Common Metoprolol Side Effects


The most commonly reported Metoprolol side effects (click to view or check a box to report):

Bradycardia (405)
Dizziness (388)
Hypotension (290)
Blood Pressure Increased (282)
Dyspnoea (270)
Fatigue (244)
Completed Suicide (243)
Syncope (217)
Nausea (190)
Headache (187)
Chest Pain (164)
Palpitations (153)
Asthenia (152)
Diarrhoea (148)
Atrial Fibrillation (145)
Hypertension (144)
Pain (136)
Myocardial Infarction (129)
Heart Rate Increased (128)
Anxiety (125)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Metoprolol Side Effects Reported to FDA



Metoprolol Side Effect Report#9999524
Bradycardia
This is a report of a 68-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Metoprolol (dosage: NA, start time:
Aug 27, 2013), combined with: NA. and developed a serious reaction and side effect(s): Bradycardia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol treatment in male patients, resulting in Bradycardia side effect.
Metoprolol Side Effect Report#9998334
Ventricular Arrhythmia, Ventricular Tachycardia, Ventricular Extrasystoles, Post-traumatic Stress Disorder, Maternal Exposure During Pregnancy, Normal Newborn, Premature Labour
This report suggests a potential Metoprolol Ventricular Arrhythmia side effect(s) that can have serious consequences. A 26-year-old female patient (weight: NA) from PL was diagnosed with the following symptoms/conditions: ventricular tachycardia,sinus tachycardia,ventricular extrasystoles and used Metoprolol (dosage: NA) starting NS. After starting Metoprolol the patient began experiencing various side effects, including: Ventricular Arrhythmia, Ventricular Tachycardia, Ventricular Extrasystoles, Post-traumatic Stress Disorder, Maternal Exposure During Pregnancy, Normal Newborn, Premature LabourAdditional drugs used concurrently: NA. Although Metoprolol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Ventricular Arrhythmia, may still occur.
Metoprolol Side Effect Report#9997938
Congenital Hydronephrosis, Ureteric Stenosis, Exposure During Pregnancy
This Congenital Hydronephrosis problem was reported by a health professional from DE. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: hypertension. On
Apr 30, 2012 this consumer started treatment with Metoprolol (dosage: 50 [mg/d ]). The following drugs were being taken at the same time:
  • Bisoprolol (5 [mg/d (2x2.5) ])
  • Insulin (8 [ie/d ])
  • Folio
  • Dopegyt (750 [mg/d (3x250) ])
  • Ass 100 (100 [mg/d ])
When using Metoprolol, the patient experienced the following unwanted symptoms/side effects: Congenital Hydronephrosis, Ureteric Stenosis, Exposure During PregnancyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Congenital Hydronephrosis, may become evident only after a product is in use by the general population.
Metoprolol Side Effect Report#9996312
Dyspnoea, Fatigue, Haemorrhage, Contusion
This Dyspnoea side effect was reported by a consumer or non-health professional from US. A 80-year-old female patient (weight:NA) experienced the following symptoms/conditions: aortic valve replacement.The patient was prescribed Metoprolol 25 Mg Tablet (drug dosage: One Tablet Twice Daily Taken By Mouth), which was initiated on
Dec 05, 2005. Concurrently used drugs: NA..After starting to take Metoprolol 25 Mg Tablet the consumer reported adverse symptoms, such as: Dyspnoea, Fatigue, Haemorrhage, ContusionThese side effects may potentially be related to Metoprolol 25 Mg Tablet.
Metoprolol Side Effect Report#9994810
Osteoarthritis, Disease Progression, Mobility Decreased, Fall, Hyperuricaemia, Urinary Tract Infection
This is a report of a 76-year-old female patient (weight: NA) from CA, suffering from the following health symptoms/conditions: NA, who was treated with Metoprolol Tartrate (dosage: NA, start time:
Aug 14, 2008), combined with: NA. and developed a serious reaction and side effect(s): Osteoarthritis, Disease Progression, Mobility Decreased, Fall, Hyperuricaemia, Urinary Tract Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Tartrate treatment in female patients, resulting in Osteoarthritis side effect. The patient was hospitalized.
Metoprolol Side Effect Report#9990062
Hypersensitivity
This report suggests a potential Metoprolol Tartrate Hypersensitivity side effect(s) that can have serious consequences. A 53-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hypertension and used Metoprolol Tartrate (dosage: NA) starting NS. After starting Metoprolol Tartrate the patient began experiencing various side effects, including: HypersensitivityAdditional drugs used concurrently:
  • Crestor (rosuvastatin Calcium) (rosuvastatin Calcium)
The patient was hospitalized. Although Metoprolol Tartrate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypersensitivity, may still occur.
Metoprolol Side Effect Report#9982826
Cardiac Flutter, Heart Rate Increased, Product Substitution Issue
This Cardiac Flutter problem was reported by a pharmacist from US. A 75-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Metoprolol Er 50mg Legacy (dosage: 1 Tablet, Qd, Oral). The following drugs were being taken at the same time:
  • Lipitor
  • Coumadin
When using Metoprolol Er 50mg Legacy, the patient experienced the following unwanted symptoms/side effects: Cardiac Flutter, Heart Rate Increased, Product Substitution IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cardiac Flutter, may become evident only after a product is in use by the general population.
Metoprolol Side Effect Report#9982505
Conjunctival Ulcer, Treatment Failure, Tachycardia, Tachycardia, Myocardial Infarction
