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Hi Sugar Levels (23)
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Gastrointestinal (11)
Itchiness (8)
Acidity (4)
Cyanocobalamin (4)
Lethargy (3)
>>View All User Submitted Mecobalamin Side Effects

Mecobalamin Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Flushing (8476775-1)
on Jun 22, 2012 Female from JAPAN , 81 years of age, was treated with Mecobalamin. Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: flushing. Mecobalamin dosage: N/A.
Associated medications used:
  • Atorvastatin
  • Metformin Hcl
  • Omeprazole
  • Zetia
  • Micamlo
  • Opaprosmon


Disseminated Intravascular Coagulation, Dermatitis Exfoliative (8399632-8)
Patient was taking Mecobalamin. Patient felt the following Mecobalamin side effects: disseminated intravascular coagulation, dermatitis exfoliative on May 23, 2012 from JAPAN Additional patient health information: Male , weighting 110.1 lb, was diagnosed with
  • prophylaxis
and. Mecobalamin dosage: 500 Milligram.
Multiple prescriptions taken:
  • Allopurinol (100 Milligram)
  • Betamethasone (5 Milligram)
  • Lenalidomide (25 Milligram)
  • Rabeprazole Sodium (10 Milligram)
  • Sulfamethoxazole (80 Milligram)
  • Betamethasone Valerate (Adequate Dose)
  • Fluconazole (100 Milligram)
Patient was hospitalized.

Disseminated Intravascular Coagulation, Dermatitis Exfoliative (8395903-X)
Adverse event was reported on May 23, 2012 by a Male taking Mecobalamin (Dosage: 500 Milligram) was diagnosed with
  • prophylaxis
and. Location: JAPAN , weighting 110.1 lb, After Mecobalamin was administered, patient encountered several Mecobalamin side effects: disseminated intravascular coagulation, dermatitis exfoliative.
Multiple concurrent drugs taken:
  • Allopurinol (100 Milligram)
  • Lenalidomide (25 Milligram)
  • Corticosteroids
  • Fluid
  • Fluconazole (100 Milligram)
  • Rabeprazole Sodium (10 Milligram)
  • Betamethasone (5 Milligram)
  • Sulfamethoxazole (80 Milligram)
Patient was hospitalized.

Inadequate Analgesia, Gastric Ulcer (8364375-3)
on Mar 16, 2012 Male from JAPAN , weighting 143.3 lb, was diagnosed with
  • pain
and was treated with Mecobalamin. Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: inadequate analgesia, gastric ulcer. Mecobalamin dosage: 500 Mg X 1 Per 1 Day.
Associated medications used:
  • Tramadol Hydrochloride And Acetaminophen
  • Amlodipine Besilate (5 Mg X 1 Per 1 Day)
  • Tramadol Hydrochloride And Acetaminophen
  • Maibastan (5 Mg X 1 Per 1 Day)



Cardiac Failure, Myelodysplastic Syndrome (8178321-9)
on Feb 24, 2012 Female from JAPAN , 85 years of age, was treated with Mecobalamin. Patient felt the following Mecobalamin side effects: cardiac failure, myelodysplastic syndrome. Mecobalamin dosage: N/A.
Multiple prescriptions taken:
  • Rantac
  • Ferrous Citrate
  • Ceftriaxone Sodium
  • Azulfidine
  • Orencia (500 Mg, Ivd)
  • Prednisolone (Unk)
  • Candesartan Cilexetil
  • Epogin


Myocardial Infarction (8165535-7)
Patient was taking Mecobalamin. After Mecobalamin was administered, patient encountered several Mecobalamin side effects: myocardial infarction on Feb 15, 2012 from CHINA Additional patient health information: Female , 62 years of age, weighting 119.0 lb, was diagnosed with
  • diabetic neuropathy
and. Mecobalamin dosage: N/A.
Multiple concurrent drugs taken:
  • Humalog (Dose:21 Unit(s))
  • Insulin Glargine (Dose:20 Unit(s))
  • Solostar
  • Metformin Hcl
Patient was hospitalized.

