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Lignocaine Side Effects

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Common Lignocaine Side Effects


The most commonly reported Lignocaine side effects (click to view or check a box to report):

Dyspnoea (7)
Headache (4)
Dizziness (4)
Anaphylactic Reaction (3)
Amaurosis (3)
Chills (3)
Exophthalmos (3)
Grand Mal Convulsion (3)
Hearing Impaired (3)
Disorientation (3)
Hypotension (3)
Overdose (3)
Intentional Overdose (3)
Hypoaesthesia Oral (3)
Rash (3)
Tachycardia (3)
Wheezing (3)
Toothache (3)
Loss Of Consciousness (2)
Injection Site Pain (2)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Lignocaine Side Effects Reported to FDA



Lignocaine Side Effect Report#9902649
Pupil Fixed
This is a report of a 15-year-old female patient (weight: NA) from GB, suffering from the following health symptoms/conditions: status epilepticus, who was treated with Lignocaine Hydrochloride (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Pupil Fixed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine Hydrochloride treatment in female patients, resulting in Pupil Fixed side effect.
Lignocaine Side Effect Report#9697968
Feeling Cold, Decreased Activity, Feeling Abnormal, Chills, Fatigue
This report suggests a potential Lignocaine Feeling Cold side effect(s) that can have serious consequences. A 79-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: cataract operation,tooth repair and used Lignocaine (dosage: NA) starting 1957. After starting Lignocaine the patient began experiencing various side effects, including: Feeling Cold, Decreased Activity, Feeling Abnormal, Chills, FatigueAdditional drugs used concurrently: NA. Although Lignocaine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Feeling Cold, may still occur.
Lignocaine Side Effect Report#9642132
Acute Hepatic Failure, Toxicity To Various Agents
This Acute Hepatic Failure problem was reported by a physician from GB. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Nov 22, 2012 this consumer started treatment with Lignocaine (dosage: NA). The following drugs were being taken at the same time:
  • Aerrane
  • Bupivacaine Hydrochloride
  • Ketamine
  • Alfentanil
  • Laudanosine
When using Lignocaine, the patient experienced the following unwanted symptoms/side effects: Acute Hepatic Failure, Toxicity To Various AgentsAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Acute Hepatic Failure, may become evident only after a product is in use by the general population.
Lignocaine Side Effect Report#9619723
Acute Hepatic Failure, Toxicity To Various Agents
This Acute Hepatic Failure side effect was reported by a health professional from GB. A female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Lignocaine (drug dosage: NA), which was initiated on
Nov 22, 2012. Concurrently used drugs:
  • Bupivacaine Hydrochloride (baxter)
  • Aerrane
  • Alfentanil
  • Ketamine
  • Laudanosine
.After starting to take Lignocaine the consumer reported adverse symptoms, such as: Acute Hepatic Failure, Toxicity To Various AgentsThese side effects may potentially be related to Lignocaine.
Lignocaine Side Effect Report#9565926
Sinoatrial Block
This is a report of a 57-year-old male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: arrhythmia prophylaxis, who was treated with Lignocaine (dosage: 1 Mg/kg In 1 Minute, start time: NS), combined with:
  • Phenytoin (250 Mg In 5 Minutes)
and developed a serious reaction and side effect(s): Sinoatrial Block after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine treatment in male patients, resulting in Sinoatrial Block side effect. The patient was hospitalized.
Lignocaine Side Effect Report#9539263
Rash, Loss Of Consciousness, Dyspnoea
This report suggests a potential Lignocaine Rash side effect(s) that can have serious consequences. A 37-year-old female patient (weight: NA) from SG was diagnosed with the following symptoms/conditions: NA and used Lignocaine (dosage: Unk) starting NS. After starting Lignocaine the patient began experiencing various side effects, including: Rash, Loss Of Consciousness, DyspnoeaAdditional drugs used concurrently: NA. Although Lignocaine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rash, may still occur.
Lignocaine Side Effect Report#9522677
Eyelid Oedema
