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Lignocaine Side Effects

Common Lignocaine Side Effects


The most commonly reported Lignocaine side effects (click to view or check a box to report):

Dyspnoea (7)
Headache (4)
Dizziness (4)
Anaphylactic Reaction (3)
Amaurosis (3)
Chills (3)
Exophthalmos (3)
Grand Mal Convulsion (3)
Hearing Impaired (3)
Disorientation (3)
Hypotension (3)
Overdose (3)
Intentional Overdose (3)
Hypoaesthesia Oral (3)
Rash (3)
Tachycardia (3)
Wheezing (3)
Toothache (3)
Loss Of Consciousness (2)
Injection Site Pain (2)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Lignocaine Side Effects Reported to FDA

The following Lignocaine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Lignocaine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Pupil Fixed
This is a report of a 15-year-old female patient (weight: NA) from GB, suffering from the following symptoms/conditions: status epilepticus, who was treated with Lignocaine Hydrochloride (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Pupil Fixed
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine Hydrochloride treatment in female patients, resulting in pupil fixed side effect.

Feeling Cold, Decreased Activity, Feeling Abnormal, Chills, Fatigue
This report suggests a potential Lignocaine Feeling Cold, Decreased Activity, Feeling Abnormal, Chills, Fatigue side effect(s) that can have serious consequences. A 79-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: cataract operation,tooth repair and used Lignocaine (dosage: NA) starting 1957. Soon after starting Lignocaine the patient began experiencing various side effects, including:
  • Feeling Cold
  • Decreased Activity
  • Feeling Abnormal
  • Chills
  • Fatigue
Drugs used concurrently: NA. Although Lignocaine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as feeling cold, may still occur.

Acute Hepatic Failure, Toxicity To Various Agents
This Acute Hepatic Failure, Toxicity To Various Agents problem was reported by a physician from GB. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Nov 22, 2012 this consumer started treatment with Lignocaine (dosage: NA). The following drugs were being taken at the same time:
  • Aerrane
  • Bupivacaine Hydrochloride
  • Ketamine
  • Alfentanil
  • Laudanosine
When commencing Lignocaine, the patient experienced the following unwanted symptoms/side effects:
  • Acute Hepatic Failure
  • Toxicity To Various Agents
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as acute hepatic failure, may become evident only after a product is in use by the general population.

Acute Hepatic Failure, Toxicity To Various Agents
This is a report of a female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: NA and was treated with Lignocaine (dosage: NA) starting Nov 22, 2012. Concurrently used drugs:
  • Bupivacaine Hydrochloride (baxter)
  • Aerrane
  • Alfentanil
  • Ketamine
  • Laudanosine
Soon after that, the consumer experienced the following side effects:
  • Acute Hepatic Failure
  • Toxicity To Various Agents
This opens a possibility that Lignocaine treatment could cause the above reactions, including acute hepatic failure, and some female subjects may be more susceptible.


Sinoatrial Block
A 57-year-old male patient (weight: NA) from GB with the following symptoms/conditions: arrhythmia prophylaxis started Lignocaine treatment (dosage: 1 Mg/kg In 1 Minute) on NS. Soon after starting Lignocaine treatment, the subject experienced various side effects, including:
  • Sinoatrial Block
Concurrently used drugs:
  • Phenytoin (250 Mg In 5 Minutes)
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Lignocaine.

Rash, Loss Of Consciousness, Dyspnoea
A 37-year-old female patient from SG (weight: NA) experienced symptoms, such as: NA and was treated with Lignocaine(dosage: Unk). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Rash
  • Loss Of Consciousness
  • Dyspnoea
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Lignocaine efficacy: NA.

Eyelid Oedema
In this report, Lignocaine was administered for the following condition: local anaesthesia.A 59-year-old male consumer from GB (weight: NA) started Lignocaine treatment (dosage: NA) on 2009.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Eyelid Oedema
A possible interaction with other drugs could have contributed to this reaction:
  • Hyalase
  • Levobupivacaine
  • Amlodipine
  • Ramipril
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Lignocaine treatment could be related to the listed above side effect(s).

Dizziness Postural, Pallor, Heart Rate Decreased
This is a report of the following Lignocaine side effect(s):
  • Dizziness Postural
  • Pallor
  • Heart Rate Decreased
A 64-year-old male patient from GB (weight: NA) presented with the following condition: NA and received a treatment with Lignocaine (dosage: NA) starting: 201303.The following concurrently used drugs could have generated interactions:
  • Amiodarone
  • Atorvastatin
  • Omacor
  • Warfarin
This report suggests that a Lignocaine treatment could be associated with the listed above side effect(s).

