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Mannitol Side Effects

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Common Mannitol Side Effects


The most commonly reported Mannitol side effects (click to view or check a box to report):

Maculopathy (14)
Pain (14)
Renal Failure (12)
Renal Failure Acute (11)
Injury (10)
Unevaluable Event (9)
Stress (9)
Death (8)
Anxiety (8)
Multi-organ Failure (8)
Emotional Distress (7)
Fear (7)
Renal Impairment (7)
Renal Injury (7)
Anhedonia (6)
Hyperkalaemia (5)
Brain Oedema (3)
Dyspnoea (3)
Hyponatraemia (3)
Hypotension (3)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Mannitol Side Effects Reported to FDA



Mannitol Side Effect Report#9835658
Extravasation, Compartment Syndrome
This is a report of a 17-year-old female patient (weight: NA) from TR, suffering from the following health symptoms/conditions: NA, who was treated with Mannitol (dosage: NA, start time: NS), combined with:
  • Atropine
  • Atropine
  • Saline
and developed a serious reaction and side effect(s): Extravasation, Compartment Syndrome after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol treatment in female patients, resulting in Extravasation side effect.
Mannitol Side Effect Report#9818683
Multi-organ Failure
This report suggests a potential Mannitol 20% Baxter Multi-organ Failure side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from PL was diagnosed with the following symptoms/conditions: NA and used Mannitol 20% Baxter (dosage: NA) starting NS. After starting Mannitol 20% Baxter the patient began experiencing various side effects, including: Multi-organ FailureAdditional drugs used concurrently:
  • Ceftriaxone
  • Vancomycin
  • Rifampicin
  • Pefloxacin
  • Dexamethasone
The patient was hospitalized. Although Mannitol 20% Baxter demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Multi-organ Failure, may still occur.
Mannitol Side Effect Report#9748344
Anaphylactic Reaction
This Anaphylactic Reaction problem was reported by a physician from US. A 19-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: polyuria,atypical teratoid/rhabdoid tumour of cns. On NS this consumer started treatment with Mannitol (dosage: 8 G/m^2 Bolus). The following drugs were being taken at the same time: NA. When using Mannitol, the patient experienced the following unwanted symptoms/side effects: Anaphylactic ReactionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anaphylactic Reaction, may become evident only after a product is in use by the general population.
Mannitol Side Effect Report#9681007
Cerebral Infarction
This Cerebral Infarction side effect was reported by a health professional from US. A 16-year-old male patient (weight:NA) experienced the following symptoms/conditions: medulloblastoma.The patient was prescribed Mannitol (drug dosage: 12 G, Once, Ia), which was initiated on
Oct 28, 2013. Concurrently used drugs:
  • Hydrocortisone Sodium Succinate
  • Sodium Thiosulfate
  • Dexamethasone
  • Ondansetron
  • Lorazepam
  • Phenobarbital
  • Diphenhydramine
  • Ranitidine
.After starting to take Mannitol the consumer reported adverse symptoms, such as: Cerebral InfarctionThese side effects may potentially be related to Mannitol. The patient was hospitalized.
Mannitol Side Effect Report#9633034
Renal Failure Acute, Hyperthermia, Altered State Of Consciousness
This is a report of a 77-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: cerebral infarction, who was treated with Mannitol 20 % Viaflo, Solution Pour Perfusion (dosage: NA, start time: NS), combined with:
  • Furosemide
and developed a serious reaction and side effect(s): Renal Failure Acute, Hyperthermia, Altered State Of Consciousness after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol 20 % Viaflo, Solution Pour Perfusion treatment in male patients, resulting in Renal Failure Acute side effect.
Mannitol Side Effect Report#9633021
Renal Failure Acute, Gastroduodenitis Haemorrhagic
This report suggests a potential Mannitol Renal Failure Acute side effect(s) that can have serious consequences. A 57-year-old patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: hyponatraemia and used Mannitol (dosage: NA) starting NS. After starting Mannitol the patient began experiencing various side effects, including: Renal Failure Acute, Gastroduodenitis HaemorrhagicAdditional drugs used concurrently:
  • Furosemide
Although Mannitol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure Acute, may still occur.
Mannitol Side Effect Report#9633017
Gastroduodenitis Haemorrhagic, Renal Failure Acute
This Gastroduodenitis Haemorrhagic problem was reported by a health professional from FR. A 71-year-old patient (weight: NA) was diagnosed with the following symptoms/conditions: cerebral infarction. On NS this consumer started treatment with Mannitol (dosage: NA). The following drugs were being taken at the same time:
  • Furosemide
When using Mannitol, the patient experienced the following unwanted symptoms/side effects: Gastroduodenitis Haemorrhagic, Renal Failure AcuteAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gastroduodenitis Haemorrhagic, may become evident only after a product is in use by the general population.
Mannitol Side Effect Report#9611164
Toxicity To Various Agents, Renal Failure Acute
This Toxicity To Various Agents side effect was reported by a health professional from IT. A 71-year-old male patient (weight:NA) experienced the following symptoms/conditions: transient ischaemic attack,hypertension.The patient was prescribed Mannitol (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Clonidine
