Lopinavir Safety Questions, Lopinavir Answers
More Here>>Side Effects - FDA Reports 2006-2008
Medications A-Z: A B C D E F G H I J K L M N O P Q R S T U V W X Y ZWelcome! Patientsville.com provides information about Lopinavir side effects. Check out Health Surveys and Health Polls. If you have questions about Lopinavir, you can post them to our Doctors or Ask Patient Community about Lopinavir.
>> Announcements
Check out our Hospital and Home Care Quality Reports.
Help Community - Post Your Side Effect
Ask Our Doctors about Lopinavir
Lopinavir Safety Reports
Total Lopinavir reports: 34.Lopinavir FDA safety alerts: 2003 2007 .
Reported deaths: 6 Reported hospitalizations: 16.
Take Lopinavir Side Effects Survey or Share Your Lopinavir Story.
Reported Lopinavir Side Effects: hypokalaemia, immune reconstitution syndrome, nephropathy toxic, lymphoedema, kaposi's sarcoma, renal failure acute, electrocardiogram qt prolonged, stevens-johnson syndrome, hepatotoxicity, cushing's syndrome, torsade de pointes.
More About Lopinavir.
Lopinavir Side Effects Report #5199917-2
Consumer or non-health professional from SPAIN reported LOPINAVIR problem on Dec 27, 2006. Male patient, 47 years of age, was diagnosed with systemic antiviral treatment, blood pressure management and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: renal failure acute. LOPINAVIR dosage: unknown. During the same period patient was treated with NIFEDIPINE, STAVUDINE, LAMIVUDINE. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5207446-2
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Jan 04, 2007. Male patient, 38 years of age, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: immune reconstitution syndrome, kaposi's sarcoma, lymphoedema. LOPINAVIR dosage: unknown. During the same period patient was treated with RITONAVIR, FOSAMPRENAVIR, TENOFOVIR DF. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5259072-7
Consumer or non-health professional from UNITED KINGDOM reported LOPINAVIR problem on Feb 26, 2007. Male patient, 42 years of age, weighting 94.80 lb, was diagnosed with systemic antiviral treatment, infection prophylaxis, hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: inappropriate antidiuretic hormone secretion. LOPINAVIR dosage: unknown. During the same period patient was treated with BACTRIM, FLUCONAZOLE, CYCLOPENTOLATE, DEXAMETHASONE, LAMIVUDINE, TENOFOVIR DISOPROXIL FUMARATE, TENOFOVIR DISOPROXIL FUMARATE. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5289749-9
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Mar 27, 2007. Male patient, 42 years of age, weighting 94.80 lb, was diagnosed with systemic antiviral treatment, infection prophylaxis, hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: inappropriate antidiuretic hormone secretion. LOPINAVIR dosage: unknown. During the same period patient was treated with BACTRIM, FLUCONAZOLE, CYCLOPENTOLATE, DEXAMETHASONE, LAMIVUDINE, TENOFOVIR. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5295733-1
Health Professional from UNITED STATES reported LOPINAVIR problem on Apr 10, 2007. Female patient, 30 years of age, weighting 194.0 lb, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: abortion spontaneous, pregnancy. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR, LAMIVUDINE, VITAMIN B COMPLETE, ASCORBIC ACID, STOP ITCH CREAM. Patient recovered.
Lopinavir Side Effects Report #5303217-7
LOPINAVIR problem was reported by a Health Professional from UNITED STATES on Apr 17, 2007. Female patient, 30 years of age, weighting 194.0 lb, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: abortion spontaneous, metrorrhagia, pregnancy. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR, LAMIVUDINE, VITAMIN B CAP, ASCORBIC ACID, STOP ITCH CREAM. Patient recovered.
Lopinavir Side Effects Report #5303619-9
Consumer or non-health professional from JAPAN reported LOPINAVIR problem on Apr 11, 2007. Male patient, 38 years of age, was diagnosed with hiv infection, kaposi's sarcoma and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: histiocytosis haematophagic. LOPINAVIR dosage: unknown. During the same period patient was treated with DOXORUBICIN, EFAVIRENZ. Patient recovered.
