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Review Lapatinib Safety Reports submitted to FDA

Total Lapatinib reports: 769.
Lapatinib FDA safety alerts: No.
Reported deaths: 73    Reported hospitalizations: 589.
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FDA Reported Lapatinib Side Effects: nausea, dehydration, diarrhoea, pyrexia, asthenia, diarrhoea haemorrhagic, vomiting, fatigue, dyspnoea, hypokalaemia, anorexia.
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Lapatinib Side Effects Report #5406023-8
Physician from FRANCE reported LAPATINIB problem on July 27, 2007. Female patient, 48 years of age, weighting 129.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, neutropenia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5406024-X
LAPATINIB problem was reported by a Physician from UNITED STATES on July 27, 2007. Female patient, 51 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: exfoliative rash, pyrexia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with BEVACIZUMAB. Patient recovered.

Lapatinib Side Effects Report #5406048-2
Physician from SPAIN reported LAPATINIB problem on July 27, 2007. Female patient, 39 years of age, weighting 99.21 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, fluid intake reduced, gastritis, oral intake reduced. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5407201-4
LAPATINIB problem was reported by a Physician from PHILIPPINES on Aug 03, 2007. Female patient, 65 years of age, weighting 101.4 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, asthenia, diarrhoea, electrolyte imbalance. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with MICARDIS, INDERAL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5407228-2
Physician from GERMANY reported LAPATINIB problem on July 31, 2007. Female patient, 54 years of age, weighting 216.1 lb, was diagnosed with breast cancer, depression and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, rash, rectal haemorrhage. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with ARIMIDEX, CYMBALTA, MAGNESIUM VERLA. Patient recovered.

Lapatinib Side Effects Report #5407252-X
LAPATINIB problem was reported by a Physician from SWITZERLAND on July 31, 2007. Female patient, 60 years of age, weighting 190.9 lb, was diagnosed with depression and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: confusional state, disorientation, hypokalaemia, paresis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, DEXAMETHASONE, FENTANYL, DOXEPIN, MIANSERIN HYDROCHLORIDE, ZOLPIDEM TARTRATE, PANTOPRAZOLE. Patient was hospitalized. Patient died on 08/03/2007.

Lapatinib Side Effects Report #5407269-5
Physician from AUSTRALIA reported LAPATINIB problem on July 27, 2007. Female patient, 64 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, rectal haemorrhage. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, METOCLOPRAMIDE, TEMAZEPAM. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5408735-9
LAPATINIB problem was reported by a Physician from ITALY on July 30, 2007. Female patient, 47 years of age, weighting 145.5 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: erysipelas, rash, skin oedema. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5409712-4
Physician from UNITED STATES reported LAPATINIB problem on July 31, 2007. Female patient, 64 years of age, weighting 157.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: herpes zoster, infection. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5409735-5
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on Aug 01, 2007. Female patient, 44 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: chest pain, dyspnoea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5409750-1
Physician from UNITED KINGDOM reported LAPATINIB problem on July 31, 2007. Female patient, 63 years of age, weighting 144.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, dehydration, diarrhoea, dyspnoea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5411208-0
LAPATINIB problem was reported by a Physician from BELGIUM on Aug 03, 2007. Female patient, 55 years of age, weighting 134.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anaemia, cardiac failure, cardiomegaly, hepatomegaly, pleural effusion. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 07/11/2007.

Lapatinib Side Effects Report #5411232-8
Physician from ITALY reported LAPATINIB problem on Aug 01, 2007. Female patient, 51 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: pericardial effusion. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5411233-X
LAPATINIB problem was reported by a Physician from SPAIN on Aug 01, 2007. Female patient, 72 years of age, weighting 211.6 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, diarrhoea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5411972-0
Physician from UNITED STATES reported LAPATINIB problem on Aug 10, 2007. Female patient, 61 years of age, weighting 156.5 lb, was diagnosed with breast cancer, ovarian cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: neutropenia, pyrexia, rash, urinary tract infection, white blood cell count decreased. LAPATINIB dosage: 7500 MG/ X2 WEEKLY ORAL. During the same period patient was treated with ABRAXANE, ZOMETA, NEUPOGEN, OXYCODONE, FAMOTIDINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5412530-4
LAPATINIB problem was reported by a Physician from AUSTRALIA on Aug 02, 2007. Female patient, 39 years of age, weighting 140.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: atrial flutter, dyspnoea, left ventricular dysfunction, palpitations, pericardial effusion, pericarditis, pyrexia. LAPATINIB dosage: 1250MGM2 PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 06/30/2007.

