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Lonafarnib Side Effects submitted to FDA

Total Lonafarnib reports: 9.
Lonafarnib FDA safety alerts: No.
Reported deaths: 3    Reported hospitalizations: 5.
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FDA Reported Lonafarnib Side Effects: septic shock, balance disorder, alanine aminotransferase increased, weight decreased, pneumocystis jiroveci pneumonia, lymphopenia, heart rate increased, haemoglobin decreased, febrile neutropenia, blood pressure decreased, asthenia,
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Lonafarnib Side Effects Report #5663610-X
Health Professional from UNITED STATES reported LONAFARNIB problem on Mar 03, 2008. Female patient, 69 years of age, weighting 202.8 lb, was diagnosed with glioblastoma multiforme and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: renal failure. LONAFARNIB dosage: 250 MG; BID; 175 MG; BID;. During the same period patient was treated with TEMODAR, KEPPRA, DIOVAN, LOTREL, LEVOXYL, LIPITOR, BONIVA. Patient was hospitalized. Patient recovered.



Lonafarnib Side Effects Report #5663748-7
LONAFARNIB problem was reported by a Health Professional from UNITED STATES on Mar 07, 2008. Female patient, 69 years of age, weighting 202.8 lb, was diagnosed with glioblastoma multiforme and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: renal failure. LONAFARNIB dosage: 250 MG; BID; 175 MG; BID. During the same period patient was treated with TEMODAR, KEPPRA, DIOVAN, LOTREL, LEVOXYL, LIPITOR, BONIVA. Patient was hospitalized. Patient recovered.



Lonafarnib Side Effects Report #5391839-7
Physician from UNITED STATES reported LONAFARNIB problem on July 12, 2007. Female patient, 44 years of age, weighting 130.1 lb, was diagnosed with glioblastoma multiforme and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blood pressure decreased, febrile neutropenia, haemoglobin decreased, heart rate increased, lymphopenia, pneumocystis jiroveci pneumonia. LONAFARNIB dosage: 200 MG; BID; PO. During the same period patient was treated with TEMODAR, AMBIEN, CENTRUM, KEPPRA, NORTRIPTYLINE, ZOFRAN. Patient was hospitalized. Patient recovered.



Lonafarnib Side Effects Report #5391839-7
LONAFARNIB problem was reported by a Physician from UNITED STATES on July 12, 2007. Female patient, 44 years of age, weighting 130.1 lb, was diagnosed with glioblastoma multiforme and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: asthenia, blood pressure decreased, febrile neutropenia, haemoglobin decreased, heart rate increased, lymphopenia, pneumocystis jiroveci pneumonia. LONAFARNIB dosage: 200 MG; BID; PO. During the same period patient was treated with TEMODAR, AMBIEN, CENTRUM, KEPPRA, NORTRIPTYLINE, ZOFRAN. Patient was hospitalized. Patient recovered.




Lonafarnib Side Effects Report #5693065-0
Consumer or non-health professional from UNITED STATES reported LONAFARNIB problem on Apr 02, 2008. Male patient, 72 years of age, weighting 162.0 lb, was diagnosed with lung cancer metastatic and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: dehydration, diarrhoea, white blood cell count decreased. LONAFARNIB dosage: 100MG PO BID. During the same period patient was treated with DOCETAXEL, PROCHLORPERAZINE, DEXAMETHASONE, PERCOCET. Patient was hospitalized. Patient recovered.



Lonafarnib Side Effects Report #5354884-3
LONAFARNIB problem was reported by a Physician from UNITED STATES on June 07, 2007. Male patient, 55 years of age, was diagnosed with malignant glioma and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased. LONAFARNIB dosage: unknown. During the same period patient was treated with TEMOZOLOMIDE. Patient recovered.



Lonafarnib Side Effects Report #5355281-7
Physician from UNITED STATES reported LONAFARNIB problem on May 31, 2007. Male patient, 55 years of age, was diagnosed with malignant glioma and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased. LONAFARNIB dosage: unknown. During the same period patient was treated with TEMOZOLOMIDE. Patient recovered.



Lonafarnib Side Effects Report #5261418-0
LONAFARNIB problem was reported by a Consumer or non-health professional from FRANCE on Mar 02, 2007. Male patient, 67 years of age, weighting 165.3 lb, was diagnosed with glioma and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: balance disorder, septic shock, weight decreased. LONAFARNIB dosage: 175 MG;BID. During the same period patient was treated with TEMOZOLOMIDE. Patient died on 02/14/2007.



Lonafarnib Side Effects Report #5281241-0
Consumer or non-health professional from FRANCE reported LONAFARNIB problem on Mar 16, 2007. Male patient, 67 years of age, weighting 165.3 lb, was diagnosed with glioma and was treated with LONAFARNIB. After drug was administered, patient experienced the following problems/side effects: balance disorder, dyspnoea, septic shock, weight decreased. LONAFARNIB dosage: 175 MG; BID. During the same period patient was treated with TEMOZOLOMIDE, MOPRAL, SOLUPRED, DETENSIEL. Patient died on 02/14/2007.




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, Lonafarnib was diagnosed with glioblastoma multiforme and Lonafarnib was diagnosed with glioblastoma multiforme and