Morphine Safety Reports submitted to FDA

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Total Morphine reports: 473.
Morphine FDA safety alerts: 2002 2003 2005 2007 .
Reported deaths: 162 Reported hospitalizations: 144.
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FDA Reported Morphine Side Effects: overdose, cardio-respiratory arrest, death, loss of consciousness, respiratory depression, nausea, somnolence, accidental overdose, confusional state, depressed level of consciousness, vomiting.
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Morphine Side Effects Report #5131030-2
Consumer or non-health professional from reported MORPHINE problem on Oct 17, 2006. Male patient was diagnosed with procedural pain, analgesic effect, hypotonia, anaesthesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: pyrexia. MORPHINE dosage: 1 MG/ML, BOLUS DOSE OF 1 MG WITH A LOCKOUT TIME OF 6 MIN (MAXIMUM 10 MG/H). During the same period patient was treated with FENTANYL, ACETAMINOPHEN, DIAZEPAM, ACETATED RINGER, ROCURONIUM, OXYGEN, NITROUS OXIDE W, SEVOFLURANE. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5132236-9
MORPHINE problem was reported by a Health Professional from UNITED STATES on Oct 04, 2006. Female patient, 64 years of age, weighting 164.0 lb, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: depressed level of consciousness, respiratory rate decreased. MORPHINE dosage: 6 MG, ONCE AS LOADING DOSE, INTRAVENOUS; 2 MG, EVERY 20 MINUTES AS NEEDED, INTRAVENOUS. During the same period patient was treated with MORPHINE SULPHATE. Patient recovered.

Morphine Side Effects Report #5132237-0
Pharmacist from UNITED STATES reported MORPHINE problem on Oct 03, 2006. Female patient, 30 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, heart rate increased, respiratory depression, unresponsive to stimuli. MORPHINE dosage: 5 MG, ONCE, INTRAVENOUS; INTRAVENOUS. During the same period patient was treated with MORPHINE SULPHATE, VERSED, DURAMORPH PF. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5132970-0
MORPHINE problem was reported by a Consumer or non-health professional from on Oct 11, 2006. Female patient, 48 years of age, was diagnosed with neuralgia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: asthenia, confusional state, glasgow coma scale abnormal, hallucination, visual, hyporeflexia, miosis, oxygen saturation decreased, rales. MORPHINE dosage: 60 MG, DAILY. During the same period patient was treated with RIVOTRIL, LEXOMIL, SERETIDE, THEOSTAT, TERCIAN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5133268-7
Pharmacist from UNITED STATES reported MORPHINE problem on June 13, 2006. Male patient, 23 years of age, weighting 207.9 lb, was diagnosed with neuralgia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: overdose. MORPHINE dosage: 120 MG (2 TABLETS), EVERY 4 HRS. During the same period patient was treated with HYDROMORPHONE, FENTANYL. Patient died on 01/31/2006.

Morphine Side Effects Report #5134015-5
MORPHINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 23, 2006. Male patient, 55 years of age, weighting 158.0 lb, was diagnosed with back pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: aphasia, convulsion, delirium, depressed level of consciousness, dyskinesia, fall, haemorrhage intracranial, hallucination. MORPHINE dosage: unknown. During the same period patient was treated with DILAUDID. Patient was hospitalized. Patient died on 10/14/2006.

Morphine Side Effects Report #5134576-6
Consumer or non-health professional from reported MORPHINE problem on Oct 11, 2006. Male patient, 87 years of age, was diagnosed with cancer pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardiac failure, condition aggravated, delirium. MORPHINE dosage: 10 MG, DAILY. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5140062-X
MORPHINE problem was reported by a Consumer or non-health professional from on Oct 20, 2006. Male patient was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: condition aggravated. MORPHINE dosage: unknown. During the same period patient was treated with MORPHINE SULPHATE, PHENOBARBITAL. Patient recovered.

Morphine Side Effects Report #5140936-X
Pharmacist from UNITED STATES reported MORPHINE problem on Oct 25, 2006. Male patient, 66 years of age, weighting 219.0 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: loss of consciousness. MORPHINE dosage: unknown. During the same period patient was treated with DIAZEPAM, ASPIRIN, TICLID, SIMVASTATIN, HYDROCHLOROTHIAZIDE, ATENOLOL, FINASTERIDE, GLIPIZIDE. Patient recovered.

Morphine Side Effects Report #5143159-3
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Oct 31, 2006. Male patient, 87 years of age, weighting 157.0 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: bradycardia, dyskinesia, somnolence. MORPHINE dosage: unknown. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5143166-0
Pharmacist from UNITED STATES reported MORPHINE problem on Oct 31, 2006. Male patient, 61 years of age, weighting 155.0 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: dyspnoea, miosis. MORPHINE dosage: unknown. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5206259-5
MORPHINE problem was reported by a Consumer or non-health professional from UNITED STATES on Mar 14, 2006. Male patient, 17 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: accidental overdose, brain oedema, pulmonary oedema. MORPHINE dosage: unknown. During the same period patient was treated with DIAZEPAM, DIPHENHYDRAMINE, ACETAMINOPHEN, IBUPROFEN. Patient died on 02/07/2006.

Morphine Side Effects Report #5206261-3
Physician from UNITED STATES reported MORPHINE problem on Aug 11, 2006. Female patient, 77 years of age, was diagnosed with dyspnoea and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: delusion of replacement. MORPHINE dosage: 30 MG ONCE PO. During the same period patient was treated with LORAZEPAM, FUROSEMIDE, DIGOXIN, METOLAZONE, SPIRONOLACTONE, POTASSIUM ACETATE, WARFARIN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5141982-2
MORPHINE problem was reported by a Consumer or non-health professional from on Oct 26, 2006. Female patient was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: anaemia, constipation, dizziness, headache, hypotension, hypoxia, nausea, pruritus, pyrexia. MORPHINE dosage: 1-MG BOLUS, 5-MIN LOCKOUT INTERVAL; UP TO 10 DOSES/HOUR (FOR UP TO 72 HOURS). Patient recovered.