Lapatinib Side Effects Report #5415517-0
Physician from GERMANY reported LAPATINIB problem on Aug 06, 2007. Female patient, 42 years of age, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, feeling cold, gastric ulcer, nausea, pyrexia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with ZOLADEX, AROMASIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5415523-6
LAPATINIB problem was reported by a Physician from SWEDEN on Aug 08, 2007. Female patient, 57 years of age, weighting 141.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blister, neutropenia, pain in extremity, pyrexia, sepsis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with HYCAMTIN, BETAPRED. Patient died on 07/28/2007.

Lapatinib Side Effects Report #5415549-2
Physician from UNITED KINGDOM reported LAPATINIB problem on Aug 06, 2007. Female patient, 44 years of age, weighting 123.9 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: axillary pain, chest pain. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5416728-0
LAPATINIB problem was reported by a Physician from SPAIN on Aug 13, 2007. Female patient, 39 years of age, weighting 99.21 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, fluid intake reduced, gastritis, oral intake reduced. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5416737-1
Physician from SLOVAKIA (Slovak Republic) reported LAPATINIB problem on Aug 07, 2007. Female patient, 55 years of age, weighting 183.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: erysipelas. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5418243-7
LAPATINIB problem was reported by a Physician from CHINA on Aug 11, 2007. Female patient, 59 years of age, weighting 111.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: neutropenia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with PACLITAXEL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5418244-9
Physician from THAILAND reported LAPATINIB problem on Aug 10, 2007. Female patient, 62 years of age, weighting 136.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: neutropenia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with PACLITAXEL. Patient recovered.

Lapatinib Side Effects Report #5419395-5
LAPATINIB problem was reported by a Physician from THAILAND on Aug 10, 2007. Female patient, 53 years of age, weighting 139.1 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain, anorexia, candidiasis, diarrhoea, escherichia infection, leukopenia, neutropenia, staphylococcal infection. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with PACLITAXEL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5419396-7
Physician from FRANCE reported LAPATINIB problem on Aug 16, 2007. Female patient, 53 years of age, weighting 134.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: bronchitis, dysphagia, fatigue, mucosal inflammation, pain. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5419397-9
LAPATINIB problem was reported by a Physician from GERMANY on Aug 10, 2007. Female patient, 46 years of age, weighting 222.7 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: capillary permeability increased, chest pain, dyspnoea, hypersensitivity, hypertension, mitral valve incompetence, tachycardia. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5419456-0
Physician from ITALY reported LAPATINIB problem on Aug 10, 2007. Female patient, 63 years of age, weighting 209.4 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis, pulmonary embolism. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, INSULIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5421074-5
LAPATINIB problem was reported by a Physician from AUSTRALIA on Aug 10, 2007. Female patient, 56 years of age, weighting 147.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: bile duct stone, cholangitis, jaundice cholestatic, left ventricular dysfunction. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5422374-5
Physician from UNITED STATES reported LAPATINIB problem on Aug 15, 2007. Female patient, 65 years of age, weighting 192.9 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, decreased appetite, defaecation urgency, dehydration, diarrhoea, escherichia urinary tract infection, nausea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5423644-7
LAPATINIB problem was reported by a Physician from INDIA on Aug 14, 2007. Female patient, 67 years of age, weighting 121.3 lb, was diagnosed with breast cancer, hypertension and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain, gastroenteritis. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with AMLODIPINE, ATENOLOL, CEFIXIME, DICLOFENAC. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5423699-X
Physician from UNITED STATES reported LAPATINIB problem on Aug 16, 2007. Female patient, 49 years of age, weighting 156.3 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, diarrhoea, fatigue, hypokalaemia. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with PACLITAXEL, TRASTUZUMAB, METOPROLOL SUCCINATE, GABAPENTIN, CARAFATE, CLONAZEPAM. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5424942-3
LAPATINIB problem was reported by a Physician from SWEDEN on Aug 17, 2007. Female patient, 57 years of age, weighting 141.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blister, neutropenia, pain in extremity, pyrexia, sepsis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with HYCAMTIN, BETAPRED. Patient died on 07/28/2007.