Troponin Increased, Electrocardiogram T Wave Inversion
This Lignocaine report was submitted by a 66-year-old consumer from AU (weight: NA). The patient was diagnosed with: NA and Lignocaine was administered (dosage: Unk) starting: Jan 25, 2013. The consumer developed a set of symptoms:
  • Troponin Increased
  • Electrocardiogram T Wave Inversion
Other drugs used simultaneously:
  • Quetiapine (Unk)
The patient was hospitalized.Those unexpected symptoms could be linked to a Lignocaine treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Hypersensitivity, Dyspnoea, Urticaria
This is a report of a possible correlation between Lignocaine use and the following symptoms/side effect(s):
  • Hypersensitivity
  • Dyspnoea
  • Urticaria
which could contribute to an assessment of Lignocaine risk profile.A 44-year-old female consumer from GB (weight: NA) was suffering from NA and was treated with Lignocaine (dosage: Total Daily Dose 100 Mg) starting Jul 09, 2013.Other concurrent medications:
  • Aspirin


Optic Neuropathy, Amaurosis
A 82-year-old male patient from AU (weight: NA) presented with the following symptoms: NA and after a treatment with Lignocaine (dosage: 4 Ml Of Mixture Of 1 % Lignocaine And 2 % Ropivacaine) experienced the following side effect(s):
  • Optic Neuropathy
  • Amaurosis
The treatment was started on NS. Lignocaine was used in combination with the following drugs:
  • Ropivacaine (4 Ml Of Mixture Of 1 % Lignocaine And 2 % Ropivacaine)
  • Warfarin
This report could alert potential Lignocaine consumers.

Rash Erythematous
In this report, a 50-year-old female patient from SG (weight: NA) was affected by a possible Lignocaine side effect.The patient was diagnosed with NA. After a treatment with Lignocaine (dosage: NA, start date: NS), the patient experienced the following side effect(s):
  • Rash Erythematous
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Lignocaine treatment.

Psychotic Disorder, Hallucination, Paranoia, Blood Pressure Increased
This is a report of a 53-year-old male patient from GB (weight: NA), who used Lignocaine With Adrenaline (dosage: 4.4 Ml, Unk) for a treatment of dental caries. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Psychotic Disorder
  • Hallucination
  • Paranoia
  • Blood Pressure Increased
The following drugs could possibly have interacted with the Lignocaine With Adrenaline treatment
  • Septanest (4.4 Ml, Unk)
  • Alcohol (Unk)
Taken together, these observations suggest that a Lignocaine With Adrenaline treatment could be related to side effect(s), such as Psychotic Disorder, Hallucination, Paranoia, Blood Pressure Increased.

Dental Discomfort, Headache, Nerve Injury, Hypoaesthesia Oral, Dysphagia, Tongue Disorder, Toothache
This dental discomfort side effect was reported by a consumer or non-health professional from GB. A 51-year-old male patient (weight:NA) experienced the following symptoms/conditions: tooth extraction. The patient was prescribed Lignocaine With Adrenaline (dosage: 2.2 Ml, Unk), which was started on Apr 08, 2009. Concurrently used drugs: NA. When starting to take Lignocaine With Adrenaline the consumer reported the following symptoms:
  • Dental Discomfort
  • Headache
  • Nerve Injury
  • Hypoaesthesia Oral
  • Dysphagia
  • Tongue Disorder
  • Toothache
These side effects may potentially be related to Lignocaine With Adrenaline.

Dental Discomfort, Headache, Dysphagia, Tongue Disorder, Toothache, Nerve Injury, Hypoaesthesia Oral
This is a Lignocaine With Adrenaline side effect report of a male patient (weight:NA) from GB, suffering from the following symptoms/conditions: tooth extraction, who was treated with Lignocaine With Adrenaline (dosage:NA, start time: Apr 08, 2009), combined with: NA., and developed a serious reaction and a dental discomfort side effect. The patient presented with:
  • Dental Discomfort
  • Headache
  • Dysphagia
  • Tongue Disorder
  • Toothache
  • Nerve Injury
  • Hypoaesthesia Oral
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Lignocaine With Adrenaline treatment in male patients suffering from tooth extraction, resulting in dental discomfort.

Autonomic Nervous System Imbalance, Hypotension, Dizziness, Syncope
This report suggests a potential Lignocaine autonomic nervous system imbalance side effect(s) that can have serious consequences. A female patient from GB (weight:NA) was diagnosed with the following health condition(s): therapeutic procedure and used Lignocaine (dosage: NA) starting Mar 29, 2011. Soon after starting Lignocaine the patient began experiencing various side effects, including:
  • Autonomic Nervous System Imbalance
  • Hypotension
  • Dizziness
  • Syncope
Drugs used concurrently:
  • P2g
The patient was hospitalized and became disabled. Although Lignocaine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as autonomic nervous system imbalance, may still occur.

Upper Respiratory Tract Inflammation
This upper respiratory tract inflammation problem was reported by a health professional from GB. A 72-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): local anaesthesia.On NS a consumer started treatment with Lignocaine With Adrenaline (dosage: Unk). The following drugs/medications were being taken at the same time:
  • Xylonor (Unk)
When commencing Lignocaine With Adrenaline, the patient experienced the following unwanted symptoms /side effects:
  • Upper Respiratory Tract Inflammation
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as upper respiratory tract inflammation, may become evident only after a product is in use by the general population.