Morphine Side Effects Report #5143651-1
Consumer or non-health professional from reported MORPHINE problem on Oct 25, 2006. Female patient, 78 years of age, was diagnosed with analgesic effect, hypertension, anaesthesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: delayed recovery from anaesthesia, laboratory test abnormal, miosis, respiratory depression. MORPHINE dosage: 10 MG, DAILY. During the same period patient was treated with FENTANYL CITRATE, ATENOLOL, CYCLIZINE, MIDAZOLAM, PROPOFOL, ROCURONIUM, SIMVASTATIN, TRAMADOL. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5143666-3
MORPHINE problem was reported by a Consumer or non-health professional from on Oct 27, 2006. Male patient was diagnosed with pain, hypertonia, myoclonus, convulsion and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: hypertonia, myoclonus, pyrexia, regurgitation of food, tachycardia, tachypnoea, tremor. MORPHINE dosage: unknown. During the same period patient was treated with PHENOBARBITAL. Patient recovered.

Morphine Side Effects Report #5143668-7
Consumer or non-health professional from reported MORPHINE problem on Oct 27, 2006. Male patient, weighting 6.61 lb, was diagnosed with procedural pain, convulsion, nystagmus, oculogyration and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: agitation, body temperature increased, crying, hyperhidrosis, myoclonus, regurgitation of food, tachycardia. MORPHINE dosage: unknown. During the same period patient was treated with FENTANYL CITRATE, PHENOBARBITAL. Patient recovered.

Morphine Side Effects Report #5144048-0
MORPHINE problem was reported by a Consumer or non-health professional from on Oct 20, 2006. Male patient was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: septic necrosis. MORPHINE dosage: unknown. During the same period patient was treated with MORPHINE SULPHATE, PHENOBARBITAL. Patient recovered.

Morphine Side Effects Report #5145945-2
Consumer or non-health professional from UNITED STATES reported MORPHINE problem on Nov 01, 2006. Male patient, 44 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: aggression, cardio-respiratory arrest, delirium, excoriation, incoherent, substance abuse. MORPHINE dosage: unknown. During the same period patient was treated with OXYCODONE HYDROCHLORIDE, COCAINE. Patient died on 07/14/2006.

Morphine Side Effects Report #5145947-6
MORPHINE problem was reported by a Health Professional from ISRAEL on Oct 30, 2006. Male patient, 36 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, amnesia, autonomic nervous system imbalance, impaired self-care, incontinence, leukoencephalopathy, muscle spasticity, myoclonus. MORPHINE dosage: unknown. Patient recovered.

Morphine Side Effects Report #5145948-8
Health Professional from UNITED KINGDOM reported MORPHINE problem on Oct 30, 2006. Female patient, 40 years of age, was diagnosed with back pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, accidental overdose, acidosis, cognitive disorder, confusional state, disorientation, distractibility, disturbance in attention, echolalia. MORPHINE dosage: 360 MG, SEE TEXT. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5146385-2
MORPHINE problem was reported by a Consumer or non-health professional from on Nov 06, 2006. Female patient was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: anaesthetic complication, hypotension. MORPHINE dosage: 0.25 MG/H (INFUSION RATE WAS REDUCED IF MOTOR BLOCK WAS ABOVE 0 ACCORDING TO A MODIFIED BROMAGE SCAL. During the same period patient was treated with BUPIVACAINE. Patient recovered.

Morphine Side Effects Report #5146736-9
Health Professional from UNITED STATES reported MORPHINE problem on Nov 07, 2006. Male patient, 85 years of age, weighting 157.0 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: mental status changes, syncope. MORPHINE dosage: PCA PROTOCOL, 1MG/HR DEMAND/BOLUS INTRAVEN 1MG. During the same period patient was treated with ACETAMINOPHEN, HYTRIN, LOVASTATIN, FINASTERIDE, ATENOLOL, SENNA, LOVENOX, DOCUSATE. Patient recovered.

Morphine Side Effects Report #5146793-X
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Nov 07, 2006. Male patient, 61 years of age, weighting 266.0 lb, was diagnosed with back pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: back pain, bedridden, immobile, mental status changes, skin ulcer. MORPHINE dosage: 60 MG BID PO. During the same period patient was treated with FUROSEMIDE, IBUPROFEN, LISINOPRIL, MORPHINE SO, PAROXETINE, POTASSIUM CHLORIDE. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5147039-9
Physician from NETHERLANDS reported MORPHINE problem on Oct 19, 2006. Male patient, 27 years of age, was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, lymphocyte transformation test positive, skin exfoliation, skin graft, skin test positive, toxic shock syndrome. MORPHINE dosage: 10 MG ONCE IV. During the same period patient was treated with ACETAMINOPHEN, DICLOFENAC, LIDOCAINE, BUPIVACAINE, EPHEDRINE, MIDAZOLAM, MANNITOL. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5150729-5
MORPHINE problem was reported by a Physician from JAPAN on Aug 31, 2006. Male patient, weighting 149.9 lb, was diagnosed with cancer pain, rectal cancer and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: anorexia, ascites, blood pressure increased, constipation, dehydration, disease progression, fatigue, hydronephrosis, inflammation. MORPHINE dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, OXALIPLATIN, MEROPEN, INOVAN, MAXIPIME. Patient was hospitalized. Patient died on 10/22/2006.

