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Itching (34)
Jerking Movements (34)
Speech Problems (25)
Back Pain (23)
Constipation (19)
Finger Numbness (19)
Agitation (16)
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Morphine Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 4170 

Throat Tightness, Injection Site Erythema, Pharyngeal Oedema (8454689-0)
on Jun 15, 2012 Female from UNITED STATES , 36 years of age, weighting 165.0 lb, was diagnosed with
  • arthralgia
and was treated with Morphine Sulfate. Directly after, patient experienced the unwanted or unexpected Morphine side effects: throat tightness, injection site erythema, pharyngeal oedema. Morphine Sulfate dosage: 2mg Iv X 1.

Feeling Abnormal (8453045-9)
Patient was taking Morphine. Patient felt the following Morphine side effects: feeling abnormal on May 06, 2012 from Additional patient health information: Male , weighting 170.2 lb, was diagnosed with
  • back pain
  • depression
  • hepatitis c
and. Morphine dosage: N/A.
Multiple prescriptions taken:
  • Zoloft
  • Ribavirin
  • Pegasys
  • Metformin Hcl
  • Glucophage
  • Incivek
  • Uretic


Memory Impairment (8450394-5)
Adverse event was reported on Jun 14, 2012 by a Female taking Morphine Sulfate (Dosage: N/A) . Location: UNITED KINGDOM , 26 years of age, After Morphine was administered, patient encountered several Morphine side effects: memory impairment.
Multiple concurrent drugs taken:
  • Zopiclone
  • Diazepam (5 Mg, Tid)


Unresponsive To Stimuli (8449762-7)
on Jun 13, 2012 Female from UNITED STATES , 54 years of age, weighting 211.4 lb, was treated with Morphine. Directly after, patient experienced the unwanted or unexpected Morphine side effects: unresponsive to stimuli. Morphine dosage: N/A.


Completed Suicide, Toxicity To Various Agents (8449355-1)
on Jun 13, 2012 Female from UNITED STATES , 22 years of age, was treated with Morphine. Patient felt the following Morphine side effects: completed suicide, toxicity to various agents. Morphine dosage: N/A.
Multiple prescriptions taken:
  • Citalopram Hydrobromide
  • Salicylate


Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Gamma-glutamyltransferase Increased (8448705-X)
Patient was taking Morphine Sulfate. After Morphine was administered, patient encountered several Morphine side effects: aspartate aminotransferase increased, alanine aminotransferase increased, gamma-glutamyltransferase increased on Apr 30, 2012 from UNITED STATES Additional patient health information: Female , 44 years of age, weighting 134.5 lb, . Morphine Sulfate dosage: N/A.
Multiple concurrent drugs taken:
  • Lactulose
  • Vismodegib (Restarted)
  • Tramadol Hcl
  • Acetaminophen


Cardiogenic Shock (8447721-1)
Adverse event was reported on Jun 12, 2012 by a Male taking Morphine Sulfate (Dosage: 90 Milligram) . Location: GERMANY , 58 years of age, weighting 199.5 lb, Directly after, patient experienced the unwanted or unexpected Morphine side effects: cardiogenic shock.
Associated medications used:
  • Fentanyl
  • Pregabalin
  • Formoterolhemifumarat
  • Albuterol
  • Potassium Chloride
  • Certoparin
  • Cotrim
  • Bisoprolol Fumarate (5 Milligram)


Amnesia, Contusion (8446403-X)
on Feb 07, 2012 Female from UNITED STATES , weighting 280.3 lb, was diagnosed with
  • arthralgia
  • gastrooesophageal reflux disease
and was treated with Morphine Sulfate. Patient felt the following Morphine side effects: amnesia, contusion. Morphine Sulfate dosage: Qd.
Multiple prescriptions taken:
  • Dexilant (Qd)
  • Fentanyl (3-4 Lozenges Daily)
  • Prednisone (Qd)
  • Atenolol (Qd)
  • Duloxetine Hydrochloride (120 Milligram;)


Spinal Column Stenosis (8446364-3)
on Jun 14, 2012 Female from SWEDEN , 77 years of age, was treated with Morphine. After Morphine was administered, patient encountered several Morphine side effects: spinal column stenosis. Morphine dosage: N/A.
Multiple concurrent drugs taken:
  • Denosumab (1 Ml, Q6mo)
Patient was hospitalized.