Lopinavir Side Effects Report #5310241-7
LOPINAVIR problem was reported by a Consumer or non-health professional from FRANCE on Apr 24, 2007. Male patient, 36 years of age, was diagnosed with hiv infection, hodgkin's disease, cardiomyopathy and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hodgkin's disease, neutropenia. LOPINAVIR dosage: unknown. During the same period patient was treated with VINBLASTINE SULPHATE, VINBLASTINE SULPHATE, VINBLASTINE SULPHATE, LAMIVUDINE, TENOFOVIR, ENFUVIRTIDE, CLINDAMYCIN. Patient recovered.
Lopinavir Side Effects Report #5310277-6
Consumer or non-health professional from JAPAN reported LOPINAVIR problem on Apr 20, 2007. Male patient, 38 years of age, was diagnosed with hiv infection, kaposi's sarcoma and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: histiocytosis haematophagic, immune reconstitution syndrome. LOPINAVIR dosage: unknown. During the same period patient was treated with DOXORUBICIN, EFAVIRENZ. Patient recovered.
Lopinavir Side Effects Report #5314138-8
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 17, 2007. Female patient, 30 years of age, weighting 97.00 lb, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hypokalaemia, nephropathy toxic. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR, LAMIVUDINE, STAVUDINE. Patient died.
Lopinavir Side Effects Report #5314139-X
Consumer or non-health professional from UNITED STATES reported LOPINAVIR problem on Apr 17, 2007. Male patient, 39 years of age, weighting 119.0 lb, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hypokalaemia. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR, LAMIVUDINE. Patient died.
Lopinavir Side Effects Report #5314142-X
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 17, 2007. Male patient, 52 years of age, weighting 110.2 lb, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hypokalaemia. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR, ABACAVIR. Patient died.
Lopinavir Side Effects Report #5332224-3
Consumer or non-health professional from INDONESIA reported LOPINAVIR problem on May 22, 2007. Male patient, 25 years of age, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: back pain, blood glucose increased, cerebral disorder, diarrhoea, headache, immune reconstitution syndrome, infection, pyrexia, vasculitis. LOPINAVIR dosage: unknown. During the same period patient was treated with TRUVADA. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5350071-3
LOPINAVIR problem was reported by a Consumer or non-health professional from SWAZILAND on May 29, 2007. Female patient, 53 years of age, was diagnosed with systemic antiviral treatment, mental disorder, abnormal behaviour, anxiety disorder and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, ascites, hepatic cirrhosis, hepatic failure, hyperlactacidaemia, mental disorder, torsade de pointes. LOPINAVIR dosage: 400/100 MG TWICE A DAY. During the same period patient was treated with METHADONE HYDROCHLORIDE, METHADONE HYDROCHLORIDE, PAROXETINE, METHYLPHENIDATE, DIDANOSINE, TENOFOVIR, FOSAMPRENAVIR, OXAZEPAM. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5357794-0
Consumer or non-health professional from UNITED STATES reported LOPINAVIR problem on June 05, 2007. Male patient, child 9 years of age, weighting 53.57 lb, was diagnosed with hiv infection cdc category a1, asthma, rhinitis allergic and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: cushing's syndrome. LOPINAVIR dosage: 216/54 MG (230/57.5 MG/M2) TWICE DAILY(230/57.5 MG/M**2 ) TWICE DAILY. During the same period patient was treated with FLUTICASONE PROPIONATE, MOMETASONE FUROATE, DIDANOSINE, LAMIVUDINE, MONTELUKAST. Patient recovered.
Lopinavir Side Effects Report #5365718-5
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED STATES on June 19, 2007. Male patient, child 9 years of age, weighting 53.57 lb, was diagnosed with hiv infection cdc category a1, asthma, rhinitis allergic and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: cushing's syndrome. LOPINAVIR dosage: 216/54 MG (230/57.5 MG/M2) TWICE DAILY(230/57.5 MG/M**2 ) TWICE DAILY. During the same period patient was treated with FLUTICASONE PROPIONATE, MOMETASONE FUROATE, DIDANOSINE, LAMIVUDINE, MONTELUKAST. Patient recovered.