Morphine Side Effects Report #5151669-8
Health Professional from UNITED STATES reported MORPHINE problem on Nov 08, 2006. Male patient, 44 years of age, weighting 340.0 lb, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, dyspnoea, loss of consciousness. MORPHINE dosage: unknown. During the same period patient was treated with FENTANYL, AMBIEN, TORADOL. Patient died on 10/25/2006.

Morphine Side Effects Report #5152548-2
MORPHINE problem was reported by a Consumer or non-health professional from on Nov 07, 2006. Male patient, 48 years of age, weighting 202.8 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: accidental poisoning, mouth haemorrhage. MORPHINE dosage: unknown. During the same period patient was treated with CYMBALTA, ATOMOXETINE, DIPHENHYDRAMINE. Patient died.

Morphine Side Effects Report #5152550-0
Consumer or non-health professional from reported MORPHINE problem on Nov 07, 2006. Female patient, 42 years of age, weighting 158.7 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: completed suicide, loss of consciousness, narcotic intoxication, unresponsive to stimuli. MORPHINE dosage: unknown. During the same period patient was treated with CYMBALTA, MIRTAZAPINE, FLUOXETINE, ALPRAZOLAM, LORAZEPAM, TEMAZEPAM, MEPROBAMATE. Patient died.

Morphine Side Effects Report #5152935-2
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Nov 14, 2006. Female patient was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: inadequate analgesia, incorrect dose administered, medical device complication. MORPHINE dosage: unknown. Patient recovered.

Morphine Side Effects Report #5154190-6
Consumer or non-health professional from reported MORPHINE problem on Nov 07, 2006. Male patient, 81 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: creatinine renal clearance decreased, febrile infection, jaundice, large intestine perforation, peritonitis. MORPHINE dosage: 120 MG, DAILY. During the same period patient was treated with PLAVIX, ASPIRIN, CORTANCYL, APROVEL, PRAXILENE, NEURONTIN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5154777-0
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Nov 15, 2006. Male patient, weighting 137.3 lb, was diagnosed with analgesic effect and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: pruritus. MORPHINE dosage: 2MG EVERY 3 HOURS AS N IV. Patient recovered.

Morphine Side Effects Report #5154870-2
Consumer or non-health professional from UNITED STATES reported MORPHINE problem on Nov 13, 2006. Female patient was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: breath odour, constipation, eructation, flatulence, gastrointestinal disorder, intestinal obstruction. MORPHINE dosage: 160 MG, TID. During the same period patient was treated with MORPHINE SULPHATE, METFORMIN, CYMBALTA, TOPROL, TRICOR, TRAZODONE, BENAZEPRIL HYDROCHLORIDE, HYDROCHLOROTHIAZIDE. Patient recovered.

Morphine Side Effects Report #5155234-8
MORPHINE problem was reported by a Physician from UNITED STATES on Nov 10, 2006. Female patient, 47 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, unevaluable event. MORPHINE dosage: unknown. During the same period patient was treated with DIAZEPAM. Patient died.

Morphine Side Effects Report #5155235-X
Physician from UNITED STATES reported MORPHINE problem on Nov 10, 2006. Female patient, 19 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest. MORPHINE dosage: unknown. During the same period patient was treated with ALPRAZOLAM. Patient died.

Morphine Side Effects Report #5155236-1
MORPHINE problem was reported by a Physician from UNITED STATES on Nov 10, 2006. Female patient, 22 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, unevaluable event. MORPHINE dosage: unknown. Patient died.

Morphine Side Effects Report #5155238-5
Physician from UNITED STATES reported MORPHINE problem on Nov 10, 2006. Female patient, 43 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest. MORPHINE dosage: unknown. Patient died.

Morphine Side Effects Report #5155246-4
MORPHINE problem was reported by a Physician from UNITED STATES on Nov 10, 2006. Female patient, 24 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: unevaluable event. MORPHINE dosage: unknown. Patient died.

Morphine Side Effects Report #5155247-6
Physician from UNITED STATES reported MORPHINE problem on Nov 10, 2006. Female patient, 37 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, unevaluable event. MORPHINE dosage: unknown. Patient died.

Morphine Side Effects Report #5155252-X
MORPHINE problem was reported by a Physician from UNITED STATES on Nov 10, 2006. Female patient, 22 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, unevaluable event. MORPHINE dosage: unknown. Patient died.

Morphine Side Effects Report #5155467-0
Consumer or non-health professional from reported MORPHINE problem on Nov 14, 2006. Female patient, 26 years of age, weighting 112.4 lb, was diagnosed with procedural pain, anaesthesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, incorrect dose administered, loss of consciousness, poisoning, post procedural complication, procedural pain, respiratory depression. MORPHINE dosage: unknown. During the same period patient was treated with FENTANYL, FLUNITRAZEPAM, THIOPENTAL, NITROUS OXIDE W, SEVOFLURANE, ATROPINE, SUXAMETHONIUM CHLORIDE, PANCURONIUM BROMIDE. Patient died.

Morphine Side Effects Report #5156578-6
MORPHINE problem was reported by a Physician from on Nov 20, 2006. Male patient, 56 years of age, was diagnosed with neuralgia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: depressive symptom. MORPHINE dosage: unknown. During the same period patient was treated with GABAPENTIN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5159060-5
Consumer or non-health professional from reported MORPHINE problem on Nov 20, 2006. Female patient, 61 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: intestinal obstruction, nausea, pruritus, vomiting. MORPHINE dosage: unknown. Patient died.

