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Review Lapatinib Safety Reports submitted to FDA

Total Lapatinib reports: 456.
Lapatinib FDA safety alerts: No.
Reported deaths: 53    Reported hospitalizations: 345.
Take Lapatinib Side Effects Survey, Discuss Lapatinib with others
FDA Reported Lapatinib Side Effects: nausea, dehydration, diarrhoea, pyrexia, asthenia, diarrhoea haemorrhagic, vomiting, fatigue, dyspnoea, hypokalaemia, anorexia.
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Lapatinib Side Effects Report #5529373-3
Physician from UNITED KINGDOM reported LAPATINIB problem on Nov 20, 2007. Female patient, 47 years of age, was diagnosed with breast infection, breast pain and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: erythema nodosum, pain of skin, pyrexia, rash macular, rash papular, skin lesion, upper respiratory tract infection, viral infection. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with METRONIDAZOLE, FLUCLOXACILLIN, GABAPENTIN, DICLOFENAC. Patient recovered.

Lapatinib Side Effects Report #5529381-2
LAPATINIB problem was reported by a Physician from BELGIUM on Nov 21, 2007. Male patient, 60 years of age, weighting 180.8 lb, was diagnosed with hypertension and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain, diarrhoea, nausea, renal failure. LAPATINIB dosage: unknown. During the same period patient was treated with CISPLATIN, FLUOROURACIL, DOCETAXEL, CARBOPLATIN, COAPROVEL, PRAVASTATIN, NORMITEN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5529382-4
Physician from CHINA reported LAPATINIB problem on Nov 20, 2007. Female patient, 52 years of age, weighting 114.6 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: leukopenia, neutropenia, thrombocytopenia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient died on 11/19/2007.

Lapatinib Side Effects Report #5529385-X
LAPATINIB problem was reported by a Physician from SLOVAKIA (Slovak Republic) on Nov 22, 2007. Female patient, 48 years of age, weighting 165.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anaemia, asthenia, diarrhoea, hypokalaemia, hyponatraemia, renal failure. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5530631-7
Physician from AUSTRIA reported LAPATINIB problem on Nov 22, 2007. Female patient, 49 years of age, weighting 158.7 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood alkaline phosphatase increased, blood lactate dehydrogenase increased, blood urea increased, face oedema, oedema peripheral, white blood cell count increased. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5530632-9
LAPATINIB problem was reported by a Physician from AUSTRIA on Nov 22, 2007. Female patient, 49 years of age, weighting 154.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: melaena. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5530638-X
Physician from DENMARK reported LAPATINIB problem on Nov 27, 2007. Female patient, 50 years of age, weighting 123.5 lb, was diagnosed with bone pain and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: pelvic venous thrombosis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, OXYCONTIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5530639-1
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Nov 20, 2007. Female patient, 58 years of age, weighting 125.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, SPIRONOLACTONE, FRUSEMIDE, LANSOPRAZOLE. Patient was hospitalized. Patient died on 11/17/2007.

Lapatinib Side Effects Report #5530645-7
Physician from GERMANY reported LAPATINIB problem on Nov 21, 2007. Female patient, 64 years of age, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, right ventricular failure. LAPATINIB dosage: unknown. During the same period patient was treated with TRASTUZUMAB. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5472919-4
LAPATINIB problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 17, 2007. Female patient was diagnosed with metastatic gastric cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: myocardial infarction, myocardial ischaemia. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5474788-5
Physician from UNITED KINGDOM reported LAPATINIB problem on Sept 27, 2007. Female patient, 43 years of age, was diagnosed with breast cancer metastatic, nausea, diarrhoea and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, haemoglobin decreased, hyperkalaemia, nausea, vomiting. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, LOPERAMIDE, DOMPERIDONE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5475796-0
LAPATINIB problem was reported by a Physician from FRANCE on Oct 01, 2007. Female patient, 53 years of age, weighting 127.9 lb, was diagnosed with breast cancer, rhinitis allergic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, cytolytic hepatitis. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CETIRIZINE. Patient recovered.