Cellulitis, Full Blood Count Decreased, Diarrhoea (8446012-2)
Patient was taking Morphine Sulfate Inj. Directly after, patient experienced the unwanted or unexpected Morphine side effects: cellulitis, full blood count decreased, diarrhoea on Nov 29, 2011 from UNITED STATES Additional patient health information: Female , 52 years of age, . Morphine Sulfate Inj dosage: N/A.
Associated medications used:
  • Klor-con
  • Ritalin
  • Zanaflex
  • Revlimid (25 Mg, 1 In 1 D, Po, 15 Mg, 1 In 1 D, Po, 10 Mg, Daily For 21 Days, Po)
  • Revlimid (25 Mg, 1 In 1 D, Po, 15 Mg, 1 In 1 D, Po, 10 Mg, Daily For 21 Days, Po)
  • Revlimid (25 Mg, 1 In 1 D, Po, 15 Mg, 1 In 1 D, Po, 10 Mg, Daily For 21 Days, Po)
  • Omeprazole
  • Lasix


Blood Albumin Decreased, Blood Potassium Decreased, Peripheral Coldness, Nodal Arrhythmia, Electrocardiogram Pr Prolongation, Excessive Granulation Tissue, Blood Pressure Decreased, Blood Bicarbonate Increased, Blood Creatine Phosphokinase Decreased (8444861-8)
Adverse event was reported on Jun 12, 2012 by a Female taking Morphine (Dosage: Unk) . Location: UNITED STATES , weighting 142.0 lb, Patient felt the following Morphine side effects: blood albumin decreased, blood potassium decreased, peripheral coldness, nodal arrhythmia, electrocardiogram pr prolongation, excessive granulation tissue, blood pressure decreased, blood bicarbonate increased, blood creatine phosphokinase decreased.
Multiple prescriptions taken:
  • Ativan (1 Df, Qid)
  • Macrobid (1 Df, Bid)
  • Gilenya (0.5 Mg, Qd)
  • Atenolol (25 Mg, Qd)
  • Omeprazole (20 Mg, Qd)
  • Propafenone Hcl (1 Df, Bid)
  • Celexa (40 Mg, Qd)
  • Naproxen (500 Mg, Qd)
Patient was hospitalized.

Skin Disorder (8444300-7)
on Jun 12, 2012 Female from UNITED STATES , weighting 170.0 lb, was diagnosed with
  • pain
  • infection
  • chronic fatigue syndrome
and was treated with Morphine. After Morphine was administered, patient encountered several Morphine side effects: skin disorder. Morphine dosage: 120 Mg Two Times A Day And 15 Mg Daily.
Multiple concurrent drugs taken:
  • Keflex (500 Mg, 4x/day)
  • Adderall 5 (40 Mg, Daily)
  • Effexor Xr (300 Mg, Daily)
  • Effexor Xr (Unk)
  • Norco (20/650 Mg, 3x/day)
  • Doxepin (100 Mg, Daily)


Cerebral Haemorrhage, Dyspnoea (8442985-2)
on Jun 08, 2012 Female from GERMANY , 81 years of age, was treated with Morphine. Directly after, patient experienced the unwanted or unexpected Morphine side effects: cerebral haemorrhage, dyspnoea. Morphine dosage: N/A.
Associated medications used:
  • Forteo (Unk, Qd)


Biliary Dyskinesia, Gallbladder Injury, Emotional Distress, Anxiety, Pain (8441461-0)
Patient was taking Morphine. Patient felt the following Morphine side effects: biliary dyskinesia, gallbladder injury, emotional distress, anxiety, pain on Jun 06, 2012 from UNITED STATES Additional patient health information: Female , 13 years of age, weighting 280.0 lb, . Morphine dosage: 4 Mg, Unk.
Multiple prescriptions taken:
  • A/b Otic (54-14mg/ml)
  • Zofran (4 Mg, Unk)
  • Percocet (5-325mg)
  • Amoxicillin (875 Mg, Unk)
  • Zoloft (50 Mg, Unk)
  • Phenergan (25 Mg, Unk)
  • Yasmin
  • Naproxen (aleve) (220 Mg, Unk)
Patient was hospitalized.