Lopinavir Side Effects Report #5058375-9
Consumer or non-health professional from UNITED KINGDOM reported LOPINAVIR problem on July 11, 2006. Female patient was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: renal tubular acidosis. LOPINAVIR dosage: 400/100 MG TWICE DAILY. During the same period patient was treated with TENOFOVIR, DIDANOSINE. Patient recovered.
Lopinavir Side Effects Report #5058376-0
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on July 11, 2006. Female patient was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: fanconi syndrome. LOPINAVIR dosage: 400/100 MG TWICE DAILY. During the same period patient was treated with TENOFOVIR, DIDANOSINE. Patient recovered.
Lopinavir Side Effects Report #5058381-4
Consumer or non-health professional from UNITED KINGDOM reported LOPINAVIR problem on July 11, 2006. Female patient was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: renal failure. LOPINAVIR dosage: 400/100 MG TWICE DAILY. During the same period patient was treated with TENOFOVIR, DIDANOSINE. Patient recovered.
Lopinavir Side Effects Report #5095858-X
LOPINAVIR problem was reported by a Health Professional from THAILAND on June 27, 2006. Female patient, 30 years of age, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: myalgia, oedema, pneumonia. LOPINAVIR dosage: 800/200 MG. During the same period patient was treated with TENOFOVIR DF. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5100161-5
Consumer or non-health professional from BELGIUM reported LOPINAVIR problem on Aug 29, 2006. Female patient, 38 years of age, was diagnosed with hiv infection, blood prolactin and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: ascites, factor viii deficiency, haematemesis, hepatosplenomegaly, homocystinaemia, hypochromic anaemia, hypotension, lipodystrophy acquired, melaena. LOPINAVIR dosage: 400 MG / 100 MG. During the same period patient was treated with STAVUDINE, ABACAVIR, CABERGOLINE, DIDANOSINE, EFAVIRENZ, ZIDOVUDINE, LAMIVUDINE, TENOFOVIR. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5117639-0
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Sept 26, 2006. Male patient, 38 years of age, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: immune reconstitution syndrome, kaposi's sarcoma, lymphoedema, mobility decreased. LOPINAVIR dosage: unknown. During the same period patient was treated with RITONAVIR, FOSAMPRENAVIR, TENOFOVIR. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5126261-1
Consumer or non-health professional from UNITED KINGDOM reported LOPINAVIR problem on Sept 26, 2006. Male patient, 38 years of age, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: immune reconstitution syndrome, kaposi's sarcoma, lymphoedema. LOPINAVIR dosage: unknown. During the same period patient was treated with RITONAVIR, FOSAMPRENAVIR, TENOFOVIR. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5150592-2
LOPINAVIR problem was reported by a Health Professional from UNITED STATES on Apr 26, 2006. Female patient, 47 years of age, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: dehydration, diarrhoea, weight decreased. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR DF, ZINACEF, IMODIUM. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5153069-3
Consumer or non-health professional from SPAIN reported LOPINAVIR problem on Nov 07, 2006. Female patient, 27 years of age, was diagnosed with hiv infection, gastroenteritis cryptosporidial and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: crohn's disease, immune reconstitution syndrome. LOPINAVIR dosage: unknown. During the same period patient was treated with STAVUDINE, LAMIVUDINE, PAROMOMYCIN. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5190959-X
LOPINAVIR problem was reported by a Consumer or non-health professional from ITALY on Dec 15, 2006. Female patient, 38 years of age, was diagnosed with systemic antiviral treatment, oesophageal candidiasis, prophylaxis and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hepatotoxicity, nephropathy toxic, stevens-johnson syndrome. LOPINAVIR dosage: unknown. During the same period patient was treated with LAMIVUDINE, STAVUDINE, FLUCONAZOLE, ATOVAQUONE. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5190968-0
Consumer or non-health professional from SPAIN reported LOPINAVIR problem on Dec 13, 2006. Male patient, 47 years of age, was diagnosed with systemic antiviral treatment, blood pressure management and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: renal failure acute. LOPINAVIR dosage: unknown. During the same period patient was treated with NIFEDIPINE, STAVUDINE, LAMIVUDINE. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5314138-8
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 17, 2007. Female patient, 30 years of age, weighting 97.00 lb, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hypokalaemia, nephropathy toxic. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR DISOPROXIL FUMARATE, LAMIVUDINE, STAVUDINE. Patient died.
