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Metformine Side Effects

Common Metformine Side Effects


The most commonly reported Metformine side effects (click to view or check a box to report):

Lactic Acidosis (8)
Renal Failure (5)
Renal Failure Acute (4)
Overdose (3)
Nausea (3)
Malaise (3)
Conjunctival Haemorrhage (2)
Hypoglycaemia (2)
Completed Suicide (2)
Gout (2)
Jaundice (2)
Ecchymosis (2)
Diarrhoea (2)
Tachycardia Paroxysmal (2)
Skin Reaction (2)
Petechiae (2)
Suicide Attempt (2)
Toxicity To Various Agents (2)
Vomiting (2)
Metabolic Acidosis (2)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Metformine Side Effects Reported to FDA

The following Metformine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Metformine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Lactic Acidosis, Renal Failure
This is a report of a 78-year-old male patient (weight: NA) from NL, suffering from the following symptoms/conditions: diabetes mellitus, who was treated with Metformine Tablet 850mg (dosage: Extra Info: Has Recently Been Increased From 2 Times Daily 1000 Mg To 3 Times Daily 850 Mg.., start time: Feb 10, 2014), combined with:
  • Lisinopril Tablet 10mg (10 Milligram Daily;)
  • Spironolacton Tablet 25mg (25 Milligram Daily;)
  • Furabid Capsule Mga 100mg (200 Milligram Daily; Prolonged-release Capsule)
  • Glimepiride Tablet 2mg (2 Milligram Daily;)
  • Xatral Xr Tablet Mva 10mg (10 Milligram Daily;)
  • Escitalopram Tablet 10mg (10 Milligram Daily;)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Lactic Acidosis
  • Renal Failure
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformine Tablet 850mg treatment in male patients, resulting in lactic acidosis side effect. The patient was hospitalized.

Incorrect Dose Administered, Hypoglycaemic Coma, Pyrexia
This report suggests a potential Metformine Incorrect Dose Administered, Hypoglycaemic Coma, Pyrexia side effect(s) that can have serious consequences. A 63-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: hyperglycaemia and used Metformine (dosage: NA) starting Nov 16, 2013. Soon after starting Metformine the patient began experiencing various side effects, including:
  • Incorrect Dose Administered
  • Hypoglycaemic Coma
  • Pyrexia
Drugs used concurrently:
  • Amarel
  • Onglyza
The patient was hospitalized. Although Metformine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as incorrect dose administered, may still occur.

Toxicity To Various Agents
This Toxicity To Various Agents problem was reported by a consumer or non-health professional from US. A 53-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Metformine (metformin) (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Metformine (metformin), the patient experienced the following unwanted symptoms/side effects:
  • Toxicity To Various Agents
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as toxicity to various agents, may become evident only after a product is in use by the general population.

Metabolic Acidosis, Renal Failure, Body Temperature Increased, Heart Rate Increased, Haemodialysis, Biopsy Kidney Abnormal, Renal Tubular Disorder, Nephritis
This is a report of a 54-year-old female patient (weight: NA) from FR. The patient developed the following symptoms/conditions: type 2 diabetes mellitus and was treated with Metformine (metformin) (dosage: NA) starting NS. Concurrently used drugs:
  • Fenofibrate
  • Flunarizine
  • Pantoprazole
  • Hydrocortisone
  • Alendronic Acid
  • Methotrexate
  • Paroxetine
  • Clorazepate
Soon after that, the consumer experienced the following side effects:
  • Metabolic Acidosis
  • Renal Failure
  • Body Temperature Increased
  • Heart Rate Increased
  • Haemodialysis
  • Biopsy Kidney Abnormal
  • Renal Tubular Disorder
  • Nephritis
The patient was hospitalized. This opens a possibility that Metformine (metformin) treatment could cause the above reactions, including metabolic acidosis, and some female subjects may be more susceptible.