This Conjunctival Ulcer side effect was reported by a health professional from US. A 70-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metoprolol Succinate - Not Given, 100 Mg (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Clopidogrel
  • Lisinopril
  • Omeprazole
  • Levothyroxine
  • Simvastatin
  • Aspirin
  • Ibuprofen
  • Acyclovir
.After starting to take Metoprolol Succinate - Not Given, 100 Mg the consumer reported adverse symptoms, such as: Conjunctival Ulcer, Treatment Failure, Tachycardia, Tachycardia, Myocardial InfarctionThese side effects may potentially be related to Metoprolol Succinate - Not Given, 100 Mg. The patient was hospitalized.
Metoprolol Side Effect Report#9981469
Malaise, Hypertension, Product Quality Issue
This is a report of a 59-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: hypertension, who was treated with Metoprolol Succinate 25 Mg (dosage: 25 Mg/ 1 Pill Once Daily Taken By Mouth, start time:
Jan 15, 2014), combined with: NA. and developed a serious reaction and side effect(s): Malaise, Hypertension, Product Quality Issue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate 25 Mg treatment in female patients, resulting in Malaise side effect.
Metoprolol Side Effect Report#9971944
Fall, Gait Disturbance, Hypoaesthesia, Musculoskeletal Stiffness, Dry Mouth, Musculoskeletal Stiffness, Hypoaesthesia
This report suggests a potential Metoprolol Fall side effect(s) that can have serious consequences. A 50-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: blood pressure and used Metoprolol (dosage: NA) starting NS. After starting Metoprolol the patient began experiencing various side effects, including: Fall, Gait Disturbance, Hypoaesthesia, Musculoskeletal Stiffness, Dry Mouth, Musculoskeletal Stiffness, HypoaesthesiaAdditional drugs used concurrently: NA. Although Metoprolol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Fall, may still occur.
Metoprolol Side Effect Report#9970160
Congenital Hydronephrosis, Ureteric Stenosis, Caesarean Section, Renal Impairment
This Congenital Hydronephrosis problem was reported by a consumer or non-health professional from DE. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: maternal exposure during pregnancy. On NS this consumer started treatment with Metoprolol (dosage: Maternal Dose: 50 {mg/d} , Gw 5+2 - 25). The following drugs were being taken at the same time:
  • Bisoprolol
  • Insulin
  • Folio
  • Dopegyt
  • Ass
When using Metoprolol, the patient experienced the following unwanted symptoms/side effects: Congenital Hydronephrosis, Ureteric Stenosis, Caesarean Section, Renal ImpairmentAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Congenital Hydronephrosis, may become evident only after a product is in use by the general population.
Metoprolol Side Effect Report#9969661
Blood Pressure Increased, Dyspnoea, Withdrawal Syndrome
This Blood Pressure Increased side effect was reported by a consumer or non-health professional from US. A 35-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metoprolol Tartrate (drug dosage: Df), which was initiated on NS. Concurrently used drugs:
  • Baclofen
  • Baclofen
  • Morphine
  • Bupivacaine (Smaller Than 3 Something Per Day)
  • Flexeril (10 Mg, Qid, 3-4 Times A Day)
  • Ativan (Df)
.After starting to take Metoprolol Tartrate the consumer reported adverse symptoms, such as: Blood Pressure Increased, Dyspnoea, Withdrawal SyndromeThese side effects may potentially be related to Metoprolol Tartrate. The patient was hospitalized.
Metoprolol Side Effect Report#9967003
Coronary Artery Occlusion, Nasopharyngitis, Cough, Off Label Use
This is a report of a 63-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: heart rate increased,acute coronary syndrome,stent placement, who was treated with Metoprolol Succinate (dosage: NA, start time:
Jan 13, 2014), combined with:
  • Brilinta
  • Brilinta
  • Asprin
  • Lipitor
and developed a serious reaction and side effect(s): Coronary Artery Occlusion, Nasopharyngitis, Cough, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate treatment in male patients, resulting in Coronary Artery Occlusion side effect.
Metoprolol Side Effect Report#9962828
Intentional Overdose, Completed Suicide, Convulsion, Somnolence, Hypotension, Bradycardia, Multi-organ Failure, Cardiac Arrest
This report suggests a potential Metoprolol Succinate Intentional Overdose side effect(s) that can have serious consequences. A 50-year-old female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: NA and used Metoprolol Succinate (dosage: NA) starting NS. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Intentional Overdose, Completed Suicide, Convulsion, Somnolence, Hypotension, Bradycardia, Multi-organ Failure, Cardiac ArrestAdditional drugs used concurrently:
  • Bupropion
  • Fenofibrate
The patient was hospitalized. Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Intentional Overdose, may still occur.
Metoprolol Side Effect Report#9959215
Nausea, Glossodynia, Dyspepsia, Dysgeusia
This Nausea problem was reported by a consumer or non-health professional from US. A 49-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: blood pressure. On
Jan 14, 2014 this consumer started treatment with Metoprolol Succinate Er (dosage: NA). The following drugs were being taken at the same time:
  • Lisinopril
  • Atorvastatin
  • Aspirin
  • Atorvastatin
When using Metoprolol Succinate Er, the patient experienced the following unwanted symptoms/side effects: Nausea, Glossodynia, Dyspepsia, DysgeusiaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Nausea, may become evident only after a product is in use by the general population.
Metoprolol Side Effect Report#9934958
Pyrexia, Malaise, Diarrhoea, Vomiting, Headache, Insomnia, Peripheral Coldness, Palpitations, Hyperhidrosis
