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Metamizol Side Effects

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Common Metamizol Side Effects


The most commonly reported Metamizol side effects (click to view or check a box to report):

Diarrhoea (7)
Pleural Effusion (7)
Left Ventricular Failure (6)
Anaemia (6)
Aplasia Pure Red Cell (5)
Hyponatraemia (5)
Agranulocytosis (5)
Nausea (5)
Right Ventricular Failure (5)
Pain (5)
Fatigue (4)
Anal Fissure (4)
Hepatic Enzyme Increased (4)
Dyspnoea (4)
Hypopnoea (4)
Muscle Twitching (4)
Vomiting (4)
Pyrexia (4)
Varicose Vein (3)
Weight Decreased (3)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Metamizol Side Effects Reported to FDA



Metamizol Side Effect Report#8819058
Pancytopenia
This is a report of a 87-year-old female patient (weight: NA) from DE, suffering from the following health symptoms/conditions: back pain,confusional state,gastrointestinal angiodysplasia,hypertension, who was treated with Metamizol (dosage: 20 Gtt, Tid, start time:
May 07, 2012), combined with:
  • Risperidon (0.5 Mg, Unk)
  • Pantoprazol (20 Mg, Unk)
  • Amlodipin (5 Mg, 0-0-1)
  • Lorazepam (0.5 Mg, Unk)
and developed a serious reaction and side effect(s): Pancytopenia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizol treatment in female patients, resulting in Pancytopenia side effect. The patient was hospitalized.
Metamizol Side Effect Report#8476412-6
Human Herpes Virus 6 Serology Positive, Rash Erythematous, Lymphadenopathy, Rash Maculo-papular, Lymphocyte Transformation Test Positive, Dermatitis, Hepatic Enzyme Increased, Pruritus
This report suggests a potential Metamizole Human Herpes Virus 6 Serology Positive side effect(s) that can have serious consequences. A 43-year-old female patient (weight: NA) from Spain was diagnosed with the following symptoms/conditions: colitis ulcerative and used Metamizole (dosage: 2 G, Q6h) starting NS. After starting Metamizole the patient began experiencing various side effects, including: Human Herpes Virus 6 Serology Positive, Rash Erythematous, Lymphadenopathy, Rash Maculo-papular, Lymphocyte Transformation Test Positive, Dermatitis, Hepatic Enzyme Increased, PruritusAdditional drugs used concurrently:
  • Piperacillin/tazobactam (4/0.5 G Every 12 Hour)
  • Acetaminophen (1 G, Q6h)
Although Metamizole demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Human Herpes Virus 6 Serology Positive, may still occur.
Metamizol Side Effect Report#8474327-0
Eye Swelling, Oedema Peripheral, Antinuclear Antibody Increased, Arthralgia, Erythema, Myalgia, Abscess, Cutaneous Tuberculosis
This Eye Swelling problem was reported by a physician from Germany. A 46-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 01, 2011 this consumer started treatment with Metamizole (dosage: Three Times A Day). The following drugs were being taken at the same time:
  • Remicade
  • Remicade
  • Remicade
  • Prednisolone
  • Allopurinol
  • Ibuprofen (Twice Daily)
  • Cefuroxime Axetil
  • Pantoprazole
When using Metamizole, the patient experienced the following unwanted symptoms/side effects: Eye Swelling, Oedema Peripheral, Antinuclear Antibody Increased, Arthralgia, Erythema, Myalgia, Abscess, Cutaneous TuberculosisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eye Swelling, may become evident only after a product is in use by the general population.
Metamizol Side Effect Report#8473300-6
Tumour Pain
This Death side effect was reported by a health professional from Spain. A 62-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metamizol (drug dosage: NA), which was initiated on
Nov 25, 2011. Concurrently used drugs:
  • Micardis
  • Dexamethasone
  • Oxycodone Hcl
  • Ipilimumab
  • Zoladex
  • Metoclopramide Hydrochloride
  • Enoxaparin
  • Furosemide
.After starting to take Metamizol the consumer reported adverse symptoms, such as: Tumour PainThese side effects may potentially be related to Metamizol. The patient was hospitalized.
Metamizol Side Effect Report#8353485-2
Diarrhoea, Vomiting, Weight Decreased, Dyspepsia, Nausea
