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Mannitol Side Effects

Report Mannitol Side Effects

If you experienced any harmful or unwanted effects of Mannitol, please share your experience. This could help to raise awareness about Mannitol side effects, identify uknown risks and inform health professionals and patients taking Mannitol.

Examples: headache, dizziness


The most commonly reported Mannitol side effects are:
Hyperglycermia (1 reports)

If you have experienced a side effect listed above, you can check a box to report it.


To view a complete list of submitted side effects, please follow the link Mannitol side effects . You can also compare Mannitol side effects or view FDA reports.

Mannitol Side Effects reported to FDA

The following Mannitol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
The FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Mannitol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has identified a causal relationship between the drug and the listed risk.

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Gamma-glutamyltransferase Increased, Jaundice, Alanine Aminotransferase Increased, Pruritus, Blood Bilirubin Increased, Decreased Appetite, Yellow Skin, Aspartate Aminotransferase Increased, Fatigue
on Dec 21, 2011 Male from CHINA , 35 years of age, was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: gamma-glutamyltransferase increased, jaundice, alanine aminotransferase increased, pruritus, blood bilirubin increased, decreased appetite, yellow skin, aspartate aminotransferase increased, fatigue. Mannitol dosage: N/A.
Associated medications used: Patient was hospitalized.

Oedema Peripheral, Pulse Absent, Gangrene, Catheter Site Swelling, Poor Peripheral Circulation
Patient was taking Mannitol 20%. Patient felt the following Mannitol side effects: oedema peripheral, pulse absent, gangrene, catheter site swelling, poor peripheral circulation on Oct 31, 2011 from INDIA Additional patient health information: Male , 18 years of age, . Mannitol 20% dosage: On Left Hand: Dorsum, Intravenous.

Stress Cardiomyopathy, Malaise, Dizziness, Pleural Effusion
Adverse event was reported on Sep 01, 2011 by a Male taking Mannitol (Dosage: N/A) . Location: JAPAN , 72 years of age, weighting 112.0 lb, After Mannitol was administered, patient encountered several Mannitol side effects: stress cardiomyopathy, malaise, dizziness, pleural effusion.
Multiple concurrent drugs taken:
  • Cisplatin
  • Docetaxel (Taken On One Day Every Week)
  • Granisetron
  • Therapeutic Radiopharmaceuticals
  • Dexamethasone Sodium Phosphate


Stress, Unevaluable Event, Renal Injury, Emotional Distress, Multi-organ Failure, Renal Impairment, Anhedonia
on Aug 24, 2011 Female from UNITED STATES , 63 years of age, weighting 138.9 lb, was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: stress, unevaluable event, renal injury, emotional distress, multi-organ failure, renal impairment, anhedonia. Mannitol dosage: N/A.
Associated medications used:
  • Amicar
  • Theophylline-sr
  • Ancef
  • Atacand (32 Mg, Unk)
  • Isosorbide Mononitrate (30 Mg, Unk)
  • Clonidine (3 Mg, Unk)
  • Plavix (75 Mg, Unk)
  • Heparin



Multi-organ Failure, Unevaluable Event, Injury, Anxiety, Fear, Stress, Pain, Emotional Distress, Renal Failure
on Aug 09, 2011 Female from UNITED STATES , 69 years of age, weighting 198.0 lb, was treated with Mannitol. Patient felt the following Mannitol side effects: multi-organ failure, unevaluable event, injury, anxiety, fear, stress, pain, emotional distress, renal failure. Mannitol dosage: 100 Ml, Unk.
Multiple prescriptions taken:
  • Phenylephrine Hcl (65 Ml, Unk)
  • Ancef (2 Gm)
  • Trasylol
  • Nitrolingual Pumpspray (Unk Unk, Prn)
  • Heparin (20000 Units)
  • Platelets (1 U, Unk)
  • Isosorbide Dinitrate (40 Mg, Qd)
  • Etomidate (20 Mg, Unk)
Patient was hospitalized.

Large Intestine Perforation
Patient was taking Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: large intestine perforation on Jul 13, 2011 from AUSTRIA Additional patient health information: Female , 91 years of age, weighting 97.00 lb, was diagnosed with and. Mannitol dosage: N/A.

