, Performance Status Decreased, Pruritus, Visual Impairment (6642532-1)
Adverse event was reported on Mar 04, 2010 by a Female taking Isoket (isoket) (Dosage: (2.5 Mg Qd Oral)) was diagnosed with
  • coronary artery insufficiency
and. Location: GERMANY , weighting 141.1 lb, Directly after, patient experienced the unwanted or unexpected Isoket side effects: dysgeusia, hyposmia, parosmia, performance status decreased, pruritus, visual impairment.
Associated medications used:
  • Dociton
Patient was hospitalized.

Acidosis, Diastolic Hypotension, Megacolon, Renal Failure, Somnolence, Suicide Attempt (6640275-1)
on Mar 02, 2010 Female from GERMANY , weighting 220.5 lb, was treated with Isoket (isoket). Patient felt the following Isoket side effects: acidosis, diastolic hypotension, megacolon, renal failure, somnolence, suicide attempt. Isoket (isoket) dosage: (84 Tablets).
Multiple prescriptions taken:
  • Piracetam (piracetam ) ((100 Tablets))
  • Acemuc (acemuc 600) ((10 Tablets))
  • Allopurinol (allopurinol 100) ((100 Tablets))
  • Amineurin (amineurin 10) ((120 Tablets))
  • Amlodipin Hexal /00972401/ (amlodipin Iiexal ) ((40 Tablets))
  • Amoxicillin ((10 Tablet))
  • Diclo-divido (diclo Divido Long) ((20 Tablet Oral))
  • Diclofenac (diclodoc) ((20 Tablets Oral))
Patient was hospitalized.

Gastrointestinal Hypomotility, Hypotension, Incorrect Dose Administered, Somnolence, Suicide Attempt (6537088-8)
on Dec 25, 2009 Female from GERMANY , weighting 220.5 lb, was treated with Isoket (isoket). After Isoket was administered, patient encountered several Isoket side effects: gastrointestinal hypomotility, hypotension, incorrect dose administered, somnolence, suicide attempt. Isoket (isoket) dosage: (84 Tablets).
Multiple concurrent drugs taken:
  • Piracetam (piracetam Al) ((100 Tablets))
  • Acemuc (acemuc 600) ((10 Tablets))
  • Allopurinol (allopurinol 100) ((100 Tablets))
  • Amineurin (amineurin 10) ((120 Tablets))
  • Amlodipin Hexal /00972401/ (amlodipin Hexal) ((40 Tablets))
  • Amoxicillin ((10 Tablet))
  • Diclo-divido (diclo Divido Long) ((20 Tablet))
  • Diclofenac (diclodoc) ((20 Tablets))
Patient was hospitalized.

Incorrect Dose Administered, Somnolence, Suicide Attempt (6509584-0)
Patient was taking Isoket (isoket). Directly after, patient experienced the unwanted or unexpected Isoket side effects: incorrect dose administered, somnolence, suicide attempt on Dec 04, 2009 from GERMANY Additional patient health information: Female , weighting 176.4 lb, . Isoket (isoket) dosage: 640 Mg, 16 Tablets Of 40mg Once Oral.
Associated medications used:
  • Acetylsalicylic Acid (asprin) (2000 Mg, 20 Tablets Of 100mg Once Oral)
  • Lormetazepam (lormatazepam) (40 Mg, 20 Tablets Of 2mg Once Oral)
  • Molsidomine (molsidomin) (80 Mg, 10 Tablets Of 8mg Once Oral)
  • Oxycodon (oxycodon) (not Specified) (200 Mg, 20 Tablets Of 10 Mg Once Oral)


Chills, Dyspnoea, Fear, Hypertension, Loss Of Consciousness, Pyrexia (6203563-9)
Adverse event was reported on May 12, 2009 by a Female taking Isoket (isoket) (Dosage: (10 Mg Qd Intravenous (not Otherwise Specified))) was diagnosed with
  • coronary artery disease
and. Location: CHINA , weighting 99.21 lb, Patient felt the following Isoket side effects: chills, dyspnoea, fear, hypertension, loss of consciousness, pyrexia.
Multiple prescriptions taken:
  • Glucose (1.5% Glucose) ((250 Ml Qd Intravenous (not Otherwise Specified)))
  • Potassium Chloride
  • Magnesium Sulfate
  • Potassium Magnesium Aspartate
  • Perindopril
Patient was hospitalized.

