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Mannitol Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 55 

Emotional Distress, Renal Failure, Multi-organ Failure, Pain, Anxiety, Fear, Injury (7367995-8)
on Sep 30, 2009 Male from UNITED STATES , weighting 163.0 lb, was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: emotional distress, renal failure, multi-organ failure, pain, anxiety, fear, injury. Mannitol dosage: 25 G, Unk.
Associated medications used:
  • Trasylol (200 Cc Followed By Continuous Infusion Of 50cc/hr)
  • Heparin (35000 U, Unk)
  • Protamine Sulfate (Unk)
  • Amiodarone Hcl (150mg Loading Dose)
  • Lidocaine (100 Ml, Unk)
  • Ancef (1 G, Unk)
  • Versed (Unk)
  • Insulin (10 U, Unk)
Patient was hospitalized.

Stress, Multi-organ Failure, Renal Impairment, Anxiety, Renal Failure, Injury, Cerebrovascular Accident, Pain, Anhedonia (7365514-3)
Patient was taking Mannitol. Patient felt the following Mannitol side effects: stress, multi-organ failure, renal impairment, anxiety, renal failure, injury, cerebrovascular accident, pain, anhedonia on Jun 25, 2009 from UNITED STATES Additional patient health information: Male , weighting 200.0 lb, . Mannitol dosage: Pump.
Multiple prescriptions taken:
  • Trasylol (200 Ml Then 50 Ml/hr)
  • Dobutrex (Unk)
  • Glucophage (500 Mg, Bid)
  • Glyburide (3 Mg, Bid)
  • Heparin (60.000 U, Pump)
  • Insulin (Unk)
  • Trasylol
  • Lisinopril (20 Mg, Unk)
Patient was hospitalized.

Emotional Distress, Renal Failure, Pain, Anxiety, Cardiac Failure, Respiratory Failure, Cardiac Failure Congestive, Injury (7365482-4)
Adverse event was reported on Oct 01, 2008 by a Male taking Mannitol (Dosage: 500 Mg) . Location: UNITED STATES , weighting 253.5 lb, After Mannitol was administered, patient encountered several Mannitol side effects: emotional distress, renal failure, pain, anxiety, cardiac failure, respiratory failure, cardiac failure congestive, injury.
Multiple concurrent drugs taken:
  • Cardioplegia
  • Lantus (60 Units Each Morning)
  • Amiodarone Hcl (Unk)
  • Nitroglycerin
  • Heparin (34000 Units)
  • Metoprolol (50 Mg Daily)
  • Crestor (10 Mg Daily)
  • Prozac (20 Mg Daily)
Patient was hospitalized.

Hypotension (7314035-2)
on Feb 16, 2011 Male from UNITED STATES , 63 years of age, weighting 104.0 lb, was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: hypotension. Mannitol dosage: 2500 Ml Once Iv. Patient was hospitalized.


Hypercreatininaemia (7311974-3)
on Jan 18, 2011 Female from KOREA, REPUBLIC OF , weighting 156.5 lb, was treated with Mannitol. Patient felt the following Mannitol side effects: hypercreatininaemia. Mannitol dosage: N/A.
Multiple prescriptions taken:
  • Furosemide
  • Bevacizumab (Last Dose: 16 June 2010)
  • Cisplatin (Last Dose: 16 June 2010)
  • Pemetrexed Disodium (Last Dose: 16 June 2010)
Patient was hospitalized.

Thrombocytopenia (7301285-4)
Patient was taking Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: thrombocytopenia on Nov 03, 2009 from UNITED STATES Additional patient health information: Male , 44 years of age, weighting 147.9 lb, . Mannitol dosage: N/A.
Multiple concurrent drugs taken:
  • Promethazine
  • Heparin
  • Thymoglobulin
  • Naloxone
  • Hydromorphone (hydromorphone)
  • Ondansetron
  • Mycophenolate Mofetil
  • Nystatin


