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Pain Just Under My Ribcage (67)
Bloating (35)
Excessive Gas (32)
Irregular Heart Beat (28)
Bad Mouth Taste (20)
Tired (16)
Diarrhea (13)
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Losec Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 131 

Angiosarcoma, Breast Cancer, Breast Cancer Recurrent, Foot Fracture, Lower Limb Fracture (6311729-2)
on Aug 07, 2009 Male from BRAZIL , 53 years of age, was diagnosed with
  • ulcer
and was treated with Losec Mups. Directly after, patient experienced the unwanted or unexpected Losec side effects: angiosarcoma, breast cancer, breast cancer recurrent, foot fracture, lower limb fracture. Losec Mups dosage: N/A. Patient was hospitalized and became disabled.

Sepsis, Urinary Tract Infection (6226888-X)
Patient was taking Losec. Patient felt the following Losec side effects: sepsis, urinary tract infection on Jun 08, 2009 from NEW ZEALAND Additional patient health information: Female , 87 years of age, . Losec dosage: Daily.

Neoplasm Malignant (6226887-8)
Adverse event was reported on Jun 08, 2009 by a Female taking Losec (Dosage: Daily) . Location: NEW ZEALAND , 71 years of age, After Losec was administered, patient encountered several Losec side effects: neoplasm malignant. Patient was hospitalized.

Abdominal Pain, Infection, Pyrexia (6191699-0)
on May 11, 2009 Female from BRAZIL , child 5 years of age, was diagnosed with
  • barrett's oesophagus
and was treated with Losec. Directly after, patient experienced the unwanted or unexpected Losec side effects: abdominal pain, infection, pyrexia. Losec dosage: N/A. Patient was hospitalized.


Blood Chromogranin A Increased (6136741-8)
on Mar 19, 2009 Male from AUSTRALIA , weighting 228.2 lb, was diagnosed with
  • gastrooesophageal reflux disease
and was treated with Losec. Patient felt the following Losec side effects: blood chromogranin a increased. Losec dosage: N/A.

Choking, Vomiting (6113235-7)
Patient was taking Losec. After Losec was administered, patient encountered several Losec side effects: choking, vomiting on Feb 27, 2009 from GREECE Additional patient health information: Patient , weighting 11.02 lb, was diagnosed with
  • oesophagitis
  • gastrooesophageal reflux disease
and. Losec dosage: N/A.
Multiple concurrent drugs taken:
  • Epadoren


Choking, Vomiting (6107851-6)
Adverse event was reported on Feb 27, 2009 by a Patient taking Losec (Dosage: N/A) was diagnosed with
  • oesophagitis
  • gastrooesophageal reflux disease
and. Location: GREECE , weighting 11.02 lb, Directly after, patient experienced the unwanted or unexpected Losec side effects: choking, vomiting.
Associated medications used:
  • Epadoren


Asthenia, Insomnia (5990389-4)
on Dec 05, 2008 Female from CANADA , 92 years of age, was treated with Losec Mups. Patient felt the following Losec side effects: asthenia, insomnia. Losec Mups dosage: N/A.
Multiple prescriptions taken:
  • Coumadin


Amaurosis Fugax, Deep Vein Thrombosis, Peripheral Arterial Occlusive Disease (5848582-7)
on Jul 24, 2008 Female from NETHERLANDS , 51 years of age, weighting 121.3 lb, was diagnosed with
  • gastrointestinal disorder
  • schizophrenia, paranoid type
and was treated with Losec Mups. After Losec was administered, patient encountered several Losec side effects: amaurosis fugax, deep vein thrombosis, peripheral arterial occlusive disease. Losec Mups dosage: N/A.
Multiple concurrent drugs taken:
  • Zyprexa
  • Prednison
  • Lorazepam
  • Ferrofumaraat
  • Mesalamine
Patient was hospitalized.

Anaphylactic Reaction, Angioedema, Bronchospasm, Dizziness, Eyelid Oedema, Fall, Nasal Oedema, Nausea, Pruritus (5797076-6)
Patient was taking Losec I.v.. Directly after, patient experienced the unwanted or unexpected Losec side effects: anaphylactic reaction, angioedema, bronchospasm, dizziness, eyelid oedema, fall, nasal oedema, nausea, pruritus on Jun 24, 2008 from GREECE Additional patient health information: Female , 38 years of age, was diagnosed with
  • peptic ulcer
and. Losec I.v. dosage: N/A.

