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Leponex Side Effects

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Common Leponex Side Effects


The most commonly reported Leponex side effects (click to view or check a box to report):

Pyrexia (104)
C-reactive Protein Increased (65)
White Blood Cell Count Increased (50)
White Blood Cell Count Decreased (49)
Somnolence (49)
Fall (46)
Neutropenia (45)
Leukopenia (43)
Salivary Hypersecretion (41)
Agranulocytosis (40)
Neutrophil Count Decreased (39)
Fatigue (36)
Infection (35)
Agitation (35)
Tachycardia (34)
Confusional State (32)
Alanine Aminotransferase Increased (31)
Constipation (31)
Haemoglobin Decreased (31)
Heart Rate Increased (29)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Leponex Side Effects Reported to FDA



Leponex Side Effect Report#9996618
Kidney Fibrosis, Renal Tubular Atrophy, Nephrogenic Diabetes Insipidus, Gait Disturbance, Fall, Dysarthria, Aphasia
This is a report of a 39-year-old male patient (weight: NA) from CH, suffering from the following health symptoms/conditions: NA, who was treated with Leponex (dosage: 3 Df, Qd, start time: 2003), combined with:
  • Priadel (1 Df, Qd)
  • Bilol (Unk)
  • Temesta (Unk)
and developed a serious reaction and side effect(s): Kidney Fibrosis, Renal Tubular Atrophy, Nephrogenic Diabetes Insipidus, Gait Disturbance, Fall, Dysarthria, Aphasia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in male patients, resulting in Kidney Fibrosis side effect. The patient was hospitalized.
Leponex Side Effect Report#9945989
Pyelonephritis, C-reactive Protein Increased, Pyrexia, White Blood Cell Count Increased, Urinary Tract Infection, Eosinophilia, Sinus Tachycardia, Palpitations, Heart Rate Increased
This report suggests a potential Leponex Pyelonephritis side effect(s) that can have serious consequences. A 69-year-old female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: NA and used Leponex (dosage: 75 Mg, Qd) starting
Jan 24, 2014. After starting Leponex the patient began experiencing various side effects, including: Pyelonephritis, C-reactive Protein Increased, Pyrexia, White Blood Cell Count Increased, Urinary Tract Infection, Eosinophilia, Sinus Tachycardia, Palpitations, Heart Rate IncreasedAdditional drugs used concurrently: NA. Although Leponex demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pyelonephritis, may still occur.
Leponex Side Effect Report#9945899
Viral Infection, C-reactive Protein Decreased, Nasopharyngitis, White Blood Cell Count Decreased, Neutrophil Count Decreased
This Viral Infection problem was reported by a consumer or non-health professional from Country Not Specified. A 23-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: schizophrenia. On 201310 this consumer started treatment with Leponex (dosage: Unk). The following drugs were being taken at the same time: NA. When using Leponex, the patient experienced the following unwanted symptoms/side effects: Viral Infection, C-reactive Protein Decreased, Nasopharyngitis, White Blood Cell Count Decreased, Neutrophil Count DecreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Viral Infection, may become evident only after a product is in use by the general population.
Leponex Side Effect Report#9943226
Schizophrenia
This Schizophrenia side effect was reported by a physician from JP. A 38-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Leponex / Clozaril (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Leponex / Clozaril the consumer reported adverse symptoms, such as: SchizophreniaThese side effects may potentially be related to Leponex / Clozaril.
Leponex Side Effect Report#9901687
Suicide Attempt, Intentional Overdose
This is a report of a 60-year-old male patient (weight: NA) from LT, suffering from the following health symptoms/conditions: suicide attempt, who was treated with Leponex (dosage: Unk, start time:
Dec 14, 2013), combined with: NA. and developed a serious reaction and side effect(s): Suicide Attempt, Intentional Overdose after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in male patients, resulting in Suicide Attempt side effect. The patient was hospitalized.