Lapatinib Side Effects Report #5475817-5
Physician from UNITED KINGDOM reported LAPATINIB problem on Sept 26, 2007. Female patient, 56 years of age, weighting 145.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dizziness, feeling cold, headache, neutropenic sepsis, pyrexia. LAPATINIB dosage: unknown. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5475825-4
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Sept 27, 2007. Female patient, 54 years of age, weighting 154.3 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis, fibrin d dimer increased, pleuritic pain. LAPATINIB dosage: 750MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5477170-X
Physician from UNITED STATES reported LAPATINIB problem on Sept 26, 2007. Female patient, 56 years of age, weighting 150.4 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased, liver function test abnormal, ocular icterus. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5477193-0
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Sept 28, 2007. Female patient, 63 years of age, weighting 144.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, dehydration, diarrhoea, dyspnoea, effusion. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5477207-8
Physician from ITALY reported LAPATINIB problem on Oct 01, 2007. Female patient, 66 years of age, weighting 183.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: hydronephrosis, renal failure. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5478372-9
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Sept 27, 2007. Female patient, 68 years of age, weighting 132.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dysphagia, neutropenia, pharyngolaryngeal pain, pyrexia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5478384-5
Physician from ITALY reported LAPATINIB problem on Sept 25, 2007. Female patient, 46 years of age, weighting 152.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient died on 09/10/2007.

Lapatinib Side Effects Report #5478390-0
LAPATINIB problem was reported by a Physician from BELGIUM on Sept 28, 2007. Female patient, 68 years of age, weighting 118.4 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, syncope, vomiting. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5478399-7
Physician from UNITED STATES reported LAPATINIB problem on Sept 27, 2007. Female patient, 51 years of age, weighting 137.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: back pain, cough, diarrhoea, dyspnoea, nausea, pain in extremity, weight decreased. LAPATINIB dosage: 1500MG PER DAY. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5479629-8
LAPATINIB problem was reported by a Physician from FRANCE on Sept 28, 2007. Female patient, 52 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, asthenia, disease progression, nausea. LAPATINIB dosage: 1500MG PER DAY. Patient was hospitalized. Patient died on 07/11/2007.

Lapatinib Side Effects Report #5479663-8
Physician from UNITED KINGDOM reported LAPATINIB problem on Sept 26, 2007. Female patient, 49 years of age, weighting 167.6 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: confusional state, convulsion, hearing impaired, loss of consciousness, mouth injury, musculoskeletal pain, somnolence, visual disturbance. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5480430-X
LAPATINIB problem was reported by a Physician from UNITED STATES on Oct 03, 2007. Male patient, 69 years of age, weighting 199.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blood creatinine increased, chronic obstructive pulmonary disease, dyspnoea, fatigue, left ventricular dysfunction. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with GEMCITABINE, COUMADIN. Patient recovered.

Lapatinib Side Effects Report #5480546-8
Physician from UNITED STATES reported LAPATINIB problem on Oct 03, 2007. Male patient, 69 years of age, weighting 199.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blood creatinine increased, chronic obstructive pulmonary disease, dyspnoea, fatigue, left ventricular dysfunction. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with GEMCITABINE, COUMADIN. Patient recovered.

Lapatinib Side Effects Report #5481403-3
LAPATINIB problem was reported by a Physician from UNITED STATES on Oct 05, 2007. Male patient, 69 years of age, weighting 199.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blood creatinine increased, chronic obstructive pulmonary disease, dyspnoea, fatigue, left ventricular dysfunction. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with GEMCITABINE, COUMADIN. Patient recovered.