Hepatic Necrosis (5796782-7)
Adverse event was reported on Jun 24, 2008 by a Female taking Losec I.v. (Dosage: N/A) was diagnosed with
  • palpitations
  • hypothyroidism
  • gastric ulcer
  • pain
and. Location: SWEDEN , 73 years of age, Patient felt the following Losec side effects: hepatic necrosis.

Optic Neuritis, Visual Acuity Reduced, Visual Field Defect (5759808-2)
on May 30, 2008 Female from NETHERLANDS , 77 years of age, was treated with Losec I.v.. After Losec was administered, patient encountered several Losec side effects: optic neuritis, visual acuity reduced, visual field defect. Losec I.v. dosage: N/A.
Multiple concurrent drugs taken:
  • Coaprovel (150/12.5mg 1 Tablet Once A Day)
  • Amlodipine
  • Metoprololtartraat
  • Simvastatin
  • Amitriptyline Hcl
  • Tramadol Hcl (50mg 3 Times Per Day As Required)
  • Tolbutamide
  • Metformine Hcl


Cough, Dysphagia, Dyspnoea, Fall, Infective Tenosynovitis, Muscle Atrophy, Oesophageal Haemorrhage, Pneumonia, Upper Limb Fracture (5747521-7)
on May 19, 2008 Male from BRAZIL , 72 years of age, weighting 79.37 lb, was diagnosed with
  • gastrooesophageal reflux disease
and was treated with Losec I.v.. Directly after, patient experienced the unwanted or unexpected Losec side effects: cough, dysphagia, dyspnoea, fall, infective tenosynovitis, muscle atrophy, oesophageal haemorrhage, pneumonia, upper limb fracture. Losec I.v. dosage: N/A. Patient was hospitalized.

Abdominal Distension, Abdominal Pain, Dizziness, Dyspepsia, Flatulence, Food Intolerance, Headache, Impaired Gastric Emptying, Nausea (5727723-6)
Patient was taking Losec I.v.. Patient felt the following Losec side effects: abdominal distension, abdominal pain, dizziness, dyspepsia, flatulence, food intolerance, headache, impaired gastric emptying, nausea on May 01, 2008 from CANADA Additional patient health information: Female , 35 years of age, was diagnosed with
  • dyspepsia
and. Losec I.v. dosage: N/A.

Eosinophilia (5725286-2)
Adverse event was reported on Apr 23, 2008 by a Female taking Losec I.v. (Dosage: 20 Mg) was diagnosed with
  • dyspepsia
  • menorrhagia
and. Location: UNITED KINGDOM , 43 years of age, weighting 169.8 lb, After Losec was administered, patient encountered several Losec side effects: eosinophilia.
Multiple concurrent drugs taken:
  • Tranexamic Acid
  • Mefenamic Acid
Patient was hospitalized.

Dyspnoea, Swelling Face, Throat Tightness (5713037-7)
on Apr 14, 2008 Female from BRAZIL , 68 years of age, weighting 123.5 lb, was diagnosed with
  • gastritis
and was treated with Losec I.v.. Directly after, patient experienced the unwanted or unexpected Losec side effects: dyspnoea, swelling face, throat tightness. Losec I.v. dosage: N/A.

Iron Deficiency (5702001-X)
on Apr 07, 2008 Female from CANADA , 48 years of age, was diagnosed with
  • dyspepsia
and was treated with Losec I.v.. Patient felt the following Losec side effects: iron deficiency. Losec I.v. dosage: N/A.

Abdominal Distension, Abdominal Pain, Dizziness, Dyspepsia, Flatulence, Food Intolerance, Headache, Impaired Gastric Emptying, Nausea (5694310-8)
Patient was taking Losec I.v.. After Losec was administered, patient encountered several Losec side effects: abdominal distension, abdominal pain, dizziness, dyspepsia, flatulence, food intolerance, headache, impaired gastric emptying, nausea on Mar 28, 2008 from CANADA Additional patient health information: Female , 35 years of age, was diagnosed with
  • dyspepsia
and. Losec I.v. dosage: N/A.