Morphine Side Effects Report #5160996-X
MORPHINE problem was reported by a Consumer or non-health professional from on Nov 20, 2006. Male patient, 56 years of age, was diagnosed with neuralgia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: depressive symptom. MORPHINE dosage: 60 MG, BID. During the same period patient was treated with NEURONTIN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5162220-0
Physician from UNITED STATES reported MORPHINE problem on Nov 10, 2006. Female patient, 40 years of age, was treated with MORPHINE. MORPHINE dosage: unknown. During the same period patient was treated with COCAINE, PHENCYCLIDINE. Patient died.

Morphine Side Effects Report #5162221-2
MORPHINE problem was reported by a Physician from UNITED STATES on Nov 10, 2006. Female patient, 43 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest. MORPHINE dosage: unknown. Patient died on 01/01/2005.

Morphine Side Effects Report #5162404-1
Physician from UNITED STATES reported MORPHINE problem on Nov 28, 2006. Male patient, 57 years of age, weighting 232.0 lb, was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: rash. MORPHINE dosage: 2 MG/ 1 ML IV. During the same period patient was treated with PERCOCET, BENADRYL, IPRATROPIUM BROMIDE, LEVALBUTEROL. Patient recovered.

Morphine Side Effects Report #5162409-0
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Nov 28, 2006. Male patient, 70 years of age, weighting 218.0 lb, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: pruritus. MORPHINE dosage: unknown. During the same period patient was treated with SIMVASTATIN, THIAMINE, ACETAMINOPHEN, OXYCODONE AND ACETAMINOPHEN, ALBUTEROL, ATENOLOL, CALCIUM CARBONATE, DIPHENHYDRAMINE. Patient recovered.

Morphine Side Effects Report #5162420-X
Physician from UNITED STATES reported MORPHINE problem on Nov 28, 2006. Male patient, 59 years of age, weighting 193.0 lb, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: pruritus, rash. MORPHINE dosage: unknown. During the same period patient was treated with TRAZODONE, RANITIDINE, OMEPRAZOLE, GABAPENTIN, SIMVASTATIN, FLUNISOLIDE, ASPIRIN, DOCUSATE ENEMA. Patient recovered.

Morphine Side Effects Report #5162562-9
MORPHINE problem was reported by a Physician from UNITED STATES on Nov 10, 2006. Female patient, 67 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: completed suicide. MORPHINE dosage: unknown. During the same period patient was treated with HYDROCODONE. Patient died on 01/01/2005.

Morphine Side Effects Report #5162732-X
Physician from UNITED STATES reported MORPHINE problem on Nov 10, 2006. Female patient, 19 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest. MORPHINE dosage: unknown. During the same period patient was treated with ALPRAZOLAM. Patient died on 01/01/2005.

Morphine Side Effects Report #5163325-0
MORPHINE problem was reported by a Health Professional from UNITED STATES on Nov 10, 2006. Male patient was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest. MORPHINE dosage: unknown. Patient died on 11/07/2006.

Morphine Side Effects Report #5164973-4
Consumer or non-health professional from UNITED STATES reported MORPHINE problem on Nov 15, 2006. Female patient, weighting 8.00 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: haematochezia, myoclonus, neonatal disorder. MORPHINE dosage: unknown. During the same period patient was treated with FENTANYL, PITOCIN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5165812-8
MORPHINE problem was reported by a Health Professional from UNITED STATES on Nov 16, 2006. Male patient, 77 years of age, weighting 230.0 lb, was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: apnoea, atrial fibrillation, blood pressure increased, cardio-respiratory arrest, convulsion, loss of consciousness, ventricular extrasystoles. MORPHINE dosage: 6 MG;EVERY HR;IV. Patient died on 11/07/2006.

Morphine Side Effects Report #5165841-4
Health Professional from TURKEY reported MORPHINE problem on Nov 15, 2006. Female patient, 55 years of age, was diagnosed with postoperative analgesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: accidental overdose, agitation, incorrect dose administered, miosis, nausea, visual disturbance, vomiting. MORPHINE dosage: 40 MG UNK EP. During the same period patient was treated with BUPIVACAINE. Patient recovered.

Morphine Side Effects Report #5214519-7
MORPHINE problem was reported by a Health Professional from UNITED STATES on Mar 14, 2006. Male patient, 17 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: accidental overdose, brain oedema, pulmonary oedema. MORPHINE dosage: unknown. During the same period patient was treated with DIAZEPAM, DIPHENHYDRAMINE, IBUPROFEN, ACETAMINOPHEN. Patient died on 02/07/2006.

Morphine Side Effects Report #5214528-8
Physician from UNITED STATES reported MORPHINE problem on Aug 11, 2006. Female patient, 77 years of age, was diagnosed with dyspnoea and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: delusion of replacement. MORPHINE dosage: 30 MG ONCE PO. During the same period patient was treated with LORAZEPAM, FUROSEMIDE, DIGOXIN, METOLAZONE, SPIRONOLACTONE, POTASSIUM ACETATE. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5164029-0
MORPHINE problem was reported by a Physician from on Dec 01, 2006. Female patient, 51 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction. MORPHINE dosage: unknown. During the same period patient was treated with BUPIVACAINE, AMOXICILLIN, FENTANYL, ONDANSETRON, PARECOXIB, PROPOFOL. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5164031-9
Consumer or non-health professional from reported MORPHINE problem on Dec 01, 2006. Female patient, 55 years of age, was diagnosed with postoperative analgesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: accidental overdose, agitation, incorrect dose administered, miosis, nausea, visual disturbance, vomiting. MORPHINE dosage: unknown. Patient recovered.