Lapatinib Side Effects Report #5483764-8
Physician from UNITED STATES reported LAPATINIB problem on Oct 04, 2007. Female patient, 56 years of age, weighting 150.4 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased, infection, jaundice, liver function test abnormal, ocular icterus. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5483780-6
LAPATINIB problem was reported by a Physician from GERMANY on Oct 02, 2007. Female patient, 63 years of age, weighting 90.39 lb, was diagnosed with pain and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood glucose increased. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, VALORON. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5483781-8
Physician from UNITED KINGDOM reported LAPATINIB problem on Oct 05, 2007. Female patient, 58 years of age, weighting 136.7 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: chest pain. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5483791-0
LAPATINIB problem was reported by a Physician from SWITZERLAND on Oct 02, 2007. Female patient, 44 years of age, was diagnosed with pain, nausea and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cardiac tamponade, dyspnoea, oxygen saturation decreased, pericardial effusion. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, MORPHINE, EMEND. Patient recovered.

Lapatinib Side Effects Report #5483793-4
Physician from ITALY reported LAPATINIB problem on Oct 04, 2007. Female patient, 46 years of age, weighting 152.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, metastases to bone, metastases to liver, metastases to lung, pulmonary embolism. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient died on 09/10/2007.

Lapatinib Side Effects Report #5486469-2
LAPATINIB problem was reported by a Physician from UNITED STATES on Oct 08, 2007. Male patient, 82 years of age, was diagnosed with metastatic gastric cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: myocardial infarction, myocardial ischaemia. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5486470-9
Physician from UNITED STATES reported LAPATINIB problem on Oct 08, 2007. Male patient, 72 years of age, was diagnosed with metastatic gastric cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cerebral ischaemia. LAPATINIB dosage: 1500MG PER DAY. Patient died.

Lapatinib Side Effects Report #5486780-5
LAPATINIB problem was reported by a Physician from NETHERLANDS on Oct 04, 2007. Female patient, 48 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: hepatic enzyme increased, malaise. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5488324-0
Physician from GERMANY reported LAPATINIB problem on Oct 10, 2007. Female patient, 56 years of age, weighting 185.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: gastroenteritis, subileus. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CEFUROXIME, ASPIRIN, HYLAKTE, METAMIZOL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5488327-6
LAPATINIB problem was reported by a Physician from IRELAND on Oct 16, 2007. Female patient, 65 years of age, weighting 155.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: febrile neutropenia. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with TAXOTERE, TRASTUZUMAB. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5489657-4
Physician from TAIWAN, PROVINCE OF CHINA reported LAPATINIB problem on Oct 09, 2007. Female patient, 60 years of age, weighting 113.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, mouth ulceration, vomiting. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, PREDNISOLONE, SENNOSIDE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5490708-1
LAPATINIB problem was reported by a Physician from LITHUANIA on Oct 10, 2007. Female patient, 45 years of age, weighting 176.4 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: jaundice. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5491974-9
Physician from DENMARK reported LAPATINIB problem on Oct 12, 2007. Female patient, 68 years of age, weighting 142.0 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, diarrhoea, fatigue, nausea, weight decreased. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5493204-0
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Oct 15, 2007. Female patient, 61 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: hypoglycaemia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with LETROZOLE. Patient recovered.

Lapatinib Side Effects Report #5494954-2
Physician from AUSTRIA reported LAPATINIB problem on Oct 16, 2007. Female patient, 49 years of age, weighting 158.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: face oedema, oedema peripheral. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5496940-5
LAPATINIB problem was reported by a Physician from LITHUANIA on Oct 17, 2007. Female patient, 45 years of age, weighting 176.4 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: hepatitis toxic. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5496950-8
Physician from UNITED KINGDOM reported LAPATINIB problem on Oct 11, 2007. Female patient, 58 years of age, weighting 136.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: chest pain. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5499364-X
LAPATINIB problem was reported by a Physician from CANADA on Oct 19, 2007. Female patient, 36 years of age, weighting 97.00 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: epistaxis, hepatic enzyme increased, hepatic function abnormal, jaundice, thrombocytopenia, vomiting. LAPATINIB dosage: unknown. During the same period patient was treated with FEMARA, ZOLADEX. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5499423-1
Physician from GERMANY reported LAPATINIB problem on Oct 25, 2007. Female patient, 74 years of age, weighting 167.6 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: conjunctivitis, erythema, insomnia, pruritus. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with TRASTUZUMAB, BISOPROLOL FUMARATE. Patient was hospitalized and became disabled. Patient recovered.