This is a report of a 54-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Metamizol (dosage: NA, start time:
Mar 30, 2011), combined with:
  • Oxycodone Hcl
  • Bupropion Hcl
  • Zofran
  • Xeloda
  • Protonix
  • Xgeva
  • Tykerb (1250mg Per Day)
  • Citalopram Hydrobromide
and developed a serious reaction and side effect(s): Diarrhoea, Vomiting, Weight Decreased, Dyspepsia, Nausea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizol treatment in female patients, resulting in Diarrhoea side effect.
Metamizol Side Effect Report#8352702-2
Faecaloma, Hyperglycaemia, Perineal Pain
This report suggests a potential Metamizole (metamizole) Faecaloma side effect(s) that can have serious consequences. A 83-year-old male patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Metamizole (metamizole) (dosage: NA) starting
Feb 06, 2008. After starting Metamizole (metamizole) the patient began experiencing various side effects, including: Faecaloma, Hyperglycaemia, Perineal PainAdditional drugs used concurrently:
  • Ibuprofen
  • Tamsulosin Hcl
  • Cp-751, 871 (1280 Milligram) ((1280 Mg, 1 In 3 Wk), Intravenous)
  • Prednisone ((123.9 Mg, 1 In 3 Wk), Intravenous)
  • Actiq
  • Decapepyl
  • Magnesium Hydroxide Tab
  • Docetaxel (1in 3 Weeks , Intravenous)
The patient was hospitalized. Although Metamizole (metamizole) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Faecaloma, may still occur.
Metamizol Side Effect Report#8301462-X
Intervertebral Disc Protrusion, Nerve Root Lesion, Osteoarthritis
This Intervertebral Disc Protrusion problem was reported by a physician from Germany. A 70-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 03, 2012 this consumer started treatment with Metamizol (dosage: NA). The following drugs were being taken at the same time:
  • Actemra (Last Dose Prior To Sae:15/mar/2012)
When using Metamizol, the patient experienced the following unwanted symptoms/side effects: Intervertebral Disc Protrusion, Nerve Root Lesion, OsteoarthritisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Intervertebral Disc Protrusion, may become evident only after a product is in use by the general population.
Metamizol Side Effect Report#8241351-2
Maternal Exposure During Pregnancy, Oligohydramnios, Syncope, Premature Delivery
This Maternal Exposure During Pregnancy side effect was reported by a health professional from Spain. A 23-year-old female patient (weight:NA) experienced the following symptoms/conditions: pyelonephritis acute.The patient was prescribed Metamizole (drug dosage: 2 G, Q8h), which was initiated on NS. Concurrently used drugs:
  • Amoxicillin And Clavulanate Potassium
.After starting to take Metamizole the consumer reported adverse symptoms, such as: Maternal Exposure During Pregnancy, Oligohydramnios, Syncope, Premature DeliveryThese side effects may potentially be related to Metamizole.
Metamizol Side Effect Report#8215272-5
Toxic Epidermal Necrolysis
This is a report of a 59-year-old female patient (weight: NA) from Germany, suffering from the following health symptoms/conditions: NA, who was treated with Metamizole (dosage: NA, start time: NS), combined with:
  • Piperacillin And Tazobactam
and developed a serious reaction and side effect(s): Toxic Epidermal Necrolysis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizole treatment in female patients, resulting in Toxic Epidermal Necrolysis side effect.
Metamizol Side Effect Report#8213037-1
Disease Progression, Eastern Cooperative Oncology Group Performance Status Worsened
This report suggests a potential Metamizol Disease Progression side effect(s) that can have serious consequences. A male patient (weight: NA) from Germany was diagnosed with the following symptoms/conditions: bone pain and used Metamizol (dosage: Dose = 130.0 Units Not Specified) starting
May 27, 2009. After starting Metamizol the patient began experiencing various side effects, including: Disease Progression, Eastern Cooperative Oncology Group Performance Status WorsenedAdditional drugs used concurrently:
  • Leuprolide Acetate (Dose = 130.0 Units Not Specified)