Morphine Side Effects Report #5164033-2
MORPHINE problem was reported by a Physician from on Dec 01, 2006. Male patient, 36 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, amnesia, autonomic nervous system imbalance, impaired self-care, incontinence, leukoencephalopathy, muscle spasticity, myoclonus, overdose. MORPHINE dosage: unknown. Patient recovered.

Morphine Side Effects Report #5164778-4
Consumer or non-health professional from UNITED STATES reported MORPHINE problem on Nov 27, 2006. Male patient, 19 years of age, was diagnosed with alcohol use and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: substance abuse. MORPHINE dosage: unknown. During the same period patient was treated with XANAX, ALCOHOL. Patient died on 11/19/2006.

Morphine Side Effects Report #5164782-6
MORPHINE problem was reported by a Consumer or non-health professional from UNITED STATES on Nov 27, 2006. Female patient, 18 years of age, was diagnosed with alcohol use and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: substance abuse. MORPHINE dosage: unknown. During the same period patient was treated with XANAX, ALCOHOL. Patient died on 11/19/2006.

Morphine Side Effects Report #5164857-1
Consumer or non-health professional from reported MORPHINE problem on Nov 22, 2006. Male patient, 77 years of age, was diagnosed with pain, neuralgia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: confusional state, transient ischaemic attack, unresponsive to stimuli. MORPHINE dosage: unknown. During the same period patient was treated with OXYCODONE, LYRICA, DICLOFENAC. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5165014-5
MORPHINE problem was reported by a Consumer or non-health professional from on Nov 30, 2006. Male patient, child 12 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: megacolon. MORPHINE dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, DICLOFENAC. Patient recovered.

Morphine Side Effects Report #5165015-7
Consumer or non-health professional from reported MORPHINE problem on Nov 30, 2006. Female patient, child 12 years of age, was diagnosed with abdominal pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: hallucination, visual, lethargy, megacolon, pallor, pyrexia. MORPHINE dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, NSAIDS. Patient recovered.

Morphine Side Effects Report #5166574-0
MORPHINE problem was reported by a Health Professional from BRAZIL on Apr 25, 2006. Female patient, 44 years of age, was diagnosed with spinal anaesthesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: body temperature decreased, hyperhidrosis, hypothermia, somnolence. MORPHINE dosage: unknown. During the same period patient was treated with BUPIVACAINE. Patient recovered.

Morphine Side Effects Report #5169289-8
Consumer or non-health professional from reported MORPHINE problem on Nov 28, 2006. Female patient, 55 years of age, was diagnosed with epidural anaesthesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: accidental overdose, agitation, incorrect dose administered, miosis, myopia, nausea, visual disturbance, visual field defect, vomiting. MORPHINE dosage: 40 MG, SINGLE. During the same period patient was treated with BUPIVACAINE, FENTANYL. Patient recovered.

Morphine Side Effects Report #5175257-2
MORPHINE problem was reported by a Physician from UNITED STATES on Dec 11, 2006. Female patient, weighting 142.0 lb, was diagnosed with intervertebral disc protrusion and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: constipation, depression, dizziness, dyskinesia, hypoaesthesia facial, hypoaesthesia oral, nausea, nightmare. MORPHINE dosage: 30 MG 2/11 TID PO. During the same period patient was treated with METHADONE. Patient recovered.

Morphine Side Effects Report #5176527-4
Consumer or non-health professional from UNITED STATES reported MORPHINE problem on Nov 01, 2006. Male patient, 44 years of age, weighting 165.3 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: aggression, cardio-respiratory arrest, delirium, excoriation, incoherent, substance abuse, theft. MORPHINE dosage: unknown. During the same period patient was treated with OXYCODONE HYDROCHLORIDE, COCAINE. Patient died on 07/14/2006.

Morphine Side Effects Report #5178317-5
MORPHINE problem was reported by a Physician from NETHERLANDS on Nov 27, 2006. Male patient, 27 years of age, was diagnosed with pain prophylaxis and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, c-reactive protein increased, eosinophilia, leukocytosis, neutrophilia, red blood cell sedimentation rate increased, skin graft. MORPHINE dosage: unknown. During the same period patient was treated with NADROPARIN, CEFAZOLIN, ACETAMINOPHEN, DICLOFENAC, LIDOCAINE, BUPIVACAINE, EPHEDRINE SUL CAP, MIDAZOLAM. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5179101-9
Health Professional from UNITED STATES reported MORPHINE problem on Dec 14, 2006. Male patient, 84 years of age, weighting 164.2 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: asthenia, dizziness, hypotension. MORPHINE dosage: 15MG, Q12H, BY MOUTH. During the same period patient was treated with PERPHENAZINE, SIMVASTATIN, CALCIUM CARBONATE, LISINOPRIL, FINASTERIDE, CLONAZEPAM, MECLIZINE. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5179574-1
MORPHINE problem was reported by a Consumer or non-health professional from on Dec 13, 2006. Male patient, 16 years of age, weighting 132.3 lb, was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: nausea, pruritus, sedation, urinary retention. MORPHINE dosage: AVERAGE DAILY USE WAS 120 MG (BOLUS OF 1.2 MG WITH A LOCKOUT OF 6 MIN). During the same period patient was treated with ACETAMINOPHEN, IBUPROFEN, KETAMINE. Patient recovered.

Morphine Side Effects Report #5179575-3
Consumer or non-health professional from reported MORPHINE problem on Dec 13, 2006. Male patient, 13 years of age, weighting 119.0 lb, was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: insomnia, pain, pruritus, sedation. MORPHINE dosage: BOLUS OF 0.8 MG WITH A LOCKOUT OF 6 MIN. During the same period patient was treated with ACETAMINOPHEN, KETAMINE, KETOROLAC TROMETHAMINE, DIAZEPAM. Patient recovered.