This Eyelid Oedema problem was reported by a physician from GB. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: local anaesthesia. On 2009 this consumer started treatment with Lignocaine (dosage: NA). The following drugs were being taken at the same time:
  • Hyalase
  • Levobupivacaine
  • Amlodipine
  • Ramipril
When using Lignocaine, the patient experienced the following unwanted symptoms/side effects: Eyelid OedemaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eyelid Oedema, may become evident only after a product is in use by the general population.
Lignocaine Side Effect Report#9508314
Dizziness Postural, Pallor, Heart Rate Decreased, Dizziness
This Dizziness Postural side effect was reported by a consumer or non-health professional from GB. A 64-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Lignocaine (drug dosage: NA), which was initiated on 201303. Concurrently used drugs:
  • Amiodarone
  • Atorvastatin
  • Omacor
  • Warfarin
.After starting to take Lignocaine the consumer reported adverse symptoms, such as: Dizziness Postural, Pallor, Heart Rate Decreased, DizzinessThese side effects may potentially be related to Lignocaine.
Lignocaine Side Effect Report#9496841
Troponin Increased, Electrocardiogram T Wave Inversion
This is a report of a 66-year-old patient (weight: NA) from AU, suffering from the following health symptoms/conditions: NA, who was treated with Lignocaine (dosage: Unk, start time:
Jan 25, 2013), combined with:
  • Quetiapine (Unk)
and developed a serious reaction and side effect(s): Troponin Increased, Electrocardiogram T Wave Inversion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine treatment in patients, resulting in Troponin Increased side effect. The patient was hospitalized.
Lignocaine Side Effect Report#9433776
Hypersensitivity, Dyspnoea, Urticaria
This report suggests a potential Lignocaine Hypersensitivity side effect(s) that can have serious consequences. A 44-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: NA and used Lignocaine (dosage: Total Daily Dose 100 Mg) starting
Jul 09, 2013. After starting Lignocaine the patient began experiencing various side effects, including: Hypersensitivity, Dyspnoea, UrticariaAdditional drugs used concurrently:
  • Aspirin
Although Lignocaine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypersensitivity, may still occur.
Lignocaine Side Effect Report#9296267
Optic Neuropathy, Amaurosis
This Optic Neuropathy problem was reported by a health professional from AU. A 82-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Lignocaine (dosage: 4 Ml Of Mixture Of 1 % Lignocaine And 2 % Ropivacaine). The following drugs were being taken at the same time:
  • Ropivacaine (4 Ml Of Mixture Of 1 % Lignocaine And 2 % Ropivacaine)
  • Warfarin
When using Lignocaine, the patient experienced the following unwanted symptoms/side effects: Optic Neuropathy, AmaurosisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Optic Neuropathy, may become evident only after a product is in use by the general population.
Lignocaine Side Effect Report#9068294
Rash Erythematous
This Rash Erythematous side effect was reported by a health professional from SG. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Lignocaine (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Lignocaine the consumer reported adverse symptoms, such as: Rash ErythematousThese side effects may potentially be related to Lignocaine.
Lignocaine Side Effect Report#9002046
Psychotic Disorder, Hallucination, Paranoia, Blood Pressure Increased
This is a report of a 53-year-old male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: dental caries, who was treated with Lignocaine With Adrenaline (dosage: 4.4 Ml, Unk, start time: NS), combined with:
  • Septanest (4.4 Ml, Unk)
  • Alcohol (Unk)
and developed a serious reaction and side effect(s): Psychotic Disorder, Hallucination, Paranoia, Blood Pressure Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine With Adrenaline treatment in male patients, resulting in Psychotic Disorder side effect.
Lignocaine Side Effect Report#8998386
Dental Discomfort, Headache, Headache, Nerve Injury, Hypoaesthesia Oral, Dysphagia, Tongue Disorder, Toothache
This report suggests a potential Lignocaine With Adrenaline Dental Discomfort side effect(s) that can have serious consequences. A 51-year-old male patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: tooth extraction and used Lignocaine With Adrenaline (dosage: 2.2 Ml, Unk) starting