Constipation, Depression, Hypercholesterolaemia, Insomnia, Pruritus, Vision Blurred (5655354-5)
Adverse event was reported on Mar 05, 2008 by a Female taking Losec I.v. (Dosage: N/A) was diagnosed with
  • gastrooesophageal reflux disease
and. Location: GREECE , 55 years of age, Directly after, patient experienced the unwanted or unexpected Losec side effects: constipation, depression, hypercholesterolaemia, insomnia, pruritus, vision blurred.
Associated medications used:
  • Laprazol
  • Zurcazol


Abdominal Distension, Abdominal Pain, Dizziness, Dyspepsia, Flatulence, Food Intolerance, Headache, Impaired Gastric Emptying, Nausea (5632197-X)
on Feb 15, 2008 Female from CANADA , 35 years of age, was diagnosed with
  • irritable bowel syndrome
and was treated with Losec I.v.. Patient felt the following Losec side effects: abdominal distension, abdominal pain, dizziness, dyspepsia, flatulence, food intolerance, headache, impaired gastric emptying, nausea. Losec I.v. dosage: N/A.

Cerebrovascular Accident, Chromaturia, Urine Odour Abnormal (5622978-0)
on Feb 07, 2008 Male from BRAZIL , 80 years of age, was diagnosed with
  • gastritis
and was treated with Losec I.v.. After Losec was administered, patient encountered several Losec side effects: cerebrovascular accident, chromaturia, urine odour abnormal. Losec I.v. dosage: N/A.

Laryngeal Oedema, Urticaria (5609461-3)
Patient was taking Losec I.v.. Directly after, patient experienced the unwanted or unexpected Losec side effects: laryngeal oedema, urticaria on Jan 08, 2008 from CHINA Additional patient health information: Female , 34 years of age, was diagnosed with
  • duodenal ulcer
and. Losec I.v. dosage: N/A.

Choking, Respiratory Arrest (5575006-X)
Adverse event was reported on Dec 21, 2007 by a Male taking Losec I.v. (Dosage: 2.5 Ml (5 Mg)) . Location: CANADA , weighting 11.90 lb, Patient felt the following Losec side effects: choking, respiratory arrest.

Colonic Polyp, Dry Skin, Pruritus, Urticaria (5545484-0)
on Dec 06, 2007 Female from CANADA , 65 years of age, was diagnosed with
  • gastrooesophageal reflux disease
  • hypothyroidism
and was treated with Losec. After Losec was administered, patient encountered several Losec side effects: colonic polyp, dry skin, pruritus, urticaria. Losec dosage: N/A.
Multiple concurrent drugs taken:
  • Synthroid
Patient was hospitalized.

Chest Pain, Dystonia, Gastrooesophageal Reflux Disease, Headache, Restlessness, Speech Disorder (5523614-4)
on Nov 09, 2007 Female from UNITED KINGDOM , 16 years of age, weighting 83.78 lb, was diagnosed with
  • gastrooesophageal reflux disease
  • reflux gastritis
and was treated with Losec. Directly after, patient experienced the unwanted or unexpected Losec side effects: chest pain, dystonia, gastrooesophageal reflux disease, headache, restlessness, speech disorder. Losec dosage: N/A.
Associated medications used:
  • Domperidone
  • Movicol
Patient was hospitalized.

Showing 1-25 of 131 

Losec Health Episodes

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from extended use of losec, MANY stomach polyps. large ones were removed ...Keep Reading

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It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Losec Information

Alternative LOSEC Names:OMEPRAZOL

Active Ingredient: OMEPRAZOL

More About Losec

Side Effects reported to FDA: 131. View Losec Adverse Reports

Losec safety alerts: 2009 2007

Reported deaths: 7

Reported hospitalizations: 45

Clopidogrel (marketed as Plavix) and Omeprazole (marketed as Prilosec) - Drug Interaction

Audience: Cardiovascular healthcare professionals, pharmacists

[Posted 11/17/2009] FDA notified healthcare professionals of new safety information concerning an interaction between clopidogrel (Plavix), an anti-clotting medication, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid.  New data show that when clopidogrel and omeprazole are taken together, the effectiveness of clopidogrel is reduced. Patients at risk for heart attacks or strokes who use clopidogrel to prevent blood clots will not get the full effect of this medicine if they are also taking omeprazole. Separating the dose of clopidogrel and omeprazole in time will not reduce this drug interaction.

Other drugs that are expected to have a similar effect and should be avoided in combination with clopidogrel include: cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine, and ticlopidine. 

Recommendations for healthcare professionals are provided in the "Information for Healthcare Professionals" sheet.

[11/17/2009 - Information for Healthcare Professionals - FDA]
[11/17/2009 - Public Health Advisory - FDA]
[11/17/2009 - Follow-Up to January 2009 Early Communication - FDA]

Previous MedWatch Alert:

[01/26/2009] Clopidogrel bisulfate (marketed as Plavix) Early Communication 

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