This Pyrexia side effect was reported by a consumer or non-health professional from US. A 70-year-old female patient (weight:NA) experienced the following symptoms/conditions: ventricular fibrillation.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on
Sep 23, 2013. Concurrently used drugs: NA..After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: Pyrexia, Malaise, Diarrhoea, Vomiting, Headache, Insomnia, Peripheral Coldness, Palpitations, HyperhidrosisThese side effects may potentially be related to Metoprolol Succinate.
Metoprolol Side Effect Report#9934954
Headache, Blood Pressure Increased, Tinnitus
This is a report of a 44-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: hypertension, who was treated with Metoprolol Succinate (dosage: NA, start time: 201308), combined with: NA. and developed a serious reaction and side effect(s): Headache, Blood Pressure Increased, Tinnitus after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate treatment in female patients, resulting in Headache side effect.
Metoprolol Side Effect Report#9934927
Hypersensitivity, Dyspnoea
This report suggests a potential Metoprolol Succinate Hypersensitivity side effect(s) that can have serious consequences. A 59-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: heart rate increased,hypertension,blood cholesterol abnormal and used Metoprolol Succinate (dosage: NA) starting 2002. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Hypersensitivity, DyspnoeaAdditional drugs used concurrently:
  • Diovan
  • Lescol
  • Benecar
Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypersensitivity, may still occur.
Metoprolol Side Effect Report#9934881
Therapeutic Response Decreased, Nausea, Heart Rate Irregular
This Therapeutic Response Decreased problem was reported by a health professional from US. A 76-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Metoprolol Succinate (dosage: NA). The following drugs were being taken at the same time:
  • Aspirin (Unk)
  • Simvastatin (Unk)
When using Metoprolol Succinate, the patient experienced the following unwanted symptoms/side effects: Therapeutic Response Decreased, Nausea, Heart Rate IrregularAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Therapeutic Response Decreased, may become evident only after a product is in use by the general population.
Metoprolol Side Effect Report#9934694
Fall, Spinal Fracture, Stress, Photophobia, Osteoporosis, Body Height Decreased, Hypotension, Alopecia
This Fall side effect was reported by a consumer or non-health professional from US. A 82-year-old female patient (weight:NA) experienced the following symptoms/conditions: hypertension.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: Fall, Spinal Fracture, Stress, Photophobia, Osteoporosis, Body Height Decreased, Hypotension, AlopeciaThese side effects may potentially be related to Metoprolol Succinate.
Metoprolol Side Effect Report#9934693
Alopecia
This is a report of a 49-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: blood pressure increased, who was treated with Metoprolol Succinate (dosage: NA, start time:
May 10, 2013), combined with: NA. and developed a serious reaction and side effect(s): Alopecia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate treatment in female patients, resulting in Alopecia side effect.
Metoprolol Side Effect Report#9934690
Dizziness, Vertigo, Chest Discomfort, Flatulence, Panic Attack, Off Label Use
This report suggests a potential Metoprolol Succinate Dizziness side effect(s) that can have serious consequences. A 67-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: heart rate decreased and used Metoprolol Succinate (dosage: NA) starting
Oct 16, 2013. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Dizziness, Vertigo, Chest Discomfort, Flatulence, Panic Attack, Off Label UseAdditional drugs used concurrently: NA. Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dizziness, may still occur.
Metoprolol Side Effect Report#9934689
Pruritus, Rash, Off Label Use
This Pruritus problem was reported by a physician from US. A 41-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: ventricular extrasystoles. On 2007 this consumer started treatment with Metoprolol Succinate Az (dosage: NA). The following drugs were being taken at the same time: NA. When using Metoprolol Succinate Az, the patient experienced the following unwanted symptoms/side effects: Pruritus, Rash, Off Label UseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pruritus, may become evident only after a product is in use by the general population.
Metoprolol Side Effect Report#9934662
Nausea, Diarrhoea, Asthenia
This Nausea side effect was reported by a consumer or non-health professional from US. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: cardiac disorder,blood pressure,multiple allergies.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Triamterne Hct
  • Xanax
  • Zyrtec
  • Prednisone
.After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: Nausea, Diarrhoea, AstheniaThese side effects may potentially be related to Metoprolol Succinate.
Metoprolol Side Effect Report#9934643
Pruritus, Burning Sensation, Off Label Use
This is a report of a 88-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: atrial fibrillation,heart rate abnormal,hypertension,thyroid disorder,blood cholesterol increased, who was treated with Metoprolol Succinate (dosage: NA, start time: 2008), combined with: NA. and developed a serious reaction and side effect(s): Pruritus, Burning Sensation, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate treatment in female patients, resulting in Pruritus side effect.