Lopinavir Side Effects Report #5314139-X
Consumer or non-health professional from UNITED STATES reported LOPINAVIR problem on Apr 17, 2007. Male patient, 39 years of age, weighting 119.0 lb, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hypokalaemia. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR DISOPROXIL FUMARATE, LAMIVUDINE. Patient died.
Lopinavir Side Effects Report #5314142-X
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 17, 2007. Male patient, 52 years of age, weighting 110.2 lb, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hypokalaemia. LOPINAVIR dosage: unknown. During the same period patient was treated with TENOFOVIR DISOPROXIL FUMARATE, ABACAVIR. Patient died.
Lopinavir Side Effects Report #5389488-X
Consumer or non-health professional from UNITED STATES reported LOPINAVIR problem on July 11, 2007. Male patient, 47 years of age, was diagnosed with hiv infection and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: basedow's disease, hyperthyroidism. LOPINAVIR dosage: unknown. During the same period patient was treated with EFAVIRENZ, LAMIVUDINE. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5452379-X
LOPINAVIR problem was reported by a Consumer or non-health professional from ITALY on Sept 04, 2007. Female patient, 38 years of age, was diagnosed with systemic antiviral treatment, oesophageal candidiasis, prophylaxis and was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: hepatotoxicity, nephropathy toxic, stevens-johnson syndrome. LOPINAVIR dosage: unknown. During the same period patient was treated with LAMIVUDINE, STAVUDINE, FLUCONAZOLE, ATOVAQUONE. Patient was hospitalized. Patient recovered.
Lopinavir Side Effects Report #5453247-X
Consumer or non-health professional from UNITED STATES reported LOPINAVIR problem on Sept 04, 2007. Male patient, 62 years of age, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, electrocardiogram qt prolonged. LOPINAVIR dosage: 3 CAPSULES (400 MG/100 MG), TWICE DAILY. During the same period patient was treated with ENFURVITIDE, DIDANOSINE, DELAVIRDINE, STAVUDINE, LAMIVUDINE, FLUCONAZOLE, VERAPAMIL, FUROSEMIDE. Patient recovered.
Lopinavir Side Effects Report #5453262-6
LOPINAVIR problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 04, 2007. Male patient, 40 years of age, was treated with LOPINAVIR. After drug was administered, patient experienced the following problems/side effects: electrocardiogram qt prolonged, torsade de pointes. LOPINAVIR dosage: unknown. During the same period patient was treated with ZIDOVUDINE, LAMIVUDINE, BACTRIM, AZITHROMYCIN. Patient recovered.
Drug Information: Lopinavir and Ritonavir
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602015.html
(loe pin' a veer) (ri toe' na veer)IMPORTANT WARNING:
| [Posted 03/12/2008] FDA and Tibotec Therapeutics notified healthcare professionals of changes to the WARNINGS section of the prescribing information for darunavir (Prezista) tablets regarding the risk of hepatotoxicity. In clinical trials and postmarketing experience, drug induced hepatitis has been reported in patients receiving combination therapy with darunavir/ritonavir. Appropriate laboratory testing should be conducted prior to initiating therapy with darunavir/ritonavir and patients should be monitored during treatment. Increased AST/ALT monitoring should be considered in patients with underlying chronic hepatitis, cirrhosis, or in patients who have pretreatment elevations of transaminases, especially during the first several months of darunavir/ritonavir treatment. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Prezista, http://www.fda.gov/medwatch/safety/2008/prezista_DHCP.pdf and http://www.fda.gov/cder/foi/label/2008/021976s003s004lbl.pdf.[Posted 08/14/2007] Abbott Laboratories disseminated a Dear Healthcare Provider Letter throughout the world to physicians and pharmacists that prescribe/distribute lopinavir and ritonavir (Kaletra Oral Solution). The letter informed healthcare professionals of an accidental overdose that occurred with a pediatric patient taking lopinavir and ritonavir oral solution. The infant received a significantly large dose of lopinavir and ritonavir oral solution and subsequently died. Healthcare professionals should pay special attention to accurate calculation of the dose of lopinavir and ritonavir oral solution, transcription of the medication order, dispensing information and dosing instructions to minimize the risk for medication errors. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2007/safety07.htm#kaletra, http://www.fda.gov/medwatch/safety/2007/Kaletra_DHCP.pdf and http://www.fda.gov/medwatch/safety/2007/Mar_PI/Kaletra_PI_200703.pdf. |
Why is this medication prescribed?
