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Edema (4)
Swolen Feet (4)
Palpitations (2)
Urticaria (2)
Palpitations, Edema (1)
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Manidipine Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Blood Pressure Inadequately Controlled, Formication, Bacterial Infection, Headache, Escherichia Infection (7982712-6)
on Dec 07, 2011 Female from BRAZIL , 53 years of age, weighting 218.3 lb, was diagnosed with
  • blood pressure
  • thyroid disorder
and was treated with Manidipine Hcl. Directly after, patient experienced the unwanted or unexpected Manidipine side effects: blood pressure inadequately controlled, formication, bacterial infection, headache, escherichia infection. Manidipine Hcl dosage: 0.5 Tab In The Mrng Started On 2yrs Ago.
Associated medications used:
  • Levothyroxine Sodium (1 Tab In Fasting Longtime Ago Started)
  • Rasilez (1 Tab Before Lunch Longtime Ago Started)
  • Epogen
  • Hygroton (Started On Long Time Ago)
  • Humulin 70/30 (56 Iu In The Morning And 28iu In The Night)
  • Irbesartan (2df=1tab In The Morning And 1 Tab In The Night)
  • Apidra (1df=2-6iu Started On 1yr Ago)
  • Lexotan (0.5 Tab Is Moring Started On 3yrs Ago)
Patient was hospitalized.

Pneumonia (7825302-8)
Patient was taking Manidipine. Patient felt the following Manidipine side effects: pneumonia on Oct 12, 2011 from GREECE Additional patient health information: Male , weighting 160.9 lb, was diagnosed with
  • hypertension
and. Manidipine dosage: 20mg Per Day.
Multiple prescriptions taken:
  • Irbesartan And Hydrochlorothiazide
  • Propafenone Hydrochloride (150mg Three Times Per Day)
  • Lapatinib (1500mg Per Day)
  • Zantac (150mg Twice Per Day)
  • Plavix (75mg Per Day)
  • Medrol (4mg Twice Per Day)
Patient was hospitalized.

Blood Cholesterol Increased, Weight Increased, Bedridden (7772746-9)
Adverse event was reported on Mar 01, 2011 by a Female taking Manidipine (Dosage: N/A) was diagnosed with
  • depression
and. Location: UNITED STATES , 39 years of age, weighting 218.0 lb, After Manidipine was administered, patient encountered several Manidipine side effects: blood cholesterol increased, weight increased, bedridden.
Multiple concurrent drugs taken:
  • Seroquel Xr
  • Hydrochlorothiazide


Diabetes Mellitus, Amnesia (7605924-X)
on Jun 29, 2011 Male from BRAZIL , weighting 176.4 lb, was diagnosed with
  • hypertension
and was treated with Manidipine Hydrochloride. Directly after, patient experienced the unwanted or unexpected Manidipine side effects: diabetes mellitus, amnesia. Manidipine Hydrochloride dosage: 1 Df In The Morning.
Associated medications used:
  • Diovan Hct (1 Df,320/12,5mg 1 Tablet Daily)



Hepatitis, Antinuclear Antibody Positive (7531546-5)
on Jun 01, 2011 Female from ITALY , 70 years of age, was diagnosed with
  • hypertension
  • breast cancer
and was treated with Manidipine. Patient felt the following Manidipine side effects: hepatitis, antinuclear antibody positive. Manidipine dosage: N/A.
Multiple prescriptions taken:
  • Anastrozole
  • Anastrozole (1 Mg)
  • Bisoprolol Fumarate
Patient was hospitalized.

Neurosurgery, Oedema Peripheral, Pain In Extremity, Hyperaemia (7403617-5)
Patient was taking Manidipine. After Manidipine was administered, patient encountered several Manidipine side effects: neurosurgery, oedema peripheral, pain in extremity, hyperaemia on Mar 28, 2011 from BRAZIL Additional patient health information: Female , 61 years of age, was diagnosed with
  • hypertension
and. Manidipine dosage: 10 Mg, Daily.
Multiple concurrent drugs taken:
  • Amlodipine Besylate And Olmesartan Medoxomil (40/10mg, 1x/day)
  • Amlodipine Besylate (5 Mg, Daily)
  • Ramipril (10 Mg, Daily)
  • Phenobarbital
  • Phenytoin
Patient was hospitalized.

Vein Disorder, Oedema Peripheral, Blood Pressure Inadequately Controlled (7240909-7)
Adverse event was reported on Jan 11, 2011 by a Male taking Manidipine Hydrochloride (Dosage: Unk) . Location: BRAZIL , weighting 165.3 lb, Directly after, patient experienced the unwanted or unexpected Manidipine side effects: vein disorder, oedema peripheral, blood pressure inadequately controlled.
Associated medications used:
  • Atenolol (Unk)
  • Epogen (Unk)
  • Diovan (Unk)
  • Midazolam (Unk)


Myelodysplastic Syndrome (5273225-3)
on Mar 16, 2007 Female from JAPAN , 72 years of age, was diagnosed with
  • hypertension
  • osteoporosis
and was treated with Manidipine Hydrochloride. Patient felt the following Manidipine side effects: myelodysplastic syndrome. Manidipine Hydrochloride dosage: N/A.
Multiple prescriptions taken:
  • Fosamax
  • Fosamax
  • Alfacalcidol
  • Enalapril Maleate
  • Benet
  • Brotizolam
  • Riohard
  • Riohard


Anxiety, Arthralgia, Body Temperature Increased, Dizziness, Flushing, Migraine, Myalgia, Paraesthesia, Pulmonary Embolism (4900039-3)
on Jan 26, 2006 Male from BRAZIL , 75 years of age, weighting 143.3 lb, was treated with Manidipine Hydrochloride. After Manidipine was administered, patient encountered several Manidipine side effects: anxiety, arthralgia, body temperature increased, dizziness, flushing, migraine, myalgia, paraesthesia, pulmonary embolism. Manidipine Hydrochloride dosage: 5 Mg/day.
Multiple concurrent drugs taken:
  • Monocordil (40 Mg, Bid)
  • Simvastatin (10 Mg/day)
  • Apresoline (25 Mg, Tid)
  • Apresoline (50 Mg, Tid)
Patient was hospitalized.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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