Lapatinib Side Effects Report #5499424-3
LAPATINIB problem was reported by a Physician from BELGIUM on Oct 22, 2007. Female patient, 62 years of age, weighting 116.8 lb, was diagnosed with pain, nausea, hypophysitis, prophylaxis and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with TAMOXIFEN CITRATE, IBUPROFEN, VALTRAN, DAFALGAN, MOTILIUM, MINIRIN, CALCIUM D, PANTOPRAZOLE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5500846-2
Physician from UNITED KINGDOM reported LAPATINIB problem on Oct 22, 2007. Female patient, 44 years of age, weighting 176.8 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: emotional disorder, pain. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, IBANDRONATE, SERTRALINE, METOCLOPRAMIDE, ACETAMINOPHEN, FRUSEMIDE, ENALAPRIL MALEATE, DURAGESIC. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5501980-3
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Oct 22, 2007. Female patient, 47 years of age, weighting 196.2 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain, abdominal pain upper, diarrhoea, intestinal perforation. LAPATINIB dosage: 1500MG PER DAY. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5502916-1
Physician from UNITED STATES reported LAPATINIB problem on Oct 26, 2007. Female patient, 78 years of age, weighting 129.9 lb, was diagnosed with colorectal cancer, hypertension and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased, dehydration, hypokalaemia, nausea, vomiting. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with OXALIPLATIN, CAPECITABINE, POTASSIUM CHLORIDE, HYDROCHLOROTHIAZIDE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5502956-2
LAPATINIB problem was reported by a Physician from KOREA, REPUBLIC OF on Oct 25, 2007. Female patient, 49 years of age, weighting 160.9 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: body temperature increased, fatigue, rash macular, rash papular, urticaria. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, MS CONTIN, OXYCONTIN, NEURONTIN, ETRAVIL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5443350-2
Physician from GERMANY reported LAPATINIB problem on Aug 27, 2007. Female patient, 46 years of age, weighting 222.7 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: capillary permeability increased, chest pain, dyspnoea, hypersensitivity, hypertension, mitral valve incompetence, tachycardia. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5443390-3
LAPATINIB problem was reported by a Physician from DENMARK on Aug 28, 2007. Female patient, 51 years of age, weighting 167.6 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, pneumonia, pyrexia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, KALEORID. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5443392-7
Physician from AUSTRIA reported LAPATINIB problem on Aug 27, 2007. Female patient, 53 years of age, weighting 141.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, diarrhoea, hepatitis b, palmar-plantar erythrodysaesthesia syndrome, transaminases increased. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5443426-X
LAPATINIB problem was reported by a Physician from AUSTRIA on Aug 24, 2007. Female patient, 49 years of age, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: face oedema, oedema peripheral. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5444149-3
Health Professional from UNITED STATES reported LAPATINIB problem on Sept 04, 2007. Female patient, 67 years of age, weighting 189.6 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, diarrhoea, nausea, vomiting. LAPATINIB dosage: 1500 MG DAILY. During the same period patient was treated with IMODIUM, ASPIRIN, ATIVAN, CALCIUM D. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5446339-2
LAPATINIB problem was reported by a Physician from KOREA, REPUBLIC OF on Aug 31, 2007. Female patient, 62 years of age, weighting 148.4 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cellulitis, skin toxicity. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with OMEPRAZOLE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5446347-1
Physician from UNITED STATES reported LAPATINIB problem on Aug 31, 2007. Female patient, 56 years of age, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, dehydration, diarrhoea, nausea, vomiting. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with BEVACIZUMAB. Patient recovered.