Cardio-respiratory Arrest, Hypoxic-ischaemic Encephalopathy, Shock Haemorrhagic, Convulsion, Cognitive Disorder, Overdose (8440226-3)
Adverse event was reported on Jun 08, 2012 by a Male taking Morphine Sulfate (Dosage: N/A) was diagnosed with
  • sciatica
and. Location: FRANCE , weighting 260.1 lb, After Morphine was administered, patient encountered several Morphine side effects: cardio-respiratory arrest, hypoxic-ischaemic encephalopathy, shock haemorrhagic, convulsion, cognitive disorder, overdose.
Multiple concurrent drugs taken:
  • Tamsulosin Hcl
  • Ranibizumab (Dose: 10 Mg/ml)
  • Tiotropium Bromide
  • Insulin
  • Atorvastatin Calcium
  • Ranibizumab (Dose: 10 Mg/ml, Last Dose Prior To Sae: 18/aug/2011)
  • Bisoprolol Fumarate
  • Albuterol
Patient was hospitalized and became disabled.

Dyspnoea, Upper Respiratory Tract Infection, Abdominal Pain Upper, Chest Pain, Heart Rate Irregular, Chronic Obstructive Pulmonary Disease (8440069-0)
on Jun 05, 2012 Female from UNITED STATES , 67 years of age, was diagnosed with
  • pain
  • gastrooesophageal reflux disease
  • diarrhoea
  • nausea
and was treated with Morphine. Directly after, patient experienced the unwanted or unexpected Morphine side effects: dyspnoea, upper respiratory tract infection, abdominal pain upper, chest pain, heart rate irregular, chronic obstructive pulmonary disease. Morphine dosage: N/A.
Associated medications used:
  • Omeprazole
  • Diphen Atrop (As Required)
  • Zofran
  • Multi-vitamin (Daily)
  • Prednisone Tab (Daily, Currently On Taper)
  • Lidoderm (Patch Applied To Abdomen)
  • Lovoxyl (Daily)
  • Mupirocin
Patient was hospitalized.

Respiratory Depression, Substance Abuse (8439628-0)
on Jun 07, 2012 Male from AUSTRALIA , 41 years of age, was treated with Morphine Sulfate. Patient felt the following Morphine side effects: respiratory depression, substance abuse. Morphine Sulfate dosage: Unk.
Multiple prescriptions taken:
  • Ethanol


Sedation, Dysarthria, Toxicity To Various Agents, Pneumonia Aspiration, Respiratory Depression (8439460-8)
Patient was taking Morphine Sulfate. After Morphine was administered, patient encountered several Morphine side effects: sedation, dysarthria, toxicity to various agents, pneumonia aspiration, respiratory depression on Jun 01, 2012 from KOREA, REPUBLIC OF Additional patient health information: Male , 46 years of age, . Morphine Sulfate dosage: 4.0 Ml, Prn. Patient was hospitalized.

Myoclonus (8439411-6)
Adverse event was reported on Jun 01, 2012 by a Female taking Morphine Sulfate (Dosage: 0.4 Ml/hr, Unk) was diagnosed with
  • pain
and. Location: KOREA, REPUBLIC OF , 61 years of age, Directly after, patient experienced the unwanted or unexpected Morphine side effects: myoclonus.
Associated medications used:
  • Famvir /01226201/ (250 Mg, Tid)
  • Ultracet (Unk, Daily)


Fatigue, Intestinal Perforation, Arthralgia, Abdominal Pain Upper, Intestinal Haemorrhage, Colitis Ulcerative, Somnolence (8435565-6)
on Jun 07, 2012 Male from SWEDEN , 25 years of age, was diagnosed with
  • pain
and was treated with Morphine. Patient felt the following Morphine side effects: fatigue, intestinal perforation, arthralgia, abdominal pain upper, intestinal haemorrhage, colitis ulcerative, somnolence. Morphine dosage: Unk.
Multiple prescriptions taken:
  • Refacto (3000 Iu, Unk)


Off Label Use (8434837-9)
on Jun 06, 2012 Female from UNITED STATES , 95 years of age, was treated with Morphine. After Morphine was administered, patient encountered several Morphine side effects: off label use. Morphine dosage: N/A.
Multiple concurrent drugs taken:
  • Benadryl