Alopecia
A 52-year-old male patient (weight: NA) from FR with the following symptoms/conditions: NA started Metformine Teva treatment (dosage: NA) on 200901. Soon after starting Metformine Teva treatment, the subject experienced various side effects, including:
  • Alopecia
Concurrently used drugs:
  • Pravadual (1 Dosage Forms Daily;)
  • Pravadual
  • Ramipril Biogaran 10mg (1 Dosage Forms Daily;)
  • Procoralan (1 Dosage Forms Daily;)
  • Ezetrol 10mg (1 Dosage Forms Daily;)
  • Verapamil Biogaran L.p 240mg (1 Dosage Forms Daily;)
  • Novonorm (1 Dosage Forms Daily;)
  • Novorapid
This finding indicates that some male patients could be more vulnerable to Metformine Teva.

Completed Suicide, Overdose
A 48-year-old male patient from US (weight: NA) experienced symptoms, such as: NA and was treated with Metformine (metformin)(dosage: NA). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Completed Suicide
  • Overdose
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Metformine (metformin) efficacy:
  • Amlodipine W/valsartan
  • Metoprolol (metoprolol)


Bladder Neoplasm, Renal Failure Acute, Sepsis, Lactic Acidosis
In this report, Metformine Tablet 500mg was administered for the following condition: diabetes mellitus.A 76-year-old male consumer from NL (weight: NA) started Metformine Tablet 500mg treatment (dosage: 1500 Milligram Daily; 3 Times A Day 1 Piece) on 2012.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Bladder Neoplasm
  • Renal Failure Acute
  • Sepsis
  • Lactic Acidosis
A possible interaction with other drugs could have contributed to this reaction:
  • Pravastatine Tablet 40mg (40 Milligram Daily; 1 Time A Day 1 Piece)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Metformine Tablet 500mg treatment could be related to the listed above side effect(s).

Lactic Acidosis, Renal Failure, Hepatic Failure, Vomiting
This is a report of the following Metformine Tablet 1000mg side effect(s):
  • Lactic Acidosis
  • Renal Failure
  • Hepatic Failure
  • Vomiting
A 66-year-old female patient from NL (weight: NA) presented with the following condition: type 2 diabetes mellitus and received a treatment with Metformine Tablet 1000mg (dosage: 3000 Milligram Daily;) starting: 2006.The following concurrently used drugs could have generated interactions:
  • Glimepiride Tablet 1mg (2 Milligram Daily;)
  • Enalapril Tablet 20mg (40 Milligram Daily;)
The patient was hospitalized.This report suggests that a Metformine Tablet 1000mg treatment could be associated with the listed above side effect(s).

Premature Rupture Of Membranes, Abortion Spontaneous, Exposure During Pregnancy, Myalgia, Gestational Diabetes, Shortened Cervix, Amniotic Cavity Infection, Radiculitis
This Metformine report was submitted by a 32-year-old female consumer from FR (weight: NA). The patient was diagnosed with: NA and Metformine was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Premature Rupture Of Membranes
  • Abortion Spontaneous
  • Exposure During Pregnancy
  • Myalgia
  • Gestational Diabetes
  • Shortened Cervix
  • Amniotic Cavity Infection
  • Radiculitis
Other drugs used simultaneously:
  • Insulin
Those unexpected symptoms could be linked to a Metformine treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Suicide Attempt, Overdose, Toxicity To Various Agents, Lactic Acidosis, Shock
This is a report of a possible correlation between Metformine use and the following symptoms/side effect(s):
  • Suicide Attempt
  • Overdose
  • Toxicity To Various Agents
  • Lactic Acidosis
  • Shock
which could contribute to an assessment of Metformine risk profile.A 42-year-old male consumer from FR (weight: NA) was suffering from NA and was treated with Metformine (dosage: Unk) starting NS.Other concurrent medications:
  • Insulin (Unk)
  • Clarithromycin (Unk)
  • Domperidone (Unk)
  • Ibuprofen (Unk)
  • Buflomedil (Unk)
  • Tiaprofenic Acid (Unk)
The patient was hospitalized.