Toxic Epidermal Necrolysis, Pulmonary Thrombosis (7299558-7)
Adverse event was reported on Feb 11, 2011 by a Male taking Mannitol (Dosage: N/A) . Location: POLAND , 52 years of age, weighting 198.4 lb, Directly after, patient experienced the unwanted or unexpected Mannitol side effects: toxic epidermal necrolysis, pulmonary thrombosis.
Associated medications used:
  • Lerivon
  • Simvastatin
  • Dexaven
  • Lorafen
  • Gasec
  • Furosemid
  • Furosemid
  • Enarenal


Blood Sodium Decreased, Cardiac Arrest, Cardiac Disorder, Hyperkalaemia, Hypocalcaemia, Hypokinesia, Ventricular Fibrillation, Ventricular Tachycardia (6835353-8)
on Jun 17, 2010 Male from UNITED STATES , 41 years of age, was diagnosed with
  • intracranial pressure increased
and was treated with Mannitol. Patient felt the following Mannitol side effects: blood sodium decreased, cardiac arrest, cardiac disorder, hyperkalaemia, hypocalcaemia, hypokinesia, ventricular fibrillation, ventricular tachycardia. Mannitol dosage: N/A.
Multiple prescriptions taken:
  • Anesthesia


Acidosis, Renal Failure Acute (6818736-1)
on Jun 15, 2010 Male from JAPAN , 56 years of age, weighting 159.6 lb, was diagnosed with
  • abnormal sensation in eye
and was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: acidosis, renal failure acute. Mannitol dosage: N/A.
Multiple concurrent drugs taken:
  • Acetazolamide


Abdominal Discomfort, Diverticulitis (6649999-3)
Patient was taking Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: abdominal discomfort, diverticulitis on Mar 24, 2010 from UNITED STATES Additional patient health information: Female , 66 years of age, weighting 135.0 lb, was diagnosed with
  • blood pressure
and. Mannitol dosage: 1x Day Oral. Patient was hospitalized.

Brain Oedema, Hypotension, Ischaemic Cerebral Infarction, Nephropathy (6317258-4)
Adverse event was reported on Aug 11, 2009 by a Female taking Mannitol Hexanitrate (Dosage: Intravenous) . Location: UNITED STATES , 30 years of age, weighting 194.0 lb, Patient felt the following Mannitol side effects: brain oedema, hypotension, ischaemic cerebral infarction, nephropathy.
Multiple prescriptions taken:
  • Potassium Phosphates (120 Mmol; Intravenous)
  • Phosporus (Intravenous Drip)
  • Insulin
  • Morphine
  • Vancomycin
  • Parenteral
  • Dopamine Hcl
  • Ceftriaxone


Brain Oedema, Hyponatraemia, Mental Status Changes (5813576-4)
on Jul 16, 2008 Male from UNITED STATES , 48 years of age, was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: brain oedema, hyponatraemia, mental status changes. Mannitol dosage: See Above. Patient was hospitalized.