Cholangitis Acute (8035558-7)
Adverse event was reported on Jan 06, 2012 by a Male taking Mecobalamin (Dosage: N/A) was diagnosed with
  • pain
and. Location: JAPAN , weighting 145.5 lb, Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: cholangitis acute.
Associated medications used:
  • Mucosta
  • Zolpidem
  • Sunbazon
  • Rebamipide
  • Gabexate Mesilate
  • Dextrose
  • Midazolam
  • Amlodin Od
Patient was hospitalized.

Rheumatoid Arthritis, Dementia (7920646-3)
on Nov 04, 2011 Female from JAPAN , 70 years of age, was diagnosed with
  • arteriosclerosis
and was treated with Mecobalamin. Patient felt the following Mecobalamin side effects: rheumatoid arthritis, dementia. Mecobalamin dosage: N/A.
Multiple prescriptions taken:
  • Atorvastatin Calcium
  • Ketoprofen (Qs)
  • Quazepam
  • Sulpiride
  • Carbamazepine
  • Lansoprazole
  • Folic Acid
  • Ketoprofen (Qs)
Patient was hospitalized.

Vomiting, Haemorrhoids, Ingrowing Nail, Hyperkeratosis, Conjunctivitis (7909455-9)
on Nov 01, 2011 Male from JAPAN , 50 years of age, weighting 154.3 lb, was treated with Mecobalamin. After Mecobalamin was administered, patient encountered several Mecobalamin side effects: vomiting, haemorrhoids, ingrowing nail, hyperkeratosis, conjunctivitis. Mecobalamin dosage: Unk.
Multiple concurrent drugs taken:
  • Dexamethasone Sodium Phosphate (Unk)
  • Motilium (Unk)
  • Panitumumab (6 Mg/kg, Q2wk)
  • Panitumumab (6 Mg/kg, Q2wk)
  • Topotecan (150 Mg/m2, Q2wk)
  • Antebate (Unk)
  • Emend (Unk)
  • Posterisan (Unk)


Gastrooesophageal Reflux Disease, Headache, Haematemesis (7861395-X)
Patient was taking Mecobalamin. Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: gastrooesophageal reflux disease, headache, haematemesis on Oct 24, 2011 from JAPAN Additional patient health information: Female , 57 years of age, weighting 95.24 lb, was diagnosed with
  • diabetic neuropathy
and. Mecobalamin dosage: 500 Ug, 3x/day.
Associated medications used:
  • Mexitil (50 Mg, 2x/day)
  • Amitriptyline Hcl (10 Mg, 1x/day)
  • Glyburide (2.5 Mg, 1x/day)
  • Lyrica (75 Mg, 2x/day)
  • Glyburide (1.25 Mg, 1x/day)
  • Clonazepam (0.5 Mg, 1x/day)
  • Voglibose (0.3 Mg, 3x/day)
Patient was hospitalized.

Diabetes Mellitus Inadequate Control, Blood Glucose Decreased (7790249-2)
Adverse event was reported on May 14, 2011 by a Female taking Mecobalamin (Dosage: Unk) . Location: CHINA , 55 years of age, Patient felt the following Mecobalamin side effects: diabetes mellitus inadequate control, blood glucose decreased.
Multiple prescriptions taken:
  • Novorapid (1u+1u+1u Bolus)
  • Estazolam (Unk)
  • Aspirin (Unk)
  • Novolog (30 U, Bid)
  • Levemir (12u At Bed Time)
  • Novorapid (6u+6u+5.2u Bolus, 38.9u Basal (maximum))
  • Simvastatin (Unk)
  • Novorapid (6u+6u+7u Bolus)
Patient was hospitalized.

