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Very Sleepy Next Day (34)
Massive Weight Increasing Enormous Apetite Pulse R (26)
Anxiety (14)
Sleepy (12)
Drooling (10)
Sleep (9)
Feel My Body So Cold (9)
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Leponex Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 606 

Suicide Attempt, Intentional Overdose (7334771-1)
on Feb 22, 2011 Male from LITHUANIA , 27 years of age, was treated with Leponex. Directly after, patient experienced the unwanted or unexpected Leponex side effects: suicide attempt, intentional overdose. Leponex dosage: 10 Or 20 Tablets.
Associated medications used:
  • Parkopan
Patient was hospitalized.

Blood Uric Acid Increased, Skin Infection, Dermatitis, Blood Cholesterol Increased (7328125-1)
Patient was taking Leponex. Patient felt the following Leponex side effects: blood uric acid increased, skin infection, dermatitis, blood cholesterol increased on Feb 18, 2011 from BRAZIL Additional patient health information: Male , 52 years of age, weighting 180.8 lb, was diagnosed with
  • bipolar disorder
  • blood cholesterol increased
  • depression
  • anxiety
and. Leponex dosage: 1 Df, Qd.
Multiple prescriptions taken:
  • Simvastatin (1 Tablet Daily)
  • Fenatyl (1 Tablet Daily)
  • Alprazolam (Unk)


Tooth Infection (7322922-4)
Adverse event was reported on Feb 15, 2011 by a Female taking Leponex (Dosage: 100 Mg, Qd) was diagnosed with
  • schizophrenia
and. Location: FRANCE , 47 years of age, After Leponex was administered, patient encountered several Leponex side effects: tooth infection.

Gaze Palsy, Granulocytopenia (7311715-X)
on Jan 20, 2011 Male from GERMANY , 28 years of age, was treated with Leponex. Directly after, patient experienced the unwanted or unexpected Leponex side effects: gaze palsy, granulocytopenia. Leponex dosage: 250 Mg, Qd.


Neutrophil Count Decreased, Lymphocytic Leukaemia (7310933-4)
on Feb 10, 2011 Male from FRANCE , 47 years of age, was treated with Leponex. Patient felt the following Leponex side effects: neutrophil count decreased, lymphocytic leukaemia. Leponex dosage: 100 Mg, Five Times A Day.
Multiple prescriptions taken:
  • Chloraminophene (Unk)


Pyrexia, Oedema Peripheral, Contusion, Myalgia, Pain In Extremity, Arthralgia, Gait Disturbance, Monoplegia (7308665-1)
Patient was taking Leponex. After Leponex was administered, patient encountered several Leponex side effects: pyrexia, oedema peripheral, contusion, myalgia, pain in extremity, arthralgia, gait disturbance, monoplegia on Feb 09, 2011 from NETHERLANDS Additional patient health information: Female , weighting 187.4 lb, was diagnosed with
  • psychotic disorder
and. Leponex dosage: 25 Mg, Unk.

Hypotension (7297206-3)
Adverse event was reported on Feb 10, 2011 by a Female taking Leponex (Dosage: N/A) was diagnosed with
  • schizophrenia, paranoid type
and. Location: SWITZERLAND , 60 years of age, Directly after, patient experienced the unwanted or unexpected Leponex side effects: hypotension.
Associated medications used:
  • Belok Zoc
  • Tenormin
  • Risperdal
  • Lyrica
  • Nexium
  • Risperdal
  • Rivotril
  • Aspirin


(7290222-7)
on Feb 09, 2011 Male from BRAZIL , 30 years of age, was diagnosed with
  • dystonia
and was treated with Leponex. . Leponex dosage: N/A.