Lapatinib Side Effects Report #5424944-7
Physician from CHINA reported LAPATINIB problem on Aug 21, 2007. Female patient, 59 years of age, weighting 111.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: neutropenia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with PACLITAXEL. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5424973-3
LAPATINIB problem was reported by a Physician from GERMANY on Aug 15, 2007. Female patient, 51 years of age, weighting 176.4 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: fatigue, pulmonary embolism. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5427569-2
Physician from UNITED KINGDOM reported LAPATINIB problem on Aug 20, 2007. Female patient, 44 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: arteriospasm coronary, dyspnoea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5427574-6
LAPATINIB problem was reported by a Physician from AUSTRALIA on Aug 23, 2007. Female patient, 56 years of age, weighting 147.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, bile duct stone, cholangitis, jaundice cholestatic, left ventricular dysfunction, nausea, vomiting. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, TRASTUZUMAB. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5427586-2
Physician from UNITED KINGDOM reported LAPATINIB problem on Aug 17, 2007. Female patient, 54 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: chest pain, pain in jaw. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5429461-6
LAPATINIB problem was reported by a Physician from FRANCE on Aug 21, 2007. Female patient, 48 years of age, weighting 129.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anaemia, neutropenia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5429483-5
Physician from AUSTRALIA reported LAPATINIB problem on Aug 20, 2007. Female patient, 30 years of age, weighting 132.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: catheter related infection, lipase increased. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, ZOMETA. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5429495-1
LAPATINIB problem was reported by a Physician from GERMANY on Aug 21, 2007. Female patient, 46 years of age, weighting 229.3 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: thrombophlebitis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient recovered.

Lapatinib Side Effects Report #5429496-3
Physician from AUSTRALIA reported LAPATINIB problem on Aug 20, 2007. Female patient, 54 years of age, weighting 202.8 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, pyrexia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5430961-3
LAPATINIB problem was reported by a Physician from LITHUANIA on Aug 23, 2007. Female patient, 45 years of age, weighting 176.4 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: jaundice. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5430970-4
Physician from GERMANY reported LAPATINIB problem on Aug 23, 2007. Female patient, 69 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: retrograde amnesia, syncope. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with TOPOTECAN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5430975-3
LAPATINIB problem was reported by a Physician from DENMARK on Aug 22, 2007. Female patient, 58 years of age, weighting 210.5 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, fatigue, hepatotoxicity, jaundice, nausea, vomiting, weight decreased. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5431000-0
Physician from ISRAEL reported LAPATINIB problem on Aug 23, 2007. Female patient, 44 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: condition aggravated, dyspnoea, lymphangitis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient died on 07/28/2007.

Lapatinib Side Effects Report #5436003-8
LAPATINIB problem was reported by a Physician from UNITED STATES on Aug 29, 2007. Female patient, 62 years of age, weighting 111.3 lb, was diagnosed with pancreatic carcinoma and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain lower, arteriovenous malformation, gastritis, gastrointestinal haemorrhage, haematemesis, haematochezia, hyperbilirubinaemia, hypokalaemia, jaundice. LAPATINIB dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5436008-7
Physician from UNITED STATES reported LAPATINIB problem on Aug 29, 2007. Male patient, 69 years of age, weighting 199.5 lb, was diagnosed with pancreatic carcinoma and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blood creatinine increased, chronic obstructive pulmonary disease, dyspnoea, fatigue, left ventricular dysfunction. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with GEMCITABINE, COUMADIN. Patient recovered.

Lapatinib Side Effects Report #5436020-8
LAPATINIB problem was reported by a Physician from AUSTRIA on Aug 22, 2007. Female patient, 66 years of age, weighting 114.6 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: catheter related infection, diarrhoea, nausea, neck pain. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5436024-5
Physician from UNITED KINGDOM reported LAPATINIB problem on Aug 24, 2007. Female patient, 44 years of age, weighting 123.9 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: angina pectoris, axillary pain, chest pain. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5436028-2
LAPATINIB problem was reported by a Physician from AUSTRALIA on Aug 22, 2007. Female patient, 64 years of age, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, rectal haemorrhage. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, METOCLOPRAMIDE, TEMAZEPAM. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5436029-4
Physician from AUSTRALIA reported LAPATINIB problem on Aug 23, 2007. Female patient, 56 years of age, weighting 147.7 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: bile duct stone, cholangitis, jaundice cholestatic, left ventricular dysfunction. LAPATINIB dosage: unknown. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5436030-0
LAPATINIB problem was reported by a Physician from SLOVAKIA (Slovak Republic) on Aug 22, 2007. Female patient, 55 years of age, weighting 183.0 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: erysipelas. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5436034-8
Physician from UNITED KINGDOM reported LAPATINIB problem on Aug 24, 2007. Female patient, 51 years of age, weighting 148.4 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, pulmonary embolism. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient recovered.