Morphine Side Effects Report #5179576-5
MORPHINE problem was reported by a Consumer or non-health professional from on Dec 14, 2006. Female patient, 37 years of age, weighting 99.21 lb, was diagnosed with impaired gastric emptying, nausea, migraine prophylaxis and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, impaired gastric emptying, nausea, vomiting. MORPHINE dosage: unknown. During the same period patient was treated with ACETAMINOPHEN AND HYDROCODONE BITARTRATE, AMITRIPTYLINE, PROMETHAZINE, ONDANSETRON, NADOLOL. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5179577-7
Consumer or non-health professional from reported MORPHINE problem on Dec 13, 2006. Female patient, weighting 123.5 lb, was diagnosed with spinal anaesthesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: atelectasis, lung disorder, pleural effusion, pulmonary congestion, pulmonary embolism, respiratory depression. MORPHINE dosage: unknown. During the same period patient was treated with FENTANYL, BUPIVACAINE, GELOFUSINE, HARTMANN. Patient recovered.

Morphine Side Effects Report #5187959-2
MORPHINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 20, 2006. Female patient, 19 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: rash. MORPHINE dosage: unknown. Patient recovered.

Morphine Side Effects Report #5188373-6
Consumer or non-health professional from reported MORPHINE problem on Dec 19, 2006. Female patient was diagnosed with cancer pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: somnolence. MORPHINE dosage: 340 MG, DAILY. During the same period patient was treated with NAPROXEN, ACETAMINOPHEN, PAMIDRONATE DI. Patient died.

Morphine Side Effects Report #5189242-8
MORPHINE problem was reported by a Health Professional from UNITED STATES on Dec 11, 2006. Male patient, 58 years of age, weighting 229.0 lb, was diagnosed with arthralgia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: injection site cellulitis, injection site infection. MORPHINE dosage: unknown. During the same period patient was treated with TRAZODONE, ATENOLOL, AMBIEN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5190691-2
Consumer or non-health professional from reported MORPHINE problem on Dec 14, 2006. Female patient, 26 years of age, was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, hypoxic encephalopathy, loss of consciousness, respiratory failure. MORPHINE dosage: unknown. Patient died.

Morphine Side Effects Report #5190713-9
MORPHINE problem was reported by a Consumer or non-health professional from on Dec 19, 2006. Female patient was diagnosed with cancer pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: nightmare, somnolence. MORPHINE dosage: 60 MG, DAILY. During the same period patient was treated with CISPLATIN, DEXAMETHASONE, DICLOFENAC, GABAPENTIN, GEFITINIB, OXYCODONE, VINORELBINE. Patient died.

Morphine Side Effects Report #5190719-X
Consumer or non-health professional from reported MORPHINE problem on Dec 15, 2006. Female patient, 46 years of age, was diagnosed with antibiotic prophylaxis, hypotension, anaesthesia reversal and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: abdominal distension, acute hepatic failure, breath sounds abnormal, coagulopathy, hepatomegaly, oxygen saturation decreased, post procedural complication, somnolence, stridor. MORPHINE dosage: unknown. During the same period patient was treated with AMOXICILLIN, DICLOFENAC, EPHEDRINE, FENTANYL, GLYCOPYRROLATE, ISOFLURANE, NEOSTIGMINE, NITROUS OXIDE W. Patient recovered.

Morphine Side Effects Report #5191164-3
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Dec 20, 2006. Female patient, 48 years of age, weighting 186.0 lb, was diagnosed with procedural pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: loss of consciousness, oxygen saturation decreased, respiratory rate decreased, resuscitation, somnolence. MORPHINE dosage: 30 MG IV PACU ;+ 23 MG PCA. During the same period patient was treated with HYDROXYZINE, EFFEXOR, XANAX, CEPHADYN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5192012-8
Pharmacist from UNITED STATES reported MORPHINE problem on Dec 20, 2006. Female patient, 63 years of age, weighting 229.0 lb, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: hypoxia, mental status changes postoperative, sedation. MORPHINE dosage: 38 MG PER PCA (TOTAL). During the same period patient was treated with KEFLEX, LOTENSIN, NEURONTIN, OXYBUTYNIN. Patient recovered.

Morphine Side Effects Report #5192019-0
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Dec 20, 2006. Female patient, 54 years of age, weighting 310.0 lb, was diagnosed with pain, nausea and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: confusional state, depressed level of consciousness, hypoventilation, sedation, somnolence. MORPHINE dosage: 1 MG PCA. During the same period patient was treated with PROMETHAZINE, ULTRAM, FLEXERIL, VALIUM, SYNTHROID, NEXIUM. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5192711-8
Consumer or non-health professional from UNITED KINGDOM reported MORPHINE problem on Dec 22, 2006. Male patient, child 12 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: abdominal pain, colitis ulcerative, hypovolaemia, megacolon, pallor, rectal haemorrhage. MORPHINE dosage: unknown. During the same period patient was treated with PARACETAMOL, DICLOFENAC. Patient recovered.