Bundle Branch Block Left, Palpitations (7283222-4)
on Jan 27, 2011 Male from FINLAND , 37 years of age, was diagnosed with
  • schizophrenia, paranoid type
  • heart rate irregular
  • dyspepsia
  • hyperlipidaemia
and was treated with Leponex. After Leponex was administered, patient encountered several Leponex side effects: bundle branch block left, palpitations. Leponex dosage: 100 Mg, Qd.
Multiple concurrent drugs taken:
  • Bisoprolol (5 Mg, Qd)
  • Nexium (20 Mg, Qd)
  • Simvastatin (20 Mg, Qd)


Dyspepsia, Urinary Retention, Upper Airway Obstruction, Fatigue, Platelet Count Decreased, Left Ventricular Hypertrophy, Blood Bilirubin Increased, Constipation, Agitation (7282738-4)
Patient was taking Leponex. Directly after, patient experienced the unwanted or unexpected Leponex side effects: dyspepsia, urinary retention, upper airway obstruction, fatigue, platelet count decreased, left ventricular hypertrophy, blood bilirubin increased, constipation, agitation on Jan 27, 2011 from BRAZIL Additional patient health information: Male , 40 years of age, weighting 187.4 lb, . Leponex dosage: 100 Mg, Unk.
Associated medications used:
  • Medrol (50 Mg, Unk)


Agranulocytosis, Hyperthermia (7277459-8)
Adverse event was reported on Jan 31, 2011 by a Female taking Leponex (Dosage: N/A) was diagnosed with
  • psychotic disorder
and. Location: FRANCE , 73 years of age, Patient felt the following Leponex side effects: agranulocytosis, hyperthermia.
Multiple prescriptions taken:
  • Parkinane (Parkinane Sr 5 Mg 1df:1 Tabs)
  • Previscan
  • Loxen (Loxen Sr 50mg Caps)
  • Fumafer
  • Trimeprazine Tartrate (Theralene 4%)
  • Mestinon
  • Dafalgan
  • Pariet


Polyneuropathy (7243593-1)
on Jan 13, 2011 Female from GERMANY , 66 years of age, was treated with Leponex. After Leponex was administered, patient encountered several Leponex side effects: polyneuropathy. Leponex dosage: 50 Mg, Qd.
Multiple concurrent drugs taken:
  • Gabapentin


Gastric Banding (7226237-4)
on Jan 04, 2011 Female from CHILE , 52 years of age, was diagnosed with
  • schizophrenia
and was treated with Leponex. Directly after, patient experienced the unwanted or unexpected Leponex side effects: gastric banding. Leponex dosage: 200 Mg, Daily. Patient was hospitalized.

Hypotension, Nasopharyngitis, Tachycardia, Viral Infection, Renal Failure (7221468-1)
Patient was taking Leponex. Patient felt the following Leponex side effects: hypotension, nasopharyngitis, tachycardia, viral infection, renal failure on Jan 03, 2011 from SAUDI ARABIA Additional patient health information: Female , 38 years of age, . Leponex dosage: 600 Mg, Qd.
Multiple prescriptions taken:
  • Antipsychotics


Arthralgia, Contusion, Gait Disturbance, Monoplegia, Myalgia, Oedema Peripheral, Pain In Extremity, Pyrexia (7204531-0)
Adverse event was reported on Dec 16, 2010 by a Female taking Leponex (Dosage: 25 Mg, Unk) was diagnosed with
  • psychotic disorder
and. Location: NETHERLANDS , weighting 187.4 lb, After Leponex was administered, patient encountered several Leponex side effects: arthralgia, contusion, gait disturbance, monoplegia, myalgia, oedema peripheral, pain in extremity, pyrexia.

Visual Impairment (7202102-3)
on Dec 15, 2010 Female from GERMANY , 21 years of age, was treated with Leponex. Directly after, patient experienced the unwanted or unexpected Leponex side effects: visual impairment. Leponex dosage: 100 Mg.

Cognitive Disorder, Dystonia, Eosinophil Count Increased, Peripheral Vascular Disorder, Pleurothotonus (7197135-X)
on Dec 14, 2010 Male from GERMANY , 70 years of age, was diagnosed with
  • psychotic disorder
and was treated with Leponex. Patient felt the following Leponex side effects: cognitive disorder, dystonia, eosinophil count increased, peripheral vascular disorder, pleurothotonus. Leponex dosage: 75 Mg/day.