Lapatinib Side Effects Report #5436038-5
LAPATINIB problem was reported by a Physician from AUSTRALIA on Aug 27, 2007. Female patient, 67 years of age, weighting 114.6 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: gastric haemorrhage. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5376089-2
Physician from GERMANY reported LAPATINIB problem on June 22, 2007. Female patient, 46 years of age, weighting 222.7 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: capillary permeability increased, chest pain, dyspnoea, hypertension, mitral valve incompetence, tachycardia. LAPATINIB dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5377388-0
LAPATINIB problem was reported by a Physician from IRELAND on July 02, 2007. Female patient, 42 years of age, weighting 148.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: ejection fraction decreased. LAPATINIB dosage: 500MG PER DAY. During the same period patient was treated with DOCETAXEL, TRASTUZUMAB, OXYNORM, NEURONTIN, ZOLPIDEM TARTRATE, CITALOPRAM HYDROBROMIDE. Patient recovered.

Lapatinib Side Effects Report #5377389-2
Physician from POLAND reported LAPATINIB problem on June 25, 2007. Female patient, 68 years of age, weighting 185.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: fatigue, neutropenia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with TAXOL. Patient recovered.

Lapatinib Side Effects Report #5377390-9
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on June 25, 2007. Male patient, 50 years of age, weighting 247.8 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: hyperuricaemia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CISPLATIN, ALLOPURINOL, OMEPRAZOLE. Patient recovered.

Lapatinib Side Effects Report #5377393-4
Physician from GERMANY reported LAPATINIB problem on June 27, 2007. Female patient, 42 years of age, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, feeling cold, nausea, pyrexia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with ZOLADEX, AROMASIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5377416-2
LAPATINIB problem was reported by a Physician from GERMANY on June 25, 2007. Female patient, 64 years of age, weighting 123.5 lb, was diagnosed with pain and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: nausea, neoplasm, oedema, pyrexia, vomiting. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, DUROGESIC PATCH, IBUPROFEN, LASIX. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5378692-2
Physician from UNITED STATES reported LAPATINIB problem on June 28, 2007. Female patient, 71 years of age, weighting 127.0 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abasia, asthenia, dizziness, fall, hyponatraemia, inappropriate antidiuretic hormone secretion, musculoskeletal pain. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with LETROZOLE, DYAZIDE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5378693-4
LAPATINIB problem was reported by a Physician from UNITED STATES on July 02, 2007. Female patient, 81 years of age, weighting 123.2 lb, was diagnosed with hypertension, osteoporosis, neuropathy and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: ejection fraction decreased, haematemesis, myocardial infarction, rhabdomyolysis. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with LETROZOLE, DIOVAN, TOPROL, LASIX, ACTONEL, CALCIUM WITH VITAMIN D, LYRICA. Patient recovered.

Lapatinib Side Effects Report #5378696-X
Physician from POLAND reported LAPATINIB problem on June 25, 2007. Female patient, 68 years of age, weighting 185.2 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: fatigue, neutropenia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with TAXOL. Patient recovered.

Lapatinib Side Effects Report #5380051-3
LAPATINIB problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 06, 2007. Female patient was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, nausea. LAPATINIB dosage: unknown. During the same period patient was treated with XELODA, CALCIUM CHLORIDE. Patient recovered.

Lapatinib Side Effects Report #5380060-4
Consumer or non-health professional from UNITED STATES reported LAPATINIB problem on Apr 11, 2007. Female patient, 59 years of age, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, vomiting. LAPATINIB dosage: unknown. During the same period patient was treated with XELODA, SYNTHROID, CYTOMEL, CELEXA, BENADRYL, IMODIUM. Patient recovered.

Lapatinib Side Effects Report #5380751-5
LAPATINIB problem was reported by a Physician from HUNGARY on July 06, 2007. Female patient, 55 years of age, weighting 130.1 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, dehydration, diarrhoea, gamma-glutamyltransferase increased, nausea, vomiting. LAPATINIB dosage: 1500MG PER DAY. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5380794-1
Physician from GERMANY reported LAPATINIB problem on June 28, 2007. Female patient, 55 years of age, weighting 147.7 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: bile duct cancer, cholestasis, hyperbilirubinaemia, jaundice. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5381969-8
LAPATINIB problem was reported by a Physician from UNITED STATES on July 03, 2007. Female patient, 56 years of age, weighting 175.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased, cellulitis, erythema, haemorrhage, pain in extremity, palmar-plantar erythrodysaesthesia syndrome, purulent discharge, skin exfoliation, staphylococcal infection. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient recovered.