Lactic Acidosis, Ventricular Tachycardia, Intentional Overdose, Suicide Attempt
A 17-year-old female patient from TR (weight: NA) presented with the following symptoms: NA and after a treatment with Metformine (dosage: 75 Pills Of 1000mg) experienced the following side effect(s):
  • Lactic Acidosis
  • Ventricular Tachycardia
  • Intentional Overdose
  • Suicide Attempt
The treatment was started on NS. Metformine was used in combination with the following drugs:
  • Rupatadine (20 Pills Of 10mg)
  • Amitriptyline (10 Mg/day)
This report could alert potential Metformine consumers.

Lactic Acidosis, Renal Failure, Multi-organ Failure
In this report, a 68-year-old male patient from NL (weight: NA) was affected by a possible Metformine Tablet 1000mg side effect.The patient was diagnosed with type 2 diabetes mellitus. After a treatment with Metformine Tablet 1000mg (dosage: 3 Times A Day One Piece, start date: 2011), the patient experienced the following side effect(s):
  • Lactic Acidosis
  • Renal Failure
  • Multi-organ Failure
The following simultaneously used drugs could have led to this reaction:
  • Acenocoumarol Tablet 1mg (Va)
  • Slow K Tablet Mga 600mg (1dd1)
  • Lanoxin Tablet 0,25mg (1dd1)
  • Furosemide Tablet 40mg (2dd1)
  • Losartan Tablet Fo 100mg (1dd1)
  • Colchicine Tablet 0,5mg (3dd1)
  • Simvastatine Tablet 40mg (1dd1)
  • Spironolacton Tablet 25mg (1dd1)
The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Metformine Tablet 1000mg treatment.

Lactic Acidosis, Renal Failure Acute, Respiratory Distress, Hypoglycaemia, Oliguria, Hypothermia, Vomiting, Tachycardia
This is a report of a 70-year-old female patient from FR (weight: NA), who used Metformine (dosage: 3000 Mg/day) for a treatment of type 2 diabetes mellitus. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Lactic Acidosis
  • Renal Failure Acute
  • Respiratory Distress
  • Hypoglycaemia
  • Oliguria
  • Hypothermia
  • Vomiting
  • Tachycardia
The following drugs could possibly have interacted with the Metformine treatment
  • Indapamide
  • Ketoprofen
  • Metformin (metformin)
  • Acetaminophen (acetaminophen)
  • Morphine
The patient was hospitalized.Taken together, these observations suggest that a Metformine treatment could be related to side effect(s), such as Lactic Acidosis, Renal Failure Acute, Respiratory Distress, Hypoglycaemia, Oliguria, Hypothermia, Vomiting, Tachycardia.

Angioedema
This angioedema side effect was reported by a physician from NL. A 61-year-old female patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus. The patient was prescribed Metformine Tablet 500mg (dosage: 1000 Milligram Daily; Twice Daily One Piece, Extra Info: 2x 500 Mg), which was started on 1990. Concurrently used drugs:
  • Hydrochloorthiazide Tablet 12,5mg (12.5 Milligram Daily; Once Daily One Piece, Extra Info: 12.5 Mg)
  • Metoprolol Tablet 50mg (50 Milligram Daily; Once Daily One Piece)
  • Symbicort Turbuhaler Inhalpdr 100/6mcg/do 120do (2 Dosage Forms Daily; 2 Times A Day 1 Piece (s))
When starting to take Metformine Tablet 500mg the consumer reported the following symptoms:
  • Angioedema
These side effects may potentially be related to Metformine Tablet 500mg.

Metabolic Acidosis, Malaise, Fall, Dehydration
This is a Metformine side effect report of a 80-year-old female patient (weight:NA) from FR, suffering from the following symptoms/conditions: NA, who was treated with Metformine (dosage:850 Milligram Daily;, start time: Dec 22, 2004), combined with:
  • Ramipril (5 Milligram Daily;)
  • Bisoprolol (10 Milligram Daily;)
  • Depamide 300 Mg (900 Milligram Daily;)
, and developed a serious reaction and a metabolic acidosis side effect. The patient presented with:
  • Metabolic Acidosis
  • Malaise
  • Fall
  • Dehydration
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Metformine treatment in female patients suffering from NA, resulting in metabolic acidosis.