  • Utk Uno (Dose = 130.0 Units Not Specified)
  • Calcium-sandoz D Osteo (Dose = 130.0 Units Not Specified)
  • Abiraterone Acetate
  • Prednisolone
  • Ciprofloxacin (Dose = 130.0 Units Not Specified)
  • Fentanyl (Start Date = 08-nov-2010)
The patient was hospitalized and became disabled. Although Metamizol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Disease Progression, may still occur.
Metamizol Side Effect Report#8204479-9
Gastroenteritis
This Gastroenteritis problem was reported by a physician from Germany. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: post herpetic neuralgia. On
Oct 07, 2011 this consumer started treatment with Metamizole (dosage: NA). The following drugs were being taken at the same time:
  • Nsaid's
  • Metoprolol Succinate
  • Tapentadol Hydrochloride (Twice A Day)
When using Metamizole, the patient experienced the following unwanted symptoms/side effects: GastroenteritisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gastroenteritis, may become evident only after a product is in use by the general population.
Metamizol Side Effect Report#8160050-9
Pain, Pyrexia
This Pain side effect was reported by a physician from Poland. A female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metamizol (drug dosage: 500mg Three Times Per Day), which was initiated on
Aug 30, 2011. Concurrently used drugs: NA..After starting to take Metamizol the consumer reported adverse symptoms, such as: Pain, PyrexiaThese side effects may potentially be related to Metamizol. The patient was hospitalized.
Metamizol Side Effect Report#8155119-9
Hydrocephalus, Anaemia
This is a report of a 54-year-old male patient (weight: NA) from Germany, suffering from the following health symptoms/conditions: NA, who was treated with Metamizol (dosage: NA, start time:
Oct 25, 2011), combined with:
  • Dexamethasone Sodium Phosphate
  • Restex (100/25 Mg)
  • Fentanyl (12 Mg/hour)
  • Pantoprazole
  • Vemurafenib (Last Dos Eprior To Sae 21 Nov 2011)
  • Ibuprofen
  • Moviprep
  • Zoledronic Acid
and developed a serious reaction and side effect(s): Hydrocephalus, Anaemia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizol treatment in male patients, resulting in Hydrocephalus side effect. The patient was hospitalized.
Metamizol Side Effect Report#8154133-7
Deep Vein Thrombosis
This report suggests a potential Metamizol Natrii Deep Vein Thrombosis side effect(s) that can have serious consequences. A 66-year-old female patient (weight: NA) from Russian Federation was diagnosed with the following symptoms/conditions: pain and used Metamizol Natrii (dosage: 2 Ml) starting
Jul 21, 2011. After starting Metamizol Natrii the patient began experiencing various side effects, including: Deep Vein ThrombosisAdditional drugs used concurrently:
  • Ketoprofen (300 Mg)
  • Indapamidum
  • Pradaxa (220 Mg)
  • Tramadol Hydrochloride And Acetaminophen (225 Mg/1950 Mg)
  • Omeprazole (20 Mg)
  • Cefazolin (2000 Mg)
  • Diphenhydraminum (1 Mg)
  • Midazolam (5 Mg)
The patient was hospitalized. Although Metamizol Natrii demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Deep Vein Thrombosis, may still occur.
Metamizol Side Effect Report#8151181-8
Pyrexia, Pain
This Pyrexia problem was reported by a physician from Poland. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Aug 30, 2011 this consumer started treatment with Metamizol (dosage: 500mg Three Times Per Day). The following drugs were being taken at the same time:
  • Vinorelbine Tartrate (20mgm2 Cyclic)
When using Metamizol, the patient experienced the following unwanted symptoms/side effects: Pyrexia, PainThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pyrexia, may become evident only after a product is in use by the general population.
Metamizol Side Effect Report#8151015-1
Neoplasm Malignant, Dehydration, Hyponatraemia, Diarrhoea
This Neoplasm Malignant side effect was reported by a consumer or non-health professional from Romania. A 32-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metamizole (drug dosage: 1df=1 Vial), which was initiated on