Lapatinib Side Effects Report #5382986-4
Physician from DENMARK reported LAPATINIB problem on June 28, 2007. Female patient, 51 years of age, weighting 167.6 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, pneumonia, pyrexia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5384198-7
LAPATINIB problem was reported by a Physician from ITALY on July 04, 2007. Female patient, 44 years of age, weighting 372.6 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: hyperbilirubinaemia, ill-defined disorder, thrombocytopenia. LAPATINIB dosage: 1250MGM2 PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5384209-9
Physician from IRELAND reported LAPATINIB problem on July 03, 2007. Female patient, 56 years of age, weighting 101.6 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, dizziness, fatigue, headache, metastases to central nervous system, nausea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5385542-7
LAPATINIB problem was reported by a Physician from BELGIUM on July 03, 2007. Female patient, 55 years of age, weighting 134.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anaemia, cardiac failure. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient recovered.

Lapatinib Side Effects Report #5385546-4
Physician from BELGIUM reported LAPATINIB problem on July 03, 2007. Female patient, 55 years of age, weighting 116.8 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, pulmonary embolism. LAPATINIB dosage: 1250MGM2 PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5385548-8
LAPATINIB problem was reported by a Physician from AUSTRIA on July 03, 2007. Female patient, 61 years of age, weighting 132.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain, leukopenia, nausea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5386553-8
Physician from UNITED STATES reported LAPATINIB problem on July 06, 2007. Female patient, 39 years of age, weighting 130.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: bile duct obstruction. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 04/27/2007.

Lapatinib Side Effects Report #5386583-6
LAPATINIB problem was reported by a Physician from ITALY on July 04, 2007. Female patient, 47 years of age, weighting 145.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: rash, skin oedema. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5389232-6
Physician from FRANCE reported LAPATINIB problem on July 13, 2007. Male patient, 68 years of age, weighting 172.0 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: pneumonia aspiration, renal failure. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5389235-1
LAPATINIB problem was reported by a Physician from UNITED STATES on July 09, 2007. Female patient, 56 years of age, weighting 175.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased, cellulitis, erythema, haemorrhage, oedema peripheral, pain in extremity, palmar-plantar erythrodysaesthesia syndrome, purulent discharge, skin exfoliation. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient recovered.

Lapatinib Side Effects Report #5389237-5
Physician from UNITED STATES reported LAPATINIB problem on July 09, 2007. Female patient, 28 years of age, weighting 124.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: thrombosis. LAPATINIB dosage: 1000MG IN THE MORNING. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5389243-0
LAPATINIB problem was reported by a Physician from PERU on July 12, 2007. Female patient, 42 years of age, weighting 144.2 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, decreased appetite, dehydration, hyperglycaemia, hypernatraemia, renal failure, sinus tachycardia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5390081-3
Physician from UNITED STATES reported LAPATINIB problem on July 11, 2007. Male patient, 55 years of age, was diagnosed with malignant glioma, hypothyroidism and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain, chromaturia, constipation, dysuria, faeces discoloured, haematochezia, pollakiuria. LAPATINIB dosage: 250MG PER DAY. During the same period patient was treated with PAZOPANIB, PHENYTEK, DECADRON, SYNTHROID, AVODART, DEXAMETHASONE, KEPPRA, VITAMIN CAP. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5390102-8
LAPATINIB problem was reported by a Physician from NETHERLANDS on July 11, 2007. Female patient, 57 years of age, weighting 165.3 lb, was diagnosed with breast cancer metastatic, thrombosis, pruritus and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dyspnoea, localised oedema. LAPATINIB dosage: 1250MG TWICE PER DAY. During the same period patient was treated with CAPECITABINE, NADROPARINE, CEFATRIZINE. Patient was hospitalized. Patient died on 06/09/2007.

Lapatinib Side Effects Report #5390117-X
Physician from AUSTRALIA reported LAPATINIB problem on July 10, 2007. Female patient, 62 years of age, weighting 143.3 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: blood pressure decreased, diarrhoea, neutropenic sepsis. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 07/04/2007.

Lapatinib Side Effects Report #5392405-X
LAPATINIB problem was reported by a Physician from ITALY on July 12, 2007. Female patient, 60 years of age, weighting 121.3 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, dehydration, diarrhoea, nausea, vomiting. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized and became disabled. Patient recovered.