Delirium, Hyponatraemia, Overdose, Paranoia, Polydipsia (7197124-5)
Patient was taking Leponex. After Leponex was administered, patient encountered several Leponex side effects: delirium, hyponatraemia, overdose, paranoia, polydipsia on Dec 13, 2010 from GERMANY Additional patient health information: Male , 58 years of age, was diagnosed with
  • mania
  • hallucination
and. Leponex dosage: Upto 700 Mg/daily. Patient was hospitalized.

Intentional Overdose, Suicide Attempt (7197118-X)
Adverse event was reported on Dec 13, 2010 by a Male taking Leponex (Dosage: 10 Or 20 Tablets) . Location: LITHUANIA , 27 years of age, Directly after, patient experienced the unwanted or unexpected Leponex side effects: intentional overdose, suicide attempt.
Associated medications used:
  • Parkopan
Patient was hospitalized.

Altered State Of Consciousness, Atonic Seizures, Dyskinesia, Gait Disturbance (7179289-4)
on Dec 07, 2010 Male from JAPAN , 45 years of age, was diagnosed with
  • schizophrenia
and was treated with Leponex / Clozaril (clozapine) Lex+tab. Patient felt the following Leponex side effects: altered state of consciousness, atonic seizures, dyskinesia, gait disturbance. Leponex / Clozaril (clozapine) Lex+tab dosage: Unk.

Body Mass Index Increased, Diabetes Mellitus, Weight Increased (7178994-3)
on Dec 13, 2010 Male from GERMANY , 47 years of age, was diagnosed with
  • schizophrenia, residual type
and was treated with Leponex. After Leponex was administered, patient encountered several Leponex side effects: body mass index increased, diabetes mellitus, weight increased. Leponex dosage: 12.5 Mg/day.

Abnormal Behaviour, Logorrhoea, Malaise, Weight Increased (7166454-5)
Patient was taking Leponex. Directly after, patient experienced the unwanted or unexpected Leponex side effects: abnormal behaviour, logorrhoea, malaise, weight increased on Dec 02, 2010 from BRAZIL Additional patient health information: Male , 50 years of age, weighting 154.3 lb, was diagnosed with
  • hallucination
and. Leponex dosage: 100 Mg, Qid.

Abdominal Pain, Cachexia, Coagulopathy, Colitis Ischaemic, Constipation, Delirium, Diarrhoea, Diarrhoea Haemorrhagic, Discomfort (7153097-2)
Adverse event was reported on Nov 29, 2010 by a Male taking Leponex (Dosage: 200 Mg, Qd) was diagnosed with
  • schizophrenia, paranoid type
and. Location: SPAIN , 34 years of age, Patient felt the following Leponex side effects: abdominal pain, cachexia, coagulopathy, colitis ischaemic, constipation, delirium, diarrhoea, diarrhoea haemorrhagic, discomfort. Patient was hospitalized.

Cerebral Venous Thrombosis, Fatigue, Hemiparesis, Irritability, Vomiting (7153090-X)
on Nov 29, 2010 Female from UNITED STATES , 30 years of age, was diagnosed with
  • schizophrenia, paranoid type
and was treated with Leponex. After Leponex was administered, patient encountered several Leponex side effects: cerebral venous thrombosis, fatigue, hemiparesis, irritability, vomiting. Leponex dosage: 400 Mg, Qd.

Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Creatine Phosphokinase Increased, Neuroleptic Malignant Syndrome, Rhabdomyolysis, Transaminases Increased (7152853-4)
on Dec 07, 2010 Male from GERMANY , 49 years of age, weighting 209.4 lb, was diagnosed with
  • schizophrenia
and was treated with Leponex. Directly after, patient experienced the unwanted or unexpected Leponex side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood creatine phosphokinase increased, neuroleptic malignant syndrome, rhabdomyolysis, transaminases increased. Leponex dosage: 100 Mg, Qd.
Associated medications used:
  • Bisoprolol (5 Mg, Qd)


Showing 1-25 of 606 

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Leponex Information

More About Leponex

Side Effects reported to FDA: 606. View Leponex Adverse Reports

Leponex safety alerts: No

Reported deaths: 68

Reported hospitalizations: 271

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