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
The combination of lopinavir and ritonavir is used with other antiviral medications to treat human immunodeficiency virus (HIV) in patients with acquired immunodeficiency syndrome (AIDS). Lopinavir is in a class of medications called protease (pro' tee ace) inhibitors. It works by slowing the spread of HIV in the body. In this combination, ritonavir is used to increase the amount of lopinavir in the body so it can work better. Lopinavir and ritonavir is not a cure and may not decrease the number of HIV-related illnesses. Lopinavir and ritonavir does not prevent the spread of HIV to other people.
How should this medicine be used?
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
The combination of lopinavir and ritonavir comes as a capsule and a solution (liquid) to take by mouth. It is usually taken twice a day with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lopinavir and ritonavir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take lopinavir and ritonavir even if you feel well. Do not stop taking lopinavir and ritonavir without talking to your doctor.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking lopinavir and ritonavir,
- tell your doctor and pharmacist if you are allergic to lopinavir, ritonavir (Norvir), or any other medications.
- do not take lopinavir and ritonavir if you are taking astemizole (Hismanal), cisapride (Propulsid), dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate Maleate), ergotamine (Cafatine, Cafergot, Cafetrate, others), flecainide (Tambocor), methylergonovine (Methergine), midazolam (Versed), pimozide (Orap), propafenone (Rythmol), terfenadine (Seldane), or triazolam (Halcion).
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: anticoagulants (''blood thinners'') such as warfarin (Coumadin); antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); atovaquone (Mepron); calcium-channel blockers such as felodipine (Plendil), nicardipine (Cardene), and nifedipine (Adalat, Procardia); cholesterol-lowering medications such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); clarithromycin (Biaxin); disulfiram (Antabuse); medications for irregular heartbeats such as amiodarone (Cordarone, Pacerone), bepridil (Vascor), and quinidine (Quinidex); medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); medications that suppress the immune system such as cyclosporine (Neoral, Sandimmune), Rapamune (sirolimus), and tacrolimus (Prograf); methadone (Dolophine); metronidazole (Flagyl); oral steroids such as dexamethasone (Decadron, Dexone); other antiviral medications such as amprenavir (Agenerase), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); and sildenafil (Viagra). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking didanosine, take it 1 hour before or 2 hours after lopinavir and ritonavir.
- tell your doctor what herbal products you are taking, especially products containing St. John's wort.
- you should know that lopinavir and ritonavir may decrease the effectiveness of oral contraceptives (birth control pills). Talk to your doctor about using another form of birth control.
- tell your doctor if you have ever had pancreas disease and if you have or have ever had diabetes, liver disease, or hemophilia.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lopinavir and ritonavir, call your doctor. You should not breast-feed while taking lopinavir and ritonavir.
- you should know that lopinavir and ritonavir solution contains alcohol and may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- remember that alcohol can add to the drowsiness caused by this medication.
- you should be aware that your body fat may increase or move to different areas of your body, such as your breasts and your upper back.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Lopinavir and ritonavir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- weakness
- heartburn
- headache
- difficulty falling asleep or staying asleep
- rash
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
- upset stomach
- vomiting
- stomach pain
- unusual bleeding or bruising
- extreme tiredness
- loss of appetite
- pain in the upper right part of the stomach
- yellowing of the skin or eyes
- flu-like symptoms
Lopinavir and ritonavir may cause high blood sugar. If you experience any of the following symptoms, call your doctor immediately:
- thirst
- dry mouth
- tiredness
- flushing
- dry skin
- frequent urination
- loss of appetite
- trouble breathing
Lopinavir and ritonavir may cause increases in levels of cholesterol and other fats (triglycerides) in the blood.
Lopinavir and ritonavir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. If you store lopinavir and ritonavir capsules or solution in the refrigerator, they can be used until the expiration date printed on the label. If you store them at room temperature, the capsules or solution should be used within 2 months. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to lopinavir and ritonavir.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Brand name(s) of combination products:
|