Oedema
This report suggests a potential Metformine oedema side effect(s) that can have serious consequences. A female patient from FR (weight:NA) was diagnosed with the following health condition(s): type 2 diabetes mellitus,rheumatoid arthritis and used Metformine (dosage: 2 Dosage Forms Daily;) starting 201001. Soon after starting Metformine the patient began experiencing various side effects, including:
  • Oedema
Drugs used concurrently:
  • Roactemra
  • Victoza (1.2 Milligram Daily;)
  • Farlutal
  • Furosemide (20 Milligram Daily;)
  • Gliclazide (60 Milligram Daily;)
  • Kerlone (20 Milligram Daily;)
  • Amlodipine (10 Milligram Daily;)
  • Allopurinol (100 Milligram Daily;)
Although Metformine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as oedema, may still occur.

Hepatitis, Jaundice, Hepatic Necrosis, Hepatitis E, Hepatic Fibrosis, Hepatic Steatosis
This hepatitis problem was reported by a health professional from FR. A 59-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): type 2 diabetes mellitus,osteoarthritis,hypercholesterolaemia,phlebitis,dermatosis,hypertension,depression.On Sep 09, 2010 a consumer started treatment with Metformine (dosage: 1.5 Gram Daily; Taken For 4 Years). The following drugs/medications were being taken at the same time:
  • Piascledine (300 Milligram Daily; 1 Df=300 Mg)
  • Crestor (5 Milligram Daily; Taken For 4 Years At Least)
  • Previscan (25 Milligram Daily; Taken For At Least 4 Years)
  • Fucidine
  • Zofenopril (30 Milligram Daily; Taken For More Than 1 Year)
  • Moclamine (450 Milligram Daily;)
  • Dafalgan (4 Gram Daily; Taken For More Than 1 Year)
  • Zanidip (10 Milligram Daily; Taken For At Least 4 Years)
When commencing Metformine, the patient experienced the following unwanted symptoms /side effects:
  • Hepatitis
  • Jaundice
  • Hepatic Necrosis
  • Hepatitis E
  • Hepatic Fibrosis
  • Hepatic Steatosis
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as hepatitis, may become evident only after a product is in use by the general population.

Poisoning, Completed Suicide
This is a Metformine side effect report of a 53-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Metformine (dosage: NA) starting NS. Concurrently used drugs:
  • Verapamil
Soon after that, the consumer experienced the following of symptoms:
  • Poisoning
  • Completed Suicide
This opens a possibility that Metformine could cause poisoning and that some female patients may be more susceptible.

Fatigue, Diarrhoea
A 46-year-old male patient (weight: NA) from NL with the following symptoms: diabetes mellitus started Metformine treatment (dosage: NA) on 201112. Soon after starting Metformine treatment, the consumer experienced several side effects, including:
  • Fatigue
  • Diarrhoea
. Concurrently used drugs:
  • Ezetrol Tablet 10mg
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Metformine side effects, such as fatigue.

Gout
This gout side effect was reported by a consumer or non-health professional from NL. A 85-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metformine (dosage: 500 Mg, Bid), which was started on 2010. Concurrently used drugs:
  • Hydrochloorthiazide (25 Mg, Qod)
  • Ofloxacin (200 Mg, Qd)
  • Carbasalate Calcium (100 Mg, Qd)
  • Enalapril (10 Mg, Bid)
  • Omeprazol (20 Mg, Qd)
  • Isosorbide Mononitrate (30 Mg, Qd)
.When starting to take Metformine the consumer reported symptoms, such as:
  • Gout
These side effects may potentially be related to Metformine.

Lactic Acidosis, Renal Failure, Gastroenteritis, Dialysis
This is a report of a 53-year-old female patient (weight: NA) from NL, suffering from the following symptoms/conditions: diabetes mellitus,vomiting, who was treated with Metformine Tablet 1000mg (dosage: NA, start time: Oct 15, 2012), combined with:
  • Domperidon Zetpil 60mg
  • Gliclazide Tablet Mga 80mg
  • Hydrochloorthiazide Tablet 12,5mg
  • Irbesartan Tablet 150mg
  • Simvastatine Tablet 40mg
  • Lansoprazol Capsule Mga 30mg
  • Paracetamol Tablet 500mg
and developed a serious reaction and side effect(s). The consumer presented with:
  • Lactic Acidosis
  • Renal Failure
  • Gastroenteritis
  • Dialysis
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformine Tablet 1000mg treatment in female patients, resulting in lactic acidosis side effect.