Jan 09, 2012. Concurrently used drugs:
  • Zometa
  • Yervoy
  • Morphine Sulfate
.After starting to take Metamizole the consumer reported adverse symptoms, such as: Neoplasm Malignant, Dehydration, Hyponatraemia, DiarrhoeaThese side effects may potentially be related to Metamizole. The patient was hospitalized.
Metamizol Side Effect Report#8123455-8
Oedema Peripheral, Pulmonary Oedema, Cough, Cardiac Failure Congestive, Hypertension, Dilatation Ventricular, Dyspnoea
This is a report of a female patient (weight: NA) from Germany, suffering from the following health symptoms/conditions: pain,renal cell carcinoma, who was treated with Metamizole (dosage: NA, start time:
Jun 10, 2011), combined with:
  • Afinitor (10 Mg, Per Day)
  • Steroids Nos (1333 Mg, Prednisolone Equivalent)
  • Proton Pump Inhibitors
  • Omeprazole (40 Mg, Daily)
and developed a serious reaction and side effect(s): Oedema Peripheral, Pulmonary Oedema, Cough, Cardiac Failure Congestive, Hypertension, Dilatation Ventricular, Dyspnoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizole treatment in female patients, resulting in Oedema Peripheral side effect. The patient was hospitalized.
Metamizol Side Effect Report#8113639-7
Cholecystectomy
This report suggests a potential Metamizole Cholecystectomy side effect(s) that can have serious consequences. A female patient (weight: NA) from Spain was diagnosed with the following symptoms/conditions: back pain,osteoporosis prophylaxis,rheumatoid arthritis,hypertension and used Metamizole (dosage: NA) starting
Feb 18, 2009. After starting Metamizole the patient began experiencing various side effects, including: CholecystectomyAdditional drugs used concurrently:
  • Calcium With Vitamin D
  • Celecoxib
  • Nebivolol Hcl
  • Alendronate Sodium
  • Prednisone Tab
  • Folic Acid
  • Omeprazole
  • Omeprazole
The patient was hospitalized. Although Metamizole demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Cholecystectomy, may still occur.
Metamizol Side Effect Report#8105101-2
Acute Coronary Syndrome
This Acute Coronary Syndrome problem was reported by a physician from Spain. A 78-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: musculoskeletal chest pain,prostate cancer. On
Feb 10, 2010 this consumer started treatment with Metamizole (dosage: 375 Mg, As Needed). The following drugs were being taken at the same time:
  • Cyclophosphamide (50 Mg, 1x/day)
  • Prednisone Tab (Tdd 10 Mg)
  • Sunitinib Malate (25 Mg, 1x/day)
  • Enalapril (5 Mg, 1x/day)
  • Metoclopramide (Unk)
  • Metoclopramide
  • Amiloride Hcl And Hydrochlorothiazide (5 Mg/ 50 Mg 1x/day)
  • Omeprazole (10 Mg, 1x/day)
When using Metamizole, the patient experienced the following unwanted symptoms/side effects: Acute Coronary SyndromeThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Acute Coronary Syndrome, may become evident only after a product is in use by the general population.
Metamizol Side Effect Report#8104605-6
Agranulocytosis
This Agranulocytosis side effect was reported by a physician from Denmark. A 26-year-old male patient (weight:NA) experienced the following symptoms/conditions: phantom pain.The patient was prescribed Metamizole (metamizole) (drug dosage: 500 Mg; ; Po), which was initiated on
Apr 01, 2011. Concurrently used drugs:
  • Tramadol Hydrochloride (100 Mg; ; Po)
  • Ibuprofen (600 Mg; ; Po)
  • Pregabalin (300 Mg; ; Po)
  • Amoxicillin
.After starting to take Metamizole (metamizole) the consumer reported adverse symptoms, such as: AgranulocytosisThese side effects may potentially be related to Metamizole (metamizole). The patient was hospitalized.
Metamizol Side Effect Report#8095408-X
Pain In Extremity, Nausea, Dyspnoea, Angina Pectoris, Hyponatraemia, Restlessness, Productive Cough, Agitation
This is a report of a 69-year-old female patient (weight: NA) from Germany, suffering from the following health symptoms/conditions: pain,korsakoff's syndrome,hypertension, who was treated with Metamizol (dosage: 1000 Mg, Unk, start time:
Mar 15, 2009), combined with:
  • Dipiperon (120 Mg, 1x/day)