Cardiac Failure, Myelodysplastic Syndrome (7774288-3)
on Sep 19, 2011 Female from JAPAN , 85 years of age, was treated with Mecobalamin. After Mecobalamin was administered, patient encountered several Mecobalamin side effects: cardiac failure, myelodysplastic syndrome. Mecobalamin dosage: N/A.
Multiple concurrent drugs taken:
  • Lasix
  • Prednisolone (Unk)
  • Mobic
  • Folic Acid
  • Rantac
  • Rheumatrex (2 Mg, 1 Week)
  • Cerocral
  • Amlodipine


Liver Carcinoma Ruptured, Blood Pressure Diastolic Decreased (7702962-3)
on Aug 12, 2011 Male from JAPAN , weighting 123.5 lb, was treated with Mecobalamin. Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: liver carcinoma ruptured, blood pressure diastolic decreased. Mecobalamin dosage: 0.5 Mg, Unk.
Associated medications used:
  • Promac (150 Mg, Unk)
  • Candesartan Cilexetil (4 Mg, Unk)
  • Sigmart (15 Mg, Unk)
  • Lansoprazole (15 Mg, Unk)
  • Valsartan (40 Mg, Qd)
  • Gasmotin (15 Mg, Unk)
Patient was hospitalized.

Liver Disorder, Melaena, C-reactive Protein Increased, Gastrointestinal Haemorrhage, Rectal Ulcer Haemorrhage, Blood Albumin Decreased, Ascites (7619013-1)
Patient was taking Mecobalamin. Patient felt the following Mecobalamin side effects: liver disorder, melaena, c-reactive protein increased, gastrointestinal haemorrhage, rectal ulcer haemorrhage, blood albumin decreased, ascites on Jul 08, 2011 from JAPAN Additional patient health information: Female , weighting 103.6 lb, . Mecobalamin dosage: 1500 Mcg Daily. Patient was hospitalized.

Cardiac Failure, Myelodysplastic Syndrome (7555498-7)
Adverse event was reported on Jun 13, 2011 by a Female taking Mecobalamin (Dosage: N/A) . Location: JAPAN , 85 years of age, After Mecobalamin was administered, patient encountered several Mecobalamin side effects: cardiac failure, myelodysplastic syndrome.
Multiple concurrent drugs taken:
  • Mucodyne
  • Ceftriaxone Sodium
  • Rantac
  • Cerocral
  • Candesartan Cilexetil
  • Rheumatrex (2 Mg, 1 Week)
  • Folic Acid
  • Prednisolone (Unk)


Hypotension, Blood Pressure Decreased, Renal Impairment, Hyperkalaemia, Dehydration, Decreased Appetite, Dizziness, Metabolic Acidosis, Heart Rate Decreased (7511781-2)
on May 10, 2011 Male from JAPAN , 68 years of age, weighting 165.3 lb, was treated with Mecobalamin. Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: hypotension, blood pressure decreased, renal impairment, hyperkalaemia, dehydration, decreased appetite, dizziness, metabolic acidosis, heart rate decreased. Mecobalamin dosage: N/A.
Associated medications used:
  • Ternelin (tizanidine Hydrochloride)
  • Juvela (tocopheryl Acetate)
  • Celecoxib
  • Olmesartan Medoxomil (20 Mg (20 Mg, 1 In 1 D), Per Oral; 10 Mg (10 Mg, 1 In 1 D), Per Oral)
  • Olmesartan Medoxomil (20 Mg (20 Mg, 1 In 1 D), Per Oral; 10 Mg (10 Mg, 1 In 1 D), Per Oral)
  • Amaryl
  • Prorenal (limaprost)
  • Metformin Hydrochloride
Patient was hospitalized.

Blood Pressure Diastolic Decreased (7480421-3)
on May 11, 2011 Male from JAPAN , weighting 123.5 lb, was treated with Mecobalamin. Patient felt the following Mecobalamin side effects: blood pressure diastolic decreased. Mecobalamin dosage: 0.5 Mg, Unk.
Multiple prescriptions taken:
  • Promac (150 Mg, Unk)
  • Candesartan Cilexetil (4 Mg, Unk)
  • Sigmart (15 Mg, Unk)
  • Takepron (15 Mg, Unk)
  • Gasmotin (15 Mg, Unk)
  • Valsartan (40 Mg, Qd)


Malaise, Dizziness, Decreased Appetite (7335311-3)
Patient was taking Mecobalamin. After Mecobalamin was administered, patient encountered several Mecobalamin side effects: malaise, dizziness, decreased appetite on Feb 25, 2011 from JAPAN Additional patient health information: Male , 74 years of age, . Mecobalamin dosage: Unk.
Multiple concurrent drugs taken:
  • Troxipide (Unk)
  • Pioglitazone Hydrochloride (Unk)
  • Metoclopramide Hcl (Unk)
  • Pilsicainide Hydrochloride (Unk)
  • Sulpiride (Unk)
  • Candesartan Cilexetil (Unk)
  • Warfarin Potassium (Unk)
  • Famvir (1500 Mg Daily)
Patient was hospitalized.