Gout
This report suggests a potential Metformine Gout side effect(s) that can have serious consequences. A male patient (weight: NA) from NL was diagnosed with the following symptoms/conditions: NA and used Metformine (dosage: NA) starting 2010. Soon after starting Metformine the patient began experiencing various side effects, including:
  • Gout
Drugs used concurrently:
  • Hydrochlorothiazide
  • Ofloxacine
  • Carbasalate Calcium
  • Enalapril
  • Omeprazol
  • Isosorbide Mononitrate
Although Metformine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as gout, may still occur.

Renal Failure Acute, Overdose, Blood Pressure Decreased, Renal Tubular Necrosis
This Renal Failure Acute, Overdose, Blood Pressure Decreased, Renal Tubular Necrosis problem was reported by a physician from NL. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus,hypertension. On NS this consumer started treatment with Metformine (dosage: 20 Dosage Forms Daily; 20tabletsx500mg). The following drugs were being taken at the same time:
  • Olmetec (olmesartan Medoxomil) (14 Dosage Forms Daily; 14 Tab. X10mg)
  • Simvastatine Tablet 10mg (10 Mg)
When commencing Metformine, the patient experienced the following unwanted symptoms/side effects:
  • Renal Failure Acute
  • Overdose
  • Blood Pressure Decreased
  • Renal Tubular Necrosis
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as renal failure acute, may become evident only after a product is in use by the general population.

Petechiae, Ecchymosis, Skin Reaction, Conjunctival Haemorrhage
This is a report of a female patient (weight: NA) from PORTUGAL. The patient developed the following symptoms/conditions: type 2 diabetes mellitus,hypercholesterolaemia,depression,myasthenia gravis and was treated with Metformine Hydrochlorde (dosage: 1 Anz) starting Feb 17, 2012. Concurrently used drugs:
  • Rosuvastatin (5 Mg)
  • Sertraline Hydrochloride (100 Mg)
  • Pyridostigmine Bromide (240 Mg)
  • Prednisolone (30 Mg)
  • Pradaxa (220 Mg)
  • Pantoprazole Sodium Sesquihydrate (40 Mg)
  • Glyburide (1 Anz)
  • Indapamide (1.5 Mg)
Soon after that, the consumer experienced the following side effects:
  • Petechiae
  • Ecchymosis
  • Skin Reaction
  • Conjunctival Haemorrhage
This opens a possibility that Metformine Hydrochlorde treatment could cause the above reactions, including petechiae, and some female subjects may be more susceptible.

Petechiae, Conjunctival Haemorrhage, Skin Reaction, Ecchymosis
A female patient (weight: NA) from PORTUGAL with the following symptoms/conditions: type 2 diabetes mellitus,hypertension,atrial fibrillation,myasthenia gravis started Metformine Hydrochlorde treatment (dosage: 1 Anz) on Feb 17, 2012. Soon after starting Metformine Hydrochlorde treatment, the subject experienced various side effects, including:
  • Petechiae
  • Conjunctival Haemorrhage
  • Skin Reaction
  • Ecchymosis
Concurrently used drugs:
  • Diltiazem Hydrochloride (60 Mg)
  • Pradaxa (220 Mg)
  • Pyridostigmine Bromide (240 Mg)
  • Lisinopril (20 Mg)
  • Sertraline Hydrochloride (100 Mg)
  • Glyburide (1 Anz)
  • Pantoprazole Sodium Sesquihydrate (40 Mg)
  • Rosuvastatin Calcium (5 Mg)
This finding indicates that some female patients could be more vulnerable to Metformine Hydrochlorde.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    More About Metformine

    Side Effects reported to FDA: 35

    Metformine safety alerts: No

    Reported deaths: 2

    Reported hospitalizations: 13

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