.After starting to take Mannitol the consumer reported adverse symptoms, such as: Toxicity To Various Agents, Renal Failure AcuteThese side effects may potentially be related to Mannitol. The patient was hospitalized.
Mannitol Side Effect Report#9611162
Pulmonary Oedema, Oliguria
This is a report of a 46-year-old male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: polyuria, who was treated with Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Pulmonary Oedema, Oliguria after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l treatment in male patients, resulting in Pulmonary Oedema side effect.
Mannitol Side Effect Report#9554690
Consciousness Fluctuating, Respiratory Disorder, Listeriosis
This report suggests a potential Mannitol 20% Baxter Death side effect(s) that can have serious consequences. A 61-year-old patient (weight: NA) from PL was diagnosed with the following symptoms/conditions: NA and used Mannitol 20% Baxter (dosage: NA) starting NS. After starting Mannitol 20% Baxter the patient began experiencing various side effects, including: Consciousness Fluctuating, Respiratory Disorder, ListeriosisAdditional drugs used concurrently:
  • Acyclovir
  • Dexamethasone
Although Mannitol 20% Baxter demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Mannitol Side Effect Report#9544005
Renal Failure Acute, Cardiomegaly, Angina Pectoris, Pulmonary Congestion, Dyspnoea, Nausea
This Renal Failure Acute problem was reported by a health professional from NL. A 71-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: complex regional pain syndrome. On NS this consumer started treatment with Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l (dosage: NA). The following drugs were being taken at the same time: NA. When using Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l, the patient experienced the following unwanted symptoms/side effects: Renal Failure Acute, Cardiomegaly, Angina Pectoris, Pulmonary Congestion, Dyspnoea, NauseaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Failure Acute, may become evident only after a product is in use by the general population.
Mannitol Side Effect Report#9530072
Grand Mal Convulsion, Blood Sodium Decreased
This Grand Mal Convulsion side effect was reported by a health professional from PL. A 40-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Mannitol 20% Baxter (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Acyclovir
.After starting to take Mannitol 20% Baxter the consumer reported adverse symptoms, such as: Grand Mal Convulsion, Blood Sodium DecreasedThese side effects may potentially be related to Mannitol 20% Baxter.
Mannitol Side Effect Report#9331734
Electrolyte Imbalance, Blood Sodium Increased, Blood Potassium Decreased, Hyperkalaemia, Ventricular Tachycardia, Tachycardia, Hypotension, Stress Cardiomyopathy
This is a report of a 19-year-old male patient (weight: NA) from IE, suffering from the following health symptoms/conditions: NA, who was treated with Mannitol (dosage: NA, start time: NS), combined with:
  • Potassium (potassium)
  • Norepinephrine (norepinephrine)
  • Sedatives
  • Analgesics (analgesics)
and developed a serious reaction and side effect(s): Electrolyte Imbalance, Blood Sodium Increased, Blood Potassium Decreased, Hyperkalaemia, Ventricular Tachycardia, Tachycardia, Hypotension, Stress Cardiomyopathy after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol treatment in male patients, resulting in Electrolyte Imbalance side effect.
Mannitol Side Effect Report#9171207
Renal Failure Acute, Lung Infection
This report suggests a potential Mannitol Renal Failure Acute side effect(s) that can have serious consequences. A 77-year-old male patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: intracranial pressure increased and used Mannitol (dosage: NA) starting NS. After starting Mannitol the patient began experiencing various side effects, including: Renal Failure Acute, Lung InfectionAdditional drugs used concurrently: NA. Although Mannitol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure Acute, may still occur.
Mannitol Side Effect Report#9154981
Dyspnoea, Rash Erythematous
This Dyspnoea problem was reported by a health professional from GB. A 42-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 16, 2013 this consumer started treatment with Mannitol (dosage: NA). The following drugs were being taken at the same time:
  • Buscopan (buscopan Comp.)
  • Carobel
  • Dotarem (meglumine Gadoterate)
  • Metoclopramide (metoclopramide)
When using Mannitol, the patient experienced the following unwanted symptoms/side effects: Dyspnoea, Rash ErythematousAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dyspnoea, may become evident only after a product is in use by the general population.
Mannitol Side Effect Report#9150609
Pollakiuria, Product Formulation Issue
This Pollakiuria side effect was reported by a consumer or non-health professional from US. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Mannitol (drug dosage: Po Daily), which was initiated on NS. Concurrently used drugs:
  • Levothyroxine
.After starting to take Mannitol the consumer reported adverse symptoms, such as: Pollakiuria, Product Formulation IssueThese side effects may potentially be related to Mannitol.
Mannitol Side Effect Report#9117889
Dyspnoea, Rash Erythematous
