Memantine Side Effects
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Memantine Safety Reports reported to FDA
Total Memantine reports: 154.Memantine FDA safety alerts: No.
Reported deaths: 24 Reported hospitalizations: 103.
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Reported Memantine Side Effects: fall, condition aggravated, blood creatine phosphokinase increased, aspartate aminotransferase increased, cholelithiasis, agitation, depressed level of consciousness, dehydration, alanine aminotransferase increased, cerebral atrophy, anorexia.
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Memantine Side Effects Report #5466864-8Health Professional from FRANCE reported MEMANTINE problem on Aug 13, 2007. Male patient, 85 years of age, was treated with MEMANTINE. After drug was administered, patient experienced the following problems/side effects: blood urea increased, cerebral atrophy, dehydration, rhabdomyolysis. MEMANTINE dosage: 10 MG BID PO. During the same period patient was treated with GALANTAMINE HYDROBROMIDE, RISPERDAL. Patient was hospitalized. Patient recovered.
Memantine Side Effects Report #5468659-8
MEMANTINE problem was reported by a Physician from ARGENTINA on Sept 13, 2007. Female patient, 80 years of age, weighting 160.9 lb, was diagnosed with dementia alzheimer's type and was treated with MEMANTINE. After drug was administered, patient experienced the following problems/side effects: asthenia, dehydration, dermatitis bullous, diabetes mellitus inadequate control, diabetic foot, localised infection, malaise, microcytosis, red blood cell count decreased. MEMANTINE dosage: 28 MG QD PO. During the same period patient was treated with INSULIN, OLANZAPINE, PAROXETINE, DONEPEZIL, ALPRAZOLAM, OXYBUTYNIN CHLORIDE. Patient was hospitalized. Patient recovered.
Memantine Side Effects Report #5468661-6
Health Professional from FRANCE reported MEMANTINE problem on Sept 06, 2007. Male patient, 79 years of age, was treated with MEMANTINE. After drug was administered, patient experienced the following problems/side effects: blood glucose increased, blood sodium increased, dehydration, lung infection, renal failure acute, somnolence. MEMANTINE dosage: 10 MG QD PO. During the same period patient was treated with VALSARTAN AND HYDROCHLOROTHIAZIDE, ARICEPT, DEROXAT, RISPERDAL. Patient was hospitalized. Patient recovered.
Memantine Side Effects Report #5468662-8
MEMANTINE problem was reported by a Health Professional from ITALY on Sept 10, 2007. Female patient, 92 years of age, was diagnosed with dementia and was treated with MEMANTINE. After drug was administered, patient experienced the following problems/side effects: hepatitis cholestatic. MEMANTINE dosage: 10 MG QD PO. During the same period patient was treated with DIGOXIN, LISINOPRIL, TIAPRIDE, ALPRAZOLAM, PROMAZINE HYDROCHLORIDE. Patient recovered.
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Drug Information: Memantine
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a604006.html
mem'-an-teenWhy is this medication prescribed?
Memantine is used to treat the symptoms of Alzheimer's disease. Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal excitement in the brain. Memantine can help people with Alzheimer's disease to think more clearly and perform daily activities more easily, but it is not a cure and does not stop the progression of the disease.
How should this medicine be used?
Memantine comes as a tablet to take by mouth. It is usually taken once or twice a day with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. To help you remember to take memantine, take it at around the same time(s) every day. Take memantine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of memantine and gradually increase your dose, not more than once every week.
Memantine controls Alzheimer's disease but does not cure it. Continue to take memantine even if you feel well. Do not stop taking memantine without talking to your doctor.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking memantine,
- tell your doctor and pharmacist if you are allergic to memantine or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: acetazolamide (Diamox); amantadine (Symmetrel); brinzolamide (Azopt); cimetidine (Tagamet); dextromethorphan (Robitussin, others); dichlorphenamide (Daranide); dorzolamide (Trusopt); methazolamide (GlaucTabs, Nepatazane); nicotine (Nicoderm, Nicorette, others); potassium citrate and citric acid (Cytra-K, Polycitra-K); ranitidine (Zantac); sodium bicarbonate (Soda Mint, baking soda); sodium citrate and citric acid (Bicitra, Oracit); and quinidine (Quinaglute, Quinidex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had asthma, seizures, kidney disease, or repeated urinary tract infections.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking memantine, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking memantine.
- you should know that memantine may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.
What special dietary instructions should I follow?
Tell your doctor if you are a vegetarian or if you usually eat large amounts of citrus fruits, vegetables, beans, or peas. Your doctor will tell you if you need to change your diet. If you do not regularly eat these foods, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Memantine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- extreme tiredness
- dizziness
- confusion
- headache
- sleepiness
- constipation
- vomiting
- pain anywhere in your body, especially your back
- coughing
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
- shortness of breath
- hallucination (seeing things or hearing voices that do not exist)
Memantine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- restlessness
- hallucination (seeing things or hearing voices that do not exist)
- sleepiness
- loss of consciousness
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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