Respiratory Failure
Adverse event was reported on Jul 07, 2011 by a Female taking Mannitol (Dosage: N/A) . Location: UNITED STATES , 32 years of age, Directly after, patient experienced the unwanted or unexpected Mannitol side effects: respiratory failure.
Associated medications used:
  • Dantrolene Sodium (600 Mg, Total, Intravenous)
  • Succinylcholine Chloride
  • Lasix
  • Thiopental (thiopental Sodium)
  • Lidocaine (lidocaine Hydrochloride)
  • Bicarbonate (sodium Bicarbonate)
  • Fentanyl
  • Isoflurane


Fear, Renal Impairment, Stress, Renal Tubular Necrosis, Pain, Renal Failure Acute, Postoperative Wound Infection, Emotional Disorder
on Jan 31, 2011 Female from UNITED STATES , 67 years of age, weighting 264.8 lb, was treated with Mannitol. Patient felt the following Mannitol side effects: fear, renal impairment, stress, renal tubular necrosis, pain, renal failure acute, postoperative wound infection, emotional disorder. Mannitol dosage: Unk.
Multiple prescriptions taken:
  • Trasylol (1 Ml (test Dose), Unk)
  • Vecuronium Bromide (10 Unk)
  • Calcium Chloride Dihydrate (1 G, Unk)
  • Lipitor (10 Mg, Unk)
  • Norvasc (5 Mg, Unk)
  • Propofol (100 Mg, Unk)
  • Ketamine Hcl (100 Mg, Unk)
  • Phenylephrine Hcl (Unk)


Pain, Anxiety, Fear, Renal Impairment, Renal Injury, Renal Failure, Unevaluable Event, Emotional Distress
on Jan 12, 2009 Male from UNITED STATES , 82 years of age, weighting 160.9 lb, was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: pain, anxiety, fear, renal impairment, renal injury, renal failure, unevaluable event, emotional distress. Mannitol dosage: 375 G, Unk.
Multiple concurrent drugs taken:
  • Zestril (20 Mg, Unk)
  • Trasylol
  • Plasma (4 Units)
  • Dobutamine Hydrochloride (Titrated)
  • Heparin (10,000 Units)
  • Fentanyl (4 To 8 Mg)
  • Trasylol (200 Ml Cardiopulmonary Bypass Prime)
  • Lasix (10 Mg, Qd)


Anxiety, Fear, Renal Failure, Injury, Unevaluable Event, Depression, Pain, Anhedonia
Patient was taking Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: anxiety, fear, renal failure, injury, unevaluable event, depression, pain, anhedonia on Apr 11, 2009 from UNITED STATES Additional patient health information: Female , 70 years of age, weighting 93.26 lb, . Mannitol dosage: Infusion.
Associated medications used:
  • Trasylol (Unk)
  • Zocor (30 Mg, Qd)
  • Hyzaar (100.25 Mg, Qd)
  • Protonix (40 Mg, Qd)
  • Vasopressin (50 Mcgs Infusion)
  • Morphine Sulfate (Infusion)
  • Dopamine Hcl (Infusion)
  • Milrinone (Infusion)
Patient was hospitalized.

Hemiparesis, Unevaluable Event, Motor Dysfunction, Pain, Hypoaesthesia, Insomnia, Speech Disorder, Injury, Emotional Distress
Adverse event was reported on Oct 19, 2008 by a Male taking Mannitol (Dosage: Unk) . Location: UNITED STATES , 45 years of age, weighting 216.1 lb, Patient felt the following Mannitol side effects: hemiparesis, unevaluable event, motor dysfunction, pain, hypoaesthesia, insomnia, speech disorder, injury, emotional distress.
Multiple prescriptions taken:
  • Trasylol (2 Ml, Initial Dose)
  • Accuretic (20 / 12.5mg Daily)
  • Heparin (10000 U, Unk)
  • Azithromycin (2 G, Unk)
  • Fresh Frozen Plasma (2 U, Unk)
Patient was hospitalized and became disabled.

Renal Failure, Cerebrovascular Accident, Anhedonia, Renal Injury, Stress, Fear, Renal Impairment, Pain
on Nov 13, 2009 Female from UNITED STATES , 53 years of age, weighting 242.5 lb, was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: renal failure, cerebrovascular accident, anhedonia, renal injury, stress, fear, renal impairment, pain. Mannitol dosage: 50ml.
Multiple concurrent drugs taken: Patient was hospitalized.