Morphine Side Effects Report #5194816-4
MORPHINE problem was reported by a Consumer or non-health professional from on Dec 21, 2006. Female patient, 39 years of age, weighting 119.0 lb, was diagnosed with epidural anaesthesia and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: accidental overdose, cyanosis, electrocardiogram qt corrected interval, respiratory depression, somnolence. MORPHINE dosage: 400 MG, SINGLE. During the same period patient was treated with MORPHINE SULPHATE, BUPIVACAINE. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5195695-1
Consumer or non-health professional from UNITED STATES reported MORPHINE problem on Dec 26, 2006. Female patient, 68 years of age, weighting 110.0 lb, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: asthenia, depression, feeling abnormal. MORPHINE dosage: 100 MG, 50 MG, 25 MG. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5198442-2
MORPHINE problem was reported by a Pharmacist from UNITED STATES on Dec 28, 2006. Female patient, 65 years of age, weighting 123.5 lb, was diagnosed with arthralgia, pain, breakthrough pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: blister. MORPHINE dosage: 15 MG PO BID. During the same period patient was treated with PERCOCET, ASPIRIN, ACTOS, AMBIEN, COREG, DIALYVITE, DIOVAN. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5376311-2
Consumer or non-health professional from UNITED STATES reported MORPHINE problem on June 18, 2007. Male patient, child 4 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: status epilepticus. MORPHINE dosage: unknown. During the same period patient was treated with MIDAZOLAM, CHLORAL HYDRATE, FENTANYL. Patient recovered.

Morphine Side Effects Report #5379243-9
MORPHINE problem was reported by a Consumer or non-health professional from on July 04, 2007. Female patient was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: anaphylactoid reaction. MORPHINE dosage: 0.1 MG/KG, FOLLOWED BY ADDITIONAL 3 MG EVERY 5 MINUTES UNTIL DEFINED PAIN RELIEF (VAS SCORE {/=30/10. During the same period patient was treated with ANTIBIOTIC. Patient recovered.

Morphine Side Effects Report #5383334-6
Consumer or non-health professional from reported MORPHINE problem on July 09, 2007. Male patient was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: speech disorder, unresponsive to stimuli. MORPHINE dosage: UNK MG, UNK. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5385083-7
MORPHINE problem was reported by a Pharmacist from UNITED STATES on July 10, 2007. Female patient, 62 years of age, weighting 150.4 lb, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: pruritus. MORPHINE dosage: unknown. Patient recovered.

Morphine Side Effects Report #5385349-0
Consumer or non-health professional from reported MORPHINE problem on July 03, 2007. Male patient, 19 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: brain oedema, pulmonary oedema. MORPHINE dosage: unknown. During the same period patient was treated with DEANXIT, DIHYDROCODEINE BITARTRATE, TRUXAL, VENLAFAXINE, VALIUM, OXAZEPAM, FLUNITRAZEPAM, AMITRIPTYLINE. Patient died on 04/24/2007.

Morphine Side Effects Report #5385431-8
MORPHINE problem was reported by a Pharmacist from UNITED STATES on July 06, 2007. Male patient, 88 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: intestinal obstruction. MORPHINE dosage: 30MG TID PO. During the same period patient was treated with OXYCODONE. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5386212-1
Health Professional from UNITED STATES reported MORPHINE problem on July 10, 2007. Male patient, 39 years of age, weighting 160.0 lb, was diagnosed with osteoarthritis and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: malaise, nausea. MORPHINE dosage: 60MG 2X A DAY PO. Patient recovered.

Morphine Side Effects Report #5386540-X
MORPHINE problem was reported by a Consumer or non-health professional from UNITED STATES on June 28, 2007. Male patient, child 4 years of age, was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: status epilepticus. MORPHINE dosage: unknown. During the same period patient was treated with MIDAZOLAM, CHLORAL HYDRATE, FENTANYL TRANSDERMAL SYSTEM. Patient recovered.

Morphine Side Effects Report #5387624-2
Pharmacist from UNITED STATES reported MORPHINE problem on July 12, 2007. Male patient, 47 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: confusional state, depressed level of consciousness, sedation. MORPHINE dosage: unknown. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5388415-9
MORPHINE problem was reported by a Consumer or non-health professional from on July 03, 2007. Male patient, 64 years of age, was diagnosed with oesophageal carcinoma and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: paradoxical pain. MORPHINE dosage: 180 MG, DAILY. During the same period patient was treated with FENTANYL, DICLOFENAC, MIDAZOLAM. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5389342-3
Pharmacist from UNITED STATES reported MORPHINE problem on July 13, 2007. Male patient, 66 years of age, was diagnosed with pain and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: respiratory depression, stupor, unresponsive to stimuli. MORPHINE dosage: 4MG PRN IV. Patient was hospitalized. Patient recovered.

Morphine Side Effects Report #5393697-3
MORPHINE problem was reported by a Consumer or non-health professional from on July 11, 2007. Male patient, 69 years of age, was diagnosed with nasopharyngeal cancer and was treated with MORPHINE. After drug was administered, patient experienced the following problems/side effects: intestinal ischaemia. MORPHINE dosage: unknown. During the same period patient was treated with FLUOROURACIL, CISPLATIN. Patient died.

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Drug Information: Morphine Oral

URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682133.html

(mor' feen)

IMPORTANT WARNING:

Morphine is available as long acting capsules or tablets. These capsules or tablets contain enough morphine to relieve pain for 12 or 24 hours and are designed to release the medication slowly over that period of time. It is very important not to split, chew, or crush these tablets or capsules and not to dissolve the beads contained in the capsules in any liquid before you swallow them. This would release all of the medication into your body at once and could cause serious health problems or death.If you are taking Oramorph® SR or MS Contin® brand long-acting tablets or Avinza® or Kadian® brand long-acting capsules, you should swallow the tablets or capsules whole. If you are unable to swallow the capsules, you can carefully open a capsule, sprinkle all of the beads that it contains on a spoonful of cold or room temperature applesauce, and swallow the entire mixture immediately without chewing or crushing the beads. Then rinse your mouth with a little water and swallow the water to be sure that you have swallowed all the medication. Do not save mixtures of medication and applesauce for later.If you are taking Avinza® brand long-acting capsules, you should not drink any drinks that contain alcohol or take any prescription or non-prescription medications that contain alcohol. Ask your doctor or pharmacist or check the list of ingredients if you do not know if a medication contains alcohol. Alcohol may cause the morphine in Avinza® brand long-acting capsules to be released in your body too quickly, causing serious health problems or death.