Leponex Side Effect Report#9893230
Depression, Contusion, Malaise, Psychiatric Symptom, Tension, Headache
This report suggests a potential Leponex Depression side effect(s) that can have serious consequences. A 53-year-old female patient (weight: NA) from CL was diagnosed with the following symptoms/conditions: bipolar disorder,off label use,depression and used Leponex (dosage: 50 Mg, Qd (at Night)) starting 1998. After starting Leponex the patient began experiencing various side effects, including: Depression, Contusion, Malaise, Psychiatric Symptom, Tension, HeadacheAdditional drugs used concurrently: NA. Although Leponex demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Depression, may still occur.
Leponex Side Effect Report#9886437
Urosepsis
This Urosepsis problem was reported by a physician from FI. A 58-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: schizophrenia, disorganised type. On 1991 this consumer started treatment with Leponex (dosage: Unk). The following drugs were being taken at the same time: NA. When using Leponex, the patient experienced the following unwanted symptoms/side effects: UrosepsisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Urosepsis, may become evident only after a product is in use by the general population.
Leponex Side Effect Report#9878333
Apparent Life Threatening Event, Haemorrhage, Pneumothorax, Hepatic Rupture, Hip Fracture, Abnormal Behaviour, Confusional State, Anxiety, Nerve Injury
This Apparent Life Threatening Event side effect was reported by a consumer or non-health professional from Country Not Specified. A 40-year-old male patient (weight:NA) experienced the following symptoms/conditions: schizophrenia.The patient was prescribed Leponex (drug dosage: 550 Mg Per Day), which was initiated on 201402. Concurrently used drugs: NA..After starting to take Leponex the consumer reported adverse symptoms, such as: Apparent Life Threatening Event, Haemorrhage, Pneumothorax, Hepatic Rupture, Hip Fracture, Abnormal Behaviour, Confusional State, Anxiety, Nerve InjuryThese side effects may potentially be related to Leponex. The patient was hospitalized.
Leponex Side Effect Report#9865703
Gastroenteritis, Diarrhoea, Dehydration, Hypovolaemia, Rhabdomyolysis, Renal Failure, Hepatitis, Somnolence, Myocarditis
This is a report of a 60-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: schizophrenia, who was treated with Leponex (dosage: 450 Mg, Daily, start time: NS), combined with:
  • Loxapac (12.5 Mg, In The Evening)
and developed a serious reaction and side effect(s): Gastroenteritis, Diarrhoea, Dehydration, Hypovolaemia, Rhabdomyolysis, Renal Failure, Hepatitis, Somnolence, Myocarditis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in male patients, resulting in Gastroenteritis side effect. The patient was hospitalized.
Leponex Side Effect Report#9863982
Chronic Sinusitis
This report suggests a potential Leponex / Clozaril Chronic Sinusitis side effect(s) that can have serious consequences. A 37-year-old male patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: schizophrenia and used Leponex / Clozaril (dosage: Unk) starting
Jan 21, 2014. After starting Leponex / Clozaril the patient began experiencing various side effects, including: Chronic SinusitisAdditional drugs used concurrently: NA. Although Leponex / Clozaril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Chronic Sinusitis, may still occur.
Leponex Side Effect Report#9857561
Delusion, Foreign Body, Suicide Attempt
This Delusion problem was reported by a physician from JP. A 40-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: schizophrenia, paranoid type. On
Aug 01, 2013 this consumer started treatment with Leponex / Clozaril (dosage: 12.5 Mg, Daily). The following drugs were being taken at the same time: NA. When using Leponex / Clozaril, the patient experienced the following unwanted symptoms/side effects: Delusion, Foreign Body, Suicide AttemptAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Delusion, may become evident only after a product is in use by the general population.
Leponex Side Effect Report#9853357
Convulsion, Heart Rate Increased, Body Temperature Decreased
This Convulsion side effect was reported by a physician from JP. A 39-year-old female patient (weight:NA) experienced the following symptoms/conditions: schizophrenia, paranoid type.The patient was prescribed Leponex / Clozaril (drug dosage: 12.5 Mg, Daily), which was initiated on
Jan 11, 2011. Concurrently used drugs: NA..After starting to take Leponex / Clozaril the consumer reported adverse symptoms, such as: Convulsion, Heart Rate Increased, Body Temperature DecreasedThese side effects may potentially be related to Leponex / Clozaril.