Neoplasm Malignant, Cardiac Failure
on Jun 24, 2010 Female from CHINA , 37 years of age, was diagnosed with and was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: neoplasm malignant, cardiac failure. Mannitol dosage: N/A.
Associated medications used:
  • Acyclovir
  • Diazepam
  • Valproate Sodium
  • Sporanox
  • Tienam
  • Vancomycin
  • Sporanox
  • Sporanox


White Blood Cell Count Increased
Patient was taking Mannitol. Patient felt the following Mannitol side effects: white blood cell count increased on Apr 14, 2011 from KOREA, REPUBLIC OF Additional patient health information: Male , 56 years of age, . Mannitol dosage: N/A.
Multiple prescriptions taken:
  • Magnesium Hydroxide
  • Amlodipine
  • Levetiracetam (500, 1000 Mg, Bid, Oral)
  • Bromhexine
  • Itopride Hydrochloride
  • Meropenem
  • Ursodiol
  • Streptodornase


Stress, Cardiac Failure, Multi-organ Failure, Anhedonia, Renal Impairment, Renal Injury, Unevaluable Event, Pain
Adverse event was reported on Nov 30, 2009 by a Male taking Mannitol (Dosage: 25 G, Unk) . Location: UNITED STATES , 74 years of age, weighting 200.0 lb, After Mannitol was administered, patient encountered several Mannitol side effects: stress, cardiac failure, multi-organ failure, anhedonia, renal impairment, renal injury, unevaluable event, pain.
Multiple concurrent drugs taken:
  • Coumadin
  • Red Blood Cells, Concentrated (1 U, Unk)
  • Trasylol (Unk)
  • Acetylsalicylic Acid Srt (Unk)
  • Amiodarone
  • Heparin (15000 U, Unk)
  • Neo Synephrin (400)
  • Lanoxin


Renal Failure, Pain, Unevaluable Event, Injury, Renal Injury
on Oct 31, 2009 Male from UNITED STATES , 69 years of age, weighting 206.0 lb, was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: renal failure, pain, unevaluable event, injury, renal injury. Mannitol dosage: N/A.
Associated medications used:
  • Heparin (10,000 Units)
  • Ancef (2 G, Unk)
  • Lasix (20 Mg, Unk)
  • Gentamicin (80 Mg, Unk)
  • Trasylol (200 Cc. [aprotinin, 4 Units (600 Ml) Charged])
  • Dopamine Hcl (2 G, Unk)
  • Aspirin (1 Daily)
  • Protamine Sulfate (1400 Mg, Unk)


Pulmonary Oedema, Renal Failure, Low Cardiac Output Syndrome, Injury, Unevaluable Event, Myocardial Infarction, Pain, Renal Failure Acute, Ileus
on Nov 14, 2009 Male from UNITED STATES , weighting 211.6 lb, was treated with Mannitol. Patient felt the following Mannitol side effects: pulmonary oedema, renal failure, low cardiac output syndrome, injury, unevaluable event, myocardial infarction, pain, renal failure acute, ileus. Mannitol dosage: 50 Ml, Cardiopulmonary Bypass.
Multiple prescriptions taken:
  • Reglan
  • Atenolol (Unk)
  • Heparin (Unk)
  • Lidocaine (6, Cardiopulmonary Bypass)
  • Lisinopril
  • Hydrochlorothiazide (Unk)
  • Lasix
  • Humulin 70/30 (Unk)
Patient was hospitalized.

Multi-organ Failure, Renal Failure, Anhedonia, Stress, Anxiety, Emotional Distress, Unevaluable Event, Pain, Renal Injury
Patient was taking Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: multi-organ failure, renal failure, anhedonia, stress, anxiety, emotional distress, unevaluable event, pain, renal injury on Dec 05, 2008 from UNITED STATES Additional patient health information: Female , weighting 120.0 lb, . Mannitol dosage: Unk.
Multiple concurrent drugs taken:
  • Nitroglycerin (Intravenous And Topical)
  • Humalog (Unk)
  • Famotidine (Unk)
  • Cefazolin (Unk)
  • Warfarin Sodium (3 Mg, Tuesday, Thursday)
  • Vancomycin (1 G, Preoperatively)
  • Versed (Unk)
  • Red Blood Cells (1 U, Unk)
Patient was hospitalized.

Stevens-johnson Syndrome
Adverse event was reported on Mar 26, 2011 by a Female taking Mannitol (Dosage: N/A) . Location: PHILIPPINES , 78 years of age, Directly after, patient experienced the unwanted or unexpected Mannitol side effects: stevens-johnson syndrome.
Associated medications used:
  • Acetylcysteine
  • Zonegran
  • Warfarin
  • Doxofylline
  • Levofloxacin
  • Aliskiren
  • Citicoline
  • Olmesartan Medoxomil
Patient was hospitalized.