This is a report of a 42-year-old female patient (weight: NA) from GB, suffering from the following health symptoms/conditions: NA, who was treated with Mannitol (dosage: NA, start time:
Jan 16, 2013), combined with:
  • Buscopan
  • Dotarem
  • Metoclopramide
and developed a serious reaction and side effect(s): Dyspnoea, Rash Erythematous after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol treatment in female patients, resulting in Dyspnoea side effect.
Mannitol Side Effect Report#9009136
Renal Failure Acute
This report suggests a potential Mannitol Renal Failure Acute side effect(s) that can have serious consequences. A 77-year-old male patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: cerebral infarction,intracranial pressure increased and used Mannitol (dosage: NA) starting
Feb 05, 2011. After starting Mannitol the patient began experiencing various side effects, including: Renal Failure AcuteAdditional drugs used concurrently: NA. Although Mannitol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure Acute, may still occur.
Mannitol Side Effect Report#8974663
Renal Failure Acute
This Renal Failure Acute problem was reported by a pharmacist from US. A 56-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: intracranial pressure increased. On
Sep 06, 2012 this consumer started treatment with Mannitol (dosage: 90 Mg Q6hrs Iv Drip). The following drugs were being taken at the same time:
  • Pantoprazole
  • Amlodipine
  • Nicardipine
  • Lorazepam
  • Labetalol
When using Mannitol, the patient experienced the following unwanted symptoms/side effects: Renal Failure AcuteAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Failure Acute, may become evident only after a product is in use by the general population.
Mannitol Side Effect Report#8775979
Brain Neoplasm Malignant, Product Label Confusion, Polyuria, Condition Aggravated
This Brain Neoplasm Malignant side effect was reported by a physician from SE. A 4-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Mannitol (drug dosage: NA), which was initiated on
Aug 28, 2012. Concurrently used drugs: NA..After starting to take Mannitol the consumer reported adverse symptoms, such as: Brain Neoplasm Malignant, Product Label Confusion, Polyuria, Condition AggravatedThese side effects may potentially be related to Mannitol.
Mannitol Side Effect Report#8434880-X
Small Bowel Angioedema, Anaphylactic Reaction
This is a report of a 46-year-old male patient (weight: NA) from China, suffering from the following health symptoms/conditions: scan with contrast, who was treated with Mannitol (dosage: 1000 Ml, Scan Preparation, Oral, start time: NS), combined with:
  • Iohexol (iohexol) (370 Mg, Per Ml, Intravenous (not Otherwise Specified))
and developed a serious reaction and side effect(s): Small Bowel Angioedema, Anaphylactic Reaction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol treatment in male patients, resulting in Small Bowel Angioedema side effect.
Mannitol Side Effect Report#8434872-0
Anaphylactic Reaction, Diarrhoea, Small Bowel Angioedema
This report suggests a potential Mannitol Anaphylactic Reaction side effect(s) that can have serious consequences. A 55-year-old male patient (weight: NA) from China was diagnosed with the following symptoms/conditions: scan with contrast and used Mannitol (dosage: 400 Ml, Oral) starting NS. After starting Mannitol the patient began experiencing various side effects, including: Anaphylactic Reaction, Diarrhoea, Small Bowel AngioedemaAdditional drugs used concurrently:
  • Ultravist 150 (90 Ml)
  • Iopamidol
Although Mannitol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Anaphylactic Reaction, may still occur.
Mannitol Side Effect Report#8393322-3
Encephalopathy
This Encephalopathy problem was reported by a physician from United States. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Apr 26, 2012 this consumer started treatment with Mannitol (dosage: 200mg/ml). The following drugs were being taken at the same time:
  • Mycophenolate Mofetil (Bid)
  • Lisinopril
  • Ergocalciferol
  • Desflurane (1df)
  • Morphine (10mg/ml)
  • Atorvastatin Calcium
  • Propofol (10mg/ml)
  • Rocuronium Bromide (10mg/ml)
When using Mannitol, the patient experienced the following unwanted symptoms/side effects: EncephalopathyThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Encephalopathy, may become evident only after a product is in use by the general population.
Mannitol Side Effect Report#8304315-6
Chest Discomfort, Panic Attack
This Chest Discomfort side effect was reported by a consumer or non-health professional from United States. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Mannitol (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Copaxone (One Syringe)
.After starting to take Mannitol the consumer reported adverse symptoms, such as: Chest Discomfort, Panic AttackThese side effects may potentially be related to Mannitol.
Mannitol Side Effect Report#8013692-5
Brain Oedema, Brain Stem Microhaemorrhage, Nervous System Disorder
This is a report of a 57-year-old male patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Mannitol 25% (dosage: 10 Ml Over 2 Minutes Ia, start time:
Dec 08, 2011), combined with:
  • Temodar (100 Mg/m2 X 1 Ia)
and developed a serious reaction and side effect(s): Brain Oedema, Brain Stem Microhaemorrhage, Nervous System Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol 25% treatment in male patients, resulting in Brain Oedema side effect.