Lapatinib Side Effects Report #5446364-1
LAPATINIB problem was reported by a Physician from AUSTRIA on Sept 05, 2007. Female patient, 67 years of age, weighting 114.6 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: gastric haemorrhage. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5446378-1
Physician from UNITED KINGDOM reported LAPATINIB problem on Aug 30, 2007. Female patient, 63 years of age, weighting 144.4 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: sepsis. LAPATINIB dosage: unknown. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5446387-2
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Aug 31, 2007. Female patient, 68 years of age, weighting 132.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: neutropenia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5447498-8
Physician from GERMANY reported LAPATINIB problem on Aug 31, 2007. Female patient, 45 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cardiovascular disorder, diarrhoea, ejection fraction, nausea, somnolence, vertigo, vomiting. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with CAPECITABINE, BONDRONAT. Patient was hospitalized. Patient died on 07/19/2007.

Lapatinib Side Effects Report #5447527-1
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Aug 31, 2007. Female patient, 54 years of age, weighting 154.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis. LAPATINIB dosage: 750MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5448689-2
Physician from UNITED STATES reported LAPATINIB problem on Sept 06, 2007. Female patient, 62 years of age, weighting 111.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain lower, gastritis, gastrointestinal haemorrhage, haematemesis, haematochezia, hyperbilirubinaemia, hypokalaemia, jaundice, mesenteric vein thrombosis. LAPATINIB dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5448732-0
LAPATINIB problem was reported by a Physician from BELGIUM on Sept 04, 2007. Female patient, 55 years of age, weighting 134.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anaemia, cardiac failure, cardiomegaly, hepatomegaly, pleural effusion. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 07/11/2007.

Lapatinib Side Effects Report #5449683-8
Health Professional from UNITED STATES reported LAPATINIB problem on Sept 10, 2007. Female patient, 64 years of age, weighting 149.7 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal discomfort, anorexia, dehydration, diarrhoea, infection, nausea, pyrexia, urinary tract infection. LAPATINIB dosage: 1250MG DAILY PO. During the same period patient was treated with DOCETAXEL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5450148-8
LAPATINIB problem was reported by a Physician from GERMANY on Sept 03, 2007. Female patient, 46 years of age, weighting 229.3 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: thrombophlebitis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient recovered.

Lapatinib Side Effects Report #5451414-2
Physician from UNITED STATES reported LAPATINIB problem on Sept 10, 2007. Female patient, 64 years of age, weighting 149.7 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal discomfort, anorexia, dehydration, diarrhoea, klebsiella infection, nausea, pyrexia, urinary tract infection. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with DOCETAXEL, DEXAMETHASONE, NEULASTA, LEVAQUIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5451418-X
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Sept 07, 2007. Female patient, 56 years of age, weighting 145.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dizziness, feeling cold, headache, neutropenic sepsis, pyrexia. LAPATINIB dosage: unknown. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5452873-1
Physician from SWEDEN reported LAPATINIB problem on Sept 07, 2007. Female patient, 57 years of age, weighting 141.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: arthralgia, asthenia, blister, convulsion, erysipelas, fatigue, loss of consciousness, neutropenia, pain in extremity. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with HYCAMTIN, BETAPRED. Patient died on 07/28/2007.

Lapatinib Side Effects Report #5452878-0
LAPATINIB problem was reported by a Physician from GERMANY on Sept 05, 2007. Female patient, 69 years of age, was diagnosed with incontinence, wound and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: amnesia, syncope. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with TOPOTECAN, DRIDASE, TRAUMANASE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5453869-6
Physician from UNITED KINGDOM reported LAPATINIB problem on Sept 10, 2007. Female patient, 54 years of age, weighting 154.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis, fibrin d dimer increased, pleuritic pain. LAPATINIB dosage: 750MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5453870-2
LAPATINIB problem was reported by a Physician from ISRAEL on Sept 14, 2007. Female patient, 49 years of age, weighting 183.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, eating disorder, monoplegia, stomatitis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, DEXACORT, VALPROATE, LOSEC, EPANUTIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5453876-3
Physician from ITALY reported LAPATINIB problem on Sept 10, 2007. Female patient, 26 years of age, weighting 149.9 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, anaphylactic reaction, dyspnoea, hyperhidrosis, tachycardia. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with TAXOL, TRASTUZUMAB. Patient recovered.