Maculopathy (5414757-4)
on Aug 03, 2007 Patient from UNITED STATES , 66 years of age, was diagnosed with
  • blood brain barrier defect
  • lymphoma
and was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: maculopathy. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Associated medications used:
  • Methotrexate (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Maculopathy (5414756-2)
Patient was taking Mannitol. Patient felt the following Mannitol side effects: maculopathy on Aug 03, 2007 from UNITED STATES Additional patient health information: Patient , 66 years of age, was diagnosed with
  • blood brain barrier defect
  • central nervous system lymphoma
and. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Multiple prescriptions taken:
  • Methotrexate (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Maculopathy, Visual Disturbance (5414755-0)
Adverse event was reported on Aug 03, 2007 by a Patient taking Mannitol (Dosage: 2 Days Once Monthly, Intra-arterial) was diagnosed with
  • blood brain barrier defect
  • lymphoma
and. Location: UNITED STATES , 65 years of age, After Mannitol was administered, patient encountered several Mannitol side effects: maculopathy, visual disturbance.
Multiple concurrent drugs taken:
  • Methotrexate (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Blood Brain Barrier Defect, Central Nervous System Lymphoma, Maculopathy (5414754-9)
on Aug 03, 2007 Patient from UNITED STATES , 57 years of age, was diagnosed with
  • blood brain barrier defect
  • central nervous system lymphoma
and was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: blood brain barrier defect, central nervous system lymphoma, maculopathy. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Associated medications used:
  • Methotrexate (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Maculopathy (5414753-7)
on Aug 03, 2007 Patient from UNITED STATES , 54 years of age, was treated with Mannitol. Patient felt the following Mannitol side effects: maculopathy. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Multiple prescriptions taken:
  • Methotrexate (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Maculopathy (5414743-4)
Patient was taking Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: maculopathy on Aug 03, 2007 from UNITED STATES Additional patient health information: Patient , 34 years of age, was diagnosed with
  • blood brain barrier defect
  • lymphoma
and. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Multiple concurrent drugs taken:
  • Methotrexate (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Maculopathy (5414742-2)
Adverse event was reported on Aug 03, 2007 by a Patient taking Mannitol (Dosage: 2 Days Once Monthly, Intra-arterial) was diagnosed with
  • blood brain barrier defect
  • central nervous system lymphoma
and. Location: UNITED STATES , 73 years of age, Directly after, patient experienced the unwanted or unexpected Mannitol side effects: maculopathy.
Associated medications used:
  • Methotrexate (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Electrocardiogram T Wave Peaked, Hyperkalaemia, Hyponatraemia (5405827-5)
on Jul 23, 2007 Female from UNITED STATES , 31 years of age, weighting 189.6 lb, was diagnosed with
  • intracranial pressure increased
and was treated with Mannitol Injetion (mannitol) (mannitol). Patient felt the following Mannitol side effects: electrocardiogram t wave peaked, hyperkalaemia, hyponatraemia. Mannitol Injetion (mannitol) (mannitol) dosage: 40 Gm, Slow Iv.
Multiple prescriptions taken:
  • Midazolam Hcl
  • Oxygen (oxygen)
  • Propofol


Maculopathy (5404985-6)
on Jul 22, 2007 Patient from UNITED STATES , 34 years of age, was diagnosed with
  • nervous system disorder
  • central nervous system lymphoma
and was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: maculopathy. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Multiple concurrent drugs taken:
  • Methotrexate Sodium (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate )
  • Cytarabine


Maculopathy (5404984-4)
Patient was taking Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: maculopathy on Jul 22, 2007 from UNITED STATES Additional patient health information: Patient , 73 years of age, was diagnosed with
  • brain operation
  • central nervous system lymphoma
and. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Associated medications used:
  • Methotrexate Sodium (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate )
  • Cytarabine


Macular Oedema, Maculopathy, Visual Acuity Reduced (5404982-0)
Adverse event was reported on Jul 22, 2007 by a Patient taking Mannitol (Dosage: 2 Days Once Monthly, Intra-arterial) was diagnosed with
  • nervous system disorder
  • central nervous system lymphoma
and. Location: UNITED STATES , 66 years of age, Patient felt the following Mannitol side effects: macular oedema, maculopathy, visual acuity reduced.
Multiple prescriptions taken:
  • Methotrexate Sodium (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate )
  • Cytarabine


Macular Oedema, Maculopathy, Visual Disturbance (5404978-9)
on Jul 22, 2007 Patient from UNITED STATES , 66 years of age, was diagnosed with
  • blood brain barrier defect
  • central nervous system lymphoma
and was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: macular oedema, maculopathy, visual disturbance. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Multiple concurrent drugs taken:
  • Methotrexate Sodium (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate )
  • Cytarabine


Maculopathy (5404977-7)
on Jul 22, 2007 Patient from UNITED STATES , 65 years of age, was diagnosed with
  • nervous system disorder
  • central nervous system lymphoma
and was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: maculopathy. Mannitol dosage: 2 Days Once Monthly, Intra-arterial.
Associated medications used:
  • Methotrexate Sodium (5000 Mg/m2, 1 In 1 M, Intra-arterial)
  • Cyclophosphamide
  • Etoposide Phosphate (etoposide Phosphate)
  • Cytarabine


Showing 1-25 of 55 

Mannitol Health Episodes

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Mannitol Information

SORBITOL

Active Ingredient: MANNITOL MANNITOL;

Mannitol Dosage, Warnings, Usage.

Side Effects reported to FDA: 55. View Mannitol Adverse Reports

Mannitol safety alerts: No

Reported deaths: 13

Reported hospitalizations: 16

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