Apr 08, 2009. After starting Lignocaine With Adrenaline the patient began experiencing various side effects, including: Dental Discomfort, Headache, Headache, Nerve Injury, Hypoaesthesia Oral, Dysphagia, Tongue Disorder, ToothacheAdditional drugs used concurrently: NA. Although Lignocaine With Adrenaline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dental Discomfort, may still occur.
Lignocaine Side Effect Report#8993076
Dental Discomfort, Headache, Headache, Dysphagia, Tongue Disorder, Toothache, Nerve Injury, Hypoaesthesia Oral
This Dental Discomfort problem was reported by a consumer or non-health professional from GB. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: tooth extraction. On
Apr 08, 2009 this consumer started treatment with Lignocaine With Adrenaline (dosage: NA). The following drugs were being taken at the same time: NA. When using Lignocaine With Adrenaline, the patient experienced the following unwanted symptoms/side effects: Dental Discomfort, Headache, Headache, Dysphagia, Tongue Disorder, Toothache, Nerve Injury, Hypoaesthesia OralAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dental Discomfort, may become evident only after a product is in use by the general population.
Lignocaine Side Effect Report#8923856
Autonomic Nervous System Imbalance, Hypotension, Dizziness, Syncope
This Autonomic Nervous System Imbalance side effect was reported by a consumer or non-health professional from GB. A female patient (weight:NA) experienced the following symptoms/conditions: therapeutic procedure.The patient was prescribed Lignocaine (drug dosage: NA), which was initiated on
Mar 29, 2011. Concurrently used drugs:
  • P2g
.After starting to take Lignocaine the consumer reported adverse symptoms, such as: Autonomic Nervous System Imbalance, Hypotension, Dizziness, SyncopeThese side effects may potentially be related to Lignocaine. The patient was hospitalized and became disabled.
Lignocaine Side Effect Report#8846127
Upper Respiratory Tract Inflammation
This is a report of a 72-year-old male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: local anaesthesia, who was treated with Lignocaine With Adrenaline (dosage: Unk, start time: NS), combined with:
  • Xylonor (Unk)
and developed a serious reaction and side effect(s): Upper Respiratory Tract Inflammation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine With Adrenaline treatment in male patients, resulting in Upper Respiratory Tract Inflammation side effect.
Lignocaine Side Effect Report#8841662
Upper Respiratory Tract Inflammation, Asthenia, Listless, Pyrexia, Decreased Appetite, Hearing Impaired, Weight Decreased, Toothache
This report suggests a potential Lignocaine With Adrenaline Upper Respiratory Tract Inflammation side effect(s) that can have serious consequences. A 72-year-old male patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: local anaesthesia and used Lignocaine With Adrenaline (dosage: NA) starting NS. After starting Lignocaine With Adrenaline the patient began experiencing various side effects, including: Upper Respiratory Tract Inflammation, Asthenia, Listless, Pyrexia, Decreased Appetite, Hearing Impaired, Weight Decreased, ToothacheAdditional drugs used concurrently:
  • Xylonor
Although Lignocaine With Adrenaline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Upper Respiratory Tract Inflammation, may still occur.
Lignocaine Side Effect Report#8807238
Pulmonary Oedema, Convulsion
This Pulmonary Oedema problem was reported by a health professional from IN. A 42-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: local anaesthesia. On NS this consumer started treatment with Lignocaine (dosage: NA). The following drugs were being taken at the same time: NA. When using Lignocaine, the patient experienced the following unwanted symptoms/side effects: Pulmonary Oedema, ConvulsionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pulmonary Oedema, may become evident only after a product is in use by the general population.
Lignocaine Side Effect Report#7762750-9
Aphonia
This Aphonia side effect was reported by a health professional from India. A 30-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Lignocaine With Epinephrine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Diazepam (10 Mg)