Lapatinib Side Effects Report #5453877-5
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Sept 07, 2007. Female patient, 43 years of age, was diagnosed with nausea and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, haemoglobin decreased, hyperkalaemia, nausea, vomiting. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, LOPERAMIDE, DOMPERIDONE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5456548-4
Physician from GERMANY reported LAPATINIB problem on Sept 12, 2007. Female patient, 45 years of age, weighting 136.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cardiovascular disorder, ejection fraction, nausea, somnolence, vertigo, vomiting. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with CAPECITABINE, BONDRONAT. Patient was hospitalized. Patient died on 07/19/2007.

Lapatinib Side Effects Report #5459482-9
LAPATINIB problem was reported by a Physician from UNITED STATES on Sept 18, 2007. Female patient, 64 years of age, weighting 149.7 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal discomfort, anorexia, bone pain, dehydration, diarrhoea, myalgia, nausea, pain in extremity. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with DOCETAXEL, DEXAMETHASONE, NEULASTA, LEVAQUIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5462176-7
Health Professional from UNITED STATES reported LAPATINIB problem on Sept 18, 2007. Female patient, 64 years of age, weighting 149.0 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal discomfort, anorexia, dehydration, diarrhoea, infection, nausea, pyrexia, urinary tract infection. LAPATINIB dosage: 1250MG DAILY PO. During the same period patient was treated with DOCETAXEL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5463163-5
LAPATINIB problem was reported by a Physician from UNITED STATES on Sept 11, 2007. Female patient, 67 years of age, weighting 233.7 lb, was diagnosed with pain, hypertension and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, pneumonia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, OXYCODONE, OXYCONTIN, ATENOLOL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5463210-0
Physician from AUSTRIA reported LAPATINIB problem on Sept 11, 2007. Female patient, 53 years of age, weighting 141.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, diarrhoea, hepatitis b, palmar-plantar erythrodysaesthesia syndrome. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5463218-5
LAPATINIB problem was reported by a Physician from ISRAEL on Sept 17, 2007. Female patient, 49 years of age, weighting 183.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, eating disorder, monoplegia, stomatitis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, DEXACORT, VALPROATE, LOSEC, EPANUTIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5465747-7
Physician from DENMARK reported LAPATINIB problem on Sept 17, 2007. Female patient, 58 years of age, weighting 210.5 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, fatigue, hepatotoxicity, jaundice, nausea, pyrexia, vomiting, weight decreased. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5465766-0
LAPATINIB problem was reported by a Physician from GERMANY on Sept 20, 2007. Female patient, 45 years of age, weighting 136.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cardiovascular disorder, ejection fraction, nausea, somnolence, vertigo, vomiting. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with CAPECITABINE, BONDRONAT. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5465781-7
Physician from SPAIN reported LAPATINIB problem on Sept 17, 2007. Female patient, 57 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: pulmonary embolism. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5465783-0
LAPATINIB problem was reported by a Physician from BELGIUM on Sept 18, 2007. Female patient, 43 years of age, weighting 140.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, headache, peripheral sensory neuropathy. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5467000-4
Physician from UNITED STATES reported LAPATINIB problem on Sept 17, 2007. Female patient, 50 years of age, weighting 202.4 lb, was diagnosed with pulmonary embolism and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: haematuria, international normalised ratio increased, urinary tract infection. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, AZITHROMYCIN, COUMADIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5467002-8
LAPATINIB problem was reported by a Physician from UNITED STATES on Sept 18, 2007. Female patient, 56 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, dehydration, diarrhoea, nausea, overdose, vomiting. LAPATINIB dosage: 3000MG PER DAY. During the same period patient was treated with BEVACIZUMAB. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5467034-X
Physician from GERMANY reported LAPATINIB problem on Sept 20, 2007. Female patient, 45 years of age, weighting 136.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cardiovascular disorder, diarrhoea, ejection fraction, nausea, skin reaction, somnolence, vertigo, vomiting. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with CAPECITABINE, BONDRONAT. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5468359-4
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Sept 18, 2007. Female patient, 49 years of age, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: confusional state, convulsion, fall, grand mal convulsion, hallucinations, mixed, hearing impaired, loss of consciousness, mouth injury, musculoskeletal pain. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5468361-2
Physician from SWITZERLAND reported LAPATINIB problem on Sept 18, 2007. Female patient, 44 years of age, was diagnosed with pain, nausea and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: pericardial effusion. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, MORPHINE, EMEND. Patient recovered.