Leponex Side Effect Report#9850099
Extrapyramidal Disorder
This is a report of a 75-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: bipolar disorder, who was treated with Leponex (dosage: Unk, start time: NS), combined with:
  • Tazocilline (Unk)
  • Atrovent (Unk)
  • Doliprane (Unk)
  • Ventoline (Unk)
  • Inexium (Unk)
  • Aspegic (Unk)
and developed a serious reaction and side effect(s): Extrapyramidal Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in female patients, resulting in Extrapyramidal Disorder side effect. The patient was hospitalized.
Leponex Side Effect Report#9848377
Papule, Erythema, Erythema Annulare
This report suggests a potential Leponex / Clozaril Papule side effect(s) that can have serious consequences. A 35-year-old female patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: schizophrenia and used Leponex / Clozaril (dosage: 125 Mg, Daily) starting
Sep 02, 2010. After starting Leponex / Clozaril the patient began experiencing various side effects, including: Papule, Erythema, Erythema AnnulareAdditional drugs used concurrently: NA. Although Leponex / Clozaril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Papule, may still occur.
Leponex Side Effect Report#9840700
Embolism, Psychotic Disorder, Aggression
This Embolism problem was reported by a physician from DE. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: psychotic disorder. On
Dec 17, 2013 this consumer started treatment with Leponex (dosage: Unk). The following drugs were being taken at the same time:
  • Lorazepam (4 Mg, 1 Df Qd)
When using Leponex, the patient experienced the following unwanted symptoms/side effects: Embolism, Psychotic Disorder, AggressionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Embolism, may become evident only after a product is in use by the general population.
Leponex Side Effect Report#9836003
Acute Myeloid Leukaemia
This Acute Myeloid Leukaemia side effect was reported by a physician from SY. A 48-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Leponex (drug dosage: 100 Mg, Qd), which was initiated on NS. Concurrently used drugs: NA..After starting to take Leponex the consumer reported adverse symptoms, such as: Acute Myeloid LeukaemiaThese side effects may potentially be related to Leponex.
Leponex Side Effect Report#9832523
Pyelonephritis, Neutropenia, Leukopenia, Pyrexia, Dysphonia, Tearfulness, Emotional Distress, Panic Disorder, Hiatus Hernia
This is a report of a 64-year-old female patient (weight: NA) from FI, suffering from the following health symptoms/conditions: schizophrenia, who was treated with Leponex (dosage: 700 Mg, Daily (3 X100 Mg + 4 X100 Mg), start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Pyelonephritis, Neutropenia, Leukopenia, Pyrexia, Dysphonia, Tearfulness, Emotional Distress, Panic Disorder, Hiatus Hernia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in female patients, resulting in Pyelonephritis side effect. The patient was hospitalized.
Leponex Side Effect Report#9830920
Coma
This report suggests a potential Leponex Coma side effect(s) that can have serious consequences. A 58-year-old male patient (weight: NA) from CH was diagnosed with the following symptoms/conditions: bipolar i disorder and used Leponex (dosage: NA) starting
Nov 09, 2013. After starting Leponex the patient began experiencing various side effects, including: ComaAdditional drugs used concurrently: NA.The patient was hospitalized. Although Leponex demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Coma, may still occur.
Leponex Side Effect Report#9818094
Appendicitis
This Appendicitis problem was reported by a pharmacist from JP. A 42-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: schizophrenia. On
Jan 11, 2014 this consumer started treatment with Leponex / Clozaril (dosage: 12.5 Mg, Daily). The following drugs were being taken at the same time: NA. When using Leponex / Clozaril, the patient experienced the following unwanted symptoms/side effects: AppendicitisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Appendicitis, may become evident only after a product is in use by the general population.