Hypotension, Suicide Attempt (6196480-4)
on May 13, 2009 Male from GERMANY , weighting 198.4 lb, was treated with Isoket Retard (isoket Retard). After Isoket was administered, patient encountered several Isoket side effects: hypotension, suicide attempt. Isoket Retard (isoket Retard) dosage: (15 Df, 15 Tablets Over Several Hours Oral).
Multiple concurrent drugs taken:
  • Bisoprolol Fumarate ((10 Df, 10 Tablets Over Several Hours Oral))
  • Metformin Hcl ((12 Df, 12 Tablerts Over Several Hours Oral))
Patient was hospitalized.

Angioedema, Eyelid Oedema (6150652-3)
on Apr 08, 2009 Male from GERMANY , 79 years of age, weighting 132.3 lb, was diagnosed with
  • coronary artery disease
and was treated with Isoket Retard (isoket Retard). Directly after, patient experienced the unwanted or unexpected Isoket side effects: angioedema, eyelid oedema. Isoket Retard (isoket Retard) dosage: 40 Mg Qd Oral.
Associated medications used:
  • Methotrexate Sodium
  • Prednisolone


Disorientation, Hypotension, Incorrect Dose Administered, Intentional Self-injury, Polyuria, Somnolence, Suicidal Ideation, Tachycardia (6031975-5)
Patient was taking Isoket Retard (isoket-retard-120). Patient felt the following Isoket side effects: disorientation, hypotension, incorrect dose administered, intentional self-injury, polyuria, somnolence, suicidal ideation, tachycardia on Dec 22, 2008 from GERMANY Additional patient health information: Female , weighting 105.8 lb, . Isoket Retard (isoket-retard-120) dosage: (120 Mg, 8400 Mg Maximum Once Oral).
Multiple prescriptions taken:
  • L-thyroxine /00068001/ (l-thyroxine) ((50 Ug, 5 Mg Maximum Once Oral))
  • Torem /01036501/ (torem) (not Specified) ((10 Mg, 100 Mg Maximum Once Oral))
Patient was hospitalized.

Amaurosis, Chromatopsia, Foreign Body Trauma, Impaired Driving Ability, Road Traffic Accident (5106840-8)
Adverse event was reported on Aug 22, 2006 by a Male taking Isoket-retard-40 (isosorbide Dinitrate) (Dosage: 40 Mg (40 Mg 1 In 1 Day (s)), Oral) was diagnosed with
  • cardiac disorder
and. Location: GERMANY , 86 years of age, After Isoket was administered, patient encountered several Isoket side effects: amaurosis, chromatopsia, foreign body trauma, impaired driving ability, road traffic accident.
Multiple concurrent drugs taken:
  • Bisoprolol Fumarate
  • Nifedipine
  • Metformin Hcl
  • Esomeprazole Magnesium
  • Aspirin


Blood Creatinine Increased (4638160-X)
on Mar 30, 2005 Male from , 84 years of age, was treated with Isoket Retard. Directly after, patient experienced the unwanted or unexpected Isoket side effects: blood creatinine increased. Isoket Retard dosage: N/A.
Associated medications used:
  • Aspirin
  • Delix (2.5 Mg Daily)
  • Actraphane Hm
  • Locol (40 Mg, Qd)
  • Allopurinol (300 Mg Daily)


Blood Creatinine Increased (4626114-9)
on Mar 30, 2005 Male from , 84 years of age, was treated with Isoket Retard. Patient felt the following Isoket side effects: blood creatinine increased. Isoket Retard dosage: N/A.
Multiple prescriptions taken:
  • Aspirin
  • Delix (5 Mg, Qd)
  • Actraphane Hm
  • Locol (40 Mg, Qd)


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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

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Isoket Information

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Side Effects reported to FDA: 17. View Isoket Adverse Reports

Isoket safety alerts: No

Reported deaths: 1

Reported hospitalizations: 4

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