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Keppra Side Effects

Common Keppra Side Effects


The most commonly reported Keppra side effects (click to view or check a box to report):

Convulsion (849)
Pregnancy (286)
Grand Mal Convulsion (225)
Thrombocytopenia (207)
Somnolence (198)
Condition Aggravated (191)
Depression (185)
Fatigue (170)
Aggression (157)
Suicidal Ideation (136)
Caesarean Section (134)
Dizziness (128)
Status Epilepticus (125)
Asthenia (119)
Headache (118)
Epilepsy (115)
Abortion Spontaneous (113)
Premature Baby (111)
Fall (108)
Vomiting (106)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Keppra Side Effects Reported to FDA

The following Keppra reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Keppra on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Gestational Diabetes, Pregnancy
This is a report of a 24-year-old female patient (weight: NA) from DE, suffering from the following symptoms/conditions: epilepsy, who was treated with Keppra (dosage: NA, start time: 2008), combined with:
  • Ergenyl Chrono
  • Folic Acid
and developed a serious reaction and side effect(s). The consumer presented with:
  • Gestational Diabetes
  • Pregnancy
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Keppra treatment in female patients, resulting in gestational diabetes side effect.

Pneumonia Aspiration, Status Epilepticus, Prescribed Underdose
This report suggests a potential Keppra Pneumonia Aspiration, Status Epilepticus, Prescribed Underdose side effect(s) that can have serious consequences. A 68-year-old female patient (weight: NA) from IE was diagnosed with the following symptoms/conditions: epilepsy and used Keppra (dosage: Reduced Dose) starting 2012. Soon after starting Keppra the patient began experiencing various side effects, including:
  • Pneumonia Aspiration
  • Status Epilepticus
  • Prescribed Underdose
Drugs used concurrently: NA. Although Keppra demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pneumonia aspiration, may still occur.

Rhabdomyolysis
This Rhabdomyolysis problem was reported by a physician from IT. A 55-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: epilepsy. On Oct 23, 2013 this consumer started treatment with Keppra (dosage: Strength: 1000 Mg). The following drugs were being taken at the same time:
  • Cefazolin
  • Dexamethasone
  • Propofol
  • Nexium
  • Lasix
When commencing Keppra, the patient experienced the following unwanted symptoms/side effects:
  • Rhabdomyolysis
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as rhabdomyolysis, may become evident only after a product is in use by the general population.

Decreased Interest
This is a report of a 77-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: convulsion prophylaxis and was treated with Keppra (levetiracetam) (dosage: NA) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Decreased Interest
This opens a possibility that Keppra (levetiracetam) treatment could cause the above reactions, including decreased interest, and some male subjects may be more susceptible.


Back Pain, Stress
A 78-year-old female patient (weight: NA) from DE with the following symptoms/conditions: NA started Keppra treatment (dosage: Morning And Evening) on 2013. Soon after starting Keppra treatment, the subject experienced various side effects, including:
  • Back Pain
  • Stress
Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Keppra.

Hyperammonaemia
A 83-year-old male patient from DE (weight: NA) experienced symptoms, such as: NA and was treated with Keppra(dosage: NA). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Hyperammonaemia
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Keppra efficacy: NA.The patient was hospitalized.

Sepsis, Pneumonia Aspiration, Multi-organ Failure, Partial Seizures, Grand Mal Convulsion, Dysphagia
In this report, Keppra was administered for the following condition: grand mal convulsion.A 80-year-old male consumer from DE (weight: NA) started Keppra treatment (dosage: NA) on Aug 22, 2013.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Sepsis
  • Pneumonia Aspiration
  • Multi-organ Failure
  • Partial Seizures
  • Grand Mal Convulsion
  • Dysphagia
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Keppra treatment could be related to the listed above side effect(s).

Convulsion, Pyelonephritis, Dizziness, Diplopia, Distractibility, Memory Impairment, Overdose
This is a report of the following Keppra side effect(s):
  • Convulsion
  • Pyelonephritis
  • Dizziness
  • Diplopia
  • Distractibility
  • Memory Impairment
  • Overdose
A female patient from US (weight: NA) presented with the following condition: convulsion and received a treatment with Keppra (dosage: Strength: 500 Mg, 10/daily, 1500 Mg Morning And Afternoon, 1750 Mg At Night) starting: Jul 27, 2009.The following concurrently used drugs could have generated interactions:
  • Folic Acid (1 Mg Daily)
  • Trileptal (Strength: 150 Mg, 600 Mg Morning, 450 Mg Afternoon And 600 Mg Mg At Night)
  • Lamictal
  • Lamictal (Strength: 100 Mg, 1/2 Tablet)
  • Midazolam (10 Mg/2 Ml (2ml=10 Mg Sprayed Nasally))
  • Pyridoxine (100 Mg Daily)
  • Riboflavin
  • Ativan (2 Mg Tablet, 1/2 To 1 Tablet Every 12 Hours)
The patient was hospitalized.This report suggests that a Keppra treatment could be associated with the listed above side effect(s).

Cryptorchism, Congenital Central Nervous System Anomaly, Penile Curvature, Persistent Foetal Circulation, Congenital Foot Malformation, Foetal Exposure During Pregnancy
This Keppra report was submitted by a male consumer from DE (weight: NA). The patient was diagnosed with: epilepsy and Keppra was administered (dosage: NA) starting: 200812. The consumer developed a set of symptoms:
  • Cryptorchism
  • Congenital Central Nervous System Anomaly
  • Penile Curvature
  • Persistent Foetal Circulation
  • Congenital Foot Malformation
  • Foetal Exposure During Pregnancy
Other drugs used simultaneously:
  • Ergenyl Chrono
  • Folic Acid
  • Cytotec
The patient was hospitalized.Those unexpected symptoms could be linked to a Keppra treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Convulsion, Diabetes Mellitus
This is a report of a possible correlation between Keppra use and the following symptoms/side effect(s):
  • Convulsion
  • Diabetes Mellitus
which could contribute to an assessment of Keppra risk profile.A 25-year-old male consumer from US (weight: NA) was suffering from convulsion and was treated with Keppra (dosage: Dose-750 Twice) starting NS.Other concurrent medications:
  • Dilantin (Dose-150)
The patient was hospitalized.

Coma, Cerebrovascular Accident, Somnolence
A 83-year-old male patient from DE (weight: NA) presented with the following symptoms: NA and after a treatment with Keppra (dosage: NA) experienced the following side effect(s):
  • Coma
  • Cerebrovascular Accident
  • Somnolence
The treatment was started on 2013. Keppra was used in combination with the following drugs: NA.The patient was hospitalized.This report could alert potential Keppra consumers.

Sphincter Of Oddi Dysfunction
In this report, a 51-year-old female patient from US (weight: NA) was affected by a possible Keppra side effect.The patient was diagnosed with epilepsy. After a treatment with Keppra (dosage: 2xday Twice Daily, start date: Nov 16, 2004), the patient experienced the following side effect(s):
  • Sphincter Of Oddi Dysfunction
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Keppra treatment.

Depressed Level Of Consciousness, Fatigue
This is a report of a 73-year-old male patient from SE (weight: NA), who used Keppra (dosage: NA) for a treatment of NA. After starting a treatment on 201203, the patient experienced the following side effect(s):
  • Depressed Level Of Consciousness
  • Fatigue
The following drugs could possibly have interacted with the Keppra treatment NA.Taken together, these observations suggest that a Keppra treatment could be related to side effect(s), such as Depressed Level Of Consciousness, Fatigue.

Premature Delivery, Twin Pregnancy
This premature delivery side effect was reported by a physician from FR. A 27-year-old female patient (weight:NA) experienced the following symptoms/conditions: epilepsy. The patient was prescribed Keppra (dosage: Daily Dose: 1000 Mg), which was started on NS. Concurrently used drugs:
  • Lamictal (Daily Dose: 200 Mg)
When starting to take Keppra the consumer reported the following symptoms:
  • Premature Delivery
  • Twin Pregnancy
The patient was hospitalized. These side effects may potentially be related to Keppra.

Convulsion, Performance Status Decreased, Somnolence
This is a Keppra side effect report of a female patient (weight:NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Keppra (dosage:NA, start time: 201310), combined with:
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
  • Xyrem (Nightly (dose Strength:500 Mg/ml))
, and developed a serious reaction and a convulsion side effect. The patient presented with:
  • Convulsion
  • Performance Status Decreased
  • Somnolence
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Keppra treatment in female patients suffering from NA, resulting in convulsion.

Haemorrhage
This report suggests a potential Keppra haemorrhage side effect(s) that can have serious consequences. A 27-year-old female patient from NO (weight:NA) was diagnosed with the following health condition(s): NA and used Keppra (dosage: NA) starting NS. Soon after starting Keppra the patient began experiencing various side effects, including:
  • Haemorrhage
Drugs used concurrently:
  • Zonegram
Although Keppra demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as haemorrhage, may still occur.

Thrombocytopenia
This thrombocytopenia problem was reported by a physician from LB. A 70-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): epilepsy.On 201301 a consumer started treatment with Keppra (dosage: 500 Mg). The following drugs/medications were being taken at the same time:
  • Depakine Chrono
When commencing Keppra, the patient experienced the following unwanted symptoms /side effects:
  • Thrombocytopenia
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as thrombocytopenia, may become evident only after a product is in use by the general population.

Sepsis, Encephalopathy, Confusional State, Brain Oedema, Dehydration
This is a Keppra side effect report of a 55-year-old female patient (weight: NA) from IE. The patient developed the following symptoms/conditions: convulsion and was treated with Keppra (dosage: Dose: 250 3-4 Dose Taken) starting Sep 29, 2013. Concurrently used drugs:
  • Epilim Chrono
  • Valproate (Dose: 300 Daily)
  • Topiramate
  • Metoclopramide (Dose: Tds/prn (10 Mg 3 In 1 Day))
Soon after that, the consumer experienced the following of symptoms:
  • Sepsis
  • Encephalopathy
  • Confusional State
  • Brain Oedema
  • Dehydration
The patient was hospitalized. This opens a possibility that Keppra could cause sepsis and that some female patients may be more susceptible.