Paronychia, Tremor, Chills, Vertigo, Dermatitis (7272653-4)
Adverse event was reported on Jan 24, 2011 by a Male taking Mecobalamin (Dosage: Unk Unk, Unk) . Location: JAPAN , 74 years of age, weighting 136.7 lb, Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: paronychia, tremor, chills, vertigo, dermatitis.
Associated medications used:
  • Livalo
  • Gasmotin
  • Aspirin
  • Lasix
  • Gaster D
  • Norvasc
  • Plavix
  • Lasix
Patient was hospitalized.

Muscular Weakness, Stem Cell Transplant, Diffuse Large B-cell Lymphoma, Memory Impairment, Neoplasm Malignant, Metastases To Central Nervous System, Disorientation (7241462-4)
on Dec 28, 2010 Male from JAPAN , 52 years of age, weighting 116.8 lb, was treated with Mecobalamin (mecobalamin). Patient felt the following Mecobalamin side effects: muscular weakness, stem cell transplant, diffuse large b-cell lymphoma, memory impairment, neoplasm malignant, metastases to central nervous system, disorientation. Mecobalamin (mecobalamin) dosage: N/A.
Multiple prescriptions taken:
  • Etoposide
  • Thymoglobulin (50 Mg, Qd, Intravenous)
  • Itraconazole
  • Cytarabine
  • Lansoprazole
  • Platelets, Concentrated (platelets, Concentrated)
  • Melphalan Hydrochloride
  • Rebamipide (rebamipide)
Patient was hospitalized.

Epilepsy (5945943-2)
on Oct 29, 2008 Patient from JAPAN , 74 years of age, was treated with Mecobalamin. After Mecobalamin was administered, patient encountered several Mecobalamin side effects: epilepsy. Mecobalamin dosage: Unk.
Multiple concurrent drugs taken:
  • Plavix (75 Mg)


Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Glucose Decreased, Blood Lactate Dehydrogenase Increased, Hepatic Function Abnormal, Hypoglycaemia, Pyrexia (5243541-X)
Patient was taking Mecobalamin. Directly after, patient experienced the unwanted or unexpected Mecobalamin side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood glucose decreased, blood lactate dehydrogenase increased, hepatic function abnormal, hypoglycaemia, pyrexia on Feb 08, 2007 from JAPAN Additional patient health information: Male , 24 years of age, was diagnosed with
  • hypoaesthesia
and. Mecobalamin dosage: Unk, Unk.
Associated medications used:
  • Goshajinkigan (Unk, Unk)
  • Insulin
  • Troglitazone (Unk, Unk)
  • Tegretol
Patient was hospitalized.

Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Glucose Decreased, Blood Lactate Dehydrogenase Increased, Hepatic Function Abnormal, Hypoglycaemia, Pyrexia (5213962-X)
Adverse event was reported on Jan 09, 2007 by a Male taking Mecobalamin (Dosage: N/A) was diagnosed with
  • hypoaesthesia
and. Location: JAPAN , 24 years of age, Patient felt the following Mecobalamin side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood glucose decreased, blood lactate dehydrogenase increased, hepatic function abnormal, hypoglycaemia, pyrexia.
Multiple prescriptions taken:
  • Goshajinkigan
  • Insulin
  • Troglitazone
  • Carbamazepine
Patient was hospitalized.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Mecobalamin Information

More About Mecobalamin

Side Effects reported to FDA: 23. View Mecobalamin Adverse Reports

Mecobalamin safety alerts: No

Reported deaths: 5

Reported hospitalizations: 14

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