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Methylcobal Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Visual Impairment, Toxicity To Various Agents, Nystagmus, Areflexia, Memory Impairment, Speech Disorder, Convulsion, Incorrect Dose Administered (7823258-5)
on Sep 27, 2011 Male from JAPAN , 20 years of age, weighting 125.7 lb, was treated with Methylcobalamin (no Pref. Name). Directly after, patient experienced the unwanted or unexpected Methylcobal side effects: visual impairment, toxicity to various agents, nystagmus, areflexia, memory impairment, speech disorder, convulsion, incorrect dose administered. Methylcobalamin (no Pref. Name) dosage: 1.5 Mg.
Associated medications used:
  • Phenytoin (250 Mg)
Patient was hospitalized and became disabled.

Platelet Count Decreased, Off Label Use, Skin Ulcer, Purpura, Oesophageal Candidiasis, Pneumonia Bacterial, Herpes Dermatitis, Cytomegalovirus Mucocutaneous Ulcer (7802884-3)
Patient was taking Methylcobal (mecobalamin). Patient felt the following Methylcobal side effects: platelet count decreased, off label use, skin ulcer, purpura, oesophageal candidiasis, pneumonia bacterial, herpes dermatitis, cytomegalovirus mucocutaneous ulcer on Sep 26, 2011 from JAPAN Additional patient health information: Male , 75 years of age, weighting 165.3 lb, . Methylcobal (mecobalamin) dosage: N/A.
Multiple prescriptions taken:
  • Bonalon (alendronate Sodium)
  • Ganciclovir
  • Methylprednisolone (1 G, Iv Drip)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Prednisolone (15 Mg, Oral, 60 Mg, Oral, Oral, 6 Mg, Oral, 40 Mg, Oral, 11 Mg, Oral, 30 Mg, Oral, Oral)
  • Itraconazole
Patient was hospitalized.

Pharyngitis, Increased Upper Airway Secretion, Petechiae (7610689-1)
Adverse event was reported on Jul 14, 2011 by a Female taking Methylcobalamin/multivitamin (Dosage: Unk) . Location: CHINA , 37 years of age, After Methylcobal was administered, patient encountered several Methylcobal side effects: pharyngitis, increased upper airway secretion, petechiae.
Multiple concurrent drugs taken:
  • Carbamazepine (Unk)
  • Lyrica (75 Mg, 2x/day)


Renal Impairment, Sick Sinus Syndrome (7363560-7)
on Mar 15, 2011 Female from JAPAN , weighting 108.0 lb, was treated with Methylcobal. Directly after, patient experienced the unwanted or unexpected Methylcobal side effects: renal impairment, sick sinus syndrome. Methylcobal dosage: 1500 Mcg.
Associated medications used:
  • Ketoprofen (1df)
  • Coniel (8 Mg)
  • Ketobun (100 Mg)
  • Pantosin (3 G)
  • Micombi Combination (Telmisartan 40 Mg/hydrochlorothiazide 12.5 Mg)
  • Escelase (3df)
  • Heavy Magnesium Oxide (1 G)
  • Uritos (0.1 Mg)
Patient was hospitalized.

Methylcobal Health Episodes

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Methylcobal Information

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