Why is this medication prescribed?

Morphine is used to relieve moderate to severe pain. Morphine long-acting tablets and capsules are only used by patients who are expected to need medication to relieve moderate to severe pain around-the-clock for longer than a few days. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the body senses pain.

How should this medicine be used?

Morphine comes as a tablet, a solution (liquid), a controlled- or extended-release (long-acting) tablet, and a controlled- or sustained-release (long-acting) capsule all to take by mouth. The regular tablet and liquid usually are taken every 4 hours. The long acting tablet is usually taken every 8-12 hours. Kadian ^®brand long-acting capsules are usually taken with or without food every 12 hours or every 24 hours. Avinza^® brand long acting capsules are usually taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

If you are taking morphine solution, use the spoon or dropper that comes with the medication to measure your dose. Be sure that you know how many milliliters of the solution you should take. Ask your pharmacist if you have any questions about how much medication you should take or how to use the spoon or dropper.

If you are taking Kadian^® brand long-acting capsules and you have a gastrostomy tube (surgically inserted feeding tube), ask your doctor or pharmacist how to administer the medication through your tube.

Your doctor may start you on a low dose of morphine and gradually increase your dose until your pain is controlled. Your doctor may adjust your dose at any time during your treatment if your pain is not controlled. If you feel that your pain is not controlled, call your doctor. Do not change the dose of your medication without talking to your doctor.

Morphine can be habit-forming. Take morphine exactly as directed. Do not take a larger dose, take it more often, or take it for a longer period of time or in a different way than prescribed by your doctor.

Do not stop taking morphine without talking to your doctor. Your doctor may decrease your dose gradually. If you suddenly stop taking morphine, you may experience withdrawal symptoms such as anxiety; sweating; difficulty falling asleep or staying asleep; chills; shaking of a part of your body that you cannot control; upset stomach; diarrhea; runny nose, sneezing or coughing; hair on your skin standing on end; or hallucinating (seeing things or hearing voices that do not exist).

Other uses for this medicine

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking morphine,

tell your doctor and pharmacist if you are allergic to morphine, any other medications, or any of the inactive ingredients in the type of morphine tablets, capsules, or liquid you plan to take. Ask your pharmacist for a list of the inactive ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin);antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines (found in cold and allergy medications); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); buprenorphine (Subutex, in Suboxone);butorphanol (Stadol); cimetidine (Tagamet); diuretics ('water pills'); medications for anxiety, mental illness, pain, seizures, or upset stomach; muscle relaxants; nalbuphine (Nubain); pentazocine (Talwin, in Talacen); sedatives; sleeping pills; and tranquilizers. Also tell your doctor if you are taking any of the following medications or if you have stopped taking them within the past 2 weeks: monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), procarbazine (Matulane), selegiline (Eldepryl), and tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
tell your doctor if you drink or have ever drunk large amounts of alcoholand if you have ever had major surgery. Also tell your doctor if you have or have ever had a head injury; a brain tumor; seizures; mental illness; difficulty swallowing; lung disease such as asthma, chronic obstructive pulmonary disease (COPD; a group of diseases that cause gradual loss of lung function), or other breathing problems; prostatic hypertrophy (enlargement of a male reproductive gland); urinary problems; low blood pressure; irregular heartbeat; Addison's disease (condition in which the body does not make enough of certain natural substances); or liver, kidney, pancreatic, intestinal, or gallbladder disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking morphine, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking morphine.
you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
talk to your doctor about the safe use of alcohol while you are taking this medication.
you should know that morphine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

What special dietary instructions should I follow?

Drink plenty of fluids while you are taking this medication.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Morphine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

dizziness
lightheadedness
drowsiness
upset stomach
vomiting
constipation
diarrhea
loss of appetite
weight loss
changes in ability to taste food
dry mouth
sweating
weakness
headache
agitation
nervousness
mood changes
confusion
difficulty falling asleep or staying asleep
stiff muscles
shaking of a part of your body that you cannot control
double vision
red eyes
small pupils (black circles in the middle of the eyes
eye movements that you cannot control
chills
flu symptoms
decreased sexual desire or ability
difficulty urinating or pain when urinating

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

slow, shallow, or irregular breathing
blue or purple color to the skin
fast or slow heartbeat
seizures
hallucinations (seeing things or hearing voices that do not exist)
blurred vision
fainting
hives
rash
itching
tightness in the throat
difficulty swallowing
swelling of the arms, hands, feet, ankles, or lower legs

Morphine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Store morphine in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or capsules or how much liquid is left so you will know if any medication is missing.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

slow, shallow, or irregular breathing
sleepiness
loss of consciousness
limp muscles
cold, clammy skin
small pupils
slow heartbeat
blurred vision
upset stomach
fainting

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. This prescription is not refillable. If you are taking morphine to control your pain on a long term basis, be sure to schedule appointments with your doctor so that you do not run out of medication. If you are taking morphine on a short term basis, call your doctor if you continue to experience pain after you finish the medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):

Avinza®
Kadian®
MS Contin®

Oramorph® SR
Roxanol® 100
Roxanol®

Roxanol®-T

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