Upper Respiratory Tract Inflammation, Asthenia, Listless, Pyrexia, Decreased Appetite, Hearing Impaired, Weight Decreased, Toothache
This is a Lignocaine With Adrenaline side effect report of a 72-year-old male patient (weight: NA) from GB. The patient developed the following symptoms/conditions: local anaesthesia and was treated with Lignocaine With Adrenaline (dosage: NA) starting NS. Concurrently used drugs:
  • Xylonor
Soon after that, the consumer experienced the following of symptoms:
  • Upper Respiratory Tract Inflammation
  • Asthenia
  • Listless
  • Pyrexia
  • Decreased Appetite
  • Hearing Impaired
  • Weight Decreased
  • Toothache
This opens a possibility that Lignocaine With Adrenaline could cause upper respiratory tract inflammation and that some male patients may be more susceptible.

Pulmonary Oedema, Convulsion
A 42-year-old male patient (weight: NA) from IN with the following symptoms: local anaesthesia started Lignocaine treatment (dosage: NA) on NS. Soon after starting Lignocaine treatment, the consumer experienced several side effects, including:
  • Pulmonary Oedema
  • Convulsion
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Lignocaine side effects, such as pulmonary oedema.

Aphonia
This aphonia side effect was reported by a health professional from INDIA. A 30-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Lignocaine With Epinephrine (dosage: NA), which was started on NS. Concurrently used drugs:
  • Diazepam (10 Mg)
  • Bupivacaine Hcl
.When starting to take Lignocaine With Epinephrine the consumer reported symptoms, such as:
  • Aphonia
These side effects may potentially be related to Lignocaine With Epinephrine.

Disorientation, Tachycardia
This is a report of a 50-year-old female patient (weight: NA) from UNITED KINGDOM, suffering from the following symptoms/conditions: migraine,dental care, who was treated with Lignocaine With Adrenaline (dosage: NA, start time: Feb 24, 2010), combined with:
  • Citanest With Octapressin
  • Rizatriptan Benzoate
  • Scandonest Plain
  • Septanest
  • Pizotifen
  • Sertraline Hydrochloride
and developed a serious reaction and side effect(s). The consumer presented with:
  • Disorientation
  • Tachycardia
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine With Adrenaline treatment in female patients, resulting in disorientation side effect.

Disorientation, Hearing Impaired, Visual Acuity Reduced, Brain Stem Stroke, Confusional State, Speech Disorder, Gait Disturbance, Injection Site Pain
This report suggests a potential Lignocaine Disorientation, Hearing Impaired, Visual Acuity Reduced, Brain Stem Stroke, Confusional State, Speech Disorder, Gait Disturbance, Injection Site Pain side effect(s) that can have serious consequences. A 55-year-old male patient (weight: NA) from AU was diagnosed with the following symptoms/conditions: nerve block and used Lignocaine (dosage: Unk) starting Oct 31, 2008. Soon after starting Lignocaine the patient began experiencing various side effects, including:
  • Disorientation
  • Hearing Impaired
  • Visual Acuity Reduced
  • Brain Stem Stroke
  • Confusional State
  • Speech Disorder
  • Gait Disturbance
  • Injection Site Pain
Drugs used concurrently:
  • Lyrica (Unk)
  • Celestone (Unk)
Although Lignocaine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as disorientation, may still occur.

Delirium, Paralysis
This Delirium, Paralysis problem was reported by a physician from NEW ZEALAND. A 49-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Sep 21, 2004 this consumer started treatment with Lignocaine (dosage: Single Dose). The following drugs were being taken at the same time:
  • Lorazepam
When commencing Lignocaine, the patient experienced the following unwanted symptoms/side effects:
  • Delirium
  • Paralysis
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as delirium, may become evident only after a product is in use by the general population.

Anaphylactic Reaction
This is a report of a 56-year-old male patient (weight: NA) from NEW ZEALAND. The patient developed the following symptoms/conditions: NA and was treated with Lignocaine (dosage: NA) starting Jul 17, 2004. Concurrently used drugs:
  • Simvastatin
  • Omeprazole
  • Felodipine
  • Flucloxacillin
Soon after that, the consumer experienced the following side effects:
  • Anaphylactic Reaction
This opens a possibility that Lignocaine treatment could cause the above reactions, including anaphylactic reaction, and some male subjects may be more susceptible.

Dyspnoea, Heart Rate Increased, Loss Of Consciousness
A 80-year-old female patient (weight: NA) from AUSTRALIA with the following symptoms/conditions: NA started Lignocaine treatment (dosage: NA) on Jan 27, 2009. Soon after starting Lignocaine treatment, the subject experienced various side effects, including:
  • Dyspnoea
  • Heart Rate Increased
  • Loss Of Consciousness
Concurrently used drugs:
  • Fentanyl
  • Hyalase
  • Midazolam Hcl
This finding indicates that some female patients could be more vulnerable to Lignocaine.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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