Sedation (8430458-2)
Patient was taking Morphine. Directly after, patient experienced the unwanted or unexpected Morphine side effects: sedation on Jun 06, 2012 from UNITED STATES Additional patient health information: Male , 54 years of age, weighting 165.8 lb, . Morphine dosage: Mg Po.
Associated medications used:
  • Lorazepam (0.5 Mg Bid Po)


Secondary Hypogonadism, Amenorrhoea (8428821-9)
Adverse event was reported on May 21, 2012 by a Female taking Morphine Sulfate Inj (Dosage: 110 Mg, Bid) was diagnosed with
  • musculoskeletal pain
and. Location: , 37 years of age, Patient felt the following Morphine side effects: secondary hypogonadism, amenorrhoea.

Pulmonary Embolism, Post Procedural Complication (8428809-8)
on May 23, 2012 Male from CANADA , 63 years of age, was treated with Morphine Sulfate. After Morphine was administered, patient encountered several Morphine side effects: pulmonary embolism, post procedural complication. Morphine Sulfate dosage: N/A.
Multiple concurrent drugs taken:
  • Ferrous Fumarate
  • Docusate Sodium
  • Gabapentin
  • Hydrochlorothiazide
  • Levothyroxine Sodium
  • Acetaminophen
  • Cefazolin
  • Warfarin Sodium (5 Mg, Qd, Po)


Nausea, Dehydration, Vomiting (8426433-4)
on Jun 05, 2012 Female from FRANCE , 61 years of age, was treated with Morphine Sulfate. Directly after, patient experienced the unwanted or unexpected Morphine side effects: nausea, dehydration, vomiting. Morphine Sulfate dosage: N/A.
Associated medications used:
  • Sutent (50 Mg, 1x/day)
  • Zometa
  • Sutent (Unk)
  • Sutent (Unk)
Patient was hospitalized.

Showing 1-25 of 4170 

Morphine Health Episodes

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It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Morphine Information

Alternative MORPHINE Names:ASTRAMORPH AVINZA DURAMORPH EMBEDA INFUMORPH 200 INFUMORPH 500 KADIAN KADIAN ER MORPHINUM MORPHINUM MURIATICU MS CONTIN OPIUM TINCTURE (DEO OPIUM TINCTURE DEOD

Active Ingredient: MORPHINE

More About Morphine

Side Effects reported to FDA: 4170. View Morphine Adverse Reports

Morphine safety alerts: 2012 2011 2008 2005 2003

Reported deaths: 663

Reported hospitalizations: 1019

Morphine Sulfate Injection USP, 4 mg/mL (C-II), 1 mL fill in 2.5 mL Carpuject by Hospira, Inc: Recall - May Contain More Than Intended Fill Volume

 

[Posted 04/18/2012]

AUDIENCE: Risk Manager, Pain Management

ISSUE: Customer report of two Carpujects syringes containing more than the 1 mL labeled fill volume. Opioid pain medications such as morphine have life-threatening consequences if overdosed. Those consequences can include respiratory depression (slowed breathing or suspension of breathing), and low blood pressure.

BACKGROUND: The affected product is a prefilled glass cartridge for use with the Carpuject Syringe system. The affected lot number is 10830LL, with an expiration date of April 1, 2013. Morphine Sulfate Carpujects 4 mg/mL are packaged in Slim-Pak tamper detection packages with each box containing 10 Carpujects (NDC 0409-1258-30). 

The affected lot was distributed in January 2012. It was initially distributed to wholesalers and a limited number of hospitals in Arizona, Colorado, Hawaii, Illinois, Indiana, Michigan, Minnesota, Ohio, Texas and Virginia. 

RECOMMENDATION: Anyone with an existing inventory of affected product should stop use and distribution and quarantine the product immediately and call Stericycle at 1-888-912-7088 to arrange for the return of the product.

Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

  • Complete and submit the report Online: www.fda.gov/MedWatch/report.htm
  • Download form or call 1-800-332-1088 to request a reporting form, then complete and return to the address on the pre-addressed form, or submit by fax to 1-800-FDA-0178


[04/17/2012 - Press Release - Hospira, Inc]
 

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