  • Bupivacaine Hcl
.After starting to take Lignocaine With Epinephrine the consumer reported adverse symptoms, such as: AphoniaThese side effects may potentially be related to Lignocaine With Epinephrine.
Lignocaine Side Effect Report#6960207-6
Disorientation, Tachycardia
This is a report of a 50-year-old female patient (weight: NA) from United Kingdom, suffering from the following health symptoms/conditions: migraine,dental care, who was treated with Lignocaine With Adrenaline (dosage: NA, start time:
Feb 24, 2010), combined with:
  • Citanest With Octapressin
  • Rizatriptan Benzoate
  • Scandonest Plain
  • Septanest
  • Pizotifen
  • Sertraline Hydrochloride
and developed a serious reaction and side effect(s): Disorientation, Tachycardia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine With Adrenaline treatment in female patients, resulting in Disorientation side effect.
Lignocaine Side Effect Report#6927264
Disorientation, Hearing Impaired, Visual Acuity Reduced, Brain Stem Stroke, Confusional State, Speech Disorder, Gait Disturbance, Injection Site Pain
This report suggests a potential Lignocaine Disorientation side effect(s) that can have serious consequences. A 55-year-old male patient (weight: NA) from AU was diagnosed with the following symptoms/conditions: nerve block and used Lignocaine (dosage: Unk) starting
Oct 31, 2008. After starting Lignocaine the patient began experiencing various side effects, including: Disorientation, Hearing Impaired, Visual Acuity Reduced, Brain Stem Stroke, Confusional State, Speech Disorder, Gait Disturbance, Injection Site PainAdditional drugs used concurrently:
  • Lyrica (Unk)
  • Celestone (Unk)
Although Lignocaine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Disorientation, may still occur.
Lignocaine Side Effect Report#6435775-3
Delirium, Paralysis
This Delirium problem was reported by a physician from New Zealand. A 49-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Sep 21, 2004 this consumer started treatment with Lignocaine (dosage: Single Dose). The following drugs were being taken at the same time:
  • Lorazepam
When using Lignocaine, the patient experienced the following unwanted symptoms/side effects: Delirium, ParalysisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Delirium, may become evident only after a product is in use by the general population.
Lignocaine Side Effect Report#6427894-2
Anaphylactic Reaction
This Anaphylactic Reaction side effect was reported by a physician from New Zealand. A 56-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Lignocaine (drug dosage: NA), which was initiated on
Jul 17, 2004. Concurrently used drugs:
  • Simvastatin
  • Omeprazole
  • Felodipine
  • Flucloxacillin
.After starting to take Lignocaine the consumer reported adverse symptoms, such as: Anaphylactic ReactionThese side effects may potentially be related to Lignocaine.
Lignocaine Side Effect Report#6299283-5
Dyspnoea, Heart Rate Increased, Loss Of Consciousness
This is a report of a 80-year-old female patient (weight: NA) from Australia, suffering from the following health symptoms/conditions: NA, who was treated with Lignocaine (dosage: NA, start time:
Jan 27, 2009), combined with:
  • Fentanyl
  • Hyalase
  • Midazolam Hcl
and developed a serious reaction and side effect(s): Dyspnoea, Heart Rate Increased, Loss Of Consciousness after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Lignocaine treatment in female patients, resulting in Dyspnoea side effect.


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The appearance of Lignocaine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Lignocaine Side Effects for Women?

Women Side EffectsReports
Dyspnoea 6
Exophthalmos 3
Rash 3
Wheezing 3
Acute Hepatic Failure 2
Conjunctival Oedema 2
Dizziness 2
Eye Inflammation 2
Eye Movement Disorder 2
Hypersensitivity 2

What are common Lignocaine Side Effects for Men?

Men Side EffectsReports
Headache 4
Amaurosis 3
Grand Mal Convulsion 3
Toothache 3
Anaphylactic Reaction 2
Colon Gangrene 2
Convulsion 2
Dental Discomfort 2
Dizziness 2
Dysphagia 2

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Lignocaine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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