Lapatinib Side Effects Report #5392407-3
Physician from ITALY reported LAPATINIB problem on July 13, 2007. Female patient, 47 years of age, weighting 145.5 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: rash, skin oedema. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5392415-2
LAPATINIB problem was reported by a Physician from SWITZERLAND on July 10, 2007. Female patient, 56 years of age, weighting 143.3 lb, was diagnosed with diabetes mellitus and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea, hypokalaemia. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with CAPECITABINE, DIAMICRON, IMODIUM. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5392429-2
Physician from SPAIN reported LAPATINIB problem on July 13, 2007. Female patient, 45 years of age, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea haemorrhagic, eating disorder, hepatotoxicity, mucosal inflammation, multi-organ failure, neutropenia. LAPATINIB dosage: unknown. During the same period patient was treated with XELODA. Patient died on 07/08/2007.

Lapatinib Side Effects Report #5393853-4
LAPATINIB problem was reported by a Physician from UNITED STATES on July 18, 2007. Female patient, 74 years of age, weighting 180.8 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: anaemia, atrial fibrillation, palpitations, pulmonary embolism, renal failure acute. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient died on 07/13/2007.

Lapatinib Side Effects Report #5395439-4
Physician from UNITED STATES reported LAPATINIB problem on July 18, 2007. Female patient, 39 years of age, weighting 130.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: bile duct obstruction, disease progression, jaundice. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 04/27/2007.

Lapatinib Side Effects Report #5395463-1
LAPATINIB problem was reported by a Physician from SPAIN on July 23, 2007. Female patient, 50 years of age, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: arthralgia, diarrhoea, disease progression, jaundice, metastases to lung, palmar-plantar erythrodysaesthesia syndrome. LAPATINIB dosage: unknown. During the same period patient was treated with XELODA. Patient recovered.

Lapatinib Side Effects Report #5395472-2
Physician from SPAIN reported LAPATINIB problem on July 23, 2007. Female patient, 45 years of age, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: diarrhoea haemorrhagic, eating disorder, hepatotoxicity, hyperbilirubinaemia, mucosal inflammation, multi-organ failure, neutropenia. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with XELODA. Patient died on 07/08/2007.

Lapatinib Side Effects Report #5396652-2
LAPATINIB problem was reported by a Physician from AUSTRALIA on July 17, 2007. Female patient, 51 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: injury, nail infection, osteopenia, pubic rami fracture. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, COLOXYL, LACTULOSE, DEXAMETHASONE, ENOXAPARIN, OXYCODONE, ESOMEPRAZOLE MAGNESIUM, METHADONE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5396656-X
Physician from AUSTRIA reported LAPATINIB problem on July 18, 2007. Female patient, 53 years of age, weighting 141.1 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: hepatitis b, palmar-plantar erythrodysaesthesia syndrome, transaminases increased. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5396658-3
LAPATINIB problem was reported by a Physician from UNITED KINGDOM on July 16, 2007. Female patient, 44 years of age, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: chest pain, dyspnoea. LAPATINIB dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5396673-X
Physician from ITALY reported LAPATINIB problem on July 19, 2007. Female patient, 43 years of age, weighting 136.7 lb, was diagnosed with breast cancer metastatic and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, disease progression. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with HEPARIN. Patient recovered.

Lapatinib Side Effects Report #5396674-1
LAPATINIB problem was reported by a Physician from UNITED STATES on July 19, 2007. Female patient, 76 years of age, weighting 170.4 lb, was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, diverticulitis, febrile neutropenia. LAPATINIB dosage: 1000MG PER DAY. During the same period patient was treated with TRASTUZUMAB, ABRAXANE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5397746-8
Physician from PERU reported LAPATINIB problem on July 17, 2007. Female patient, 42 years of age, weighting 144.2 lb, was diagnosed with squamous cell carcinoma and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: asthenia, decreased appetite, dehydration, hyperglycaemia, hypernatraemia, renal failure, sinus tachycardia. LAPATINIB dosage: 1500MG PER DAY. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5399243-2
LAPATINIB problem was reported by a Physician from PHILIPPINES on July 19, 2007. Female patient, weighting 101.4 lb, was diagnosed with breast cancer and was treated with LAPATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration. LAPATINIB dosage: 1500MG PER DAY. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5399263-8
Physician from NETHERLANDS reported LAPATINIB problem on July 19, 2007. Female patient, 57 years of age, weighting 165.3 lb, was diagnosed with thrombosis, pruritus and was treated with LAPATINIB. Af