Fear, Pain, Injury, Myocardial Infarction, Renal Failure, Renal Impairment, Renal Injury, Multi-organ Failure, Anxiety
on Jan 14, 2010 Female from UNITED STATES , weighting 148.0 lb, was treated with Mannitol. Patient felt the following Mannitol side effects: fear, pain, injury, myocardial infarction, renal failure, renal impairment, renal injury, multi-organ failure, anxiety. Mannitol dosage: 50 Ml, Unk.
Multiple prescriptions taken:
  • Lidocaine (100 Mg, Unk)
  • Dopamine (Unk)
  • Heparin (25000 U, Unk)
  • Cardioplegia (Unk)
  • Inocor (100 Mg, Unk)
  • Sufentanil Citrate (750 Mcg)
  • Lasix (20 Mg, Unk)
  • Midazolam (3 Mg, Unk)


Emotional Distress, Renal Failure, Multi-organ Failure, Pain, Anxiety, Fear, Injury
on Sep 30, 2009 Male from UNITED STATES , weighting 163.0 lb, was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: emotional distress, renal failure, multi-organ failure, pain, anxiety, fear, injury. Mannitol dosage: 25 G, Unk.
Multiple concurrent drugs taken:
  • Trasylol (200 Cc Followed By Continuous Infusion Of 50cc/hr)
  • Heparin (35000 U, Unk)
  • Protamine Sulfate (Unk)
  • Amiodarone Hcl (150mg Loading Dose)
  • Lidocaine (100 Ml, Unk)
  • Ancef (1 G, Unk)
  • Versed (Unk)
  • Insulin (10 U, Unk)
Patient was hospitalized.

Stress, Multi-organ Failure, Renal Impairment, Anxiety, Renal Failure, Injury, Cerebrovascular Accident, Pain, Anhedonia
Patient was taking Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: stress, multi-organ failure, renal impairment, anxiety, renal failure, injury, cerebrovascular accident, pain, anhedonia on Jun 25, 2009 from UNITED STATES Additional patient health information: Male , weighting 200.0 lb, . Mannitol dosage: Pump.
Associated medications used:
  • Trasylol (200 Ml Then 50 Ml/hr)
  • Dobutrex (Unk)
  • Glucophage (500 Mg, Bid)
  • Glyburide (3 Mg, Bid)
  • Heparin (60.000 U, Pump)
  • Insulin (Unk)
Patient was hospitalized.

Emotional Distress, Renal Failure, Pain, Anxiety, Cardiac Failure, Respiratory Failure, Cardiac Failure Congestive, Injury
Adverse event was reported on Oct 01, 2008 by a Male taking Mannitol (Dosage: 500 Mg) . Location: UNITED STATES , weighting 253.5 lb, Patient felt the following Mannitol side effects: emotional distress, renal failure, pain, anxiety, cardiac failure, respiratory failure, cardiac failure congestive, injury.
Multiple prescriptions taken:
  • Cardioplegia
  • Lantus (60 Units Each Morning)
  • Amiodarone Hcl (Unk)
  • Nitroglycerin
  • Heparin (34000 Units)
  • Metoprolol (50 Mg Daily)
  • Crestor (10 Mg Daily)
  • Prozac (20 Mg Daily)
Patient was hospitalized.

Hypotension
on Feb 16, 2011 Male from UNITED STATES , 63 years of age, weighting 104.0 lb, was treated with Mannitol. After Mannitol was administered, patient encountered several Mannitol side effects: hypotension. Mannitol dosage: 2500 Ml Once Iv. Patient was hospitalized.

Hypercreatininaemia
on Jan 18, 2011 Female from KOREA, REPUBLIC OF , weighting 156.5 lb, was treated with Mannitol. Directly after, patient experienced the unwanted or unexpected Mannitol side effects: hypercreatininaemia. Mannitol dosage: N/A.
Associated medications used:
  • Furosemide
  • Bevacizumab (Last Dose: 16 June 2010)
  • Cisplatin (Last Dose: 16 June 2010)
  • Pemetrexed Disodium (Last Dose: 16 June 2010)
Patient was hospitalized.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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Safety Alerts, Active Ingredients, Usage Information

SORBITOL

Active Ingredient: MANNITOL MANNITOL;

Mannitol Dosage, Warnings, Usage.

Side Effects reported to FDA: 75

Mannitol safety alerts: No

Reported deaths: 18

Reported hospitalizations: 18

Latest Mannitol clinical trials