Leponex Side Effect Report#9817938
Appendicitis
This Appendicitis side effect was reported by a physician from JP. A 42-year-old female patient (weight:NA) experienced the following symptoms/conditions: schizophrenia.The patient was prescribed Leponex / Clozaril (drug dosage: Unk Ukn, Unk), which was initiated on
Jan 11, 2014. Concurrently used drugs: NA..After starting to take Leponex / Clozaril the consumer reported adverse symptoms, such as: AppendicitisThese side effects may potentially be related to Leponex / Clozaril. The patient was hospitalized.
Leponex Side Effect Report#9808987
Extrapyramidal Disorder, Agitation
This is a report of a 66-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: abnormal behaviour, who was treated with Leponex (dosage: 50 Mg, Qd (progressive Dose Increase Starting With Of 50 Mg Once A Day ), start time:
Jan 23, 2013), combined with: NA. and developed a serious reaction and side effect(s): Extrapyramidal Disorder, Agitation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in male patients, resulting in Extrapyramidal Disorder side effect. The patient was hospitalized.
Leponex Side Effect Report#9805782
Pericarditis, Myocarditis
This report suggests a potential Leponex Pericarditis side effect(s) that can have serious consequences. A 60-year-old male patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: NA and used Leponex (dosage: 25- 200 Mg, Qd) starting
Jan 08, 2013. After starting Leponex the patient began experiencing various side effects, including: Pericarditis, MyocarditisAdditional drugs used concurrently:
  • Falithrom (Unk Ukn, Unk)
  • Valproic Acid (900 Mg, Unk)
  • Vitamin B Complex /00003501/ (1 Df, Unk)
  • Folsan (5 Mg, Unk)
The patient was hospitalized. Although Leponex demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pericarditis, may still occur.
Leponex Side Effect Report#9801760
Dementia With Lewy Bodies, Extrapyramidal Disorder, Libido Increased, Hot Flush, Libido Decreased, Sensory Disturbance
This Dementia With Lewy Bodies problem was reported by a consumer or non-health professional from FR. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: dementia. On
Aug 27, 2013 this consumer started treatment with Leponex (dosage: 50 Mg, Qd). The following drugs were being taken at the same time: NA. When using Leponex, the patient experienced the following unwanted symptoms/side effects: Dementia With Lewy Bodies, Extrapyramidal Disorder, Libido Increased, Hot Flush, Libido Decreased, Sensory DisturbanceAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dementia With Lewy Bodies, may become evident only after a product is in use by the general population.
Leponex Side Effect Report#9801481
Renal Disorder, Epididymitis, Scrotal Swelling, Balanoposthitis, Renal Impairment, Pneumonia, Pyrexia, Haemoglobin Decreased, Haematocrit Decreased
This Renal Disorder side effect was reported by a physician from JP. A 53-year-old male patient (weight:NA) experienced the following symptoms/conditions: schizophrenia.The patient was prescribed Leponex / Clozaril (drug dosage: 12.5 Mg, Daily), which was initiated on
Mar 11, 2013. Concurrently used drugs: NA..After starting to take Leponex / Clozaril the consumer reported adverse symptoms, such as: Renal Disorder, Epididymitis, Scrotal Swelling, Balanoposthitis, Renal Impairment, Pneumonia, Pyrexia, Haemoglobin Decreased, Haematocrit DecreasedThese side effects may potentially be related to Leponex / Clozaril. The patient was hospitalized.
Leponex Side Effect Report#9792306
Urinary Tract Infection, C-reactive Protein Increased, White Blood Cell Count Increased, Pneumonia Aspiration, Blood Creatine Phosphokinase Increased, Myoclonus, Asthenia, Constipation
This is a report of a 46-year-old female patient (weight: NA) from JP, suffering from the following health symptoms/conditions: schizophrenia, paranoid type, who was treated with Leponex / Clozaril (dosage: 12.5 Mg, Daily, start time:
Mar 01, 2013), combined with: NA. and developed a serious reaction and side effect(s): Urinary Tract Infection, C-reactive Protein Increased, White Blood Cell Count Increased, Pneumonia Aspiration, Blood Creatine Phosphokinase Increased, Myoclonus, Asthenia, Constipation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex / Clozaril treatment in female patients, resulting in Urinary Tract Infection side effect.


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The appearance of Leponex on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Leponex reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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