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Methylcobal Side Effects

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Common Methylcobal Side Effects


The most commonly reported Methylcobal side effects (click to view or check a box to report):

Nystagmus (1)
Toxicity To Various Agents (1)
Speech Disorder (1)
Skin Ulcer (1)
Muscle Spasms (1)
Convulsion (1)
Dizziness (1)
Diarrhoea (1)
Cytomegalovirus Mucocutaneous Ulcer (1)
Sick Sinus Syndrome (1)
Renal Impairment (1)
Petechiae (1)
Off Label Use (1)
Oesophageal Candidiasis (1)
Pharyngitis (1)
Platelet Count Decreased (1)
Purpura (1)
Product Contamination Microbial (1)
Pneumonia Bacterial (1)
Areflexia (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Methylcobal Side Effects Reported to FDA



Methylcobal Side Effect Report#9470046
Diarrhoea, Headache, Product Contamination Microbial, Escherichia Infection
This is a report of a 56-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: gene mutation, who was treated with Methylcobalamine/folinic Acid/ Hydroxocalbalamine/p5p (dosage: Iject 0.3 Once Daily Into The Muscle, start time:
Aug 18, 2013), combined with: NA. and developed a serious reaction and side effect(s): Diarrhoea, Headache, Product Contamination Microbial, Escherichia Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Methylcobalamine/folinic Acid/ Hydroxocalbalamine/p5p treatment in female patients, resulting in Diarrhoea side effect.
Methylcobal Side Effect Report#9462053
Dizziness, Muscle Spasms, Fatigue, Dyspnoea, Hypoaesthesia
This report suggests a potential Methylcobalamin Dizziness side effect(s) that can have serious consequences. A 38-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: multiple sclerosis and used Methylcobalamin (dosage: 0.5 Ml- 4 Times/week At Bedtime Into The Muscle) starting
Nov 01, 2011. After starting Methylcobalamin the patient began experiencing various side effects, including: Dizziness, Muscle Spasms, Fatigue, Dyspnoea, HypoaesthesiaAdditional drugs used concurrently: NA. Although Methylcobalamin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dizziness, may still occur.
Methylcobal Side Effect Report#7823258-5
Visual Impairment, Toxicity To Various Agents, Nystagmus, Areflexia, Memory Impairment, Speech Disorder, Convulsion, Incorrect Dose Administered
This Visual Impairment problem was reported by a health professional from Japan. A 20-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Methylcobalamin (no Pref. Name) (dosage: 1.5 Mg). The following drugs were being taken at the same time:
  • Phenytoin (250 Mg)
When using Methylcobalamin (no Pref. Name), the patient experienced the following unwanted symptoms/side effects: Visual Impairment, Toxicity To Various Agents, Nystagmus, Areflexia, Memory Impairment, Speech Disorder, Convulsion, Incorrect Dose AdministeredThe patient was hospitalized and became disabled.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Visual Impairment, may become evident only after a product is in use by the general population.
Methylcobal Side Effect Report#7802884-3
Platelet Count Decreased, Off Label Use, Skin Ulcer, Purpura, Oesophageal Candidiasis, Pneumonia Bacterial, Herpes Dermatitis, Cytomegalovirus Mucocutaneous Ulcer
This Platelet Count Decreased side effect was reported by a physician from Japan. A 75-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Methylcobal (mecobalamin) (drug dosage: NA), which was initiated on
Jan 01, 2009. Concurrently used drugs:
  • Bonalon (alendronate Sodium)
  • Ganciclovir
  • Methylprednisolone (1 G, Iv Drip)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Itraconazole
.After starting to take Methylcobal (mecobalamin) the consumer reported adverse symptoms, such as: Platelet Count Decreased, Off Label Use, Skin Ulcer, Purpura, Oesophageal Candidiasis, Pneumonia Bacterial, Herpes Dermatitis, Cytomegalovirus Mucocutaneous UlcerThese side effects may potentially be related to Methylcobal (mecobalamin). The patient was hospitalized.
Methylcobal Side Effect Report#7610689-1
Pharyngitis, Increased Upper Airway Secretion, Petechiae
This is a report of a 37-year-old female patient (weight: NA) from China, suffering from the following health symptoms/conditions: NA, who was treated with Methylcobalamin/multivitamin (dosage: Unk, start time:
Jul 07, 2011), combined with:
  • Carbamazepine (Unk)
  • Lyrica (75 Mg, 2x/day)
and developed a serious reaction and side effect(s): Pharyngitis, Increased Upper Airway Secretion, Petechiae after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Methylcobalamin/multivitamin treatment in female patients, resulting in Pharyngitis side effect.
Methylcobal Side Effect Report#7363560-7
Renal Impairment, Sick Sinus Syndrome
This report suggests a potential Methylcobal Renal Impairment side effect(s) that can have serious consequences. A female patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: NA and used Methylcobal (dosage: 1500 Mcg) starting
Nov 08, 2010. After starting Methylcobal the patient began experiencing various side effects, including: Renal Impairment, Sick Sinus SyndromeAdditional drugs used concurrently:
  • Ketoprofen (1df)
  • Coniel (8 Mg)
  • Ketobun (100 Mg)
  • Pantosin (3 G)
  • Micombi Combination (Telmisartan 40 Mg/hydrochlorothiazide 12.5 Mg)
  • Escelase (3df)
  • Heavy Magnesium Oxide (1 G)
  • Uritos (0.1 Mg)
The patient was hospitalized. Although Methylcobal demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Impairment, may still occur.



The appearance of Methylcobal on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.


Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Methylcobal reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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