Lapatinib Side Effects Report #5469722-8
LAPATINIB problem was reported by a Health Professional from UNITED STATES on Sept 26, 2007. Female patient, 67 years of age, weighting 194.0 lb, was diagnosed with breast cancer, diarrhoea and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, diarrhoea, loss of consciousness, syncope, vomiting. LAPATINIB dosage: 5 PILLS DAILY (1250 MG). During the same period patient was treated with OPIUM TINTURE, ESOMEPRAZOLE MAGNESIUM, CALCIUM D, ASPIRIN, ATIVAN. Patient recovered.

Lapatinib Side Effects Report #5470985-3
Physician from UNITED STATES reported LAPATINIB problem on Sept 26, 2007. Female patient, 67 years of age, weighting 190.5 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, decreased appetite, dehydration, diarrhoea, eating disorder, hypokalaemia, nausea, syncope. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with OPIUM TINCTURE, IMODIUM, ASPIRIN, ATIVAN, CALCIUM, ESOMEPRAZOLE MAGNESIUM, NEXIUM, DIPHENOXYLATE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5471029-X
LAPATINIB problem was reported by a Physician from ITALY on Sept 20, 2007. Female patient, 66 years of age, weighting 183.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: renal failure. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5471034-3
Consumer or non-health professional from UNITED STATES reported LAPATINIB problem on Sept 17, 2007. Female patient was diagnosed with metastatic gastric cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: cerebral ischaemia. LAPATINIB dosage: 1500MG PER DAY. Patient died.

Lapatinib Side Effects Report #5402673-3
LAPATINIB problem was reported by a Physician from UNITED STATES on July 23, 2007. Female patient, 50 years of age, weighting 202.4 lb, was diagnosed with pulmonary embolism and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: haematuria, international normalised ratio increased, urinary tract infection. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, AZITHROMYCIN, COUMADIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5403985-X
Physician from SWITZERLAND reported LAPATINIB problem on July 27, 2007. Female patient, 56 years of age, weighting 143.3 lb, was diagnosed with diabetes mellitus and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, diarrhoea, hypokalaemia. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with CAPECITABINE, VISIPAQUE, IOXITALAMIC ACID, DIAMICRON, IMODIUM. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5405290-4
LAPATINIB problem was reported by a Physician from AUSTRALIA on July 26, 2007. Female patient, 51 years of age, was diagnosed with breast cancer metastatic, metastases to central nervous system, coagulopathy, analgesia, gastrooesophageal reflux disease and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: fall, injury, nail infection, osteopenia, pubic rami fracture. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, LACTULOSE, DEXAMETHASONE, ENOXAPARIN, OXYCODONE, ESOMEPRAZOLE MAGNESIUM, METHADONE, CHOLECALCIFEROL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5405307-7
Physician from UNITED KINGDOM reported LAPATINIB problem on July 24, 2007. Female patient, 44 years of age, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: chest pain. LAPATINIB dosage: unknown. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5405320-X
LAPATINIB problem was reported by a Physician from UNITED STATES on Aug 01, 2007. Female patient, 51 years of age, weighting 137.1 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: