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Itchiness (5)
Hyperglycemia (1)
Itching (1)
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Kremezin Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Bleeding Time Prolonged, Thrombocytopenia (8422664-8)
on May 29, 2012 Male from JAPAN , weighting 72.75 lb, was diagnosed with
  • renal failure chronic
  • hyperuricaemia
  • hypertension
and was treated with Kremezin. Directly after, patient experienced the unwanted or unexpected Kremezin side effects: bleeding time prolonged, thrombocytopenia. Kremezin dosage: N/A.
Associated medications used:
  • Allopurinol
  • Lasix (40-80mg)
  • Uralyt
  • Mircera
  • Famotidine
Patient was hospitalized.

Thirst (8349082-5)
Patient was taking Kremezin (charcoal, Activated). Patient felt the following Kremezin side effects: thirst on Apr 21, 2012 from JAPAN Additional patient health information: Male , 87 years of age, weighting 167.6 lb, . Kremezin (charcoal, Activated) dosage: N/A.
Multiple prescriptions taken:
  • Lansoprazole
  • Samsca (15 Mg Milligram(s), Qam, Oral)
  • Diart (azosemide) Tablet (60 Mg Milligram(s), Daily Dose, Oral)
  • Coughnol (ambroxol Hydrochloride)
  • Warfarin Sodium
  • Glucose (ascorbic Acid, Glucose)
  • Lasix (40 Mg Milligram(s), Daily Dose, Oral)
  • Calblock (azelnidipine)


Interstitial Lung Disease (8345422-1)
Adverse event was reported on Apr 19, 2012 by a Male taking Kremezin (charcoal, Activated) (Dosage: N/A) . Location: JAPAN , 79 years of age, After Kremezin was administered, patient encountered several Kremezin side effects: interstitial lung disease.
Multiple concurrent drugs taken:
  • Famotidine
  • Warfarin Sodium
  • Lanirapid (metildigoxin)
  • Pletal (100 Mg Milligram(s), Bid, Oral)
  • Amoban (zopiclone)
  • Ferromia (sodium Ferrous Citrate)
  • Furosemide
Patient was hospitalized.

Angioedema, Renal Failure, Blood Pressure Increased, Nephrogenic Anaemia (8270425-5)
on Mar 28, 2012 Female from JAPAN , weighting 127.9 lb, was treated with Kremezin. Directly after, patient experienced the unwanted or unexpected Kremezin side effects: angioedema, renal failure, blood pressure increased, nephrogenic anaemia. Kremezin dosage: 6 G.
Associated medications used:
  • Irbesartan (300 Mg)
  • Kayexalate (15 G)
  • Acetaminophen (600 Mg)
  • Aliskiren (150 Mg, Daily)
  • Amlodipine (10 Mg,)
  • Irbesartan (200 Mg)
  • Aliskiren (300 Mg, Daily)
  • Depas (1.5 Mg)



Face Oedema, Thrombocytopenia, Alanine Aminotransferase Increased, Blood Urea Increased, Oedema Peripheral, Hypothyroidism, Aspartate Aminotransferase Increased, Malaise, Palmar-plantar Erythrodysaesthesia Syndrome (7930125-5)
on Nov 18, 2011 Male from JAPAN , 70 years of age, was treated with Kremezin. Patient felt the following Kremezin side effects: face oedema, thrombocytopenia, alanine aminotransferase increased, blood urea increased, oedema peripheral, hypothyroidism, aspartate aminotransferase increased, malaise, palmar-plantar erythrodysaesthesia syndrome. Kremezin dosage: Unk.
Multiple prescriptions taken:
  • Magnesium Oxide (Unk)
  • Losartan Potassium (Unk)
  • Rabeprazole Sodium (Unk)
  • Persantin (Unk)
  • Amlodipine (Unk)
  • Sunitinib Malate (50 Mg, 1x/day, 28-day Administration And 14-day Cessation)
  • Sunitinib Malate (37.5 Mg/day)
  • Gaslon (Unk)
Patient was hospitalized.

Malaise, Face Oedema, Aspartate Aminotransferase Increased, Blood Urea Increased, Thrombocytopenia, Palmar-plantar Erythrodysaesthesia Syndrome, Alanine Aminotransferase Increased, Oedema Peripheral, Blood Creatinine Increased (7861371-7)
Patient was taking Kremezin. After Kremezin was administered, patient encountered several Kremezin side effects: malaise, face oedema, aspartate aminotransferase increased, blood urea increased, thrombocytopenia, palmar-plantar erythrodysaesthesia syndrome, alanine aminotransferase increased, oedema peripheral, blood creatinine increased on Oct 20, 2011 from JAPAN Additional patient health information: Male , 70 years of age, . Kremezin dosage: Unk.
Multiple concurrent drugs taken:
  • Amaryl (Unk)
  • Amlodipine (Unk)
  • Rabeprazole Sodium (Unk)
  • Gaslon (Unk)
  • Sunitinib Malate (50 Mg, 1x/day, 28-day Administration And 14-day Cessation)
  • Sunitinib Malate (37.5 Mg/day)
  • Magnesium Oxide (Unk)
  • Persantin (Unk)
Patient was hospitalized.

Renal Failure Chronic (7555681-0)
Adverse event was reported on Jun 01, 2011 by a Male taking Kremezin (Dosage: N/A) . Location: SWITZERLAND , weighting 172.0 lb, Directly after, patient experienced the unwanted or unexpected Kremezin side effects: renal failure chronic. Patient was hospitalized.

Diabetic Ketoacidosis, Cerebral Infarction, Cerebral Haemorrhage, Diabetic Neuropathy, Cardiac Failure, Vomiting (7437495-5)
on Apr 20, 2011 Female from JAPAN , 63 years of age, weighting 97.00 lb, was treated with Kremezin. Patient felt the following Kremezin side effects: diabetic ketoacidosis, cerebral infarction, cerebral haemorrhage, diabetic neuropathy, cardiac failure, vomiting. Kremezin dosage: N/A.
Multiple prescriptions taken:
  • Apidra (Continuous Subcutaneous Insulin Infusion (csii))
  • Apidra (Continuous Subcutaneous Insulin Infusion (csii))
  • Apidra (Continuous Subcutaneous Insulin Infusion (csii))
Patient was hospitalized.

Peritonitis, Rectal Perforation (7437335-4)
on Apr 21, 2011 Female from JAPAN , 57 years of age, was treated with Kremezin. After Kremezin was administered, patient encountered several Kremezin side effects: peritonitis, rectal perforation. Kremezin dosage: N/A.
Multiple concurrent drugs taken:
  • Diovan
  • Calblock
  • Loxonin
  • Alfarol
  • Cytotec
  • Fosrenol (750 Mg, Unk)
  • Zyloric
  • Thyradin


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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Kremezin Information

More About Kremezin

Side Effects reported to FDA: 9. View Kremezin Adverse Reports

Kremezin safety alerts: No

Reported deaths: 2

Reported hospitalizations: 5

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