  • Altace (7.5 Mg, 1x/day)
  • Haloperidol (10 Mg, 1x/day)
and developed a serious reaction and side effect(s): Pain In Extremity, Nausea, Dyspnoea, Angina Pectoris, Hyponatraemia, Restlessness, Productive Cough, Agitation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizol treatment in female patients, resulting in Pain In Extremity side effect. The patient was hospitalized.
Metamizol Side Effect Report#8065158-4
Electrolyte Depletion, Hyponatraemia, Hypokalaemia, Syncope, Prothrombin Time Prolonged
This report suggests a potential Metamizol Natrium Electrolyte Depletion side effect(s) that can have serious consequences. A 79-year-old male patient (weight: NA) from Germany was diagnosed with the following symptoms/conditions: pain,hypertension,duodenal ulcer,dementia,coronary artery disease and used Metamizol Natrium (dosage: 500 Mg, Unk) starting
Jan 01, 2000. After starting Metamizol Natrium the patient began experiencing various side effects, including: Electrolyte Depletion, Hyponatraemia, Hypokalaemia, Syncope, Prothrombin Time ProlongedAdditional drugs used concurrently:
  • Ramipril (1.25 Mg, Qd)
  • Pantoprazole (40 Mg, Qd)
  • Risperidone (0.5 Mg, Qd)
  • Simvastatin (40 Mg, Qd)
  • Torsemide (10 Mg, Qd)
  • Aldactone (25 Mg, Qd)
  • Falithrom ^hexal^ (Unk)
  • Metoclopramide (20 Gtt, Tid)
The patient was hospitalized. Although Metamizol Natrium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Electrolyte Depletion, may still occur.
Metamizol Side Effect Report#8058193-3
Sinus Bradycardia, Blood Pressure Decreased
This Sinus Bradycardia problem was reported by a health professional from Switzerland. A 48-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Dec 01, 2010 this consumer started treatment with Metamizole (metamizole) (dosage: NA). The following drugs were being taken at the same time:
  • Citalopram Hydrobromide (20 Mg Per Day,oral)
  • Tizanidine Hydrochloride (12 Mg (2 X 6 Mg Per Day) Oral; 06 Mg Daily; Oral)
  • Tranxilium (clorazepate Dispotassium)
  • Acetaminophen
  • Lyrica (300 Mg (2 X 150 Mg Per Day), Oral)
  • Bulboid (glycerol)
  • Importal (lactitol)
  • Oxycodone Hcl (10 Mg (2 X 5 Mg Per Day) Oral)
When using Metamizole (metamizole), the patient experienced the following unwanted symptoms/side effects: Sinus Bradycardia, Blood Pressure DecreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Sinus Bradycardia, may become evident only after a product is in use by the general population.
Metamizol Side Effect Report#8043073-X
Constipation, Colonic Stenosis
This Constipation side effect was reported by a physician from Germany. A female patient (weight:NA) experienced the following symptoms/conditions: crohn's disease.The patient was prescribed Metamizol (drug dosage: 4x/die), which was initiated on
Nov 18, 2010. Concurrently used drugs:
  • Pantoprazole Sodium (Bid)
  • Humira (80 Mg In Week 0; 40 Mg In Week 2; 40 Mg Eow)
  • Fraxiparin (Od)
.After starting to take Metamizol the consumer reported adverse symptoms, such as: Constipation, Colonic StenosisThese side effects may potentially be related to Metamizol. The patient was hospitalized.
Metamizol Side Effect Report#8036692-8
Agranulocytosis
This is a report of a 26-year-old male patient (weight: NA) from Germany, suffering from the following health symptoms/conditions: phantom pain, who was treated with Metamizol (dosage: NA, start time:
Apr 01, 2011), combined with:
  • Ibuprofen
  • Ibuprofen
  • Amoxicillin
  • Tramadol Hcl
  • Pregabalin
and developed a serious reaction and side effect(s): Agranulocytosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizol treatment in male patients, resulting in Agranulocytosis side effect. The patient was hospitalized.


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The appearance of Metamizol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Metamizol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Side Effects reported to FDA: 84

    Metamizol safety alerts: No

    Reported deaths: 7

    Reported hospitalizations: 27

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