Caesarean Section, Pregnancy
A 31-year-old female patient (weight: NA) from BE with the following symptoms: NA started Keppra treatment (dosage: Daily Dose: 2000 Mg) on NS. Soon after starting Keppra treatment, the consumer experienced several side effects, including:
  • Caesarean Section
  • Pregnancy
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Keppra side effects, such as caesarean section.

Overdose, Depressed Level Of Consciousness, Slow Response To Stimuli, Slow Speech, Cyanosis, Hyperhidrosis, Disturbance In Attention, Cough
This overdose side effect was reported by a health professional from IT. A 50-year-old male patient (weight:NA) experienced the following symptoms/conditions: epilepsy.The patient was prescribed Keppra (dosage: 3000 Mg All At Once), which was started on Jun 10, 2013. Concurrently used drugs: NA..When starting to take Keppra the consumer reported symptoms, such as:
  • Overdose
  • Depressed Level Of Consciousness
  • Slow Response To Stimuli
  • Slow Speech
  • Cyanosis
  • Hyperhidrosis
  • Disturbance In Attention
  • Cough
These side effects may potentially be related to Keppra. The patient was hospitalized.

Cholestatic Liver Injury
This is a report of a 54-year-old male patient (weight: NA) from CH, suffering from the following symptoms/conditions: epilepsy,latent tuberculosis, who was treated with Keppra (dosage: NA, start time: 2012), combined with:
  • Isoniazide
  • Heparine
  • Enalapril
  • Esomeprazole
  • Metoprolol
  • Spironolacton
  • Oxazepam
  • Morphine (10 Mg 6 X/day Po + 5 Mg 4 X Per Day In Reserve)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Cholestatic Liver Injury
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Keppra treatment in male patients, resulting in cholestatic liver injury side effect.

Stevens-johnson Syndrome
This report suggests a potential Keppra Stevens-johnson Syndrome side effect(s) that can have serious consequences. A 45-year-old male patient (weight: NA) from VE was diagnosed with the following symptoms/conditions: post-traumatic epilepsy and used Keppra (dosage: Nasogastric Tube) starting Oct 09, 2013. Soon after starting Keppra the patient began experiencing various side effects, including:
  • Stevens-johnson Syndrome
Drugs used concurrently:
  • Fenitoin
  • Valproic Acid
The patient was hospitalized. Although Keppra demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as stevens-johnson syndrome, may still occur.

No Adverse Event
This No Adverse Event problem was reported by a pharmacist from DE. A 41-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: status epilepticus,convulsion. On NS this consumer started treatment with Keppra (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Keppra, the patient experienced the following unwanted symptoms/side effects:
  • No Adverse Event
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as no adverse event, may become evident only after a product is in use by the general population.

Sopor
This is a report of a 79-year-old patient (weight: NA) from DE. The patient developed the following symptoms/conditions: NA and was treated with Keppra (dosage: NA) starting Oct 12, 2013. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Sopor
This opens a possibility that Keppra treatment could cause the above reactions, including sopor, and some subjects may be more susceptible.

Convulsion
A 18-year-old female patient (weight: NA) from US with the following symptoms/conditions: convulsion,vitamin supplementation started Keppra treatment (dosage: Several Doses Increased) on 2012. Soon after starting Keppra treatment, the subject experienced various side effects, including:
  • Convulsion
Concurrently used drugs:
  • Folic Acid (1 Tablet Once Daily)
This finding indicates that some female patients could be more vulnerable to Keppra.

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Top 10 Keppra Side Effects for Women

Women Side EffectsReports
Convulsion 481
Pregnancy 278
Grand Mal Convulsion 132
Thrombocytopenia 121
Condition Aggravated 120
Abortion Spontaneous 112
Caesarean Section 108
Depression 107
Somnolence 104
Fatigue 102

Top 10 Keppra Side Effects for Men

Men Side EffectsReports
Convulsion 362
Grand Mal Convulsion 92
Somnolence 92
Thrombocytopenia 83
Aggression 80
Depression 78
Fatigue 68
Condition Aggravated 67
Premature Baby 56
Anxiety 53

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Keppra Side Effects

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    Keppra Safety Alerts, Active Ingredients, Usage Information

    NDC16590-134
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameKEPPRA
    NameLEVETIRACETAM
    Dosage FormTABLET, FILM COATED
    RouteORAL
    On market since20000424
    LabelerSTAT RX USA LLC
    Active Ingredient(s)LEVETIRACETAM
    Strength(s)500
    Unit(s)mg/1
    Pharma ClassAnti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE]

    Keppra Dosage, Warnings, Usage.

    Side Effects reported to FDA: 5145

    Keppra safety alerts: 2003

    Reported deaths: 464

    Reported hospitalizations: 2333

    Latest Keppra clinical trials