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The appearance of Metoprolol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Metoprolol Side Effects for Women?

Women Side Effects Reports
Dizziness 196
Blood Pressure Increased 183
Dyspnoea 167
Fatigue 139
Nausea 126
Headache 120
Completed Suicide 114
Hypotension 107
Bradycardia 105
Palpitations 100

What are common Metoprolol Side Effects for Men?

Men Side Effects Reports
Bradycardia 300
Dizziness 188
Hypotension 181
Syncope 145
Fatigue 105
Dyspnoea 102
Completed Suicide 101
Blood Pressure Increased 98
Atrial Fibrillation 88
Asthenia 75

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Metoprolol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    How Effective is Metoprolol for You?

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    Metoprolol Safety Alerts, Active Ingredients, Usage Information

    NDC 0093-0733
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name Metoprolol Tartrate
    Name Metoprolol Tartrate
    Dosage Form TABLET, FILM COATED
    Route ORAL
    On market since 19950406
    Labeler Teva Pharmaceuticals USA Inc
    Active Ingredient(s) METOPROLOL TARTRATE
    Strength(s) 50
    Unit(s) mg/1
    Pharma Class Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]

    More About Metoprolol

    Side Effects reported to FDA: 4895

    Metoprolol safety alerts: 2005

    Reported deaths: 251

    Reported hospitalizations: 967

    Toprol-XL (metoprolol succinate)

    Audience: All healthcare professionals

    [UPDATE November 10, 2005] Letters from Novartis Pharmaceuticals Corporation added below

    [UPDATE September 30, 2005] Letters from Ortho-McNeil Neurologics, Inc. added below

    [Posted 09/26/2005] AstraZeneca and FDA notified healthcare professionals reports of medication dispensing or prescribing errors between Toprol-XL (metoprolol succinate) extended release tablets, indicated for the treatment of hypertension, long-term treatment of angina pectoris, and heart failure NYHA Class II or III, and Topamax (topiramate), a product of Ortho-McNeil Neurologics, Inc, indicated for the treatment of epilepsy and migraine prophylaxis. There have also been reports of medication errors involving confusion between Toprol-XL and Tegretol or Tegretol-XR (carbamazepine), products of Novartis Pharmaceuticals Corporation, indicated for the treatment of complex partial seizures, generalized tonic-clonic seizures, and trigeminal neuralgia. These reports include instances where Toprol-XL was incorrectly administered to patients instead of Topamax, Tegretol, or Tegretol-XR, and vice versa, some of them leading to adverse events.

    [October 2005 - Dear Healthcare Professional Letter - Novartis]
    [October 2005 - Dear Pharmacist Letter - Novartis]

    [September 2005 - Dear Healthcare Professional Letter - Ortho-McNeil Neurologics, Inc.]
    [September 2005 - Dear Pharmacist Letter - Ortho-McNeil Neurologics, Inc.]

    [September 22, 2005 - Dear Healthcare Professional Letter - AstraZeneca]
    [September 22, 2005 - Dear Pharmacist Letter - AstraZeneca]

    Latest Metoprolol clinical trials

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