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The appearance of Mannitol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Mannitol Side Effects for Women?

Women Side EffectsReports
Pain 6
Renal Failure 6
Fear 5
Stress 5
Anhedonia 4
Anxiety 4
Injury 4
Multi-organ Failure 4
Renal Impairment 4
Renal Injury 4

What are common Mannitol Side Effects for Men?

Men Side EffectsReports
Pain 8
Renal Failure Acute 7
Injury 6
Renal Failure 6
Unevaluable Event 5
Anxiety 4
Death 4
Emotional Distress 4
Hyperkalaemia 4
Multi-organ Failure 4

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Mannitol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Discuss Mannitol Side Effects

    Did You Have a Mannitol Side Effect?

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    Yes, Moderate
    Yes, Minor
    No

    How Effective is Mannitol for You?

    Exceeded Expectations
    Effective
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    Mannitol Safety Alerts, Active Ingredients, Usage Information

    NDC0264-2303
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameMannitol
    NameMannitol
    Dosage FormIRRIGANT
    RouteIRRIGATION
    On market since19780210
    LabelerB. Braun Medical Inc.
    Active Ingredient(s)MANNITOL
    Strength(s)5
    Unit(s)g/100mL
    Pharma ClassIncreased Diuresis [PE],Osmotic Activity [MoA],Osmotic Diuretic [EPC]

    Mannitol Dosage, Warnings, Usage.

    Side Effects reported to FDA: 75

    Mannitol safety alerts: No

    Reported deaths: 18

    Reported hospitalizations: 18

    Latest Mannitol clinical trials